{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:25:16Z","timestamp":1761060316929},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","revespcardiol.org","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.rec.2017.02.028","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T09:19:09Z","timestamp":1490174349000},"page":"1067-1073","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design"],"prefix":"10.1016","volume":"70","author":[{"given":"Sergio","family":"Garc\u00eda-Blas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Bonanad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Ll\u00e0cer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Chamorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"F\u00e1cila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana Mar\u00eda","family":"Vaquer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cordero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Roqu\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Racugno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicent","family":"Bod\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Valero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Santas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Carmen","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Mi\u00f1ana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Carratal\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Bondanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Pay\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Cardells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Heredia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Pellicer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Valls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Palau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Raso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Bertomeu-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Bertomeu-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Montagud-Balaguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Albiach-Monta\u00f1ana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jezabel","family":"Pend\u00e1s-Meneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goitzane","family":"Marcaida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Cervantes-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"San Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"de Mingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Chorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rec.2017.02.028_bib0165","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cardfail.2007.03.011","article-title":"High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: a report from the ADHERE database","volume":"13","author":"Heywood","year":"2007","journal-title":"J Card Fail."},{"key":"10.1016\/j.rec.2017.02.028_bib0170","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/archinte.167.14.1493","article-title":"Influence of a performance improvement initiative on quality of care for patients hospitalized with heart failure: results of the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)","volume":"167","author":"Fonarow","year":"2007","journal-title":"Arch Intern Med."},{"key":"10.1016\/j.rec.2017.02.028_bib0175","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.recesp.2014.10.016","article-title":"Cardiorenal Syndrome in Acute Heart Failure: Revisiting Paradigms","volume":"68","author":"N\u00fa\u00f1ez","year":"2015","journal-title":"Rev Esp Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0180","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.amjcard.2010.01.361","article-title":"Long-term outcomes of Medicare beneficiaries with worsening renal function during hospitalization for heart failure","volume":"105","author":"Kociol","year":"2010","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0185","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.cardfail.2007.04.008","article-title":"Worsening renal function and prognosis in heart failure: systematic review and meta-analysis","volume":"13","author":"Damman","year":"2007","journal-title":"J Card Fail."},{"key":"10.1016\/j.rec.2017.02.028_bib0190","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jacc.2007.09.043","article-title":"Elevated intra-abdominal pressure in acute decompensated heart failure: a potential contributor to worsening renal function?","volume":"51","author":"Mullens","year":"2008","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0195","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jacc.2008.08.080","article-title":"Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease","volume":"53","author":"Damman","year":"2009","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0200","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jacc.2008.05.068","article-title":"Importance of venous congestion for worsening of renal function in advanced decompensated heart failure","volume":"53","author":"Mullens","year":"2009","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/clc.20831","article-title":"Renal dysfunction in heart failure is due to congestion but not low output","volume":"34","author":"Guglin","year":"2011","journal-title":"Clin Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0210","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/eurheartj\/ehq142","article-title":"Improvement in risk stratification with the combination of the tumor marker antigen carbohydrate 125 and brain natriuretic peptide in patients with acute heart failure","volume":"31","author":"N\u00fa\u00f1ez","year":"2010","journal-title":"Eur Heart J."},{"key":"10.1016\/j.rec.2017.02.028_bib0215","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ijcard.2008.11.023","article-title":"Prognostic value of CA125 in advanced heart failure patients","volume":"140","author":"Monteiro","year":"2010","journal-title":"Int J Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0220","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/S0735-1097(03)00311-5","article-title":"Serum levels of carbohydrate antigen 125 in patients with chronic heart failure: relation to clinical severity, hemodynamic and Doppler echocardiographic abnormalities, and short-term prognosis","volume":"41","author":"D\u2019Aloia","year":"2003","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0225","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejheart.2004.07.015","article-title":"The significance of CA125 levels in patients with chronic congestive heart failure. Correlation with clinical and echocardiographic parameters","volume":"7","author":"Kouris","year":"2005","journal-title":"Eur J Heart Fail."},{"key":"10.1016\/j.rec.2017.02.028_bib0230","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1136\/hrt.2006.096016","article-title":"Carbohydrate antigen 125: an emerging prognostic risk factor in acute heart failure?","volume":"93","author":"N\u00fa\u00f1ez","year":"2007","journal-title":"Heart."},{"key":"10.1016\/j.rec.2017.02.028_bib0235","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10741-013-9402-y","article-title":"Clinical utility of antigen carbohydrate 125 in heart failure","volume":"19","author":"N\u00fa\u00f1ez","year":"2014","journal-title":"Heart Fail Rev."},{"key":"10.1016\/j.rec.2017.02.028_bib0240","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jchf.2016.06.007","article-title":"Carbohydrate Antigen 125-Guided Therapy in Acute Heart Failure: CHANCE-HF: A Randomized Study","volume":"4","author":"N\u00fa\u00f1ez","year":"2016","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.rec.2017.02.028_bib0245","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/eurjhf\/hfs105","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012","volume":"14","author":"McMurray","year":"2012","journal-title":"Eur J Heart Fail."},{"key":"10.1016\/j.rec.2017.02.028_bib0250","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J."},{"key":"10.1016\/j.rec.2017.02.028_bib0255","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ijcard.2014.04.113","article-title":"Antigen carbohydrate 125 and creatinine on admission for prediction of renal function response following loop diuretic administration in acute heart failure","volume":"174","author":"N\u00fa\u00f1ez","year":"2014","journal-title":"Int J Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0260","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.jacc.2016.02.058","article-title":"Reduced Cardiac Index Is Not the Dominant Driver of Renal Dysfunction in Heart Failure","volume":"67","author":"Hanberg","year":"2016","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0265","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.jacc.2010.10.065","article-title":"Volume status and diuretic therapy in systolic heart failure and the detection of early abnormalities in renal and tubular function","volume":"57","author":"Damman","year":"2011","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0270","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10741-012-9354-7","article-title":"Efficacy and safety of loop diuretic therapy in acute decompensated heart failure: a clinical review","volume":"19","author":"Leto","year":"2014","journal-title":"Heart Fail Rev."},{"key":"10.1016\/j.rec.2017.02.028_bib0275","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1016\/j.jacc.2010.11.062","article-title":"Diuretics: are our ideas based on knowledge?","volume":"57","author":"Gottlieb","year":"2011","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0280","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/eurjhf\/hfq045","article-title":"Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine","volume":"12","author":"Gheorghiade","year":"2010","journal-title":"Eur J Heart Fail."},{"key":"10.1016\/j.rec.2017.02.028_bib0285","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1005419","article-title":"Diuretic strategies in patients with acute decompensated heart failure","volume":"364","author":"Felker","year":"2011","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2017.02.028_bib0290","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/eurjhf\/hfq100","article-title":"Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure","volume":"12","author":"Bonfils","year":"2010","journal-title":"Eur J Heart Fail."},{"key":"10.1016\/j.rec.2017.02.028_bib0295","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.medcli.2011.05.029","article-title":"Carbohydrate antigen 125 serial measurements after an admission for acute heart failure and risk of early readmission","volume":"139","author":"Mi\u00f1ana Escriv\u00e1","year":"2012","journal-title":"Med Clin (Barc)."},{"key":"10.1016\/j.rec.2017.02.028_bib0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijcard.2011.02.001","article-title":"CA125 and BNP serial measurements for risk stratification following an episode of acute heart failure","volume":"159","author":"N\u00fa\u00f1ez","year":"2012","journal-title":"Int J Cardiol."},{"key":"10.1016\/j.rec.2017.02.028_bib0305","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/clinchem\/45.10.1695","article-title":"Kinetics of serum tumor marker concentrations and usefulness in clinical monitoring","volume":"45","author":"Bidart","year":"1999","journal-title":"Clin Chem."},{"key":"10.1016\/j.rec.2017.02.028_bib0310","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jcin.2013.02.006","article-title":"Tumor marker carbohydrate antigen 125 predicts adverse outcome after transcatheter aortic valve implantation","volume":"6","author":"Husser","year":"2013","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2017.02.028_bib0315","article-title":"Long-term serial kinetics of N-terminal pro B-type natriuretic peptide and carbohydrate antigen 125 for mortality risk prediction following acute heart failure","author":"N\u00fa\u00f1ez","year":"2016","journal-title":"Eur Heart J Acute Cardiovasc Care."},{"key":"10.1016\/j.rec.2017.02.028_bib0320","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/eurjhf\/hfs090","article-title":"Differential mortality association of loop diuretic dosage according to blood urea nitrogen and carbohydrate antigen 125 following a hospitalization for acute heart failure","volume":"14","author":"N\u00fa\u00f1ez","year":"2012","journal-title":"Eur J Heart Fail."}],"container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585717300993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585717300993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T06:46:07Z","timestamp":1601793967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1885585717300993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1885585717300993"],"URL":"https:\/\/doi.org\/10.1016\/j.rec.2017.02.028","relation":{},"ISSN":["1885-5857"],"issn-type":[{"value":"1885-5857","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2017.02.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Sociedad Espa\u00f1ola de Cardiolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}