{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:46:45Z","timestamp":1792007205830,"version":"4.4.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["S2010\/BMD-2321"],"award-info":[{"award-number":["S2010\/BMD-2321"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0009\/0016"],"award-info":[{"award-number":["RD16\/0009\/0016"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["REDinREN RD12\/0021\/0009"],"award-info":[{"award-number":["REDinREN RD12\/0021\/0009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2014-52762-R"],"award-info":[{"award-number":["SAF2014-52762-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2015-66107-R"],"award-info":[{"award-number":["SAF2015-66107-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2012-31338"],"award-info":[{"award-number":["SAF2012-31338"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.redox.2017.08.019","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T16:15:17Z","timestamp":1504282517000},"page":"88-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"special_numbering":"C","title":["Role of glutathione biosynthesis in endothelial dysfunction and fibrosis"],"prefix":"10.1016","volume":"14","author":[{"given":"Cristina","family":"Espinosa-D\u00edez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Vallejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sandoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cannata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Peir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos F.","family":"S\u00e1nchez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Lamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2017.08.019_bib1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular (endothelial) dysfunction","volume":"174","author":"Daiber","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2017.08.019_bib2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2174\/0929867043365369","article-title":"Oxidative stress, antioxidants, and endothelial function","volume":"11","author":"Schulz","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.redox.2017.08.019_bib3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ncpcardio1211","article-title":"Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies","volume":"5","author":"Forstermann","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.redox.2017.08.019_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.redox.2015.07.008","article-title":"Antioxidant responses and cellular adjustments to oxidative stress","volume":"6","author":"Espinosa-Diez","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2017.08.019_bib5","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.bbagen.2009.02.014","article-title":"Protection against reactive oxygen species by selenoproteins","volume":"1790","author":"Steinbrenner","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2017.08.019_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1515\/BC.2003.061","article-title":"Cytoprotection against oxidative stress and the regulation of glutathione synthesis","volume":"384","author":"Dickinson","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.019_bib7","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0891-5849(99)00176-8","article-title":"Biologic and pharmacologic regulation of mammalian glutathione synthesis","volume":"27","author":"Griffith","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.08.019_bib8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mam.2008.08.009","article-title":"Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase","volume":"30","author":"Franklin","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.redox.2017.08.019_bib9","doi-asserted-by":"crossref","first-page":"33766","DOI":"10.1074\/jbc.M504604200","article-title":"Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.019_bib10","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nature09599","article-title":"S-glutathionylation uncouples eNOS and regulates its cellular and vascular function","volume":"468","author":"Chen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.redox.2017.08.019_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mam.2008.08.003","article-title":"Glutathione in liver diseases and hepatotoxicity","volume":"30","author":"Yuan","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.redox.2017.08.019_bib12","first-page":"938","article-title":"The relationship between the level of glutathione, impairment of glucose metabolism and complications of diabetes mellitus","volume":"29","author":"Hakki Kalkan","year":"2013","journal-title":"Pak. J. Med. Sci."},{"key":"10.1016\/j.redox.2017.08.019_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0301-0082(99)00060-X","article-title":"Metabolism and functions of glutathione in brain","volume":"62","author":"Dringen","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.redox.2017.08.019_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2009.09.026","article-title":"Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis","volume":"48","author":"Liu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.08.019_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1067\/mlc.2000.105976","article-title":"Blood glutathione and cysteine changes in cardiovascular disease","volume":"135","author":"Mills","year":"2000","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.redox.2017.08.019_bib16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/08916930500407238","article-title":"Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset","volume":"38","author":"Bekris","year":"2005","journal-title":"Autoimmunity"},{"key":"10.1016\/j.redox.2017.08.019_bib17","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1096\/fj.10-174011","article-title":"A GAG trinucleotide-repeat polymorphism in the gene for glutathione biosynthetic enzyme, GCLC, affects gene expression through translation","volume":"25","author":"Nichenametla","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.redox.2017.08.019_bib18","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.freeradbiomed.2012.07.006","article-title":"Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice","volume":"53","author":"Weldy","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2017.08.019_bib19","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1210\/en.2015-1206","article-title":"Glutamate cysteine ligase modifier subunit (Gclm) null mice have increased ovarian oxidative stress and accelerated age-related ovarian failure","volume":"156","author":"Lim","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.redox.2017.08.019_bib20","doi-asserted-by":"crossref","first-page":"e64165","DOI":"10.1371\/journal.pone.0064165","article-title":"The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe\/ZnS quantum dot-induced lung inflammation in mice","volume":"8","author":"McConnachie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2017.08.019_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kft112","article-title":"Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration","volume":"134","author":"Liang","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.redox.2017.08.019_bib22","doi-asserted-by":"crossref","first-page":"21158","DOI":"10.1074\/jbc.M112145200","article-title":"Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1\/ARE and Fra-1","volume":"277","author":"Jardine","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.019_bib23","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1089\/ars.2014.6025","article-title":"Targeting of gamma-glutamyl-cysteine ligase by miR-433 reduces glutathione biosynthesis and promotes TGF-beta-dependent fibrogenesis","volume":"23","author":"Espinosa-Diez","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.redox.2017.08.019_bib24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.redox.2015.09.009","article-title":"Reciprocal regulation of TGF-beta and reactive oxygen species: a perverse cycle for fibrosis","volume":"6","author":"Liu","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2017.08.019_bib25","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/hep.21635","article-title":"Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure","volume":"45","author":"Chen","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2017.08.019_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta\u00a0C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.redox.2017.08.019_bib27","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/sj.bjp.0701749","article-title":"Endothelial dysfunction and metabolic control in streptozotocin-induced diabetic rats","volume":"123","author":"Rodriguez-Manas","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2017.08.019_bib28","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.redox.2017.08.019_bib29","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12088","article-title":"Automated quantification of renal fibrosis with Sirius Red and polarization contrast microscopy","volume":"2","author":"Street","year":"2014","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.redox.2017.08.019_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/gene.10117","article-title":"Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements","volume":"33","author":"Forde","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.redox.2017.08.019_bib31","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.2000.3930","article-title":"Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous","volume":"279","author":"Dalton","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2017.08.019_bib32","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/cvr\/cvq028","article-title":"Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide","volume":"87","author":"Redondo-Horcajo","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2017.08.019_bib33","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1089\/ars.2011.3904","article-title":"S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide\/reactive oxygen species-mediated signaling","volume":"14","author":"Zweier","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.redox.2017.08.019_bib34","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1074\/jbc.M106302200","article-title":"Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme","volume":"277","author":"Fulton","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.019_bib35","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1074\/jbc.M112.415992","article-title":"Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling","volume":"288","author":"Crabtree","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2017.08.019_bib36","doi-asserted-by":"crossref","first-page":"e1005800","DOI":"10.1371\/journal.pgen.1005800","article-title":"A glutathione-Nrf2-thioredoxin cross-talk ensures keratinocyte survival and efficient wound repair","volume":"12","author":"Telorack","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.redox.2017.08.019_bib37","first-page":"2193","article-title":"A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia","volume":"95","author":"Ristoff","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.redox.2017.08.019_bib38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0735-1097(02)02866-8","article-title":"Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction","volume":"41","author":"Koide","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.redox.2017.08.019_bib39","first-page":"503","article-title":"Nitric oxide as a unique signaling molecule in the vascular system: a historical overview","volume":"53","author":"Ignarro","year":"2002","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.redox.2017.08.019_bib40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00424-009-0767-7","article-title":"Molecular mechanisms underlying the activation of eNOS","volume":"459","author":"Fleming","year":"2010","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.redox.2017.08.019_bib41","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.biochi.2010.03.020","article-title":"eNOS phosphorylation in health and disease","volume":"92","author":"Kolluru","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.redox.2017.08.019_bib42","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/21218","article-title":"Regulation of endothelium-derived nitric oxide production by the protein kinase Akt","volume":"399","author":"Fulton","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.redox.2017.08.019_bib43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1124\/mi.7.6.7","article-title":"S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response","volume":"7","author":"Townsend","year":"2007","journal-title":"Mol. Interv."},{"key":"10.1016\/j.redox.2017.08.019_bib44","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/ATVBAHA.108.181610","article-title":"NADPH oxidases: functions and pathologies in the vasculature","volume":"30","author":"Lassegue","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2017.08.019_bib45","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/bph.13728","article-title":"A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice","volume":"174","author":"Chuaiphichai","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2017.08.019_bib46","doi-asserted-by":"crossref","first-page":"H194","DOI":"10.1152\/ajpheart.00767.2009","article-title":"Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways","volume":"298","author":"Sugiyama","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.redox.2017.08.019_bib47","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1073\/pnas.91.11.5212","article-title":"Induction of calcium-dependent nitric oxide synthases by sex hormones","volume":"91","author":"Weiner","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.08.019_bib48","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1073\/pnas.96.6.2788","article-title":"Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase","volume":"96","author":"Goetz","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.08.019_bib49","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/01.gme.0000182806.99137.5e","article-title":"Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats","volume":"13","author":"Lam","year":"2006","journal-title":"Menopause"},{"key":"10.1016\/j.redox.2017.08.019_bib50","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.redox.2015.01.007","article-title":"Sex-based differential regulation of oxidative stress in the vasculature by nitric oxide","volume":"4","author":"Morales","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2017.08.019_bib51","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1007\/s00467-007-0524-0","article-title":"Mechanisms of progression of chronic kidney disease","volume":"22","author":"Fogo","year":"2007","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.redox.2017.08.019_bib52","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2141.1997.1732989.x","article-title":"Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells","volume":"98","author":"Kukk","year":"1997","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.redox.2017.08.019_bib53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/35067005","article-title":"Tie receptors: new modulators of angiogenic and lymphangiogenic responses","volume":"2","author":"Jones","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2017.08.019_bib54","article-title":"Gliptins suppress inflammatory macrophage activation to mitigate inflammation, fibrosis, oxidative stress, and vascular dysfunction in models of nonalcoholic steatohepatitis and liver fibrosis","author":"Wang","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.redox.2017.08.019_bib55","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/CIRCULATIONAHA.111.034470","article-title":"Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction","volume":"124","author":"Wenzel","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2017.08.019_bib56","doi-asserted-by":"crossref","first-page":"E2803","DOI":"10.1073\/pnas.1212596109","article-title":"Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment","volume":"109","author":"Kim","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2017.08.019_bib57","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1161\/ATVBAHA.107.142109","article-title":"Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice","volume":"27","author":"Qiao","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2017.08.019_bib58","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.freeradbiomed.2015.02.004","article-title":"Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability","volume":"83","author":"Sha","year":"2015","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.redox.2017.08.019_bib59","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/TP.0000000000001608","article-title":"Kidney fibrosis: origins and interventions","volume":"101","author":"Vanhove","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.redox.2017.08.019_bib60","article-title":"Pharmacological treatment of idiopathic pulmonary fibrosis \u2013 preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine","volume":"2","author":"Myllarniemi","year":"2015","journal-title":"Eur. Clin. Respir. J."},{"key":"10.1016\/j.redox.2017.08.019_bib61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.redox.2015.09.039","article-title":"The balance of powers: redox regulation of fibrogenic pathways in kidney injury","volume":"6","author":"Okamura","year":"2015","journal-title":"Redox Biol."},{"issue":"Suppl. 8A","key":"10.1016\/j.redox.2017.08.019_bib62","doi-asserted-by":"crossref","first-page":"99S","DOI":"10.1016\/j.amjmed.2003.09.016","article-title":"Endothelial function, inflammation, and prognosis in cardiovascular disease","volume":"115","author":"Gonzalez","year":"2003","journal-title":"Am. J. Med"},{"key":"10.1016\/j.redox.2017.08.019_bib63","doi-asserted-by":"crossref","first-page":"3583956","DOI":"10.1155\/2016\/3583956","article-title":"Vascular ageing and exercise: focus on cellular reparative processes","volume":"2016","author":"Ross","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.redox.2017.08.019_bib64","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000475890","article-title":"Targeting the KEAP1-NRF2 system to prevent kidney disease progression","volume":"45","author":"Nezu","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.redox.2017.08.019_bib65","doi-asserted-by":"crossref","first-page":"313","DOI":"10.33549\/physiolres.932834","article-title":"Activation of Nrf2 by ischemic preconditioning and sulforaphane in renal ischemia\/reperfusion injury: a comparative experimental study","volume":"64","author":"Shokeir","year":"2015","journal-title":"Physiol. Res."},{"key":"10.1016\/j.redox.2017.08.019_bib66","first-page":"4574","article-title":"T-type calcium channel blocker attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis by activating the Nrf2 antioxidant pathway","volume":"8","author":"Chung","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.redox.2017.08.019_bib67","doi-asserted-by":"crossref","first-page":"e93265","DOI":"10.1371\/journal.pone.0093265","article-title":"Inhibitory role of the KEAP1-NRF2 pathway in TGFbeta1-stimulated renal epithelial transition to fibroblastic cells: a modulatory effect on SMAD signaling","volume":"9","author":"Ryoo","year":"2014","journal-title":"PLoS One"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717306523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231717306523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:06:14Z","timestamp":1761977174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231717306523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":67,"alternative-id":["S2213231717306523"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2017.08.019","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of glutathione biosynthesis in endothelial dysfunction and fibrosis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2017.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}