{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:48:02Z","timestamp":1792619282564,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401210"],"award-info":[{"award-number":["31401210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571455"],"award-info":[{"award-number":["31571455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600483"],"award-info":[{"award-number":["81600483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011403","name":"Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica","doi-asserted-by":"publisher","award":["JKLPSE 201502"],"award-info":[{"award-number":["JKLPSE 201502"]}],"id":[{"id":"10.13039\/501100011403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.redox.2018.09.007","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T12:55:23Z","timestamp":1536324923000},"page":"375-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":148,"special_numbering":"C","title":["Curcumol induces RIPK1\/RIPK3 complex-dependent necroptosis via JNK1\/2-ROS signaling in hepatic stellate cells"],"prefix":"10.1016","volume":"19","author":[{"given":"Yan","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoyi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanzhong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangjuan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.redox.2018.09.007_bib1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/hep.26790","article-title":"Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha\/c-x-c receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice","volume":"59","author":"Chen","year":"2014","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.redox.2018.09.007_bib2","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1002\/hep.26932","article-title":"Beyond liver fibrosis: hepatic stellate cell senescence links obesity to liver cancer by way of the microbiome","volume":"59","author":"Shackel","year":"2014","journal-title":"Hepatology"},{"issue":"Suppl. 1","key":"10.1016\/j.redox.2018.09.007_bib3","first-page":"S73","article-title":"Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis","volume":"22","author":"Kisseleva","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2018.09.007_bib4","article-title":"Matrix metalloproteinase functions in hepatic injury and fibrosis","author":"Roderfeld","year":"2017","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.redox.2018.09.007_bib5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cgh.2013.01.005","article-title":"Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies","volume":"11","author":"Rockey","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"Suppl. 3","key":"10.1016\/j.redox.2018.09.007_bib6","first-page":"S84","article-title":"Hepatic stellate cells and the reversal of fibrosis","volume":"21","author":"Kisseleva","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.redox.2018.09.007_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bpg.2017.04.005","article-title":"Reversal of liver fibrosis: from fiction to reality","volume":"31","author":"Zoubek","year":"2017","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"issue":"4","key":"10.1016\/j.redox.2018.09.007_bib8","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/hep.29275","article-title":"Targeting CCl4 -induced liver fibrosis by rna interference-mediated inhibition of cyclin e1 in mice","volume":"66","author":"Bangen","year":"2017","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.redox.2018.09.007_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.redox.2018.09.007_bib10","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/jcmm.13170","article-title":"Exosomes derived from mir-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation","volume":"21","author":"Qu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.redox.2018.09.007_bib11","doi-asserted-by":"crossref","first-page":"e2189","DOI":"10.1038\/cddis.2016.92","article-title":"Activation of ppargamma\/p53 signaling is required for curcumin to induce hepatic stellate cell senescence","volume":"7","author":"Jin","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2018.09.007_bib12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.redox.2016.12.021","article-title":"Autophagy regulates turnover of lipid droplets via ros-dependent rab25 activation in hepatic stellate cell","volume":"11","author":"Zhang","year":"2017","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2018.09.007_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/onc.2017.312","article-title":"Myc target gene, long intergenic noncoding rna, linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor micrornas","volume":"37","author":"Tran","year":"2018","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib14","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/hep.28676","article-title":"Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury","volume":"64","author":"Roychowdhury","year":"2016","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.redox.2018.09.007_bib15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/CS20140732","article-title":"Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis","volume":"129","author":"Afonso","year":"2015","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.redox.2018.09.007_bib16","doi-asserted-by":"crossref","first-page":"e0120713","DOI":"10.1371\/journal.pone.0120713","article-title":"Gallic acid induces necroptosis via tnf-alpha signaling pathway in activated hepatic stellate cells","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.redox.2018.09.007_bib17","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.cell.2008.12.004","article-title":"Necroptosis: a specialized pathway of programmed necrosis","volume":"135","author":"Galluzzi","year":"2008","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.redox.2018.09.007_bib18","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2008.10.044","article-title":"Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway","volume":"135","author":"Hitomi","year":"2008","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.redox.2018.09.007_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2014.06.041","article-title":"Snapshot: necroptosis","volume":"158","author":"Zhou","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib20","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.cell.2014.04.019","article-title":"Ripk1 regulates ripk3-mlkl-driven systemic inflammation and emergency hematopoiesis","volume":"157","author":"Rickard","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.redox.2018.09.007_bib21","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1038\/ncomms10274","article-title":"Cytotoxicity of crystals involves ripk3-mlkl-mediated necroptosis","volume":"7","author":"Mulay","year":"2016","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.redox.2018.09.007_bib22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1515\/hsz-2016-0102","article-title":"Regulation of necroptosis signaling and cell death by reactive oxygen species","volume":"397","author":"Fulda","year":"2016","journal-title":"Biol. Chem."},{"key":"10.1016\/j.redox.2018.09.007_bib23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fphys.2014.00323","article-title":"Necroptosis: is there a role for mitochondria?","volume":"5","author":"Marshall","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.redox.2018.09.007_bib24","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.freeradbiomed.2016.10.498","article-title":"Ros-jnk1\/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisin in liver fibrosis","volume":"101","author":"Zhang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.redox.2018.09.007_bib25","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1002\/jcp.26598","article-title":"Myricetin treatment induces apoptosis in canine osteosarcoma cells by inducing DNA fragmentation, disrupting redox homeostasis, and mediating loss of mitochondrial membrane potential","volume":"233","author":"Park","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.redox.2018.09.007_bib26","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1038\/s41598-018-21567-8","article-title":"Zearalenone altered the cytoskeletal structure via er stress- autophagy- oxidative stress pathway in mouse tm4 sertoli cells","volume":"8","author":"Zheng","year":"2018","journal-title":"Sci. Rep."},{"issue":"61","key":"10.1016\/j.redox.2018.09.007_bib27","doi-asserted-by":"crossref","first-page":"103710","DOI":"10.18632\/oncotarget.21780","article-title":"Reversion of resistance to oxaliplatin by inhibition of p38 mapk in colorectal cancer cell lines: involvement of the calpain\/nox1 pathway","volume":"8","author":"Chocry","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2018.09.007_bib28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.redox.2017.12.018","article-title":"Extracellular acidification induces ros- and mptp-mediated death in hek293 cells","volume":"15","author":"Teixeira","year":"2018","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib29","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1007\/s12035-016-9926-y","article-title":"Jnk activation contributes to oxidative stress-induced parthanatos in glioma cells via increase of intracellular ros production","volume":"54","author":"Zheng","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib30","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/hep.26200","article-title":"Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury","volume":"57","author":"Roychowdhury","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2018.09.007_bib31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejphar.2013.11.007","article-title":"Curcumol exhibits anti-inflammatory properties by interfering with the jnk-mediated ap-1 pathway in lipopolysaccharide-activated raw264.7 cells","volume":"723","author":"Chen","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.redox.2018.09.007_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jprot.2018.04.025","article-title":"Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells","volume":"182","author":"Wang","year":"2018","journal-title":"J. Proteom."},{"key":"10.1016\/j.redox.2018.09.007_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejps.2014.09.001","article-title":"Curcumol induces hsc-t6 cell death through suppression of bcl-2: involvement of pi3k and nf-kappab pathways","volume":"65","author":"Chen","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib34","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/hep.27649","article-title":"Low-molecular-weight fibroblast growth factor 2 attenuates hepatic fibrosis by epigenetic down-regulation of delta-like1","volume":"61","author":"Pan","year":"2015","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib35","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"Nlrp3 inflammasome blockade reduces liver inflammation and fibrosis in experimental nash in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.redox.2018.09.007_bib36","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of pparalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.redox.2018.09.007_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"issue":"11","key":"10.1016\/j.redox.2018.09.007_bib38","doi-asserted-by":"crossref","first-page":"e27710","DOI":"10.1371\/journal.pone.0027710","article-title":"Ndrg2 ameliorates hepatic fibrosis by inhibiting the tgf-beta1\/smad pathway and altering the mmp2\/timp2 ratio in rats","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.redox.2018.09.007_bib39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.redox.2018.09.007_bib40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/hep.28263","article-title":"The end of ripk1-ripk3-mlkl-mediated necroptosis in acetaminophen-induced hepatotoxicity?","volume":"64","author":"Yang","year":"2016","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib41","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10495-009-0334-x","article-title":"Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis","volume":"14","author":"Han","year":"2009","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.redox.2018.09.007_bib42","doi-asserted-by":"crossref","first-page":"7212","DOI":"10.3390\/ijms13067212","article-title":"Nec-1 enhances shikonin-induced apoptosis in leukemia cells by inhibition of rip-1 and erk1\/2","volume":"13","author":"Han","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.redox.2018.09.007_bib43","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"Tnf dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.redox.2018.09.007_bib44","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/pmic.201300326","article-title":"Quantitative phosphoproteomic analysis of rip3-dependent protein phosphorylation in the course of tnf-induced necroptosis","volume":"14","author":"Zhong","year":"2014","journal-title":"Proteomics"},{"issue":"23","key":"10.1016\/j.redox.2018.09.007_bib45","doi-asserted-by":"crossref","first-page":"16247","DOI":"10.1074\/jbc.M112.435545","article-title":"Diverse sequence determinants control human and mouse receptor interacting protein 3 (rip3) and mixed lineage kinase domain-like (mlkl) interaction in necroptotic signaling","volume":"288","author":"Chen","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.redox.2018.09.007_bib46","doi-asserted-by":"crossref","first-page":"e2629","DOI":"10.1038\/cddis.2017.54","article-title":"Ripk3 interactions with mlkl and camkii mediate oligodendrocytes death in the developing brain","volume":"8","author":"Qu","year":"2017","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.redox.2018.09.007_bib47","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"14","key":"10.1016\/j.redox.2018.09.007_bib48","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1158\/0008-5472.CAN-15-2637","article-title":"S-nitrosylation of the mitochondrial chaperone trap1 sensitizes hepatocellular carcinoma cells to inhibitors of succinate dehydrogenase","volume":"76","author":"Rizza","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2018.09.007_bib49","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.canlet.2017.10.047","article-title":"Mlkl-pitpalpha signaling-mediated necroptosis contributes to cisplatin-triggered cell death in lung cancer a549 cells","volume":"414","author":"Jing","year":"2018","journal-title":"Cancer Lett."},{"issue":"10","key":"10.1016\/j.redox.2018.09.007_bib50","doi-asserted-by":"crossref","first-page":"e3084","DOI":"10.1038\/cddis.2017.483","article-title":"Regulation of rip3 by the transcription factor sp1 and the epigenetic regulator uhrf1 modulates cancer cell necroptosis","volume":"8","author":"Yang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2018.09.007_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neulet.2013.01.007","article-title":"Curcumin protects against iron induced neurotoxicity in primary cortical neurons by attenuating necroptosis","volume":"536","author":"Dai","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.redox.2018.09.007_bib52","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.1249361","article-title":"Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis","volume":"343","author":"Newton","year":"2014","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.redox.2018.09.007_bib53","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2014.10.021","article-title":"RIP3 induces apoptosis independent of pro-necrotic kinase activity","volume":"56","author":"Mandal","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2018.09.007_bib54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijcard.2018.01.036","article-title":"Amp-activated protein kinase protects against necroptosis via regulation of keap1-pgam5 complex","volume":"259","author":"Wang","year":"2018","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.redox.2018.09.007_bib55","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/labinvest.2017.120","article-title":"Nadph oxidase 4 promotes cisplatin-induced acute kidney injury via ros-mediated programmed cell death and inflammation","volume":"98","author":"Meng","year":"2018","journal-title":"Lab. Invest."},{"issue":"5","key":"10.1016\/j.redox.2018.09.007_bib56","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/carcin\/bgy039","article-title":"Bufalin inhibits human breast cancer tumorigenesis by inducing cell death through the ros-mediated rip1\/rip3\/parp-1 pathways","volume":"39","author":"Li","year":"2018","journal-title":"Carcinogenesis"},{"issue":"10","key":"10.1016\/j.redox.2018.09.007_bib57","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/aps.2016.61","article-title":"Novel chop activator lgh00168 induces necroptosis in a549 human lung cancer cells via ros-mediated er stress and nf-kappab inhibition","volume":"37","author":"Ma","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"issue":"28","key":"10.1016\/j.redox.2018.09.007_bib58","doi-asserted-by":"crossref","first-page":"9338","DOI":"10.1523\/JNEUROSCI.0877-14.2014","article-title":"Mitochondrial dysfunction induces sarm1-dependent cell death in sensory neurons","volume":"34","author":"Summers","year":"2014","journal-title":"J. Neurosci."},{"issue":"5938","key":"10.1016\/j.redox.2018.09.007_bib59","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"Rip3, an energy metabolism regulator that switches tnf-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.redox.2018.09.007_bib60","doi-asserted-by":"crossref","first-page":"e2716","DOI":"10.1038\/cddis.2017.133","article-title":"Mitochondrial complex i inhibition triggers a mitophagy-dependent ros increase leading to necroptosis and ferroptosis in melanoma cells","volume":"8","author":"Basit","year":"2017","journal-title":"Cell Death Dis."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718305688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718305688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:07:54Z","timestamp":1761977274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231718305688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":60,"alternative-id":["S2213231718305688"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2018.09.007","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumol induces RIPK1\/RIPK3 complex-dependent necroptosis via JNK1\/2-ROS signaling in hepatic stellate cells","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2018.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}