{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:53:13Z","timestamp":1755600793750},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","revespcardiol.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.rec.2015.06.025","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T23:10:18Z","timestamp":1445901018000},"page":"149-158","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and Prognostic Profiles of Cardiomyopathies Caused by Mutations in the Troponin T Gene"],"prefix":"10.1016","volume":"69","author":[{"given":"Tom\u00e1s","family":"Ripoll-Vera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"G\u00e1mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Govea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Soc\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Escandell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Rosell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rec.2015.06.025_bib0145","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4144 subjects in the CARDIA study: Coronary Artery Risk Development in (Young) Adults","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.06.025_bib0150","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1001\/jama.296.13.1593","article-title":"Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program","volume":"296","author":"Corrado","year":"2006","journal-title":"JAMA."},{"key":"10.1016\/j.rec.2015.06.025_bib0155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0002-9149(87)90998-2","article-title":"Occurrence and significance of progressive left ventricular wall thinning and relative cavity dilatation in hypertrophic cardiomyopathy","volume":"60","author":"Spirito","year":"1987","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0160","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.jacc.2005.04.062","article-title":"Dilated-hypokinetic evolution of hypertrophic cardiomyopathy: prevalence, incidence, risk factors, and prognostic implications in pediatric and adult patients","volume":"46","author":"Biagini","year":"2005","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0165","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/S0735-1097(02)01900-9","article-title":"Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: a comprehensive outpatient perspective","volume":"39","author":"Ackerman","year":"2002","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/hrt.82.5.621","article-title":"A new mutation of the cardiac troponin T gene causing familial hypertrophic cardiomyopathy without left ventricular hypertrophy","volume":"82","author":"Varnava","year":"1999","journal-title":"Heart."},{"key":"10.1016\/j.rec.2015.06.025_bib0175","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1136\/hrt.2005.068577","article-title":"Historical trends in reported survival rates in patients with hypertrophic cardiomyopathy","volume":"92","author":"Elliott","year":"2006","journal-title":"Heart."},{"key":"10.1016\/j.rec.2015.06.025_bib0180","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1161\/01.CIR.0000042675.59901.14","article-title":"Prevalence and severity of \u00abbenign\u00bb mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy","volume":"106","author":"Van Driest","year":"2002","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.06.025_bib0185","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM199504203321603","article-title":"Mutations in the genes for cardiac troponin T and \u03b1-tropomyosin in hypertrophic cardiomyopathy","volume":"332","author":"Watkins","year":"1995","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2015.06.025_bib0190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0735-1097(96)00530-X","article-title":"Sudden death due to troponin T mutations","volume":"29","author":"Moolman","year":"1997","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0195","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1056\/NEJM200006153422403","article-title":"Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy","volume":"342","author":"Spirito","year":"2000","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2015.06.025_bib0200","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJM198609043151003","article-title":"Development and progression of left ventricular hypertrophy in children with hypertrophic cardiomyopathy","volume":"315","author":"Maron","year":"1986","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2015.06.025_bib0205","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0735-1097(83)80269-1","article-title":"Distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: a two-dimensional echocardiographic study","volume":"2","author":"Shapiro","year":"1983","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0210","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/hrt.77.2.130","article-title":"Experience from clinical genetics in hypertrophic cardiomyopathy: proposal for new diagnostic criteria in adult members of affected families","volume":"77","author":"McKenna","year":"1997","journal-title":"Heart."},{"key":"10.1016\/j.rec.2015.06.025_bib0215","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0735-1097(03)00827-1","article-title":"Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy: an independent marker of sudden death risk in young patients","volume":"42","author":"Monserrat","year":"2003","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0220","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0735-1097(03)00941-0","volume":"42","author":"Maron","year":"2003","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0225","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.CIR.98.5.391","article-title":"Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis","volume":"98","author":"Anan","year":"1998","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.06.025_bib0230","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.amjcard.2003.08.031","article-title":"Prevalence and clinical profile of troponin T mutations among patients with hypertrophic cardiomyopathy in Tuscany","volume":"92","author":"Torricelli","year":"2003","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0235","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/01.CIR.0000080896.52003.DF","article-title":"Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy","volume":"108","author":"Van Driest","year":"2003","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.06.025_bib0240","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1136\/jmg.40.5.e59","article-title":"Comparison of fluorescent SSCP and denaturing HPLC analysis with direct sequencing for mutation screening in hypertrophic cardiomyopathy","volume":"40","author":"Mogensen","year":"2003","journal-title":"J Med Genet."},{"key":"10.1016\/j.rec.2015.06.025_bib0245","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1161\/01.CIR.94.12.3069","article-title":"Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy","volume":"94","author":"Forissier","year":"1996","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2015.06.025_bib0250","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1006\/jmcc.1996.0322","article-title":"Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy","volume":"29","author":"Nakajima-Taniguchi","year":"1997","journal-title":"J Mol Cell Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0255","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCGENETICS.111.959973","article-title":"Long-term outcomes in hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene","volume":"5","author":"Pasquale","year":"2012","journal-title":"Circ Cardiovasc Genet."},{"key":"10.1016\/j.rec.2015.06.025_bib0260","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/S0300-8932(09)73136-7","article-title":"Miocardiopat\u00eda hipertr\u00f3fica. Estudio del gen de la troponina T en 127 familias espa\u00f1olas","volume":"62","author":"Gimeno","year":"2009","journal-title":"Rev Esp Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0265","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.amjcard.2004.03.077","article-title":"Clinical features of hypertrophic cardiomyopathy caused by an Arg278Cys missense mutation in the cardiac troponin T gene","volume":"94","author":"Theopistou","year":"2004","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0270","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0025-6196(11)60890-2","article-title":"Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy","volume":"83","author":"Olivotto","year":"2008","journal-title":"Mayo ClinProc."},{"key":"10.1016\/j.rec.2015.06.025_bib0275","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0300-8932(09)70020-X","article-title":"Espectro mutacional de los genes sarcom\u00e9ricos MYH7, MYBPC3, TNNT2, TNNI3 y TPM1 en pacientes con miocardiopat\u00eda hipertr\u00f3fica","volume":"62","author":"Garc\u00eda-Castro","year":"2009","journal-title":"Rev Esp Cardiol."},{"key":"10.1016\/j.rec.2015.06.025_bib0280","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejmg.2010.07.007","article-title":"Prevalence and spectrum of mutations in a cohort of 192 unrelated patients with hypertrophic cardiomyopathy","volume":"53","author":"Millat","year":"2010","journal-title":"Eur J Med Genet."}],"container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585715003412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585715003412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T07:28:37Z","timestamp":1537255717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1885585715003412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1885585715003412"],"URL":"https:\/\/doi.org\/10.1016\/j.rec.2015.06.025","relation":{},"ISSN":["1885-5857"],"issn-type":[{"value":"1885-5857","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Prognostic Profiles of Cardiomyopathies Caused by Mutations in the Troponin T Gene","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2015.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.recesp.2015.06.028","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Sociedad Espa\u00f1ola de Cardiolog\u00eda. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}