{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:59:26Z","timestamp":1761947966013,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Anestesiolog\u00eda y Reanimaci\u00f3n (English Edition)"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.redare.2025.501916","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:08:35Z","timestamp":1757776115000},"page":"501916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expert opinion-based recommendations promoted by GTIPO-SEDAR to optimize the therapeutic management of intra-abdominal candidiasis"],"prefix":"10.1016","volume":"72","author":[{"given":"E.","family":"Maseda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Pel\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Mart\u00edn-Loeches","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ben\u00edtez-Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Zaragoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Guinea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Aldecoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-8547","authenticated-orcid":false,"given":"A.","family":"Su\u00e1rez-de-la-Rica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.redare.2025.501916_bib0005","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s40121-021-00585-6","article-title":"Risk factors for intra-abdominal candidiasis in intensive care units: results from EUCANDICU study","volume":"11","author":"Bassetti","year":"2022","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.redare.2025.501916_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases-estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.redare.2025.501916_bib0015","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00134-019-05599-w","article-title":"ESICM\/ESCMID task force on practical management of invasive candidiasis in critically ill patients","volume":"45","author":"Martin-Loeches","year":"2019","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.redare.2025.501916_bib0020","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/jac\/dkad139","article-title":"Invasive candidiasis: current clinical challenges and unmet needs in adult populations","volume":"78","author":"Soriano","year":"2023","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0025","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s13054-023-04761-7","article-title":"Combination of serum and peritoneal 1.3-beta-D-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study","volume":"27","author":"Novy","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0030","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00710-22","article-title":"Evidence of fluconazole-resistant Candida parapsilosis genotypes spreading across hospitals located in Madrid, Spain and harboring the Y132F ERG11p substitution","volume":"66","author":"D\u00edaz-Garc\u00eda","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0035","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00986-23","article-title":"Trends in antifungal resistance in Candida from a multicenter study conducted in Madrid (CANDIMAD study): fluconazole-resistant C. parapsilosis spreading has gained traction in 2022","volume":"67","author":"D\u00edaz-Garc\u00eda","year":"2023","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0040","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s00134-024-07341-7","article-title":"Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM","volume":"50","author":"Bassetti","year":"2024","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.redare.2025.501916_bib0045","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/antibiotics11050645","article-title":"Therapeutic drug monitoring of antifungal agents in critically ill patients: is there a need for dose optimisation?","volume":"11","author":"Baracaldo-Santamar\u00eda","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.redare.2025.501916_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2024.106229","article-title":"Attributable mortality of candidemia - results from the ECMM Candida III multinational European Observational Cohort Study","volume":"89","author":"Salmanton-Garc\u00eda","year":"2024","journal-title":"J Infect"},{"key":"10.1016\/j.redare.2025.501916_bib0055","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s13054-023-04673-6","article-title":"Critical appraisal beyond clinical guidelines for intraabdominal candidiasis","volume":"27","author":"Maseda","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40635-023-00552-0","article-title":"Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis","volume":"11","author":"Novy","year":"2023","journal-title":"Intensive Care Med Exp"},{"key":"10.1016\/j.redare.2025.501916_bib0065","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1128\/IAI.70.7.3689-3700.2002","article-title":"Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs","volume":"70","author":"Felk","year":"2002","journal-title":"Infect Immun"},{"year":"2023","series-title":"Optimizing the diagnosis of intra-abdominal candidiasis: combination of \u03b2-D-glucan (\u03b2DG) and candida PCR","author":"Pel\u00e1ez","key":"10.1016\/j.redare.2025.501916_bib0070"},{"key":"10.1016\/j.redare.2025.501916_bib0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13054-015-0758-3","article-title":"Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study","volume":"19","author":"Sinnollareddy","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13054-017-1644-y","article-title":"Medicating patients during extracorporeal membrane oxygenation: the evidence is building","volume":"21","author":"Dzierba","year":"2017","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0085","first-page":"460","article-title":"Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation","volume":"18","author":"Jamal","year":"2012","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0090","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s10096-004-1228-z","article-title":"Pharmacokinetics\/pharmacodynamics of echinocandins","volume":"23","author":"Theuretzbacher","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.redare.2025.501916_bib0095","doi-asserted-by":"crossref","DOI":"10.1093\/mmy\/myac074","article-title":"Liposomal amphotericin B exposure in critically ill patients: a prospective pharmacokinetic study","volume":"60","author":"Van Daele","year":"2022","journal-title":"Med Mycol"},{"key":"10.1016\/j.redare.2025.501916_bib0100","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00225-24","article-title":"Comparative pharmacodynamics and dose optimization of liposomal amphotericin B against Candida species in an in vitro pharmacokinetic\/pharmacodynamic model","volume":"68","author":"Beredaki","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0105","article-title":"Therapeutic drug monitoring of antimicrobials in critically ill obese patients","volume":"12","author":"Gorham","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.redare.2025.501916_bib0110","doi-asserted-by":"crossref","first-page":"6550","DOI":"10.1128\/AAC.01088-16","article-title":"Effect of obesity on the population pharmacokinetics of fluconazole in critically ill patients","volume":"60","author":"Alobaid","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0115","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13054-018-2019-8","article-title":"Population pharmacokinetics\/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients","volume":"22","author":"Maseda","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0120","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00063-18","article-title":"Pharmacokinetics of anidulafungin in obese and normal-weight adults","volume":"62","author":"Wasmann","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0125","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13054-017-1774-2","article-title":"Plasma concentrations of caspofungin in a critically ill patient with morbid obesity","volume":"21","author":"Ferriols-Lisart","year":"2017","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0130","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02366-20","article-title":"Evaluation of total body weight versus adjusted body weight liposomal amphotericin b dosing in obese patients","volume":"65","author":"Ting","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0135","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/jac\/dku169","article-title":"Intra-abdominal penetration and pharmacodynamic exposure to fluconazole in three liver transplant patients with deep-seated candidiasis","volume":"69","author":"Pea","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijid.2020.09.019","article-title":"Pharmacokinetics of echinocandins in suspected candida peritonitis: a potential risk for resistance","volume":"101","author":"Gioia","year":"2020","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.redare.2025.501916_bib0145","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01249-21","article-title":"Antifungal susceptibility testing identifies the abdominal cavity as a source of Candida glabrata-resistant isolates","volume":"65","author":"D\u00edaz-Garc\u00eda","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0150","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01009-17","article-title":"Unraveling drug penetration of echinocandin antifungals at the site of infection in an intra-abdominal abscess model","volume":"61","author":"Zhao","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0155","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s13054-023-04742-w","article-title":"Pharmacokinetic and pharmacodynamic considerations for antifungal therapy optimisation in the treatment of intra-abdominal candidiasis","volume":"27","author":"Novy","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0160","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/antibiotics11050640","article-title":"Therapeutic drug monitoring of amphotericin-b in plasma and peritoneal fluid of pediatric patients after liver transplantation: a case series","volume":"11","author":"Tortora","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.redare.2025.501916_bib0165","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.riam.2012.03.005","article-title":"Echinocandins in a critically ill patient during continuous venovenous renal replacement","volume":"29","author":"Aguilar","year":"2012","journal-title":"Rev Iberoam Micol"},{"key":"10.1016\/j.redare.2025.501916_bib0170","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1007\/s00134-003-1980-z","article-title":"Pharmacokinetics and the most suitable dosing regimen of fluconazole in critically ill patients receiving continuous hemodiafiltration","volume":"29","author":"Yagasaki","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.redare.2025.501916_bib0175","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1093\/jac\/dkt542","article-title":"Anidulafungin dosing in critically ill patients with continuous venovenous haemodiafiltration","volume":"69","author":"Aguilar","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0180","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/jac\/dku013","article-title":"Micafungin pharmacokinetic\/pharmacodynamic adequacy for the treatment of invasive candidiasis in critically ill patients on continuous venovenous haemofiltration","volume":"69","author":"Maseda","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0185","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10157-020-01989-3","article-title":"The clinical usage of liposomal amphotericin B in patients receiving renal replacement therapy in Japan: a nationwide observational study","volume":"25","author":"Obata","year":"2021","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.redare.2025.501916_bib0190","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.anpedi.2017.07.010","article-title":"Experience with infections in the use of extracorporeal membrane oxygenation","volume":"89","author":"Calder\u00f3n Checa","year":"2018","journal-title":"An Pediatr (Engl Ed)"},{"key":"10.1016\/j.redare.2025.501916_bib0195","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13054-015-0891-z","article-title":"Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study","volume":"19","author":"Shekar","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0200","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00134-008-1269-3","article-title":"Potential voriconazole and caspofungin sequestration during extracorporeal membrane oxygenation","volume":"35","author":"Ruiz","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.redare.2025.501916_bib0205","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s13054-024-05101-z","article-title":"A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation","volume":"28","author":"Kim","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.redare.2025.501916_bib0210","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13613-024-01333-y","article-title":"Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study","volume":"14","author":"Mokart","year":"2024","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.redare.2025.501916_bib0215","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.redare.2025.501916_bib0220","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/jac\/dkae175","article-title":"Initial micafungin treatment does not improve outcomes compared to fluconazole treatment in immunocompromised and critically ill patients with candidaemia","volume":"79","author":"Theodore","year":"2024","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.redare.2025.501916_bib0225","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13017-024-00551-w","article-title":"Management of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use","volume":"19","author":"Sartelli","year":"2024","journal-title":"World J Emerg Surg"},{"key":"10.1016\/j.redare.2025.501916_bib0230","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1016\/S1473-3099(24)00749-7","article-title":"Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM","volume":"25","author":"Cornely","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.redare.2025.501916_bib0235","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.546","article-title":"Rezafungin treatment in mouse models of invasive candidiasis and aspergillosis: insights on the PK\/PD pharmacometrics of rezafungin efficacy","volume":"7","author":"Miesel","year":"2019","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.redare.2025.501916_bib0240","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3390\/antibiotics13080760","article-title":"A real-world data observational analysis of the impact of liposomal amphotericin B on renal function using machine learning in critically ill patients","volume":"13","author":"Sacanella","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.redare.2025.501916_bib0245","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1007\/s00134-017-4932-8","article-title":"S-TAFE Study Group. Biomarker-based strategy for early discontinuation of empirical antifungal treatment in critically ill patients: a randomized controlled trial","volume":"43","author":"Rouz\u00e9","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.redare.2025.501916_bib0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.106998","article-title":"Tolerability of pulsed high-dose L-AmB as pre-emptive therapy in patients at high risk for intra-abdominal candidiasis: a phase 2 study (LAMBDA study)","volume":"62","author":"Rinaldi","year":"2023","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.redare.2025.501916_bib0255","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1164\/rccm.201211-2069OC","article-title":"\u03b2-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis","volume":"188","author":"Tissot","year":"2013","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Revista Espa\u00f1ola de Anestesiolog\u00eda y Reanimaci\u00f3n (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2341192925002264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2341192925002264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:52:04Z","timestamp":1761947524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2341192925002264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2341192925002264"],"URL":"https:\/\/doi.org\/10.1016\/j.redare.2025.501916","relation":{},"ISSN":["2341-1929"],"issn-type":[{"type":"print","value":"2341-1929"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expert opinion-based recommendations promoted by GTIPO-SEDAR to optimize the therapeutic management of intra-abdominal candidiasis","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Anestesiolog\u00eda y Reanimaci\u00f3n (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redare.2025.501916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.redar.2025.501916","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedad Espa\u00f1ola de Anestesiolog\u00eda, Reanimaci\u00f3n y Terap\u00e9utica del Dolor. Published by Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"501916"}}