{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:15:57Z","timestamp":1789193757045,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","revespcardiol.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.rec.2025.02.021","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T20:40:18Z","timestamp":1745959218000},"page":"896-905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of phenotypes in heart failure with preserved ejection fraction among 8161 patients from 3 Spanish cohorts"],"prefix":"10.1016","volume":"78","author":[{"given":"\u00d2scar","family":"Mir\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Peyrony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Carles","family":"Trull\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor","family":"Alqu\u00e9zar-Arb\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"L\u00f3pez-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero-P\u00e9rez-Barquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Ar\u00e9valo-Lorido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Mi\u00f1ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Llorens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rec.2025.02.021_bib0145","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jama.2023.2020","article-title":"Heart failure with preserved ejection fraction: a review","volume":"329","author":"Redfield","year":"2023","journal-title":"JAMA."},{"key":"10.1016\/j.rec.2025.02.021_bib0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.recesp.2023.05.006","article-title":"Noncardiovascular morbidity and mortality across left ventricular ejection fraction categories following hospitalization for heart failure","volume":"77","author":"Santas","year":"2024","journal-title":"Rev Esp Cardiol."},{"key":"10.1016\/j.rec.2025.02.021_bib0155","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/CIRCRESAHA.116.307547","article-title":"Cardiovascular disease in women","volume":"118","author":"Garcia","year":"2016","journal-title":"Circulation Res."},{"key":"10.1016\/j.rec.2025.02.021_bib0160","doi-asserted-by":"crossref","first-page":"e018574","DOI":"10.1161\/JAHA.120.018574","article-title":"Sex differences in heart failure with preserved ejection fraction","volume":"10","author":"Sotomi","year":"2021","journal-title":"J Am Heart Assoc."},{"key":"10.1016\/j.rec.2025.02.021_bib0165","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J."},{"key":"10.1016\/j.rec.2025.02.021_bib0170","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJMoa2407107","article-title":"Finerenone in heart failure with mildly reduced or preserved ejection fraction","volume":"391","author":"Solomon","year":"2024","journal-title":"N Engl J Med."},{"key":"10.1016\/j.rec.2025.02.021_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/frai.2022.842306","article-title":"Phenotype clustering in health care: a narrative review for clinicians","volume":"5","author":"Loftus","year":"2022","journal-title":"Front Artif Intell."},{"key":"10.1016\/j.rec.2025.02.021_bib0180","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ehjqcco\/qcae067","article-title":"Profiling heart failure with preserved or mildly reduced ejection fraction by cluster analysis","volume":"11","author":"Vicent","year":"2025","journal-title":"Eur Heart J Qual Care Clin Outcomes."},{"key":"10.1016\/j.rec.2025.02.021_bib0185","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/postgradmedj-2015-133739","article-title":"The utility of heart failure registries: a descriptive and comparative study of two heart failure registries","volume":"92","author":"Trull\u00e0s","year":"2016","journal-title":"Postgrad Med J."},{"key":"10.1016\/j.rec.2025.02.021_bib0190","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejim.2023.05.037","article-title":"The modifying role of admission renal function and decongestion","volume":"115","author":"Lorenzo","year":"2023","journal-title":"Eur J Intern Med."},{"key":"10.1016\/j.rec.2025.02.021_bib0195","first-page":"437","article-title":"Use of digoxin in the emergency department to treat patients with acute heart failure and its impact on short-term outcomes","volume":"35","author":"Mart\u00edn Mojarro","year":"2023","journal-title":"Emergencias."},{"key":"10.1016\/j.rec.2025.02.021_bib0200","doi-asserted-by":"crossref","first-page":"e004926","DOI":"10.1161\/CIRCHEARTFAILURE.118.004926","article-title":"Data-driven approach to identify subgroups of heart failure with reduced ejection fraction patients with different prognoses and aldosterone antagonist response patterns","volume":"11","author":"Ferreira","year":"2018","journal-title":"Circ Heart Fail."},{"key":"10.1016\/j.rec.2025.02.021_bib0205","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jchf.2019.09.009","article-title":"Clinical phenogroups in heart failure with preserved ejection fraction: detailed phenotypes, prognosis, and response to spironolactone","volume":"8","author":"Cohen","year":"2020","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.rec.2025.02.021_bib0210","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/ejhf.2169","article-title":"Identification of distinct phenotypic clusters in heart failure with preserved ejection fraction","volume":"23","author":"Uijl","year":"2021","journal-title":"Eur J Heart Fail."},{"key":"10.1016\/j.rec.2025.02.021_bib0215","first-page":"65","article-title":"A simple sequential rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand J Statist."},{"key":"10.1016\/j.rec.2025.02.021_bib0220","doi-asserted-by":"crossref","first-page":"e370","DOI":"10.1016\/S2589-7500(23)00065-1","article-title":"Identifying subtypes of heart failure from three electronic health record sources with machine learning: an external, prognostic, and genetic validation study","volume":"5","author":"Banerjee","year":"2023","journal-title":"Lancet Digit Health."},{"key":"10.1016\/j.rec.2025.02.021_bib0225","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2147\/COPD.S31236","article-title":"The association between COPD and heart failure risk: a review","volume":"8","author":"de Miguel D\u00edez","year":"2013","journal-title":"Int J Chron Obstruct Pulmon Dis."},{"key":"10.1016\/j.rec.2025.02.021_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm9082644","article-title":"Heart failure is highly prevalent and difficult to diagnose in severe exacerbations of COPD presenting to the emergency department","volume":"9","author":"Tin\u00e8","year":"2020","journal-title":"J Clin Med."},{"key":"10.1016\/j.rec.2025.02.021_bib0235","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.rce.2023.07.007","article-title":"Prognostic impact of metformin in patients with type 2 diabetes mellitus and acute heart failure: Combined analysis of the EAHFE and RICA registries","volume":"223","author":"Povar-Echeverr\u00eda","year":"2023","journal-title":"Rev Clin Esp."},{"key":"10.1016\/j.rec.2025.02.021_bib0240","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5603\/EP.a2021.0033","article-title":"Metformin in patients with type 2 diabetes mellitus and heart failure: a review","volume":"72","author":"Ku\u0142aczkowska","year":"2021","journal-title":"Endokrynol Pol."},{"key":"10.1016\/j.rec.2025.02.021_bib0245","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","article-title":"ESC Scientific Document Group. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD","volume":"41","author":"Grant","year":"2020","journal-title":"Eur Heart J."},{"key":"10.1016\/j.rec.2025.02.021_bib0250","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ejheart.2007.02.001","article-title":"Sex differences in the effectiveness of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in patients with congestive heart failure--a population study","volume":"9","author":"Hudson","year":"2007","journal-title":"Eur J Heart Fail."},{"key":"10.1016\/j.rec.2025.02.021_bib0255","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/CIRCRESAHA.121.319914","article-title":"Sex differences and similarities in valvular heart disease","volume":"130","author":"DesJardin","year":"2022","journal-title":"Circ Res."},{"key":"10.1016\/j.rec.2025.02.021_bib0260","first-page":"196","article-title":"Performance of 3 frailty scales for predicting adverse outcomes at 30 days in older patients discharged from emergency departments","volume":"35","author":"Fern\u00e1ndez Alonso","year":"2023","journal-title":"Emergencias."},{"key":"10.1016\/j.rec.2025.02.021_bib0265","first-page":"165","article-title":"Identifying the frail patient in the emergency department: an urgent and necessary effort","volume":"35","author":"Aguil\u00f3 Mir","year":"2023","journal-title":"Emergencias."},{"key":"10.1016\/j.rec.2025.02.021_bib0270","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J."},{"key":"10.1016\/j.rec.2025.02.021_bib0275","first-page":"236","article-title":"Hospital admission influences both early and 1-year mortality in elderly patients treated for acute heart failure in hospital emergency departments","volume":"36","author":"Mart\u00ednez Salgado","year":"2024","journal-title":"Emergencias."},{"key":"10.1016\/j.rec.2025.02.021_bib0280","doi-asserted-by":"crossref","first-page":"l223","DOI":"10.1136\/bmj.l223","article-title":"Trends in survival after a diagnosis of heart failure in the United Kingdom 2000-2017: population-based cohort study","volume":"364","author":"Taylor","year":"2019","journal-title":"BMJ."}],"container-title":["Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585725001239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1885585725001239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:24:56Z","timestamp":1762561496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1885585725001239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1885585725001239"],"URL":"https:\/\/doi.org\/10.1016\/j.rec.2025.02.021","relation":{},"ISSN":["1885-5857"],"issn-type":[{"value":"1885-5857","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of phenotypes in heart failure with preserved ejection fraction among 8161 patients from 3 Spanish cohorts","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rec.2025.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.recesp.2025.02.019","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedad Espa\u00f1ola de Cardiolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}