{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:36:25Z","timestamp":1781066185222,"version":"3.54.1"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,2,26]],"date-time":"2017-02-26T00:00:00Z","timestamp":1488067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB-2012-1-178349"],"award-info":[{"award-number":["CB-2012-1-178349"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008688","name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.redox.2017.03.029","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T01:49:12Z","timestamp":1490924952000},"page":"610-624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid"],"prefix":"10.1016","volume":"12","author":[{"given":"Alejandro","family":"Silva-Palacios","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Col\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie P.","family":"L\u00f3pez-Cervantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Zazueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Luna-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"K\u00f6nigsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2017.03.029_bib1","doi-asserted-by":"crossref","unstructured":"K.M. Kennedy, N. Raz, Normal aging of the brain, in: Social Cognitive Neuroscience, Cognitive Neuroscience, Clinical Brain Mapping, vol. 3, Elsevier Inc., 2015, pp. 603\u2013617.","DOI":"10.1016\/B978-0-12-397025-1.00068-3"},{"key":"10.1016\/j.redox.2017.03.029_bib2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1523\/JNEUROSCI.2939-14.2015","article-title":"SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1\u03b2","volume":"35","author":"Cho","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.redox.2017.03.029_bib3","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.2174\/1381612822666160413123806","article-title":"Oxidative stress modulation through habitual physical activity","volume":"22","author":"Boccatonda","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.redox.2017.03.029_bib4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/acel.12078","article-title":"Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes","volume":"12","author":"Rahman","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.redox.2017.03.029_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.arr.2015.12.005","article-title":"Nrf2 signaling and redox homeostasis in the aging heart: a potential target to prevent cardiovascular diseases?","volume":"26","author":"Silva-Palacios","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.redox.2017.03.029_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuro.2014.10.004","article-title":"Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: mitochondrial dysfunction and neurodegeneration","volume":"45","author":"Hariharan","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.redox.2017.03.029_bib7","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/j.1471-4159.2005.03515.x","article-title":"3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease","volume":"95","author":"Brouillet","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.redox.2017.03.029_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.03.018","article-title":"Mitochondrial disease of the brain","volume":"63","author":"Chaturvedi","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.03.029_bib9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mito.2015.10.007","article-title":"Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry","volume":"25","author":"Burtscher","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.redox.2017.03.029_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuroscience.2013.12.025","article-title":"Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway","volume":"260","author":"Col\u00edn-Gonz\u00e1lez","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.redox.2017.03.029_bib11","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1016\/j.cellsig.2013.08.007","article-title":"Redox activation of Nrf2 & NF-\u03baB: a double end sword?","volume":"25","author":"Buelna-Chontal","year":"2013","journal-title":"Cell Signal."},{"key":"10.1016\/j.redox.2017.03.029_bib12","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1073\/pnas.1314421111","article-title":"HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response","volume":"111","author":"Rotblat","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.03.029_bib13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2011.05.013","article-title":"Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole","volume":"255","author":"Abiko","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.redox.2017.03.029_bib14","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.fct.2011.07.008","article-title":"Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats","volume":"49","author":"P\u00e9rez-Rojas","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.redox.2017.03.029_bib15","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1073\/pnas.0400282101","article-title":"Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid","volume":"101","author":"Suh","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.03.029_bib16","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.freeradbiomed.2012.02.042","article-title":"Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments","volume":"52","author":"Zhang","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.03.029_bib17","doi-asserted-by":"crossref","first-page":"22925","DOI":"10.1074\/jbc.M414635200","article-title":"Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo","volume":"280","author":"Shih","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.03.029_bib18","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.neurobiolaging.2014.01.143","article-title":"Primary cultured astrocytes from old rats are capable to activate the Nrf2 response against MPP+ toxicity after tBHQ pretreatment","volume":"35","author":"Alarc\u00f3n-Aguilar","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.redox.2017.03.029_bib19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12079-014-0248-4","article-title":"New considerations on hormetic response against oxidative stress","volume":"8","author":"Luna-L\u00f3pez","year":"2014","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.redox.2017.03.029_bib20","doi-asserted-by":"crossref","first-page":"33412","DOI":"10.1074\/jbc.M706799200","article-title":"Heat shock factor 1 attenuates 4-hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL","volume":"282","author":"Jacobs","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.03.029_bib21","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.bcp.2008.12.010","article-title":"The NF kappa B-mediated control of RS and JNK signaling in vitamin A-treated cells: duration of JNK-AP-1 pathway activation may determine cell death or proliferation","volume":"77","author":"Zanotto-Filho","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.redox.2017.03.029_bib22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ejps.2012.03.004","article-title":"Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase\/Akt-dependent mechanism in NSC34 motor neuron-like cells","volume":"46","author":"Hsu","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.redox.2017.03.029_bib23","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jnutbio.2013.07.005","article-title":"Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-\u03baB pathways","volume":"24","author":"Mukherjee","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.redox.2017.03.029_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/jbt.20053","article-title":"Potential neuroprotective effect of t-butylhydroquinone against neurotoxicity-induced by 1-methyl-4-(2'-methylphenyl)\u22121,2,3,6-tetrahydropyridine (2'-methyl-MPTP) in mice","volume":"19","author":"Abdel-Wahab","year":"2005","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.redox.2017.03.029_bib25","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/molecules15020878","article-title":"3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future","volume":"15","author":"T\u00fanez","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.redox.2017.03.029_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0149-7634(96)00027-9","article-title":"3-Nitropropionic acid animal model and Huntington's disease","volume":"21","author":"Borlongan","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.redox.2017.03.029_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brs.2012.03.015","article-title":"I, Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington's disease-like rat model","volume":"6","author":"Tasset","year":"2013","journal-title":"Brain Stimul."},{"key":"10.1016\/j.redox.2017.03.029_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.lfs.2015.06.009","article-title":"Acute restraint stress reduces hippocampal oxidative damage and behavior in rats: effect of S-allyl cysteine","volume":"135","author":"Col\u00edn-Gonz\u00e1lez","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.redox.2017.03.029_bib29","unstructured":"K.R. Bailey, J.N. Crawley, Methods of behavior analysis in neuroscience, 2nd edition, Chapter 5 Anxiety-Related Behaviors, 2009."},{"key":"10.1016\/j.redox.2017.03.029_bib30","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.2466\/pr0.1978.43.3f.1123","article-title":"Reliability of various measures obtained in open-field test","volume":"65","author":"Goma","year":"1978","journal-title":"Psychol. Rep."},{"key":"10.1016\/j.redox.2017.03.029_bib31","article-title":"Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic\/pro-oxidant model in the rat striatum","volume":"23","author":"Col\u00edn-Gonz\u00e1lez","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.redox.2017.03.029_bib32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11130-011-0251-3","article-title":"Aged garlic extract attenuates cerebral damage and cyclooxygenase-2 induction after ischemia and reperfusion in rats","volume":"66","author":"Col\u00edn-Gonz\u00e1lez","year":"2011","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.redox.2017.03.029_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0006-8993(00)02513-0","article-title":"Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration","volume":"874","author":"Schmued","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.redox.2017.03.029_bib34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.03.029_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jat.2841","article-title":"Comparing the effects of two neurotoxins in cortical astrocytes obtained from rats of different ages: involvement of oxidative damage","volume":"34","author":"Alarc\u00f3n-Aguilar","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.redox.2017.03.029_bib36","first-page":"59","article-title":"Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro","volume":"223","author":"Persky","year":"2000","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.redox.2017.03.029_bib37","first-page":"143","article-title":"Membrane potential regulates mitochondrial ATP-diphosphohydrolase activity but is not involved in progesterone biosynthesis in human syncytiotrophoblast cells","volume":"2015","author":"Flores-Herrera","year":"1847","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2017.03.029_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/9780470110423.ch3","article-title":"Determination of the activity of succinate, NADH, choline, and alphaglycerophosphate dehydrogenases","volume":"22","author":"Singer","year":"1974","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.redox.2017.03.029_bib39","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.freeradbiomed.2008.11.003","article-title":"Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease","volume":"46","author":"Du","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.03.029_bib40","doi-asserted-by":"crossref","first-page":"18291","DOI":"10.1073\/pnas.1208764110","article-title":"Neuronal activity regulates astrocytic Nrf2 signaling","volume":"110","author":"Habas","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.03.029_bib41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pbb.2008.08.011","article-title":"Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid","volume":"91","author":"Rosenstock","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.redox.2017.03.029_bib42","first-page":"120","article-title":"Age-dependent vulnerability of the striatal mitochondrial to 3-nitropropionic acid","volume":"107","author":"Nars","year":"2007","journal-title":"Ohio J. Sci."},{"key":"10.1016\/j.redox.2017.03.029_bib43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0006-8993(95)00901-2","article-title":"Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease","volume":"697","author":"Borlongan","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.redox.2017.03.029_bib44","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1385-299X(96)00037-2","article-title":"Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model","volume":"1","author":"Borlongan","year":"1997","journal-title":"Brain Res. Brain Res. Protoc."},{"key":"10.1016\/j.redox.2017.03.029_bib45","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0361-9230(94)00242-S","article-title":"Systemic 3-nitropropionic acid: behavioral deficits and striatal damage in adult rats","volume":"36","author":"Borlongan","year":"1995","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.redox.2017.03.029_bib46","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1073\/pnas.0408487101","article-title":"Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription","volume":"102","author":"Calkins","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.03.029_bib47","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0002-9440(10)62536-9","article-title":"Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice","volume":"159","author":"Gabrielson","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2017.03.029_bib48","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.pharep.2015.03.003","article-title":"Locomotor stimulation by acute propofol administration in rats: role of the nitrergic system","volume":"67","author":"Tezcan","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.redox.2017.03.029_bib49","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.nutres.2014.10.001","article-title":"Dietary broccoli mildly improves neuroinflammation in aged mice but does not reduce lipopolysaccharide-induced sickness behavior","volume":"34","author":"Townsend","year":"2014","journal-title":"Nutr. Res."},{"key":"10.1016\/j.redox.2017.03.029_bib50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0378-4274(96)03800-3","article-title":"Formation of 8-hydroxydeoxyguanosine in calf thymus DNA treated with tert-butylhydroquinone, a major metabolite of butylated hydroxyanisole","volume":"89","author":"Nagai","year":"1996","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.redox.2017.03.029_bib51","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.foodchem.2013.12.087","article-title":"Cytotoxicity and DNA damage properties of tert-butylhydroquinone (TBHQ) food additive","volume":"153","author":"Eskandani","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.redox.2017.03.029_bib52","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/carcin\/14.7.1297","article-title":"The role of prostaglandin H synthase-mediated metabolism in the induction of oxidative DNA damage by BHA metabolites","volume":"14","author":"Schilderman","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.redox.2017.03.029_bib53","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s00204-012-0841-3","article-title":"Paradoxical cytotoxicity of tert-butylhydroquinone in vitro: what kills the untreated cells?","volume":"86","author":"Braeuning","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.redox.2017.03.029_bib54","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.dnarep.2008.09.004","article-title":"Mitochondrial DNA damage is a hallmark of chemically induced and the R6\/2 transgenic model of Huntington's disease","volume":"8","author":"Acevedo-Torres","year":"2009","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.redox.2017.03.029_bib55","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1474-9726.2009.00519.x","article-title":"Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition","volume":"8","author":"Gavil\u00e1n","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.redox.2017.03.029_bib56","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.brainres.2010.07.011","article-title":"Kainic acid and 3-nitropropionic acid induced expression of laminin in vascular elements of the rat brain","volume":"1352","author":"Sarkar","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.redox.2017.03.029_bib57","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1267\/ahc.15010","article-title":"Increased expression of osteopontin in the degenerating striatum of rats treated with mitochondrial toxin 3-nitropropionic acid: a light and electron microscopy study","volume":"48","author":"Kim","year":"2015","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.redox.2017.03.029_bib58","doi-asserted-by":"crossref","first-page":"e97685","DOI":"10.1371\/journal.pone.0097685","article-title":"Tert-butylhydroquinone alleviates early brain injury and cognitive dysfunction after experimental subarachnoid hemorrhage: role of Keap1\/Nrf2\/ARE pathway","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2017.03.029_bib59","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12031-016-0722-y","article-title":"Post-injury administration of tert-butylhydroquinone attenuates acute neurological injury after intracerebral hemorrhage in mice","volume":"58","author":"Sukumari-Ramesh","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.redox.2017.03.029_bib60","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1471-4159.2012.07877.x","article-title":"Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity","volume":"123","author":"Bahia","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.redox.2017.03.029_bib61","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1460-9568.2010.07138.x","article-title":"Keap1-Nrf2 activation in the presence and absence of DJ-1","volume":"31","author":"Gan","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.redox.2017.03.029_bib62","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00204-012-0935-y","article-title":"Neuroprotective effects of tert-butylhydroquinone on paraquat-induced dopaminergic cell degeneration in C57BL\/6 mice and in PC12 cells","volume":"86","author":"Li","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.redox.2017.03.029_bib63","first-page":"1223","article-title":"Exercise preconditioning reduces acute ischemic renal injury in Hsp70.1 knockout mouse","volume":"28","author":"Lee","year":"2013","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.redox.2017.03.029_bib64","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.gene.2014.04.043","article-title":"Heart protective effects and mechanism of quercetin preconditioning on anti-myocardial ischemia reperfusion (IR) injuries in rats","volume":"545","author":"Liu","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.redox.2017.03.029_bib65","first-page":"225","article-title":"Aging-associated oxidized albumin promotes cellular senescence and endothelial damage","volume":"11","author":"Luna","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.redox.2017.03.029_bib66","doi-asserted-by":"crossref","first-page":"23019","DOI":"10.18632\/oncotarget.8552","article-title":"Adipose triglycerides lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPAR\u03b1-PGC-1\u03b1 antioxidant response","volume":"7","author":"Aquilano","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2017.03.029_bib67","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/oxim.3.1.10476","article-title":"Markers of oxidative stress in erythrocytes and plasma during aging in humans","volume":"3","author":"Pandey","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2017.03.029_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.freeradbiomed.2015.06.014","article-title":"p62 links autophagy and Nrf2 signaling","volume":"88","author":"Jiang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.03.029_bib69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2017.03.029_bib70","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.molcel.2013.08.003","article-title":"Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy","volume":"51","author":"Ichimura","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2017.03.029_bib71","first-page":"22","article-title":"Tert-butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation","volume":"2014","author":"Li","year":"1841","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2017.03.029_bib72","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0531-5565(03)00002-0","article-title":"Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis","volume":"38","author":"Del Roso","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.redox.2017.03.029_bib73","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/auto.1.3.2017","article-title":"Autophagy and aging: the importance of maintaining \"clean\" cells","volume":"1","author":"Cuervo","year":"2005","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2017.03.029_bib74","doi-asserted-by":"crossref","first-page":"28","DOI":"10.14802\/jmd.13007","article-title":"Growth hormone deteriorates the functional outcome in an experimental model of Huntington's disease induced by 3-nitropionic acid","volume":"6","author":"Park","year":"2013","journal-title":"J. Mov. Disord."},{"key":"10.1016\/j.redox.2017.03.029_bib75","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/auto.5.3.8174","article-title":"p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum","volume":"5","author":"Zhang","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2017.03.029_bib76","first-page":"1","article-title":"The 3-NP model of striatal neurodegeneration","volume":"67","author":"Brouillet","year":"2014","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.redox.2017.03.029_bib77","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1093\/hmg\/ddt242","article-title":"A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin","volume":"22","author":"Damiano","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.redox.2017.03.029_bib78","doi-asserted-by":"crossref","first-page":"e67658","DOI":"10.1371\/journal.pone.0067658","article-title":"Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats","volume":"8","author":"Colle","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2017.03.029_bib79","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2014.03.032","article-title":"Protective effects of phosphodiesterase-1 (PDE1) and ATP sensitive potassium (KATP) channel modulators against 3-nitropropionic acid induced behavioral and biochemical toxicities in experimental Huntington's disease","volume":"732","author":"Gupta","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.redox.2017.03.029_bib80","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/cdd.2009.22","article-title":"Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway","volume":"16","author":"Liot","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2017.03.029_bib81","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.freeradbiomed.2004.11.034","article-title":"Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine","volume":"38","author":"Cocco","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.03.029_bib82","doi-asserted-by":"crossref","first-page":"e19194","DOI":"10.1371\/journal.pone.0019194","article-title":"Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats","volume":"6","author":"Braidy","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2017.03.029_bib83","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jid.2016.01.017","article-title":"Age-dependent decrease of mitochondrial complex II activity in human skin fibroblasts","volume":"136","author":"Bowman","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.redox.2017.03.029_bib84","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1471-4159.1993.tb05859.x","article-title":"Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid","volume":"60","author":"Brouillet","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.redox.2017.03.029_bib85","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresbull.2014.02.007","article-title":"Pharmacological benefit of I(1)-imidazoline receptors activation and nuclear factor kappa-B (NF-\u03baB) modulation in experimental Huntington's disease","volume":"102","author":"Gupta","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.redox.2017.03.029_bib86","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neulet.2007.09.056","article-title":"NF-kB\/NOS cross-talk induced by mitochondrial complex II inhibition: implications for Huntington's disease","volume":"434","author":"Napolitano","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.redox.2017.03.029_bib87","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1385\/JMN:15:1:31","article-title":"Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease","volume":"15","author":"Yu","year":"2000","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.redox.2017.03.029_bib88","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1007\/s12035-015-9230-2","article-title":"Sulforaphane ameliorates 3-nitropropionic acid-induced striatal toxicity by activating the Keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-\u03baB pathways","volume":"53","author":"Jang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.redox.2017.03.029_bib89","doi-asserted-by":"crossref","first-page":"e6334","DOI":"10.1371\/journal.pone.0006334","article-title":"Humanin: a novel central regulator of peripheral insulin action","volume":"4","author":"Muzumdar","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2017.03.029_bib90","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/gerona\/glq113","article-title":"Mechanisms of vascular aging: new perspectives","volume":"65","author":"Ungvari","year":"2010","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."}],"updated-by":[{"DOI":"10.1016\/j.redox.2023.102809","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000}}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717301295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717301295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:00:07Z","timestamp":1761976807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231717301295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":90,"alternative-id":["S2213231717301295"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2017.03.029","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2017.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}