{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:54:54Z","timestamp":1790704494421,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008052","name":"Fundaci\u00f3n Alfonso Mart\u00edn Escudero","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","revespcardiol.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.rec.2019.07.003","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T08:10:55Z","timestamp":1569917455000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcatheter closure of patent foramen ovale in patients older than 60 years of age with cryptogenic embolism"],"prefix":"10.1016","volume":"73","author":[{"given":"J\u00e9r\u00f4me","family":"Wintzer-Wehekind","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Alperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Houde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"del Val","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rec.2019.07.003_bib0130","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1705915","article-title":"Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke","volume":"377","author":"Mas","year":"2017","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2019.07.003_bib0135","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1707404","article-title":"Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke","volume":"377","author":"S\u00f8ndergaard","year":"2017","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2019.07.003_bib0140","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.jacc.2018.02.046","article-title":"Cryptogenic Stroke and High-Risk Patent Foramen Ovale: The DEFENSE-PFO Trial","volume":"71","author":"Lee","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2019.07.003_bib0145","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJMoa1610057","article-title":"Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke","volume":"377","author":"Saver","year":"2017","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2019.07.003_bib0150","first-page":"7","article-title":"Closure, Anticoagulation, or Antiplatelet Therapy for Cryptogenic Stroke With Patent Foramen Ovale: Systematic Review of Randomized Trials, Sequential Meta-Analysis, and New Insights From the CLOSE Study","author":"Turc","year":"2018","journal-title":"J Am Heart Assoc."},{"key":"10.1016\/j.rec.2019.07.003_bib0155","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.jcin.2017.09.002","article-title":"Transcatheter Patent Foramen Ovale Closure After Cryptogenic Stroke: An Updated Meta-Analysis of Randomized Trials","volume":"10","author":"Mojadidi","year":"2017","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2019.07.003_bib0160","article-title":"European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism","author":"Pristipino","year":"2018","journal-title":"Eur Heart J."},{"key":"10.1016\/j.rec.2019.07.003_bib0165","doi-asserted-by":"crossref","first-page":"k2515","DOI":"10.1136\/bmj.k2515","article-title":"Patent foramen ovale closure, antiplatelet therapy or anticoagulation therapy alone for management of cryptogenic stroke?. A clinical practice guideline","volume":"362","author":"Kuijpers","year":"2018","journal-title":"BMJ."},{"key":"10.1016\/j.rec.2019.07.003_bib0170","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/1747493017751243","article-title":"Closure of patent foramen ovale in \u201ccryptogenic\u201d stroke: Has the story come to an end?","volume":"13","author":"Mas","year":"2018","journal-title":"Int J Stroke."},{"key":"10.1016\/j.rec.2019.07.003_bib0175","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1056\/NEJMoa071422","article-title":"Patent foramen ovale and cryptogenic stroke in older patients","volume":"357","author":"Handke","year":"2007","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2019.07.003_bib0180","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1055\/s-0029-1234146","article-title":"Patent foramen ovale and cryptogenic stroke: a matter of age?","volume":"35","author":"Handke","year":"2009","journal-title":"Semin Thromb Hemost."},{"key":"10.1016\/j.rec.2019.07.003_bib0185","first-page":"124","article-title":"Long-term follow-up after PFO device closure: Outcomes and Complications in a Single-center Experience","volume":"89","author":"Taggart","year":"2017","journal-title":"Catheter Cardiovasc Interv."},{"key":"10.1016\/j.rec.2019.07.003_bib0190","first-page":"136","article-title":"Transcatheter closure of patent foramen ovale in older adults","volume":"68","author":"Kiblawi","year":"2006","journal-title":"Catheter Cardiovasc Interv."},{"key":"10.1016\/j.rec.2019.07.003_bib0195","first-page":"966","article-title":"Recurrent events following patent foramen ovale closure in patients above 55 years of age with presumed paradoxical embolism","volume":"72","author":"Spies","year":"2008","journal-title":"Catheter Cardiovasc Interv."},{"key":"10.1016\/j.rec.2019.07.003_bib0200","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jcin.2008.09.013","article-title":"Late results after percutaneous closure of patent foramen ovale for secondary prevention of paradoxical embolism using the amplatzer PFO occluder without intraprocedural echocardiography: effect of device size","volume":"2","author":"Wahl","year":"2009","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2019.07.003_bib0205","first-page":"508","article-title":"Recurrent cerebral ischemia after patent foramen ovale percutaneous closure in older patients: A two-center registry study","volume":"87","author":"Scacciatella","year":"2016","journal-title":"Catheter Cardiovasc Interv."},{"key":"10.1016\/j.rec.2019.07.003_bib0210","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1067\/mje.2002.116718","article-title":"Interobserver and intraobserver variability in detection of patent foramen ovale and atrial septal aneurysm with transesophageal echocardiography","volume":"15","author":"Cabanes","year":"2002","journal-title":"J Am Soc Echocardiogr."},{"key":"10.1016\/j.rec.2019.07.003_bib0215","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke."},{"key":"10.1016\/j.rec.2019.07.003_bib0220","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2019.07.003_bib0225","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1212\/WNL.0b013e3182a08d59","article-title":"An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke","volume":"81","author":"Kent","year":"2013","journal-title":"Neurology."},{"key":"10.1016\/j.rec.2019.07.003_bib0230","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1161\/STROKEAHA.117.018501","article-title":"Safety Outcomes After Percutaneous Transcatheter Closure of Patent Foramen Ovale","volume":"48","author":"Merkler","year":"2017","journal-title":"Stroke."},{"key":"10.1016\/j.rec.2019.07.003_bib0235","unstructured":"Institut de la statistique du Qu\u00e9bec (2018). Le bilan d\u00e9mographique du Qu\u00e9bec. 2018. Available at: www.stat.gouv.qc.ca\/statistiques\/population-demographie\/bilan2018.pdf. Accessed 25 Mar 2019."},{"key":"10.1016\/j.rec.2019.07.003_bib0240","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.1503\/cmaj.081629","article-title":"Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors","volume":"181","author":"Lee","year":"2009","journal-title":"CMAJ."},{"key":"10.1016\/j.rec.2019.07.003_bib0245","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1161\/STROKEAHA.109.547828","article-title":"Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?","volume":"40","author":"Alsheikh-Ali","year":"2009","journal-title":"Stroke."},{"key":"10.1016\/j.rec.2019.07.003_bib0250","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.amjcard.2015.06.012","article-title":"A Comparison of Atrial Fibrillation Monitoring Strategies After Cryptogenic Stroke (from the Cryptogenic Stroke and Underlying AF Trial)","volume":"116","author":"Choe","year":"2015","journal-title":"Am J Cardiol."}],"container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585719302166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585719302166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:57:07Z","timestamp":1761821827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1885585719302166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1885585719302166"],"URL":"https:\/\/doi.org\/10.1016\/j.rec.2019.07.003","relation":{},"ISSN":["1885-5857"],"issn-type":[{"value":"1885-5857","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcatheter closure of patent foramen ovale in patients older than 60 years of age with cryptogenic embolism","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2019.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2019.09.024","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Sociedad Espa\u00f1ola de Cardiolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}