{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:12:44Z","timestamp":1791655964084,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["RO1 NS079450"],"award-info":[{"award-number":["RO1 NS079450"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.redox.2015.02.002","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T21:21:59Z","timestamp":1423603319000},"page":"363-374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6\/2 mouse model of Huntington's disease"],"prefix":"10.1016","volume":"4","author":[{"given":"Kiersten L.","family":"Berggren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Dodds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Dugas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liset","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Lothian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"McAllum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Volitakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaine","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley I.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.redox.2015.02.002_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. The Huntington\u2019s Disease Collaborative Research Group","volume":"72","year":"1993","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.redox.2015.02.002_bib2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"4","key":"10.1016\/j.redox.2015.02.002_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng0893-393","article-title":"Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington\u2019s disease","volume":"4","author":"Snell","year":"1993","journal-title":"Nature Genetics"},{"issue":"2","key":"10.1016\/j.redox.2015.02.002_bib4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/mds.24024","article-title":"Age, CAG repeat length, and clinical progression in Huntington\u2019s disease","volume":"27","author":"Rosenblatt","year":"2012","journal-title":"Movement Disorders: Official Journal of the Movement Disorder Society"},{"issue":"1","key":"10.1016\/j.redox.2015.02.002_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2217\/fnl.11.65","article-title":"Genetic modifiers of Huntington\u2019s disease: beyond CAG","volume":"7","author":"Arning","year":"2012","journal-title":"Future Neurology"},{"issue":"5576","key":"10.1016\/j.redox.2015.02.002_bib6","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington\u2019s disease","volume":"296","author":"Dunah","year":"2002","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.redox.2015.02.002_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.redox.2015.02.002_bib8","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/hmg\/dds516","article-title":"Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington\u2019s disease","volume":"22","author":"Valencia","year":"2013","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.redox.2015.02.002_bib9","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1001\/archneurol.2011.2945","article-title":"Alterations in brain transition metals in Huntington disease: an evolving and intricate story","volume":"69","author":"Rosas","year":"2012","journal-title":"Archives of Neurology"},{"issue":"10","key":"10.1016\/j.redox.2015.02.002_bib10","doi-asserted-by":"crossref","first-page":"e77023","DOI":"10.1371\/journal.pone.0077023","article-title":"Iron accumulates in Huntington\u2019s disease neurons: protection by deferoxamine","volume":"8","author":"Chen","year":"2013","journal-title":"PLOS One"},{"issue":"4","key":"10.1016\/j.redox.2015.02.002_bib11","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/114.4.1953","article-title":"Alterations in the levels of iron, ferritin and other trace metals in Parkinson\u2019s disease and other neurodegenerative diseases affecting the basal ganglia","volume":"114","author":"Dexter","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.redox.2015.02.002_bib12","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1039\/CT8946500899","article-title":"Oxidation of tartaric acid in presence of iron","volume":"65","author":"Fenton","year":"1894","journal-title":"Journal of the Chemical Society, Transactions"},{"issue":"10","key":"10.1016\/j.redox.2015.02.002_bib13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.redox.2015.02.002_bib14","article-title":"Oxidative modulation of K(+) channels in the central nervous system in neurodegenerative diseases and aging","author":"Peers","year":"2014","journal-title":"Antioxidants & Redox Signaling"},{"issue":"15","key":"10.1016\/j.redox.2015.02.002_bib15","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.febslet.2013.06.007","article-title":"Redox modification of proteins as essential mediators of CNS autophagy and mitophagy","volume":"587","author":"Lizama-Manibusan","year":"2013","journal-title":"FEBS Letters"},{"issue":"4","key":"10.1016\/j.redox.2015.02.002_bib16","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","article-title":"Systemic iron homeostasis","volume":"93","author":"Ganz","year":"2013","journal-title":"Physiological Reviews"},{"issue":"2","key":"10.1016\/j.redox.2015.02.002_bib17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/JHD-120029","article-title":"PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6\/2 mouse model of Huntington\u2019s disease","volume":"1","author":"Cherny","year":"2012","journal-title":"Journal of Huntington's Disease"},{"issue":"1","key":"10.1016\/j.redox.2015.02.002_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/taap.1999.8711","article-title":"Neonatal iron exposure induces neurobehavioral dysfunctions in adult mice","volume":"159","author":"Fredriksson","year":"1999","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"1","key":"10.1016\/j.redox.2015.02.002_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.expneurol.2005.07.017","article-title":"Selegiline protects against recognition memory impairment induced by neonatal iron treatment","volume":"196","author":"De Lima","year":"2005","journal-title":"Experimental Neurology"},{"issue":"6","key":"10.1016\/j.redox.2015.02.002_bib20","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neurobiolaging.2006.04.003","article-title":"Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age","volume":"28","author":"Kaur","year":"2007","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.redox.2015.02.002_bib21","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.nut.2010.11.007","article-title":"Diet supplementation with iron augments brain oxidative stress status in a rat model of psychological stress","volume":"27","author":"Yu","year":"2011","journal-title":"Nutrition"},{"issue":"Suppl. 3","key":"10.1016\/j.redox.2015.02.002_bib22","first-page":"511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.redox.2015.02.002_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.nbd.2014.06.022","article-title":"Altered selenium status in Huntington\u2019s disease: neuroprotection by selenite in the N171-82Q mouse model","volume":"71","author":"Lu","year":"2014","journal-title":"Neurobiology of Disease"},{"issue":"42","key":"10.1016\/j.redox.2015.02.002_bib24","doi-asserted-by":"crossref","first-page":"16685","DOI":"10.1073\/pnas.0707842104","article-title":"A small-molecule therapeutic lead for Huntington\u2019s disease: preclinical pharmacology and efficacy of C2-8 in the R6\/2 transgenic mouse","volume":"104","author":"Chopra","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"10.1016\/j.redox.2015.02.002_bib25","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1471-4159.2004.02726.x","article-title":"Cystamine increases l-cysteine levels in Huntington\u2019s disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation","volume":"91","author":"Fox","year":"2004","journal-title":"Journal of Neurochemistry"},{"issue":"3","key":"10.1016\/j.redox.2015.02.002_bib26","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1371\/journal.pone.0000334","article-title":"Mechanisms of copper ion mediated Huntington\u2019s disease progression","volume":"2","author":"Fox","year":"2007","journal-title":"PLOS One"},{"issue":"5\u20136","key":"10.1016\/j.redox.2015.02.002_bib27","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jinorgbio.2006.02.010","article-title":"Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology","volume":"100","author":"Maynard","year":"2006","journal-title":"Journal of Inorganic Biochemistry"},{"issue":"12","key":"10.1016\/j.redox.2015.02.002_bib28","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1039\/c3mt00227f","article-title":"Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma\u2013mass spectrometry","volume":"5","author":"Hare","year":"2013","journal-title":"Metallomics: Integrated Biometal Science"},{"issue":"23","key":"10.1016\/j.redox.2015.02.002_bib29","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1523\/JNEUROSCI.4196-13.2014","article-title":"Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis","volume":"34","author":"Roberts","year":"2014","journal-title":"Journal of Neuroscience"},{"issue":"13","key":"10.1016\/j.redox.2015.02.002_bib30","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.redox.2015.02.002_bib31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1326-5-26","article-title":"The mTOR kinase inhibitor everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6\/2 mouse model of Huntington\u2019s disease","volume":"5","author":"Fox","year":"2010","journal-title":"Molecular Neurodegeneration"},{"issue":"16","key":"10.1016\/j.redox.2015.02.002_bib32","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1523\/JNEUROSCI.0590-05.2005","article-title":"Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington\u2019s disease","volume":"25","author":"Van Raamsdonk","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.redox.2015.02.002_bib33","article-title":"Characterization of striatal neuronal loss and atrophy in the R6\/2 mouse model of Huntington\u2019s disease","volume":"6","author":"Dodds","year":"2014","journal-title":"PLoS Currents"},{"issue":"3","key":"10.1016\/j.redox.2015.02.002_bib34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0092-8674(00)80514-0","article-title":"Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo","volume":"90","author":"Scherzinger","year":"1997","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.redox.2015.02.002_bib35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cell.2010.08.014","article-title":"Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer\u2019s disease","volume":"142","author":"Duce","year":"2010","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.redox.2015.02.002_bib36","doi-asserted-by":"crossref","first-page":"809","DOI":"10.15252\/embr.201338064","article-title":"sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin","volume":"15","author":"McCarthy","year":"2014","journal-title":"EMBO Reports"},{"issue":"3","key":"10.1016\/j.redox.2015.02.002_bib37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.redox.2015.02.002_bib38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fnhum.2013.00585","article-title":"Perinatal iron deficiency and neurocognitive development","volume":"7","author":"Radlowski","year":"2013","journal-title":"Frontiers in Human Neuroscience"},{"issue":"4","key":"10.1016\/j.redox.2015.02.002_bib39","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1542\/peds.2008-1047","article-title":"Iron homeostasis in the neonate","volume":"123","author":"Collard","year":"2009","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.redox.2015.02.002_bib40","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB Journal"},{"issue":"5","key":"10.1016\/j.redox.2015.02.002_bib41","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.neuro.2007.01.014","article-title":"Extrapolating brain development from experimental species to humans","volume":"28","author":"Clancy","year":"2007","journal-title":"Neurotoxicology"},{"issue":"7010","key":"10.1016\/j.redox.2015.02.002_bib42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.redox.2015.02.002_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Current Neuropharmacology"},{"issue":"10","key":"10.1016\/j.redox.2015.02.002_bib44","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.freeradbiomed.2012.09.004","article-title":"Glutathione redox cycle dysregulation in Huntington\u2019s disease knock-in striatal cells","volume":"53","author":"Ribeiro","year":"2012","journal-title":"Free Radical Biology & Medicine"},{"issue":"12","key":"10.1016\/j.redox.2015.02.002_bib45","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1212\/WNL.43.12.2689","article-title":"Evidence for impairment of energy metabolism in vivo in Huntington\u2019s disease using localized 1H NMR spectroscopy","volume":"43","author":"Jenkins","year":"1993","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.redox.2015.02.002_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1353-8020(00)00028-6","article-title":"Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficits","volume":"7","author":"Fredriksson","year":"2001","journal-title":"Parkinsonism & Related Disorders"},{"issue":"6","key":"10.1016\/j.redox.2015.02.002_bib47","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jada.2004.03.022","article-title":"Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: the 1987, 1992, and 2000 National Health Interview Survey results","volume":"104","author":"Millen","year":"2004","journal-title":"Journal of the American Dietetic Association"},{"key":"10.1016\/j.redox.2015.02.002_bib48","series-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc","year":"2001"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231715000208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231715000208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:59:15Z","timestamp":1761976755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231715000208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":48,"alternative-id":["S2213231715000208"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2015.02.002","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6\/2 mouse model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2015.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}