{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:50:22Z","timestamp":1774122622280,"version":"3.50.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"NIH","award":["NIH-U19-AI-067798"],"award-info":[{"award-number":["NIH-U19-AI-067798"]}]},{"name":"IBH General Research Funds"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2014]]},"DOI":"10.1016\/j.redox.2013.12.017","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T17:30:48Z","timestamp":1389288648000},"page":"400-410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+"],"prefix":"10.1016","volume":"2","author":[{"given":"Benjamin","family":"Gauter-Fleckenstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio S.","family":"Reboucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artak","family":"Tovmasyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouros","family":"Owzar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Batinic-Haberle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljko","family":"Vujaskovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.redox.2013.12.017_bib1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1089\/ars.2009.2876","article-title":"Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential","volume":"13","author":"Batinic-Haberle","year":"2010","journal-title":"Antioxide Redox Signal"},{"key":"10.1016\/j.redox.2013.12.017_bib2","article-title":"SOD Therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways","author":"Batinic-Haberle","year":"2013","journal-title":"Antioxide Redox Signal"},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/187152011795677526","article-title":"Nitroxides as cancer imaging agents","volume":"11","author":"Davis","year":"2011","journal-title":"Anti-Cancer Agents Med. Chem."},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/187152011795255894","article-title":"Texaphyrins: tumor localizing redox active expanded porphyrins","volume":"11","author":"Arambula","year":"2011","journal-title":"Anticancer Agents Med. Chem."},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/187152011795677517","article-title":"Anti-cancer activity of nitrones and observations on mechanism of action","volume":"11","author":"Floyd","year":"2011","journal-title":"Anticancer Agents Med. Chem."},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2174\/187152011795677490","article-title":"Salen Mn complexes mitigate radiation injury in normal tissues","volume":"11","author":"Rosenthal","year":"2011","journal-title":"Anticancer Agents Med Chem"},{"issue":"5","key":"10.1016\/j.redox.2013.12.017_bib7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.freeradbiomed.2011.04.046","article-title":"Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics","volume":"51","author":"Batinic-Haberle","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000341715","article-title":"Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators","volume":"22","author":"Tovmasyan","year":"2013","journal-title":"Med. Principles Pract."},{"key":"10.1016\/j.redox.2013.12.017_bib9","doi-asserted-by":"crossref","DOI":"10.1515\/irm-2013-0004","article-title":"The complex mechanistic aspects of redox-active compounds, commonly regarded as SOD mimics","author":"Batinic Haberle","year":"2013","journal-title":"BioInorg. React. Mech."},{"issue":"6","key":"10.1016\/j.redox.2013.12.017_bib10","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.freeradbiomed.2007.10.058","article-title":"Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection","volume":"44","author":"Gauter-Fleckenstein","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.redox.2013.12.017_bib11","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.freeradbiomed.2010.01.020","article-title":"Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage","volume":"48","author":"Gauter-Fleckenstein","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.redox.2013.12.017_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00726-010-0603-6","article-title":"Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities","volume":"42","author":"Batinic-Haberle","year":"2012","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.redox.2013.12.017_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/10715760600913150","article-title":"Superoxide dismutase mimetic reduces hypoxia-induced O2\u204e-, TGF-beta, and VEGF production by macrophages","volume":"41","author":"Jackson","year":"2007","journal-title":"Free Radic. Res."},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ijrobp.2006.09.053","article-title":"Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury","volume":"67","author":"Rabbani","year":"2007","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"11","key":"10.1016\/j.redox.2013.12.017_bib15","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1080\/10715760701689550","article-title":"Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation","volume":"41","author":"Rabbani","year":"2007","journal-title":"Free Radic. Res."},{"issue":"7","key":"10.1016\/j.redox.2013.12.017_bib16","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.freeradbiomed.2009.07.001","article-title":"Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor","volume":"47","author":"Rabbani","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.redox.2013.12.017_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/HP.0b013e3182a4d967","article-title":"Pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage","volume":"106","author":"Garofalo","year":"2014","journal-title":"Health Phys."},{"issue":"1","key":"10.1016\/j.redox.2013.12.017_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2009.04.002","article-title":"Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins","volume":"47","author":"Kos","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.redox.2013.12.017_bib19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.freeradbiomed.2009.04.018","article-title":"Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells","volume":"47","author":"Pollard","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib20","first-page":"291","article-title":"Chemistry, biology and medical effects of water soluble metalloporphyrins","volume":"vol. 11","author":"Batinic-Haberle","year":"2011"},{"key":"10.1016\/j.redox.2013.12.017_bib21","series-title":"Principles of Free Radical Biomedicine.","article-title":"Superoxide dismutase mimics","author":"Spasojevic","year":"2012"},{"key":"10.1016\/j.redox.2013.12.017_bib22","article-title":"Protein damage by photo-activated Zn(II) N-alkylpyridylporphyrins","author":"Benov","year":"2010","journal-title":"Amino Acids"},{"issue":"16","key":"10.1016\/j.redox.2013.12.017_bib23","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1523\/JNEUROSCI.5986-11.2012","article-title":"Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants","volume":"32","author":"Drobyshevsky","year":"2012","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.redox.2013.12.017_bib24","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.freeradbiomed.2007.02.016","article-title":"Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia\/reperfusion","volume":"42","author":"Saba","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib25","unstructured":"Cline J.M., Dugan G., Bourland D., Perry D.L., Stitzel J.D., Weaver A.A., Jiang C., Owzar K., Spasojevic I., Batinic-Haberle I. et al., Post-irradiation treatment with MnTnHex-2-PyP5+ mitigates radiation pneumonitis and fibrosis in the lungs of non-human primates after whole-thorax exposure to ionizing radiation, Radiat. Res. (2014) in Revision."},{"key":"10.1016\/j.redox.2013.12.017_bib26","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1039\/b201057g","article-title":"Manganese(III) meso-tetrakis(ortho-N-alkylpyridyl)porphyrins. Synthesis, characterization, and catalysis of O-2 (center dot-) dismutation","volume":"13","author":"Batinic-Haberle","year":"2002","journal-title":"J. Chem. Soc. Dalton Trans."},{"issue":"1","key":"10.1016\/j.redox.2013.12.017_bib27","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijrobp.2006.12.056","article-title":"Temporal onset of hypoxia and oxidative stress after pulmonary irradiation","volume":"68","author":"Fleckenstein","year":"2007","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J. Clin. Pathol."},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin\u2013biotin\u2013peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.redox.2013.12.017_bib30","series-title":"Categorical data analysis","first-page":"59","author":"Agresti","year":"1990"},{"key":"10.1016\/j.redox.2013.12.017_bib31","series-title":"Theory of Rank Tests","author":"Hajek","year":"1999"},{"key":"10.1016\/j.redox.2013.12.017_bib32","year":"2007"},{"issue":"16","key":"10.1016\/j.redox.2013.12.017_bib33","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1039\/c0dt01321h","article-title":"Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins","volume":"40","author":"Tovmasyan","year":"2011","journal-title":"Dalton Trans."},{"issue":"11-12","key":"10.1016\/j.redox.2013.12.017_bib34","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3109\/10715762.2011.616199","article-title":"Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate","volume":"45","author":"Ye","year":"2011","journal-title":"Free Radic. Res."},{"issue":"16","key":"10.1016\/j.redox.2013.12.017_bib35","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/CIRCULATIONAHA.112.001337","article-title":"Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis","volume":"127","author":"Zeng","year":"2013","journal-title":"Circulation"},{"issue":"4-5","key":"10.1016\/j.redox.2013.12.017_bib36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0098-2997(01)00010-3","article-title":"Redox signaling in macrophages","volume":"22","author":"Forman","year":"2001","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2013.01.006","article-title":"Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP(5+) and MnTnHex-2-PyP(5+)","volume":"58","author":"Weitner","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.redox.2013.12.017_bib38","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbadis.2011.12.002","article-title":"Manganese superoxide dismutase, MnSOD and its mimics","volume":"1822","author":"Miriyala","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.redox.2013.12.017_bib39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.redox.2013.09.005","article-title":"Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications","volume":"1","author":"Ali","year":"2013","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2013.12.017_bib40","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.redox.2013.10.002","article-title":"Superoxide dismutase mimic, MnTE-2-PyP5+ ameliorates acute and chronic proctitis following focal proton irradiation of the rat Rectum","volume":"1","author":"Archambeau","year":"2013","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.redox.2013.12.017_bib41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1089\/ars.2011.4313","article-title":"Redox sensing by proteins: oxidative modifications on cysteines and the consequent events","volume":"16","author":"Wang","year":"2012","journal-title":"Antioxide Redox Signal"},{"key":"10.1016\/j.redox.2013.12.017_bib42","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.freeradbiomed.2013.11.031","article-title":"Mn Porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death","volume":"68","author":"Evans","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib43","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.freeradbiomed.2013.10.443","article-title":"Inhibition of the electron transport chain via the pro-oxidative activity of manganese porphyrin-based SOD mimetics modulates bioenergetics and enhances the response to chemotherapy","volume":"65","author":"Jaramillo","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib44","article-title":"Simple biological systems for assessing the activity of superoxide dismutase mimics","author":"Tovmasyan","year":"2013","journal-title":"Antioxide Redox Signal"},{"key":"10.1016\/j.redox.2013.12.017_bib45","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1016\/j.freeradbiomed.2013.10.731","article-title":"We have come a long way with Mn porphyrins: from superoxide dismutation to H2O2-driven pathways","volume":"65","author":"Tovmasyan","year":"2013","journal-title":"Free Rad. Biol. Med."},{"issue":"3","key":"10.1016\/j.redox.2013.12.017_bib46","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.freeradbiomed.2004.04.040","article-title":"Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity","volume":"37","author":"Okado-Matsumoto","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2174\/187152011795255975","article-title":"The potential of Zn(II) N-alkylpyridylporphyrins for anticancer therapy","volume":"11","author":"Benov","year":"2011","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.redox.2013.12.017_bib48","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M113.511642","article-title":"Effect of molecular characteristics on cellular uptake, subcellular localization and phototoxicity of Zn(II) N-alkylpyridylporphyrins","author":"Ezzeddine","year":"2013","journal-title":"J Biol. Chem."},{"issue":"22","key":"10.1016\/j.redox.2013.12.017_bib49","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.2174\/1381612811209023293","article-title":"Insights on biology and pathology of HIF-1alpha\/-2alpha, TGFbeta\/BMP, Wnt\/beta-catenin, and NF-kappaB pathways in osteoarthritis","volume":"18","author":"Wu","year":"2012","journal-title":"Curr. Pharm. Des."},{"issue":"48","key":"10.1016\/j.redox.2013.12.017_bib50","doi-asserted-by":"crossref","first-page":"34757","DOI":"10.1074\/jbc.M113.503946","article-title":"Oral administration of TGF-beta1 protects the immature gut from injury via Smad-dependent suppression of epithelial NF-kappaB signaling and pro-inflammatory cytokine production","volume":"288","author":"Shiou","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.redox.2013.12.017_bib51","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib52","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/02656730600594027","article-title":"ROS production and angiogenic regulation by macrophages in response to heat therapy","volume":"22","author":"Jackson","year":"2006","journal-title":"Int. J. Hyperthermia"},{"issue":"3","key":"10.1016\/j.redox.2013.12.017_bib53","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/mutage\/ger001","article-title":"NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability","volume":"26","author":"Pazhanisamy","year":"2011","journal-title":"Mutagenesis"},{"issue":"47","key":"10.1016\/j.redox.2013.12.017_bib54","doi-asserted-by":"crossref","first-page":"20477","DOI":"10.1073\/pnas.1006646107","article-title":"NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment","volume":"107","author":"Moon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib55","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2337\/diabetes.51.2.347","article-title":"A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone","volume":"51","author":"Piganelli","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2013.12.017_bib56","article-title":"Effects of metalloporphyrins on reducing inflammation and autoimmunity","author":"Delmastro-Greenwood","year":"2013","journal-title":"Antioxide Redox Signal"},{"issue":"8","key":"10.1016\/j.redox.2013.12.017_bib57","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.freeradbiomed.2012.02.001","article-title":"Manganese porphyrin, MnTE-2-PyP5+, acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells","volume":"52","author":"Jaramillo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib58","doi-asserted-by":"crossref","DOI":"10.1089\/ars.2012.5167","article-title":"Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells","author":"Delmastro-Greenwood","year":"2013","journal-title":"Antioxide Redox Signal"},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib59","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2003.10.029","article-title":"Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity","volume":"36","author":"Tse","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.redox.2013.12.017_bib60","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.4049\/jimmunol.1001472","article-title":"NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity","volume":"185","author":"Tse","year":"2010","journal-title":"J. Immunol."},{"issue":"14","key":"10.1016\/j.redox.2013.12.017_bib61","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/onc.2010.566","article-title":"NF-kappaB addiction and its role in cancer: \u2018one size does not fit all\u2019","volume":"30","author":"Chaturvedi","year":"2011","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00005-011-0132-3","article-title":"Targeting NF-kappaB and HIF-1 pathways for the treatment of cancer: part II","volume":"59","author":"Wilczynski","year":"2011","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"issue":"9","key":"10.1016\/j.redox.2013.12.017_bib63","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1089\/ars.2008.2400","article-title":"Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway","volume":"11","author":"Oliver","year":"2009","journal-title":"Antioxide Redox Signal"},{"key":"10.1016\/j.redox.2013.12.017_bib64","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1016\/j.freeradbiomed.2013.10.792","article-title":"TGF-\u03b2 mediates focal adhesion maturation by a Smad\/Nox4-dependent mechanism that involves regulation of Hsp27 and Hic5","volume":"65","author":"Fernandez","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib65","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.0959-9673.2004.00377.x","article-title":"Smad3 as a mediator of the fibrotic response","volume":"85","author":"Flanders","year":"2004","journal-title":"Int. J. Exp. Pathol."},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib66","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1101\/gad.14.2.187","article-title":"A mechanism of suppression of TGF-beta\/SMAD signaling by NF-kappa B\/RelA","volume":"14","author":"Bitzer","year":"2000","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.redox.2013.12.017_bib67","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bbrc.2003.11.163","article-title":"Involvement of NF-kappaB in TGF-beta-mediated suppression of IL-4 signaling","volume":"313","author":"Yamamoto","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2013.12.017_bib68","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/j.freeradbiomed.2011.10.309","article-title":"Lipophilic Mn porphyrins in the treatment of brain tumors","volume":"51","author":"Batinic-Haberle","year":"2011","journal-title":"Free. Radic. Biol. Med."},{"issue":"13","key":"10.1016\/j.redox.2013.12.017_bib69","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1158\/0008-5472.CAN-08-4031","article-title":"Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells","volume":"69","author":"Jaramillo","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2013.12.017_bib70","article-title":"Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders","author":"Sheng","year":"2013","journal-title":"Antioxide Redox Signal"},{"issue":"7","key":"10.1016\/j.redox.2013.12.017_bib71","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.freeradbiomed.2009.05.039","article-title":"Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat","volume":"47","author":"Sheng","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib72","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1158\/0008-5472.CAN-04-3334","article-title":"A mechanism-based antioxidant approach for the reduction of skin carcinogenesis","volume":"65","author":"Zhao","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2013.12.017_bib73","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1016\/j.freeradbiomed.2013.10.720","article-title":"MnTnBuOE-2-PyP5+ improves respiratory function and inhibits RAGE induced reactive oxygen species generation","volume":"65","author":"Panchatcharam","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib74","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1016\/j.freeradbiomed.2013.10.728","volume":"65","author":"Spasojevic","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2013.12.017_bib75","series-title":"Decreased Neurogenesis following Exposure to Ionizing Radiation: A Role for p16INK4a-Induced Senescence. Cell Senescence in Cancer and Ageing","author":"Beausejour","year":"2013"},{"key":"10.1016\/j.redox.2013.12.017_bib76","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1016\/j.freeradbiomed.2013.10.691","article-title":"Mechanistic considerations of the therapeutic Effects of Mn porphyrins, commonly regarded as SOD mimics, in anticancer therapy: lessons from brain and lymphoma studies","volume":"65","author":"Batinic-Haberle","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.redox.2013.12.017_bib77","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3109\/10715762.2010.522575","article-title":"Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site","volume":"45","author":"Spasojevic","year":"2011","journal-title":"Free Radic. Res."},{"issue":"5","key":"10.1016\/j.redox.2013.12.017_bib78","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1535-6108(04)00115-1","article-title":"Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules","volume":"5","author":"Moeller","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2013.12.017_bib79","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.freeradbiomed.2013.10.436","article-title":"MnTE-2-PyP inhibits prostate tumor growth and metastasis by inhibiting p300 activity","volume":"65","author":"Weaver","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.redox.2013.12.017_bib80","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1089\/ars.2012.4644","article-title":"Protein-thiol oxidation and cell death: regulatory role of glutaredoxins","volume":"17","author":"Allen","year":"2012","journal-title":"Antioxide Redox Signal"},{"issue":"3","key":"10.1016\/j.redox.2013.12.017_bib81","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1124\/jpet.110.176701","article-title":"Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage","volume":"338","author":"Sheng","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.redox.2013.12.017_bib82","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.2337\/diabetes.53.10.2559","article-title":"Response of human islets to isolation stress and the effect of antioxidant treatment","volume":"53","author":"Bottino","year":"2004","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.redox.2013.12.017_bib83","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/1091581813490203","article-title":"Nonclinical safety assessment of MnTE-2-PyP, a manganese porphyrin","volume":"32","author":"Gad","year":"2013","journal-title":"Int. J. Toxicol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231713001055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231713001055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:04:19Z","timestamp":1761977059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231713001055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":83,"alternative-id":["S2213231713001055"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2013.12.017","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2013.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}