{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:59Z","timestamp":1787237999690,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","revespcardiol.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.rec.2024.11.006","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T18:12:40Z","timestamp":1733422360000},"page":"668-678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of intensive versus nonintensive antithrombotic treatment on device-related thrombus after left atrial appendage closure"],"prefix":"10.1016","volume":"78","author":[{"given":"Philippe","family":"Garot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cepas-Guill\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Flores-Umanzor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Leduc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilhemas","family":"Bajoras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Perrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"McInerney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lafond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Farjat-Pasos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavi","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zendjebil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"de Backer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Cruz-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabit","family":"Arzamendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sanchis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"\u00d3Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Aminian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Erik","family":"Nielsen-Kudsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rec.2024.11.006_bib0150","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1016\/j.jacc.2020.04.067","article-title":"Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation","volume":"75","author":"Osmancik","year":"2020","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0155","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/j.jacc.2015.04.025","article-title":"Left Atrial Appendage Closure as an Alternative to Warfarin for Stroke Prevention in Atrial Fibrillation: A Patient-Level Meta-Analysis","volume":"65","author":"Holmes","year":"2015","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0160","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jacc.2019.12.040","article-title":"The NCDR Left Atrial Appendage Occlusion Registry","volume":"75","author":"Freeman","year":"2020","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0165","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jcin.2022.02.009","article-title":"Clinical Outcomes at 1 Year Following Transcatheter Left Atrial Appendage Occlusion in the United States","volume":"15","author":"Price","year":"2022","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0170","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1016\/j.jcin.2021.08.067","article-title":"Learning Curve and Outcomes of Left Atrial Appendage Closure","volume":"14","author":"Jung","year":"2021","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0175","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.jacep.2018.09.007","article-title":"Incidence and Clinical Impact of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion: A Meta-Analysis","volume":"4","author":"Alkhouli","year":"2018","journal-title":"JACC Clin Electrophysiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0180","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4244\/EIJ-D-21-01010","article-title":"Device-related thrombus following left atrial appendage occlusion","volume":"18","author":"Simard","year":"2022","journal-title":"EuroIntervention."},{"key":"10.1016\/j.rec.2024.11.006_bib0185","doi-asserted-by":"crossref","first-page":"E012812","DOI":"10.1161\/CIRCINTERVENTIONS.122.012812","article-title":"Antithrombotic Management After Left Atrial Appendage Closure: Current Evidence and Future Perspectives","volume":"16","author":"Mesnier","year":"2023","journal-title":"Circ Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0190","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/jamacardio.2024.2335","article-title":"Low-Dose Direct Oral Anticoagulation vs Dual Antiplatelet Therapy After Left Atrial Appendage Occlusion: The ADALA Randomized Clinical Trial","volume":"9","author":"Freixa","year":"2024","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.rec.2024.11.006_bib0195","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1016\/j.jacc.2017.10.021","article-title":"5-Year Outcomes After Left Atrial Appendage Closure: From the PREVAIL and PROTECT AF Trials","volume":"70","author":"Reddy","year":"2017","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0200","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/CIRCULATIONAHA.121.057063","article-title":"Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized Controlled Trial","volume":"144","author":"Lakkireddy","year":"2021","journal-title":"Circulation."},{"key":"10.1016\/j.rec.2024.11.006_bib0205","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.jcin.2024.05.032","article-title":"Early Nonprocedural Bleeding After Left Atrial Appendage Occlusion","volume":"17","author":"Mesnier","year":"2024","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0210","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.4244\/EIJ-D-16-00726","article-title":"Transcatheter left atrial appendage occlusion in patients with atrial fibrillation and a high bleeding risk using aspirin alone for post-implant antithrombotic therapy","volume":"12","author":"Korsholm","year":"2017","journal-title":"EuroIntervention."},{"key":"10.1016\/j.rec.2024.11.006_bib0215","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10840-021-01073-0","article-title":"Percutaneous left atrial appendage closure in patients with primary hemostasis disorders and atrial fibrillation","volume":"64","author":"Dognin","year":"2022","journal-title":"J Interv Card Electrophysiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0220","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.jcin.2023.05.045","article-title":"Impact of Device Implant Depth After Left Atrial Appendage Occlusion","volume":"16","author":"Cepas-Guill\u00e9n","year":"2023","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0225","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jcin.2016.11.029","article-title":"Incidence and Clinical Impact of Device-Associated Thrombus and Peri-Device Leak Following Left Atrial Appendage Closure With the Amplatzer Cardiac Plug","volume":"10","author":"Saw","year":"2017","journal-title":"JACC Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0230","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.4244\/EIJY19M08_01","article-title":"EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - An update","volume":"15","author":"Glikson","year":"2020","journal-title":"EuroIntervention."},{"key":"10.1016\/j.rec.2024.11.006_bib0235","doi-asserted-by":"crossref","first-page":"e008112","DOI":"10.1161\/CIRCINTERVENTIONS.119.008112","article-title":"Detection of Device-Related Thrombosis following Left Atrial Appendage Occlusion: A Comparison between Cardiac Computed Tomography and Transesophageal Echocardiography","volume":"12","author":"Korsholm","year":"2019","journal-title":"Circ Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0240","doi-asserted-by":"crossref","first-page":"e005997","DOI":"10.1161\/CIRCINTERVENTIONS.117.005997","article-title":"Device Thrombosis After Percutaneous Left Atrial Appendage Occlusion Is Related to Patient and Procedural Characteristics but Not to Duration of Postimplantation Dual Antiplatelet Therapy","volume":"11","author":"Pracon","year":"2018","journal-title":"Circ Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0245","doi-asserted-by":"crossref","first-page":"e1288","DOI":"10.4244\/EIJ-D-20-00886","article-title":"Pulmonary ridge coverage and device-related thrombosis after left atrial appendage occlusion","volume":"16","author":"Freixa","year":"2021","journal-title":"EuroIntervention."},{"key":"10.1016\/j.rec.2024.11.006_bib0250","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/eurheartj\/ehad828","article-title":"Residual leaks following percutaneous left atrial appendage occlusion and outcomes: a meta-analysis","volume":"45","author":"Samaras","year":"2024","journal-title":"Eur Heart J."},{"key":"10.1016\/j.rec.2024.11.006_bib0255","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jacc.2021.04.098","article-title":"Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion","volume":"78","author":"Simard","year":"2021","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0260","first-page":"100577","article-title":"SCAI\/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure","volume":"2","author":"Saw","year":"2023","journal-title":"J Soc Cardiovasc Angiogr Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0265","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/j.jcin.2023.10.046","article-title":"Device-Related Thrombus After Left Atrial Appendage Occlusion: Clinical Impact, Predictors Classification, and Management","volume":"16","author":"Alkhouli","year":"2023","journal-title":"J Am Coll Cardiol Intv."},{"key":"10.1016\/j.rec.2024.11.006_bib0270","doi-asserted-by":"crossref","first-page":"100136","DOI":"10.1016\/j.jacadv.2022.100136","article-title":"Left Atrial Appendage Occlusion: Current Advances and Remaining Challenges","volume":"1","author":"Alkhouli","year":"2022","journal-title":"JACC Adv."},{"key":"10.1016\/j.rec.2024.11.006_bib0275","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.jacc.2018.01.076","article-title":"Device-Related Thrombosis After Percutaneous Left Atrial Appendage Occlusion for Atrial Fibrillation","volume":"71","author":"Fauchier","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0280","doi-asserted-by":"crossref","first-page":"E010195","DOI":"10.1161\/CIRCINTERVENTIONS.120.010195","article-title":"Device-Related Thrombus After Left Atrial Appendage Closure: Data on Thrombus Characteristics Treatment Strategies, and Clinical Outcomes From the EUROC-DRT-Registry","volume":"14","author":"Sedaghat","year":"2021","journal-title":"Circ Cardiovasc Interv."},{"key":"10.1016\/j.rec.2024.11.006_bib0285","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.jacc.2022.02.047","article-title":"Antithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation","volume":"79","author":"Freeman","year":"2022","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.rec.2024.11.006_bib0290","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jacep.2022.07.014","article-title":"Incidence Predictors, and Clinical Outcomes of Device-Related Thrombus in the Amulet IDE Trial","volume":"9","author":"Boris Schmidt","year":"2023","journal-title":"JACC Clin Electrophysiol."}],"container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585724003517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585724003517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T03:09:06Z","timestamp":1753672146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1885585724003517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1885585724003517"],"URL":"https:\/\/doi.org\/10.1016\/j.rec.2024.11.006","relation":{},"ISSN":["1885-5857"],"issn-type":[{"value":"1885-5857","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of intensive versus nonintensive antithrombotic treatment on device-related thrombus after left atrial appendage closure","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2024.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2024.12.015","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.recesp.2024.11.015","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Sociedad Espa\u00f1ola de Cardiolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}