{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:39:28Z","timestamp":1792035568615,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013111","name":"Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program","doi-asserted-by":"publisher","award":["2016TQ03R517"],"award-info":[{"award-number":["2016TQ03R517"]}],"id":[{"id":"10.13039\/501100013111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313078"],"award-info":[{"award-number":["2015A030313078"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81461168028"],"award-info":[{"award-number":["81461168028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672276"],"award-info":[{"award-number":["81672276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370528"],"award-info":[{"award-number":["81370528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573142"],"award-info":[{"award-number":["81573142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.redox.2018.04.006","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T20:51:22Z","timestamp":1522961482000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":169,"special_numbering":"C","title":["Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1\/PGC-1\u03b1\/mitochondrial biosynthesis pathway"],"prefix":"10.1016","volume":"17","author":[{"given":"Sufan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingtong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-2687","authenticated-orcid":false,"given":"Yun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengzhi","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2018.04.006_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.pharmtox.44.101802.121704","article-title":"Oxidative stress, toxicology, and pharmacology of CYP2E1","volume":"44","author":"Caro","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.redox.2018.04.006_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12263-009-0159-9","article-title":"Ethanol-induced oxidative stress: basic knowledge","volume":"5","author":"Comporti","year":"2010","journal-title":"Genes Nutr."},{"key":"10.1016\/j.redox.2018.04.006_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","article-title":"NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus","volume":"22","author":"Canto","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2018.04.006_bib4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2018.04.006_bib5","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.redox.2018.04.006_bib6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2011.03.004","article-title":"PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2018.04.006_bib7","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nsmb.2990","article-title":"NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1","volume":"22","author":"Aguilar-Arnal","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.redox.2018.04.006_bib8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2008.03.005","article-title":"Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats","volume":"370","author":"Lieber","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2018.04.006_bib9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","article-title":"Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver","volume":"146","author":"Yin","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2018.04.006_bib10","doi-asserted-by":"crossref","first-page":"G833","DOI":"10.1152\/ajpgi.90358.2008","article-title":"Resveratrol alleviates alcoholic fatty liver in mice","volume":"295","author":"Ajmo","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.redox.2018.04.006_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/978-3-319-09614-8_21","article-title":"The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC)","volume":"815","author":"Thompson","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.redox.2018.04.006_bib12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tem.2009.03.008","article-title":"Caloric restriction, SIRT1 and longevity","volume":"20","author":"Canto","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.redox.2018.04.006_bib13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.1117728","article-title":"Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS","volume":"310","author":"Nisoli","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.redox.2018.04.006_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.redox.2018.04.006_bib15","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"Jager","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2018.04.006_bib16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.redox.2018.04.006_bib17","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.redox.2018.04.006_bib18","doi-asserted-by":"crossref","first-page":"21767","DOI":"10.1074\/jbc.M110.213298","article-title":"Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation","volume":"286","author":"Nikiforov","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2018.04.006_bib19","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1038\/ncomms12948","article-title":"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans","volume":"7","author":"Trammell","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2018.04.006_bib20","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity","volume":"15","author":"Canto","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2018.04.006_bib21","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/hep.28245","article-title":"Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice","volume":"63","author":"Gariani","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2018.04.006_bib22","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.aaf2693","article-title":"NAD(+) repletion improves mitochondrial and stem cell function and enhances life span in mice","volume":"352","author":"Zhang","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.redox.2018.04.006_bib23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.redox.2018.04.006_bib24","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/0960327115626254","article-title":"Safety assessment of nicotinamide riboside, a form of vitamin B3","volume":"35","author":"Conze","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.redox.2018.04.006_bib25","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.jnutbio.2012.12.012","article-title":"Protection of nicotinic acid against oxidative stress-induced cell death in hepatocytes contributes to its beneficial effect on alcohol-induced liver injury in mice","volume":"24","author":"Dou","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.redox.2018.04.006_bib26","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1093\/jn\/127.11.2199","article-title":"Nicotinamide counteracts alcohol-induced impairment of hepatic protein metabolism in humans","volume":"127","author":"Volpi","year":"1997","journal-title":"J. Nutr."},{"key":"10.1016\/j.redox.2018.04.006_bib27","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fphar.2016.00258","article-title":"Head to head comparison of short-term treatment with the NAD(+) precursor nicotinamide mononucleotide (NMN) and 6 weeks of exercise in obese female mice","volume":"7","author":"Uddin","year":"2016","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.redox.2018.04.006_bib28","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.ccell.2014.10.002","article-title":"Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage","volume":"26","author":"Tummala","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2018.04.006_bib29","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.freeradbiomed.2006.02.014","article-title":"Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation","volume":"40","author":"Kume","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2018.04.006_bib30","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1074\/jbc.M109.090266","article-title":"Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure","volume":"285","author":"Tanno","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2018.04.006_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2014.07.034","article-title":"Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1\/AMPK and the Nrf2\/antioxidant defense pathways in a rat periodontitis model","volume":"75","author":"Tamaki","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2018.04.006_bib32","doi-asserted-by":"crossref","first-page":"33959","DOI":"10.1074\/jbc.M110.122978","article-title":"SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism","volume":"285","author":"Ponugoti","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2018.04.006_bib33","doi-asserted-by":"crossref","first-page":"12861","DOI":"10.1073\/pnas.0702509104","article-title":"Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1","volume":"104","author":"Rodgers","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2018.04.006_bib34","first-page":"88","article-title":"Sirtuin 1 signaling and alcoholic fatty liver disease","volume":"4","author":"You","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.redox.2018.04.006_bib35","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jhep.2012.11.042","article-title":"Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease","volume":"58","author":"Derdak","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2018.04.006_bib36","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jhep.2016.11.004","article-title":"Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression","volume":"66","author":"Ramirez","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2018.04.006_bib37","doi-asserted-by":"crossref","first-page":"G364","DOI":"10.1152\/ajpgi.00456.2009","article-title":"Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice","volume":"298","author":"Shen","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.redox.2018.04.006_bib38","first-page":"161","article-title":"Suppression of PGC-1alpha by ethanol: implications of Its Role in Alcohol Induced Liver Injury","volume":"1","author":"Chaung","year":"2008","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.redox.2018.04.006_bib39","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1111\/acer.12576","article-title":"N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically","volume":"38","author":"Caro","year":"2014","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.redox.2018.04.006_bib40","doi-asserted-by":"crossref","first-page":"42165","DOI":"10.1074\/jbc.M112.377374","article-title":"Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations","volume":"287","author":"Han","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2018.04.006_bib41","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1\/PGC-1alpha","volume":"26","author":"Gerhart-Hines","year":"2007","journal-title":"EMBO J."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718300624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718300624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:00:45Z","timestamp":1761976845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231718300624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":41,"alternative-id":["S2213231718300624"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2018.04.006","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1\/PGC-1\u03b1\/mitochondrial biosynthesis pathway","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2018.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}