{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:02:21Z","timestamp":1790244141739,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.redox.2017.02.006","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T11:25:18Z","timestamp":1486985118000},"page":"70-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Reciprocal regulation of eNOS, H2S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin"],"prefix":"10.1016","volume":"12","author":[{"given":"Fragiska","family":"Sigala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Efentakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Karageorgiadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstadinos","family":"Filis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevas","family":"Zampas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios K.","family":"Iliodromitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Zografos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Papapetropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2017.02.006_bib1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/STROKEAHA.111.669267","article-title":"Asymptomatic carotid artery stenosis and the risk of ischemic stroke according to subtype in patients with clinical manifest arterial disease","volume":"44","author":"Den Hartog","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.redox.2017.02.006_bib2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1056\/NEJM200006083422302","article-title":"The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. North American symptomatic Carotid Endarterectomy trial Collaborators","volume":"342","author":"Inzitari","year":"2000","journal-title":"New Engl. J. Med"},{"key":"10.1016\/j.redox.2017.02.006_bib3","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1161\/01.STR.30.12.2513","article-title":"Ischemic stroke subtypes: a population-based study of incidence and risk factors","volume":"30","author":"Petty","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.redox.2017.02.006_bib4","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of plaque formation and rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2017.02.006_bib5","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/physrev.00004.2012","article-title":"Molecular biology of atherosclerosis","volume":"93","author":"Hopkins","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2017.02.006_bib6","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.redox.2017.02.006_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrd.2015.1","article-title":"Gasotransmitters in cancer: from pathophysiology to experimental therapy","volume":"15","author":"Szabo","year":"2016","journal-title":"Nat. Rev. Drug Disco."},{"key":"10.1016\/j.redox.2017.02.006_bib8","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H(2)S biogenesis, decay and signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Antiox. Redox Signal"},{"key":"10.1016\/j.redox.2017.02.006_bib9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and physiological effects of hydrogen sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antiox. Redox Signal"},{"key":"10.1016\/j.redox.2017.02.006_bib10","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.tips.2015.05.007","article-title":"The role of H2S bioavailability in endothelial dysfunction","volume":"36","author":"Wang","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.redox.2017.02.006_bib11","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0008-6363(99)00235-7","article-title":"Apoptosis in atherosclerosis: beneficial or detrimental?","volume":"45","author":"Kockx","year":"2000","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.redox.2017.02.006_bib12","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(12)60367-5","article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials","volume":"380","author":"Mihaylova","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2017.02.006_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pharmthera.2009.01.002","article-title":"Statins and cardioprotection--more than just lipid lowering?","volume":"122","author":"Ludman","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.redox.2017.02.006_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/092986707779313381","article-title":"Endothelial dysfunction, oxidative stress and inflammation in atherosclerosis: beneficial effects of statins","volume":"14","author":"Lahera","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.redox.2017.02.006_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1056\/NEJM199108153250701","article-title":"Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis","volume":"325","author":"North American Symptomatic Carotid Endarterectomy Trial Collaborators","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2017.02.006_bib16","first-page":"1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on vascular Lesions of the Council on Arteriosclerosis","volume":"92","author":"Stary","year":"1995","journal-title":"Am. Heart Assoc. Circ."},{"key":"10.1016\/j.redox.2017.02.006_bib17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000079736","article-title":"Vascular endothelial growth factor and matrix Metalloproteinase-9 expression in human carotid atherosclerotic plaques: relationship with plaque destabilization via neovascularization","volume":"18","author":"Papalambros","year":"2004","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.redox.2017.02.006_bib18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvv129","article-title":"Cardioprotection by H2S engages a cGMP-dependent protein kinase G\/phospholamban pathway","volume":"106","author":"Bibli","year":"2015","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.redox.2017.02.006_bib19","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jvs.2010.03.047","article-title":"Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability","volume":"52","author":"Sigala","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.redox.2017.02.006_bib20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/ATVBAHA.115.306861","article-title":"Smooth muscle hypoxia-inducible factor 1\u03b1 links intravascular pressure and atherosclerosis\u2014Brief Report","volume":"36","author":"Liu","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2017.02.006_bib21","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/HYPERTENSIONAHA.115.05886","article-title":"Endothelial hypoxia-inducible factor-1\u03b1 promotes atherosclerosis and monocyte recruitment by upregulating MicroRNA-19a","volume":"66","author":"Akhtar","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2017.02.006_bib22","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/ATVBAHA.115.305551","article-title":"HIF-1\u03b1 and PFKFB3 mediate a tight Relationship Between proinflammatory activation and anaerobic metabolism in atherosclerotic macrophages","volume":"35","author":"Tawakol","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2017.02.006_bib23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2741\/4395","article-title":"Hypoxia increases Nrf2-induced HO-1 expression via the PI3K\/Akt pathway","volume":"21","author":"Zhao","year":"2016","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.redox.2017.02.006_bib24","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1091\/mbc.e09-12-1003","article-title":"The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1","volume":"21","author":"Diebold","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.redox.2017.02.006_bib25","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.redox.2015.06.008","article-title":"Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase","volume":"5","author":"Idelman","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2017.02.006_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/hq0102.102189","article-title":"Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury","volume":"22","author":"Szocs","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2017.02.006_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2017.02.006_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejphar.2011.09.188","article-title":"Heme oxygenase-1 inhibits progression and destabilization of vulnerable plaques in a rabbit model of atherosclerosis","volume":"672","author":"Li","year":"2011","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.redox.2017.02.006_bib29","doi-asserted-by":"crossref","DOI":"10.1161\/str.36.9.1901","article-title":"Is heme oxygenase-1 a causal player for plaque stability?","volume":"36","author":"Espinola-Klein","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.redox.2017.02.006_bib30","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1096\/fj.03-0187fje","article-title":"Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling","volume":"17","author":"Yet","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.redox.2017.02.006_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.atherosclerosis.2014.04.020","article-title":"Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration","volume":"235","author":"Huang","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.redox.2017.02.006_bib32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/joim.12296","article-title":"Thrombosis formation on atherosclerotic lesions and plaque rupture","volume":"276","author":"Badimon","year":"2014","journal-title":"J. Int. Med."},{"key":"10.1016\/j.redox.2017.02.006_bib33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/21218","article-title":"Regulation of endothelium derived nitric oxide production by the protein kinase Akt","volume":"399","author":"Fulton","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.redox.2017.02.006_bib34","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1161\/ATVBAHA.109.196394","article-title":"Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis","volume":"29","author":"Fern\u00e1ndez-Hernando","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2017.02.006_bib35","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuint.2004.03.026","article-title":"Effect of hypercholesterolemia and of oxidative stress on the nitric oxide-cGMP pathway","volume":"45","author":"Francois","year":"2004","journal-title":"Neurochem. Int"},{"key":"10.1016\/j.redox.2017.02.006_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.phrs.2016.08.026","article-title":"Regulation and role of endogenously produced hydrogen sulfide in angiogenesis","volume":"113","author":"Katsouda","year":"2016","journal-title":"Pharmacol. Res"},{"key":"10.1016\/j.redox.2017.02.006_bib37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/cvr\/cvt146","article-title":"Role of macrophage-derived hypoxia-inducible factor (HIF)\u22121\u03b1 as a mediator of vascular remodelling","volume":"99","author":"Nakayama","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2017.02.006_bib38","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1128\/MCB.24.24.10703-10717.2004","article-title":"NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells","volume":"24","author":"Pedruzzi","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.redox.2017.02.006_bib39","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/01.CIR.0000012917.74432.66","article-title":"Superoxide production and expression of nox family proteins in human atherosclerosis","volume":"105","author":"Sorescu","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2017.02.006_bib40","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1161\/CIRCULATIONAHA.108.808618","article-title":"Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque","volume":"119","author":"Cheng","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2017.02.006_bib41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0008-6363(98)00278-8","article-title":"Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?","volume":"41","author":"Siow","year":"1999","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.redox.2017.02.006_bib42","first-page":"218","article-title":"Differential modulation of nitric oxide synthases in aging: therapeutic opportunities","volume":"3","author":"Cau","year":"2012","journal-title":"Fron. Physiol."},{"key":"10.1016\/j.redox.2017.02.006_bib43","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1089\/ars.2013.5324","article-title":"Hydrogen sulfide and the pathogenesis of atherosclerosis","volume":"20","author":"Mani","year":"2014","journal-title":"Antiox. Redox Sign"},{"key":"10.1016\/j.redox.2017.02.006_bib44","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.02.006_bib45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.atherosclerosis.2014.03.020","article-title":"Pathology of human plaque vulnerability: mechanisms and consequences of intraplaque haemorrhages","volume":"234","author":"Michel","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.redox.2017.02.006_bib46","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2017.02.006_bib47","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1073\/pnas.1105121108","article-title":"Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function","volume":"108","author":"Suzuki","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.02.006_bib48","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.freeradbiomed.2010.10.705","article-title":"Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest","volume":"50","author":"Carballal","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.02.006_bib49","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen Sulfide induces keap1 S-sulfhydration and suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 activation","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2017.02.006_bib50","doi-asserted-by":"crossref","first-page":"e75467","DOI":"10.1371\/journal.pone.0075467","article-title":"Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory","volume":"8","author":"Stuart","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.redox.2017.02.006_bib51","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/01.CIR.0000027569.76671.A8","article-title":"Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment","volume":"106","author":"Ceriello","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2017.02.006_bib52","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1007\/s11033-010-0497-0","article-title":"The effects of simvastatin on angiogenesis: studied by an original model of atherosclerosis and acute myocardial infarction in rabbit","volume":"38","author":"Shen","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.redox.2017.02.006_bib53","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/CCLM.2009.073","article-title":"Expression of heme oxygenase-1, hypoxia inducible factor-1alpha, and ubiquitin in peripheral inflammatory cells from patients with coronary heart disease","volume":"47","author":"Chen","year":"2009","journal-title":"Clin. Chem. Lab. Med"},{"key":"10.1016\/j.redox.2017.02.006_bib54","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.taap.2014.08.032","article-title":"Atorvastatin ameliorates arsenic-induced hypertension and enhancement of vascular redox signaling in rats","volume":"280","author":"Sarath","year":"2014","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.redox.2017.02.006_bib55","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2337\/db09-1057","article-title":"Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db\/db mice: role of NADPH oxidase 4","volume":"59","author":"Li","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2017.02.006_bib56","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1211\/0022357055353","article-title":"The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis","volume":"57","author":"Nachtigal","year":"2005","journal-title":"J. Pharm. Pharm."},{"key":"10.1016\/j.redox.2017.02.006_bib57","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1002\/jcb.24223","article-title":"Statins modulate transcriptional activity of heme-oxygenase-1 promoter in NIH 3T3 Cells","volume":"113","author":"Mrad","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.redox.2017.02.006_bib58","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.toxlet.2011.09.016","article-title":"Simvastatin induces the expression of hemeoxygenase-1 against ischemia-reperfusion injury on the testes in rats","volume":"207","author":"Tu","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.redox.2017.02.006_bib59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2011.09.014","article-title":"Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?","volume":"52","author":"Balakumar","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.redox.2017.02.006_bib60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phrs.2014.06.006","article-title":"Statins upregulate cystathionine gamma-lyase transcription and H2S generation via activating Akt signaling in macrophage","volume":"87","author":"Xu","year":"2014","journal-title":"Pharmacol. Res"},{"key":"10.1016\/j.redox.2017.02.006_bib61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.phrs.2010.10.011","article-title":"Differential effects of statins on endogenous H2S formation in perivascular adipose tissue","volume":"63","author":"Wojcicka","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.redox.2017.02.006_bib62","doi-asserted-by":"crossref","first-page":"34608","DOI":"10.1038\/srep34608","article-title":"Cystathionine \u03b3-lyase is expressed in human atherosclerotic plaque microvessels and is involved in micro-angiogenesis","volume":"6","author":"van den Born","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2017.02.006_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/IBPC.S5174","article-title":"Effects of antihypertensive drugs on carotid intima-media thickness: focus on angiotensin II receptor blockers. A review of randomized, controlled trials","volume":"2","author":"Cuspidi","year":"2009","journal-title":"Integr. Blood Press. Control"},{"key":"10.1016\/j.redox.2017.02.006_bib64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.STR.0000150643.08420.78","article-title":"Concurrent treatment with renin-angiotensin system blockers and acetylsalicylic acid reduces nuclear factor kappaB activation and C-reactive protein expression in human carotid artery plaques","volume":"36","author":"Sattler","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.redox.2017.02.006_bib65","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11892-006-0060-5","article-title":"Inhibition of the renin angiotensin system: implications for the endothelium","volume":"6","author":"Savoia","year":"2006","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.redox.2017.02.006_bib66","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/cvr\/cvu026","article-title":"Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition","volume":"102","author":"Bucci","year":"2014","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.redox.2017.02.006_bib67","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1124\/jpet.114.212928","article-title":"Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK\u03b2\/AMPK and heme oxygenase-1 activation","volume":"350","author":"Tian","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.redox.2017.02.006_bib68","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.pharmthera.2010.08.010","article-title":"Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases","volume":"128","author":"Tsutsui","year":"2010","journal-title":"Pharm., Ther."},{"key":"10.1016\/j.redox.2017.02.006_bib69","first-page":"420 868","article-title":"Inflammation in atherosclerosis","volume":"202","author":"Libby","year":"2002","journal-title":"Nature"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717300587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717300587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:02:31Z","timestamp":1761976951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231717300587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":69,"alternative-id":["S2213231717300587"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2017.02.006","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reciprocal regulation of eNOS, H2S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2017.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}