{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:30:15Z","timestamp":1789983015835,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2311-B-006-008"],"award-info":[{"award-number":["105-2311-B-006-008"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["106-2314-B-006-023"],"award-info":[{"award-number":["106-2314-B-006-023"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"publisher","award":["NCKUEDA10613"],"award-info":[{"award-number":["NCKUEDA10613"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.redox.2017.08.011","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T06:16:59Z","timestamp":1503555419000},"page":"72-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes"],"prefix":"10.1016","volume":"14","author":[{"given":"Ching-Hou","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Hsien","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.-Ming","family":"Jou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Kun","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hsia","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ling","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ling","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.redox.2017.08.011_bib1","first-page":"376","article-title":"Clinical aspects, pathology and pathophysiology of osteoarthritis","volume":"6","author":"Goldring","year":"2006","journal-title":"J. Musculoskelet. Neuron. Interact."},{"issue":"3","key":"10.1016\/j.redox.2017.08.011_bib2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jcp.21258","article-title":"Osteoarthritis","volume":"213","author":"Goldring","year":"2007","journal-title":"J. Cell Physiol."},{"issue":"1\u20132","key":"10.1016\/j.redox.2017.08.011_bib3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000070573","article-title":"Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies","volume":"174","author":"Malemud","year":"2003","journal-title":"Cells Tissues Organs"},{"issue":"11","key":"10.1016\/j.redox.2017.08.011_bib4","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1002\/art.22174","article-title":"Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis","volume":"54","author":"Aigner","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.redox.2017.08.011_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11926-000-0021-y","article-title":"Osteoarthritis and cartilage: the role of cytokines","volume":"2","author":"Goldring","year":"2000","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.redox.2017.08.011_bib6","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.21300","article-title":"Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions","volume":"52","author":"Roach","year":"2005","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.redox.2017.08.011_bib7","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/ar4133","article-title":"MMP13 is a critical target gene during the progression of osteoarthritis","volume":"15","author":"Wang","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"12","key":"10.1016\/j.redox.2017.08.011_bib8","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"16","key":"10.1016\/j.redox.2017.08.011_bib9","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.lfs.2005.08.024","article-title":"Double-stranded RNA-dependent protein kinase (PKR) is a stress-responsive kinase that induces NFkappaB-mediated resistance against mercury cytotoxicity","volume":"78","author":"Fremont","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.redox.2017.08.011_bib10","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1186\/ar1024","article-title":"Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?","volume":"6","author":"Gilbert","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.redox.2017.08.011_bib11","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.bcp.2007.08.002","article-title":"Requirement for protein kinase R in interleukin-1alpha-stimulated effects in cartilage","volume":"74","author":"Tam","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.redox.2017.08.011_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.22203\/eCM.v023a04","article-title":"Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes","volume":"23","author":"Gilbert","year":"2012","journal-title":"Eur. Cells Mater."},{"issue":"9","key":"10.1016\/j.redox.2017.08.011_bib13","doi-asserted-by":"crossref","first-page":"14921","DOI":"10.3390\/ijms150914921","article-title":"The DNA repair enzyme apurinic\/apyrimidinic endonuclease (Apex nuclease) 2 has the potential to protect against down-regulation of chondrocyte activity in osteoarthritis","volume":"15","author":"Yui","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2017.08.011_bib14","doi-asserted-by":"crossref","first-page":"24124","DOI":"10.1074\/jbc.M601905200","article-title":"Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes","volume":"281","author":"LaVallie","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.011_bib15","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0891-5849(97)00054-3","article-title":"Detection of superoxide and NADPH oxidase in porcine articular chondrocytes","volume":"23","author":"Hiran","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.08.011_bib16","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.joca.2007.10.004","article-title":"Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage","volume":"16","author":"Khan","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.redox.2017.08.011_bib17","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.joca.2015.02.167","article-title":"IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation ofp22(phox) and NOX4 activity in human articular chondrocytes","volume":"23","author":"Rousset","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.redox.2017.08.011_bib18","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2017.08.011_bib19","doi-asserted-by":"crossref","first-page":"50940","DOI":"10.1074\/jbc.M305107200","article-title":"Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage","volume":"278","author":"Fanning","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.011_bib20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0014-4827(03)00180-0","article-title":"Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes","volume":"288","author":"Liacini","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.redox.2017.08.011_bib21","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/ar2151","article-title":"Peroxisome proliferator-activated receptor gamma1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1beta in articular chondrocytes","volume":"9","author":"Afif","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.redox.2017.08.011_bib22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/138945007779940115","article-title":"Inflammatory signaling in cartilage: mapk and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis","volume":"8","author":"Saklatvala","year":"2007","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.redox.2017.08.011_bib23","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jbspin.2011.12.013","article-title":"Induction of the chemokine IL-8\/Kc by the articular cartilage: possible influence on osteoarthritis","volume":"79","author":"Chauffier","year":"2012","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.redox.2017.08.011_bib24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1345\/aph.1A132","article-title":"Pathophysiology and first-line treatment of osteoarthritis","volume":"36","author":"Hogue","year":"2002","journal-title":"Ann. Pharmacother."},{"issue":"4","key":"10.1016\/j.redox.2017.08.011_bib25","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1074\/jbc.M106339200","article-title":"Expression of the osteoblast differentiation factor RUNX2 (Cbfa1\/AML3\/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha","volume":"277","author":"Gilbert","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.redox.2017.08.011_bib26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N. Engl. J. Med"},{"issue":"5","key":"10.1016\/j.redox.2017.08.011_bib27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1507\/endocrj.46.643","article-title":"The increase of parathyroid hormone-related peptide and cytokine levels in synovial fluid of elderly rheumatoid arthritis and osteoarthritis","volume":"46","author":"Horiuchi","year":"1999","journal-title":"Endocr. J."},{"issue":"9","key":"10.1016\/j.redox.2017.08.011_bib28","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/jcb.25151","article-title":"Double stranded RNA-Dependent protein kinase is necessary for TNF-alpha-induced osteoclast formation in vitro and in vivo","volume":"116","author":"Shinohara","year":"2015","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.redox.2017.08.011_bib29","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.4049\/jimmunol.171.8.4406","article-title":"IL-8\/CXCL8 and growth-related oncogene alpha\/CXCL1 induce chondrocyte hypertrophic differentiation","volume":"171","author":"Merz","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2017.08.011_bib30","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.148.2.466","article-title":"Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes","volume":"148","author":"Lotz","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2017.08.011_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/art.20748","article-title":"Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes","volume":"52","author":"Cecil","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.redox.2017.08.011_bib32","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/art.10356","article-title":"Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants","volume":"46","author":"Hardy","year":"2002","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.redox.2017.08.011_bib33","doi-asserted-by":"crossref","first-page":"9691","DOI":"10.1074\/jbc.M211360200","article-title":"Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes","volume":"278","author":"Huh","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.011_bib34","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.4049\/jimmunol.165.6.3402","article-title":"The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2","volume":"165","author":"Notoya","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2017.08.011_bib35","first-page":"2509","article-title":"Chondrocyte death in experimental osteoarthritis is mediated by MEK 1\/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase","volume":"28","author":"Pelletier","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.redox.2017.08.011_bib36","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2017.08.011_bib37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI118475","article-title":"Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage","volume":"97","author":"Mitchell","year":"1996","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2017.08.011_bib38","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1172\/JCI118636","article-title":"The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis","volume":"97","author":"Reboul","year":"1996","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2017.08.011_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.matbio.2016.03.007","article-title":"MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1","volume":"56","author":"Yamamoto","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.redox.2017.08.011_bib40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.matbio.2007.01.006","article-title":"Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis","volume":"26","author":"Tchetina","year":"2007","journal-title":"Matrix Biol."},{"key":"10.1016\/j.redox.2017.08.011_bib41","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1002\/art.27512","article-title":"Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors","volume":"62","author":"Borz\u00ed","year":"2010","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.redox.2017.08.011_bib42","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1359\/jbmr.2002.17.4.639","article-title":"Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization","volume":"17","author":"Wu","year":"2002","journal-title":"J. Bone Mineral. Res."},{"key":"10.1016\/j.redox.2017.08.011_bib43","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/art.10428","article-title":"Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13","volume":"46","author":"Wu","year":"2002","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.redox.2017.08.011_bib44","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/1529-0131(199906)42:6<1147::AID-ANR11>3.0.CO;2-Y","article-title":"Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells","volume":"42","author":"Tardif","year":"1999","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.redox.2017.08.011_bib45","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1074\/jbc.M116.756601","article-title":"Cytokine-induced MMP13 expression in human chondrocytes is dependent on activating transcription Factor 3 (ATF3) regulation","volume":"292","author":"Chan","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.011_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12272-011-0113-4","article-title":"Matrix metalloproteinase-13 expression in IL-1\u03b2-treated chondrocytes by activation of the p38 MAPK\/c-Fos\/AP-1 and JAK\/STAT pathways","volume":"34","author":"Lim","year":"2011","journal-title":"Arch. Pharmacal Res."},{"issue":"6","key":"10.1016\/j.redox.2017.08.011_bib47","doi-asserted-by":"crossref","first-page":"R222","DOI":"10.1186\/ar4423","article-title":"Collagenase-3 (MMP-13) deficiency protects C57BL\/6 mice from antibody-induced arthritis","volume":"15","author":"Singh","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.redox.2017.08.011_bib48","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joca.2005.04.002","article-title":"Oxygen and reactive oxygen species in cartilage degradation: friends or foes?","volume":"13","author":"Henrotin","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.redox.2017.08.011_bib49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.bbadis.2016.01.003","article-title":"ROS\/oxidative stress signaling in osteoarthritis","volume":"1862","author":"Lepetsos","year":"2016","journal-title":"Biochim.\u00a0Biophys. Acta"},{"key":"10.1016\/j.redox.2017.08.011_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2017.08.011_bib51","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/jbmr.5650071005","article-title":"Release of oxygen radicals by articular chondrocytes: a study of luminol-dependent chemiluminescence and hydrogen peroxide secretion","volume":"7","author":"Rathakrishnan","year":"1992","journal-title":"J. Bone Mineral. Res."},{"key":"10.1016\/j.redox.2017.08.011_bib52","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4049\/jimmunol.145.2.690","article-title":"Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines","volume":"145","author":"Tiku","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2017.08.011_bib53","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthr. Cartil."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717305074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717305074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:05:23Z","timestamp":1761977123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231717305074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":53,"alternative-id":["S2213231717305074"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2017.08.011","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.730592290.793556133","asserted-by":"object"}]},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2017.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}