{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:43:55Z","timestamp":1740145435265,"version":"3.37.3"},"reference-count":23,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","revespcardiol.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.rec.2015.04.011","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T09:55:02Z","timestamp":1436781302000},"page":"743-745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recreating the Sinus Node by Somatic Reprogramming: A Dream Come True?"],"prefix":"10.1016","volume":"68","author":[{"given":"Eugenio","family":"Cingolani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Marb\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rec.2015.04.011_bib0120","first-page":"643","article-title":"A transistorized, self-contained, implantable pacemaker for the long-term correction of complete heart block","volume":"48","author":"Chardack","year":"1960","journal-title":"Surgery."},{"key":"10.1016\/j.rec.2015.04.011_bib0125","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1161\/CIR.0b013e3182618569","volume":"126","author":"Tracy","year":"2012","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.04.011_bib0130","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.hrthm.2007.10.017","article-title":"How to prevent, recognize, and manage complications of lead extraction. Part II: avoiding lead extraction-noninfectious issues","volume":"5","author":"Henrikson","year":"2008","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.rec.2015.04.011_bib0135","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ahj.2003.06.005","article-title":"Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999","volume":"147","author":"Cabell","year":"2004","journal-title":"Am Heart J."},{"key":"10.1016\/j.rec.2015.04.011_bib0140","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1001\/archinternmed.2011.441","article-title":"Mortality and cost associated with cardiovascular implantable electronic device infections","volume":"171","author":"Sohail","year":"2011","journal-title":"Arch Intern Med."},{"key":"10.1016\/j.rec.2015.04.011_bib0145","first-page":"417","article-title":"Anticuerpos anti-Ro\/SSA y bloqueo cardiaco cong\u00e9nito","volume":"80","author":"Barrios Prieto","year":"2012","journal-title":"Ginecol Obstet Mex."},{"key":"10.1016\/j.rec.2015.04.011_bib0150","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/ar3787","article-title":"Congenital heart block: evidence for a pathogenic role of maternal autoantibodies","volume":"14","author":"Ambrosi","year":"2012","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.rec.2015.04.011_bib0155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11517-007-0165-2","article-title":"Creation of a biological pacemaker by gene- or cell-based approaches","volume":"45","author":"Marb\u00e1n","year":"2007","journal-title":"Med Biol Eng Comput."},{"issue":"6 Suppl","key":"10.1016\/j.rec.2015.04.011_bib0160","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1016\/j.jelectrocard.2007.05.028","article-title":"Conference report: building a biologic pacemaker","volume":"40","author":"Rosen","year":"2007","journal-title":"J Electrocardiol."},{"key":"10.1016\/j.rec.2015.04.011_bib0165","unstructured":"Briggs H. \u2018Biological pacemaker\u2019 tested in lab. BBC Health News (2014). [cited 20 Abr 2015]. Available at: http:\/\/www.bbc.com\/news\/health-28325370"},{"key":"10.1016\/j.rec.2015.04.011_bib0170","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1056\/NEJMcibr1408897","article-title":"Gene therapy and biological pacing","volume":"371","author":"Rosen","year":"2014","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2015.04.011_bib0175","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.109.212936","article-title":"Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices?","volume":"106","author":"Cho","year":"2010","journal-title":"Circ Res."},{"key":"10.1016\/j.rec.2015.04.011_bib0180","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nbt.2465","article-title":"Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18","volume":"31","author":"Kapoor","year":"2013","journal-title":"Nat Biotechnol."},{"key":"10.1016\/j.rec.2015.04.011_bib0185","doi-asserted-by":"crossref","first-page":"245ra94","DOI":"10.1126\/scitranslmed.3008681","article-title":"Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block","volume":"6","author":"Hu","year":"2014","journal-title":"Sci Transl Med."},{"key":"10.1016\/j.rec.2015.04.011_bib0190","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1517\/14712598.5.12.1531","article-title":"Stem cells as biological heart pacemakers","volume":"5","author":"Gepstein","year":"2005","journal-title":"Expert Opin Biol Ther."},{"key":"10.1016\/j.rec.2015.04.011_bib0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.CIR.0000151313.18547.A2","article-title":"Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers","volume":"111","author":"Xue","year":"2005","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.04.011_bib0200","doi-asserted-by":"crossref","unstructured":"Cingolani E. Biological pacemakers: ready for the clinic? Trends Cardiovasc Med. 2015. Available at: http:\/\/dx.doi.org\/10.1016\/j.tcm.2015.03.003.","DOI":"10.1016\/j.tcm.2015.03.003"},{"key":"10.1016\/j.rec.2015.04.011_bib0205","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/419132b","article-title":"Biological pacemaker created by gene transfer","volume":"419","author":"Miake","year":"2002","journal-title":"Nature."},{"key":"10.1016\/j.rec.2015.04.011_bib0210","doi-asserted-by":"crossref","unstructured":"Boink GJ, Christoffels VM, Robinson RB, Tan HL. The past, present, and future of pacemaker therapies. Trends Cardiovasc Med. 2015. Available at: http:\/\/dx.doi.org\/10.1016\/j.tcm.2015.02.005.","DOI":"10.1016\/j.tcm.2015.02.005"},{"key":"10.1016\/j.rec.2015.04.011_bib0215","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.hrthm.2012.04.020","article-title":"Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block","volume":"9","author":"Cingolani","year":"2012","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.rec.2015.04.011_bib0220","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1161\/01.CIR.0000070596.30552.8B","article-title":"Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure","volume":"107","author":"Perin","year":"2003","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.04.011_bib0225","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/CIRCULATIONAHA.106.617613","article-title":"Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker","volume":"114","author":"Bucchi","year":"2006","journal-title":"Circulation."},{"year":"1944","series-title":"Ficciones","author":"Borges","key":"10.1016\/j.rec.2015.04.011_bib0230"}],"container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585715002182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585715002182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T20:23:40Z","timestamp":1537475020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1885585715002182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1885585715002182"],"URL":"https:\/\/doi.org\/10.1016\/j.rec.2015.04.011","relation":{},"ISSN":["1885-5857"],"issn-type":[{"type":"print","value":"1885-5857"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recreating the Sinus Node by Somatic Reprogramming: A Dream Come True?","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2015.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.recesp.2015.04.011","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Sociedad Espa\u00f1ola de Cardiolog\u00eda. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}