{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T21:50:31Z","timestamp":1781041831592,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["2008-0062275"],"award-info":[{"award-number":["2008-0062275"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["20150184"],"award-info":[{"award-number":["20150184"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.redox.2016.12.008","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T10:33:14Z","timestamp":1481193194000},"page":"456-468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function"],"prefix":"10.1016","volume":"11","author":[{"given":"Chul Ju","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ju","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil-Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Bae","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Wan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Kyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Tae","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6676","key":"10.1016\/j.redox.2016.12.008_bib1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.redox.2016.12.008_bib2","first-page":"209","article-title":"Parkin and defective ubiquitination in Parkinson's disease","volume":"70","author":"Dawson","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"issue":"7113","key":"10.1016\/j.redox.2016.12.008_bib3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"issue":"46","key":"10.1016\/j.redox.2016.12.008_bib4","doi-asserted-by":"crossref","first-page":"35661","DOI":"10.1074\/jbc.C000447200","article-title":"Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity","volume":"275","author":"Imai","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2016.12.008_bib5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/77060","article-title":"Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase","volume":"25","author":"Shimura","year":"2000","journal-title":"Nat. Genet."},{"issue":"24","key":"10.1016\/j.redox.2016.12.008_bib6","doi-asserted-by":"crossref","first-page":"13354","DOI":"10.1073\/pnas.240347797","article-title":"Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1","volume":"97","author":"Zhang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6701","key":"10.1016\/j.redox.2016.12.008_bib7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/26652","article-title":"The ubiquitin pathway in Parkinson's disease","volume":"395","author":"Leroy","year":"1998","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.tins.2007.03.009","article-title":"Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease","volume":"30","author":"Sulzer","year":"2007","journal-title":"Trends Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.redox.2016.12.008_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbamcr.2004.09.026","article-title":"Ubiquitin, proteasome and parkin","volume":"1695","author":"Tanaka","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"7097","key":"10.1016\/j.redox.2016.12.008_bib11","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib12","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.redox.2016.12.008_bib13","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1073\/pnas.0737556100","article-title":"Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants","volume":"100","author":"Greene","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"44","key":"10.1016\/j.redox.2016.12.008_bib14","doi-asserted-by":"crossref","first-page":"43628","DOI":"10.1074\/jbc.M308947200","article-title":"Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons","volume":"278","author":"Goldberg","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.redox.2016.12.008_bib15","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ncpneuro0924","article-title":"Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis","volume":"4","author":"Henchcliffe","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0896-6273(02)01125-X","article-title":"Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons","volume":"36","author":"Petrucelli","year":"2002","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1089\/hum.2005.16.262","article-title":"Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease","volume":"16","author":"Yamada","year":"2005","journal-title":"Hum. gene Ther."},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0896-6273(03)00143-0","article-title":"Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila","volume":"37","author":"Yang","year":"2003","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib19","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ymthe.2006.06.009","article-title":"Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease","volume":"14","author":"Vercammen","year":"2006","journal-title":"Mol. Ther.: J. Am. Soc. Gene Ther."},{"issue":"16","key":"10.1016\/j.redox.2016.12.008_bib20","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/hmg\/ddh180","article-title":"Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis","volume":"13","author":"Jiang","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib21","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1021\/acs.chemrev.5b00407","article-title":"Superoxide ion: generation and chemical implications","volume":"116","author":"Hayyan","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.redox.2016.12.008_bib22","first-page":"794","article-title":"Free radicals and antioxidants in human health: current status and future prospects","volume":"52","author":"Devasagayam","year":"2004","journal-title":"J. Assoc. Physicians India"},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib23","doi-asserted-by":"crossref","first-page":"L1324","DOI":"10.1152\/ajplung.00326.2001","article-title":"ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes","volume":"282","author":"Kulisz","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1096\/fj.04-2751com","article-title":"Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease","volume":"19","author":"Zhang","year":"2005","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"9\u201310","key":"10.1016\/j.redox.2016.12.008_bib25","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1089\/ars.2006.8.1775","article-title":"Reactive oxygen species-induced activation of the MAP kinase signaling pathways","volume":"8","author":"McCubrey","year":"2006","journal-title":"Antioxid. Redox Signal."},{"issue":"1\u20134","key":"10.1016\/j.redox.2016.12.008_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/biof.5520170128","article-title":"Redox signaling and the MAP kinase pathways","volume":"17","author":"Torres","year":"2003","journal-title":"BioFactors"},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/mds.20390","article-title":"Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease","volume":"20","author":"Silva","year":"2005","journal-title":"Mov. Disord.: Off. J. Mov. Disord. Soc."},{"issue":"4","key":"10.1016\/j.redox.2016.12.008_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.tcb.2008.01.007","article-title":"How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?","volume":"18","author":"Chipuk","year":"2008","journal-title":"Trends Cell Biol."},{"issue":"47","key":"10.1016\/j.redox.2016.12.008_bib29","doi-asserted-by":"crossref","first-page":"12500","DOI":"10.1523\/JNEUROSCI.4511-08.2008","article-title":"Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice","volume":"28","author":"Karunakaran","year":"2008","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib30","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1128\/MCB.26.6.2118-2129.2006","article-title":"p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells","volume":"26","author":"Farley","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.redox.2016.12.008_bib31","doi-asserted-by":"crossref","first-page":"e1270","DOI":"10.1038\/cddis.2014.200","article-title":"Involvement of p38 in signal switching from autophagy to apoptosis via the PERK\/eIF2alpha\/ATF4 axis in selenite-treated NB4 cells","volume":"5","author":"Jiang","year":"2014","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/cdd.2012.129","article-title":"Phosphorylation of Atg5 by the Gadd45beta-MEKK4-p38 pathway inhibits autophagy","volume":"20","author":"Keil","year":"2013","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.redox.2016.12.008_bib33","first-page":"97","article-title":"Long-term ethanol administration enhances age-dependent modulation of redox state in different brain regions in the rat: protection by acetyl carnitine","volume":"24","author":"Calabrese","year":"2002","journal-title":"Int. J. Tissue React."},{"issue":"1","key":"10.1016\/j.redox.2016.12.008_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1997.77.1.1","article-title":"Cellular and molecular neuroscience of alcoholism","volume":"77","author":"Diamond","year":"1997","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.redox.2016.12.008_bib35","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1053\/gast.2002.33613","article-title":"Alcohol and mitochondria: a dysfunctional relationship","volume":"122","author":"Hoek","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2016.12.008_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1749-6632.1999.tb07985.x","article-title":"Excitotoxicity, oxidative stress, and the neuroprotective potential of melatonin","volume":"890","author":"Skaper","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.redox.2016.12.008_bib37","first-page":"159","article-title":"Lack of CCR5 modifies glial phenotypes and population of the nigral dopaminergic neurons, but not MPTP-induced dopaminergic neurodegeneration","volume":"49C","author":"Choi","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib38","doi-asserted-by":"crossref","first-page":"e5482","DOI":"10.1371\/journal.pone.0005482","article-title":"Striatal neuroinflammation promotes Parkinsonism in rats","volume":"4","author":"Choi","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.redox.2016.12.008_bib39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nm0498-447","article-title":"Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides","volume":"4","author":"Xu","year":"1998","journal-title":"Nat. Med."},{"issue":"5733","key":"10.1016\/j.redox.2016.12.008_bib40","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.redox.2016.12.008_bib41","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1176\/ajp.155.9.1207","article-title":"Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia","volume":"155","author":"Tsai","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.redox.2016.12.008_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods Mol. Biol."},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib43","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2016.12.008_bib44","article-title":"Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells","author":"Wang","year":"2016","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.redox.2016.12.008_bib45","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1055\/s-0035-1558308","article-title":"Secondary metabolites from endophytic fungus penicillium pinophilum induce ROS-mediated apoptosis through mitochondrial pathway in pancreatic cancer cells","volume":"82","author":"Koul","year":"2016","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.redox.2016.12.008_bib46","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1039\/C6FO00027D","article-title":"Pleurotus nebrodensis polysaccharide(PN50G) evokes A549 cell apoptosis by the ROS\/AMPK\/PI3K\/AKT\/mTOR pathway to suppress tumor growth","volume":"7","author":"Cui","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.redox.2016.12.008_bib47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fonc.2012.00182","article-title":"Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration","volume":"2","author":"Braun","year":"2012","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.redox.2016.12.008_bib48","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/156720512800107618","article-title":"The role of ER stress-induced apoptosis in neurodegeneration","volume":"9","author":"Stefani","year":"2012","journal-title":"Curr. Alzheimer Res."},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib49","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.drugalcdep.2013.07.013","article-title":"Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): quantity, frequency, and timing of drinking","volume":"133","author":"May","year":"2013","journal-title":"Drug Alcohol Depend."},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib50","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11065-011-9166-x","article-title":"Fetal alcohol spectrum disorders: an overview","volume":"21","author":"Riley","year":"2011","journal-title":"Neuropsychol. Rev."},{"issue":"Suppl 3","key":"10.1016\/j.redox.2016.12.008_bib51","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1289\/ehp.00108s3421","article-title":"On categorizations in analyses of alcohol teratogenesis","volume":"108","author":"Sampson","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1096-9926(199711)56:5<317::AID-TERA5>3.0.CO;2-U","article-title":"Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder","volume":"56","author":"Sampson","year":"1997","journal-title":"Teratology"},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib53","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/nbdi.2001.0475","article-title":"Ethanol-induced caspase-3 activation in the in vivo developing mouse brain","volume":"9","author":"Olney","year":"2002","journal-title":"Neurobiol. Dis."},{"issue":"5455","key":"10.1016\/j.redox.2016.12.008_bib54","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.287.5455.1056","article-title":"Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome","volume":"287","author":"Ikonomidou","year":"2000","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib55","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1046\/j.1471-4159.1994.63020584.x","article-title":"Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: implications for neurodegeneration","volume":"63","author":"Dykens","year":"1994","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.redox.2016.12.008_bib56","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/labinvest.3780140","article-title":"DNA damage as a mechanism of cell loss in Alzheimer's disease","volume":"80","author":"de la Monte","year":"2000","journal-title":"Lab. Investig.; a J. Tech. Methods Pathol."},{"issue":"11","key":"10.1016\/j.redox.2016.12.008_bib57","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.yexcr.2012.02.006","article-title":"Autophagy is a survival force via suppression of necrotic cell death","volume":"318","author":"Shen","year":"2012","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.redox.2016.12.008_bib58","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.3025","article-title":"Autophagy and disease: always two sides to a problem","volume":"226","author":"Sridhar","year":"2012","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.redox.2016.12.008_bib59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib60","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2174\/187152710793237421","article-title":"Autophagy in the central nervous system: implications for neurodegenerative disorders","volume":"9","author":"Xilouri","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"1","key":"10.1016\/j.redox.2016.12.008_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5607\/en.2012.21.1.1","article-title":"Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival?","volume":"21","author":"Lee","year":"2012","journal-title":"Exp. Neurobiol."},{"issue":"7","key":"10.1016\/j.redox.2016.12.008_bib62","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.febslet.2010.02.060","article-title":"Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network","volume":"584","author":"Tanaka","year":"2010","journal-title":"FEBS Lett."},{"issue":"7","key":"10.1016\/j.redox.2016.12.008_bib63","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.bbadis.2008.12.007","article-title":"Mendelian forms of Parkinson's disease","volume":"1792","author":"Gasser","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"18","key":"10.1016\/j.redox.2016.12.008_bib64","doi-asserted-by":"crossref","first-page":"18614","DOI":"10.1074\/jbc.M401135200","article-title":"Mitochondrial dysfunction and oxidative damage in parkin-deficient mice","volume":"279","author":"Palacino","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.redox.2016.12.008_bib65","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.tiv.2013.05.009","article-title":"Ethanol-induced apoptosis in human liver adenocarcinoma cells (SK-Hep1): fas- and mitochondria-mediated pathways and interaction with MAPK signaling system","volume":"27","author":"Morio","year":"2013","journal-title":"Toxicol. Vitr.: Int. J. Publ. Assoc. BIBRA"},{"issue":"11","key":"10.1016\/j.redox.2016.12.008_bib66","doi-asserted-by":"crossref","first-page":"e112698","DOI":"10.1371\/journal.pone.0112698","article-title":"Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK\/ERK signaling pathway in vitro","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2016.12.008_bib67","doi-asserted-by":"crossref","first-page":"4512309","DOI":"10.1155\/2016\/4512309","article-title":"Acetaldehyde induces cytotoxicity of SH-SY5Y cells via inhibition of Akt activation and induction of Oxidative stress","volume":"2016","author":"Yan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib68","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1091\/mbc.e07-08-0811","article-title":"Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling","volume":"19","author":"Davila","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.redox.2016.12.008_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(99)00071-6","article-title":"The p38 signal transduction pathway: activation and function","volume":"12","author":"Ono","year":"2000","journal-title":"Cell. Signal."},{"issue":"35","key":"10.1016\/j.redox.2016.12.008_bib70","doi-asserted-by":"crossref","first-page":"22173","DOI":"10.1074\/jbc.272.35.22173","article-title":"Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase\/p38 kinases and GADD153","volume":"272","author":"Brenner","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.redox.2016.12.008_bib71","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/j.1471-4159.2008.05277.x","article-title":"Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways","volume":"105","author":"Hasegawa","year":"2008","journal-title":"J. Neurochem."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231716302440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231716302440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:33:52Z","timestamp":1746851632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231716302440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":71,"alternative-id":["S2213231716302440"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2016.12.008","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2016.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}