{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:58:10Z","timestamp":1789826290359,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T00:00:00Z","timestamp":1469232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL113303"],"award-info":[{"award-number":["HL113303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Malcolm Feist Cardiovascular Research Endowment","award":["LSUHSC-S"],"award-info":[{"award-number":["LSUHSC-S"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.redox.2016.08.004","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T03:55:06Z","timestamp":1470974106000},"page":"157-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Hydrogen sulfide metabolism regulates endothelial solute barrier function"],"prefix":"10.1016","volume":"9","author":[{"given":"Shuai","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibile","family":"Pardue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinggui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Steven","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Wayne","family":"Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Kevil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2016.08.004_bib1","doi-asserted-by":"crossref","first-page":"C51","DOI":"10.1152\/ajpcell.00096.2015","article-title":"Histamine activates p38 MAP kinase and alters local lamellipodia dynamics, reducing endothelial barrier integrity and eliciting central movement of actin fibers","volume":"309","author":"Adderley","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.redox.2016.08.004_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2016.08.004_bib3","doi-asserted-by":"crossref","first-page":"a006429","DOI":"10.1101\/cshperspect.a006429","article-title":"Endothelial cell heterogeneity","volume":"2","author":"Aird","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.redox.2016.08.004_bib4","doi-asserted-by":"crossref","first-page":"10573","DOI":"10.1021\/ja505371z","article-title":"Understanding hydrogen sulfide storage: probing conditions for sulfide release from hydrodisulfides","volume":"136","author":"Bailey","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.redox.2016.08.004_bib5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1073\/pnas.0406092102","article-title":"Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis","volume":"102","author":"Bauer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2016.08.004_bib6","doi-asserted-by":"crossref","first-page":"e004093","DOI":"10.1161\/JAHA.112.004093","article-title":"Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1alpha and vascular endothelial growth factor-dependent angiogenesis","volume":"1","author":"Bir","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.redox.2016.08.004_bib7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2353\/ajpath.2006.051112","article-title":"PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradation","volume":"169","author":"Biswas","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2016.08.004_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1016571830091","article-title":"Identification of an occludin cell adhesion recognition sequence","volume":"26","author":"Blaschuk","year":"2002","journal-title":"Inflammation"},{"key":"10.1016\/j.redox.2016.08.004_bib9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.devcel.2011.11.002","article-title":"VEGF-induced vascular permeability is mediated by FAK","volume":"22","author":"Chen","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.redox.2016.08.004_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10456-012-9275-z","article-title":"Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency","volume":"15","author":"Christoffersson","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.redox.2016.08.004_bib11","first-page":"536","article-title":"Murine rVEGF164b, an inhibitory VEGF reduces VEGF-A-dependent endothelial proliferation and barrier dysfunction","volume":"17","author":"Cromer","year":"2010","journal-title":"Microcirculation"},{"key":"10.1016\/j.redox.2016.08.004_bib12","doi-asserted-by":"crossref","first-page":"R549","DOI":"10.1152\/ajpregu.00455.2015","article-title":"A case of mistaken identity: are reactive oxygen species actually reactive sulfide species?","volume":"310","author":"DeLeon","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.redox.2016.08.004_bib13","first-page":"1029","article-title":"Vascular permeability factor\/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis","volume":"146","author":"Dvorak","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2016.08.004_bib14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/jcbfm.2014.223","article-title":"Hydrogen sulfide inhalation decreases early blood-brain barrier permeability and brain edema induced by cardiac arrest and resuscitation","volume":"35","author":"Geng","year":"2015","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.redox.2016.08.004_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.redox.2016.08.004_bib16","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1089\/ars.2012.5041","article-title":"Polysulfides link H2S to protein thiol oxidation","volume":"19","author":"Greiner","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.redox.2016.08.004_bib17","doi-asserted-by":"crossref","first-page":"C977","DOI":"10.1152\/ajpcell.90607.2007","article-title":"VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability","volume":"294","author":"Guo","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.redox.2016.08.004_bib18","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2016.08.004_bib19","doi-asserted-by":"crossref","first-page":"e0117982","DOI":"10.1371\/journal.pone.0117982","article-title":"Role of hydrogen sulfide in early blood-brain barrier disruption following transient focal cerebral ischemia","volume":"10","author":"Jiang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2016.08.004_bib20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1165\/rcmb.2012-0496OC","article-title":"Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling","volume":"50","author":"Joshi","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.redox.2016.08.004_bib21","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0891-5849(97)00433-4","article-title":"Role of cadherin internalization in hydrogen peroxide-mediated endothelial permeability","volume":"24","author":"Kevil","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2016.08.004_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/10623320109165320","article-title":"The role of p38 MAP kinase in hydrogen peroxide mediated endothelial solute permeability","volume":"8","author":"Kevil","year":"2001","journal-title":"Endothelium"},{"key":"10.1016\/j.redox.2016.08.004_bib23","doi-asserted-by":"crossref","first-page":"14774","DOI":"10.1038\/srep14774","article-title":"Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain","volume":"5","author":"Kimura","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2016.08.004_bib24","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2016.08.004_bib25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvv198","article-title":"Cystathionine gamma-lyase regulates arteriogenesis through NO-dependent monocyte recruitment","volume":"107","author":"Kolluru","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2016.08.004_bib26","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2016.08.004_bib27","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1021\/acs.orglett.5b01962","article-title":"Diallyl trisulfide is a fast H2S donor, but diallyl disulfide is a slow one: the reaction pathways and intermediates of glutathione with polysulfides","volume":"17","author":"Liang","year":"2015","journal-title":"Org. Lett."},{"key":"10.1016\/j.redox.2016.08.004_bib28","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1073\/pnas.1302193110","article-title":"Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production","volume":"110","author":"Lin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2016.08.004_bib29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ymeth.2013.05.020","article-title":"S-sulfhydration\/desulfhydration and S-nitrosylation\/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO","volume":"62","author":"Lu","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.redox.2016.08.004_bib30","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2016.08.004_bib31","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2016.08.004_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/ars.2011.4401","article-title":"A practical look at the chemistry and biology of hydrogen sulfide","volume":"17","author":"Olson","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.redox.2016.08.004_bib33","doi-asserted-by":"crossref","first-page":"21486","DOI":"10.1074\/jbc.M115.662098","article-title":"Intracellular Ascorbate Prevents Endothelial Barrier Permeabilization by Thrombin","volume":"290","author":"Parker","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2016.08.004_bib34","doi-asserted-by":"crossref","first-page":"H2410","DOI":"10.1152\/ajpheart.00044.2012","article-title":"The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability","volume":"302","author":"Predmore","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.redox.2016.08.004_bib35","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1038\/emboj.2011.304","article-title":"Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability","volume":"30","author":"Schulte","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2016.08.004_bib36","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.freeradbiomed.2011.01.025","article-title":"Measurement of plasma hydrogen sulfide in vivo and in vitro","volume":"50","author":"Shen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2016.08.004_bib37","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.freeradbiomed.2012.04.007","article-title":"Analytical measurement of discrete hydrogen sulfide pools in biological specimens","volume":"52","author":"Shen","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2016.08.004_bib38","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.molcel.2010.07.013","article-title":"S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability","volume":"39","author":"Thibeault","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2016.08.004_bib39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1749-6632.2012.06558.x","article-title":"Relevance of endothelial junctions in leukocyte extravasation and vascular permeability","volume":"1257","author":"Vestweber","year":"2012","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.redox.2016.08.004_bib40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2016.08.004_bib41","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1165\/rcmb.2011-0248OC","article-title":"Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation","volume":"47","author":"Wang","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.redox.2016.08.004_bib42","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/1538574413503560","article-title":"Intravascular radiocontrast iodixanol increases permeability of proximal tubule epithelium: a possible mechanism of contrast-induced nephropathy","volume":"47","author":"Yao","year":"2013","journal-title":"Vasc. Endovasc. Surg."},{"key":"10.1016\/j.redox.2016.08.004_bib43","doi-asserted-by":"crossref","first-page":"L403","DOI":"10.1152\/ajplung.00327.2014","article-title":"Working with nitric oxide and hydrogen sulfide in biological systems","volume":"308","author":"Yuan","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.redox.2016.08.004_bib44","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/(SICI)1097-4652(199803)174:3<370::AID-JCP11>3.0.CO;2-D","article-title":"Hydrogen peroxide-induced cytoskeletal rearrangement in cultured pulmonary endothelial cells","volume":"174","author":"Zhao","year":"1998","journal-title":"J. Cell. Physiol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231716300817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231716300817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:59:07Z","timestamp":1761976747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231716300817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":44,"alternative-id":["S2213231716300817"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2016.08.004","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide metabolism regulates endothelial solute barrier function","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2016.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}