{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:06:24Z","timestamp":1784909184364,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T00:00:00Z","timestamp":1490400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","award":["2016-01381 M.C."],"award-info":[{"award-number":["2016-01381 M.C."]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001728","name":"Swedish Foundation for International Cooperation in Research and Higher Education","doi-asserted-by":"publisher","award":["1499\/2014"],"award-info":[{"award-number":["1499\/2014"]}],"id":[{"id":"10.13039\/501100001728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001728","name":"Swedish Foundation for International Cooperation in Research and Higher Education","doi-asserted-by":"publisher","award":["BR2013-5512"],"award-info":[{"award-number":["BR2013-5512"]}],"id":[{"id":"10.13039\/501100001728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20140673"],"award-info":[{"award-number":["20140673"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2\u20103707\/2013 M.C."],"award-info":[{"award-number":["2\u20103707\/2013 M.C."]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.redox.2017.05.014","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T20:01:46Z","timestamp":1496088106000},"page":"163-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation"],"prefix":"10.1016","volume":"13","author":[{"given":"Zhengbing","family":"Zhuge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano L.","family":"Paulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghavan","family":"Jahandideh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.R.","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr\u00f4nio F.","family":"Athayde-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon O.","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir A.","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Carlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo F.","family":"Montenegro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.redox.2017.05.014_bib1","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-160-1-201401070-01001","article-title":"In the clinic. Stable ischemic heart disease","volume":"160","author":"Wilson","year":"2014","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"10.1016\/j.redox.2017.05.014_bib2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/ejhf.289","volume":"17","author":"Mebazaa","year":"2015","journal-title":"Eur. J. Heart Fail."},{"issue":"12","key":"10.1016\/j.redox.2017.05.014_bib3","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1073\/pnas.132271799","article-title":"After 130 years, the molecular mechanism of action of nitroglycerin is revealed","volume":"99","author":"Ignarro","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.redox.2017.05.014_bib4","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1073\/pnas.122225199","article-title":"Identification of the enzymatic mechanism of nitroglycerin bioactivation","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.redox.2017.05.014_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1526-4610.2009.01342.x","article-title":"Nitroglycerin headache and nitroglycerin-induced primary headaches from 1846 and onwards: a historical overview and an update","volume":"49","author":"Tfelt-Hansen","year":"2009","journal-title":"Headache"},{"issue":"3","key":"10.1016\/j.redox.2017.05.014_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.vph.2014.09.002","article-title":"Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction","volume":"63","author":"Munzel","year":"2014","journal-title":"Vasc. Pharmacol."},{"issue":"34","key":"10.1016\/j.redox.2017.05.014_bib7","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1093\/eurheartj\/eht249","article-title":"More answers to the still unresolved question of nitrate tolerance","volume":"34","author":"Munzel","year":"2013","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.redox.2017.05.014_bib8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/01.RES.0000184694.03262.6d","article-title":"Explaining the phenomenon of nitrate tolerance","volume":"97","author":"Munzel","year":"2005","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.redox.2017.05.014_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.niox.2012.03.008","article-title":"A comparison of organic and inorganic nitrates\/nitrites","volume":"26","author":"Omar","year":"2012","journal-title":"Nitric Oxide"},{"issue":"2","key":"10.1016\/j.redox.2017.05.014_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-5793(98)00430-X","article-title":"Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions","volume":"427","author":"Millar","year":"1998","journal-title":"FEBS Lett."},{"issue":"17","key":"10.1016\/j.redox.2017.05.014_bib11","doi-asserted-by":"crossref","first-page":"16594","DOI":"10.1074\/jbc.M411905200","article-title":"Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.05.014_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.niox.2013.02.081","article-title":"Xanthine oxidoreductase-catalyzed reduction of nitrite to nitric oxide: insights regarding where, when and how","volume":"34","author":"Cantu-Medellin","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.redox.2017.05.014_bib13","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.freeradbiomed.2016.09.004","article-title":"Enhanced XOR activity in eNOS-deficient mice: effects on the nitrate-nitrite-NO pathway and ROS homeostasis","volume":"99","author":"Peleli","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.redox.2017.05.014_bib14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrd4623","article-title":"Strategies to increase nitric oxide signalling in cardiovascular disease","volume":"14","author":"Lundberg","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2017.05.014_bib15","first-page":"e2810","article-title":"Detection of nitric oxide and superoxide radical anion by electron paramagnetic resonance spectroscopy from cells using spin traps","volume":"66","author":"Gopalakrishnan","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.redox.2017.05.014_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.redox.2016.10.011","article-title":"Profound differences between humans and rodents in the ability to concentrate salivary nitrate: implications for translational research","volume":"10","author":"Montenegro","year":"2016","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.redox.2017.05.014_bib17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1039\/B817981F","article-title":"Studies toward the analysis of S-nitrosoproteins","volume":"7","author":"Sengupta","year":"2009","journal-title":"Org. Biomol. Chem."},{"issue":"17","key":"10.1016\/j.redox.2017.05.014_bib18","doi-asserted-by":"crossref","first-page":"16939","DOI":"10.1074\/jbc.M314336200","article-title":"Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.redox.2017.05.014_bib19","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/bph.13511","article-title":"Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension","volume":"173","author":"Porpino","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2017.05.014_bib20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.freeradbiomed.2015.03.025","article-title":"Nitrite-mediated renal vasodilatation is increased during ischemic conditions via cGMP-independent signaling","volume":"84","author":"Liu","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.redox.2017.05.014_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/HYPERTENSIONAHA.116.08081","article-title":"Blood pressure-lowering effect of orally ingested nitrite is abolished by a proton pump inhibitor","volume":"69","author":"Montenegro","year":"2017","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.redox.2017.05.014_bib22","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1021\/bi026385a","article-title":"Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues","volume":"42","author":"Li","year":"2003","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.redox.2017.05.014_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(98)00460-9","article-title":"Effects of nonintermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production","volume":"355","author":"Kojda","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.redox.2017.05.014_bib24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4161\/oxim.2.5.9441","article-title":"Oxidative stress as a mediator of cardiovascular disease","volume":"2","author":"Elahi","year":"2009","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.redox.2017.05.014_bib25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.semnephrol.2011.08.007","article-title":"Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options","volume":"31","author":"Doehner","year":"2011","journal-title":"Semin. Nephrol."},{"issue":"1\u20133","key":"10.1016\/j.redox.2017.05.014_bib26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejphar.2012.06.043","article-title":"The 2-nitrate-1,3-dibuthoxypropan, a new nitric oxide donor, induces vasorelaxation in mesenteric arteries of the rat","volume":"690","author":"Franca-Silva","year":"2012","journal-title":"Eur. J. Pharmacol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717302057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717302057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:22:22Z","timestamp":1784906542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231717302057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":26,"alternative-id":["S2213231717302057"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2017.05.014","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2017.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}