{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:57:58Z","timestamp":1790171878454,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430025"],"award-info":[{"award-number":["81430025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1608282"],"award-info":[{"award-number":["U1608282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.redox.2018.101090","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T21:26:30Z","timestamp":1545341190000},"page":"101090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"special_numbering":"C","title":["Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice"],"prefix":"10.1016","volume":"21","author":[{"given":"Shuang-Feng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Qiu","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 5","key":"10.1016\/j.redox.2018.101090_bib1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson's disease: substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.redox.2018.101090_bib2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuroscience.2014.09.071","article-title":"Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease","volume":"284","author":"You","year":"2015","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.redox.2018.101090_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0896-6273(03)00126-0","article-title":"Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease","volume":"37","author":"Kaur","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.redox.2018.101090_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.expneurol.2016.03.016","article-title":"Deferoxamine-mediated up-regulation of HIF-1alpha prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice","volume":"280","author":"Guo","year":"2016","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib5","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s41598-017-01402-2","article-title":"Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson's disease","volume":"7","author":"Martin-Bastida","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.redox.2018.101090_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2013.5593","article-title":"Targeting chelatable iron as a therapeutic modality in Parkinson's disease","volume":"21","author":"Devos","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood-2006-12-065433","article-title":"Selective iron chelation in Friedreich ataxia: biologic and clinical implications","volume":"110","author":"Boddaert","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.redox.2018.101090_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12883-015-0331-3","article-title":"Ceruloplasmin activity and iron chelation treatment of patients with Parkinson's disease","volume":"15","author":"Grolez","year":"2015","journal-title":"BMC Neurol."},{"issue":"14","key":"10.1016\/j.redox.2018.101090_bib9","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/acs.inorgchem.7b00542","article-title":"Expanding the therapeutic potential of the iron chelator deferasirox in the development of aqueous stable Ti(IV) anticancer complexes","volume":"56","author":"Loza-Rosas","year":"2017","journal-title":"Inorg. Chem."},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201600244","article-title":"Iron binding and iron removal efficiency of desferrioxamine based polymeric iron chelators: influence of molecular size and chelator density","volume":"17","author":"Hamilton","year":"2017","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.redox.2018.101090_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biopha.2017.10.121","article-title":"In vitro and in vivo toxicity assessment of alginate\/eudragit S 100-enclosed chitosan-calcium phosphate-loaded iron saturated bovine lactoferrin nanocapsules (Fe-bLf NCs)","volume":"97","author":"Leng","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"14","key":"10.1016\/j.redox.2018.101090_bib12","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/ars.2015.6458","article-title":"Lactoferrin, a pleiotropic protein in health and disease","volume":"24","author":"Mayeur","year":"2016","journal-title":"Antioxid. Redox Signal."},{"issue":"13","key":"10.1016\/j.redox.2018.101090_bib13","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1038\/npp.2017.8","article-title":"Intranasal lactoferrin enhances alpha-secretase-dependent amyloid precursor protein processing via the ERK1\/2-CREB and HIF-1alpha pathways in an alzheimer's disease mouse model","volume":"42","author":"Guo","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/jcmm.12234","article-title":"Lactoferrin gene knockdown leads to similar effects to iron chelation in human adipocytes","volume":"18","author":"Moreno-Navarrete","year":"2014","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2018.101090_bib15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2017.11.001","article-title":"Alpha-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice","volume":"14","author":"Zhang","year":"2018","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.redox.2018.101090_bib16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuint.2012.12.005","article-title":"Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain","volume":"62","author":"Guo","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.redox.2018.101090_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fnagi.2015.00104","article-title":"Intranasal deferoxamine attenuates synapse loss via up-regulating the P38\/HIF-1alpha pathway on the brain of APP\/PS1 transgenic mice","volume":"7","author":"Guo","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.redox.2018.101090_bib18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.neurobiolaging.2012.05.009","article-title":"Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease","volume":"34","author":"Guo","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"7\u20138","key":"10.1016\/j.redox.2018.101090_bib19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.etp.2011.01.013","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuroblastic apoptosis in the subventricular zone is caused by 1-methy-4-phenylpiridinium (MPP(+)) converted from MPTP through MAO-B","volume":"64","author":"Ito","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF03033264","article-title":"MPTP-induced apoptosis in the retina of goldfish","volume":"3","author":"Villani","year":"2001","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.redox.2018.101090_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fnmol.2017.00455","article-title":"New progress on the role of glia in iron metabolism and iron-induced degeneration of dopamine neurons in parkinson's disease","volume":"10","author":"Xu","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.redox.2018.101090_bib22","doi-asserted-by":"crossref","first-page":"15946","DOI":"10.1038\/srep15946","article-title":"CFTR-regulated MAPK\/NF-kappaB signaling in pulmonary inflammation in thermal inhalation injury","volume":"5","author":"Dong","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.31887\/DCNS.2017.19.1\/rpal","article-title":"The potential role of neuroinflammation and transcription factors in Parkinson disease","volume":"19","author":"Tiwari","year":"2017","journal-title":"Dialog-. Clin. Neurosci."},{"key":"10.1016\/j.redox.2018.101090_bib24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0006-3002(60)91478-5","article-title":"Preparation and properties of lactosiderophilin (lactotransferrin) of human milk","volume":"45","author":"Montreuil","year":"1960","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41598-017-00913-2","article-title":"LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1\/E2F3 pathway","volume":"7","author":"Ren","year":"2017","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.redox.2018.101090_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.etp.2017.05.007","article-title":"Wyse ATS. Argininic acid alters markers of cellular oxidative damage in vitro: protective role of antioxidants","volume":"69","author":"Delwing-de Lima","year":"2017","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.redox.2018.101090_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2013.01.017","article-title":"Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators","volume":"62","author":"Weinreb","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.redox.2018.101090_bib28","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1523\/JNEUROSCI.1722-12.2013","article-title":"Axonally synthesized beta-actin and GAP-43 proteins support distinct modes of axonal growth","volume":"33","author":"Donnelly","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.redox.2018.101090_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fncir.2013.00025","article-title":"Structural plasticity of climbing fibers and the growth-associated protein GAP-43","volume":"7","author":"Grasselli","year":"2013","journal-title":"Front. Neural Circuits"},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/bpa.12346","article-title":"Altered expression of growth associated protein-43 and Rho kinase in human patients with parkinson's disease","volume":"27","author":"Saal","year":"2017","journal-title":"Brain Pathol."},{"issue":"11","key":"10.1016\/j.redox.2018.101090_bib31","first-page":"820","article-title":"[The neuroprotection of brain-derived neurotrophic factor in experimental retinal detachment reattached]","volume":"50","author":"Zeng","year":"2014","journal-title":"Zhonghua Yan Ke Za Zhi"},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/term.1796","article-title":"Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine","volume":"10","author":"Liu","year":"2016","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1095\/biolreprod.115.134965","article-title":"The MAPK\/ERK-signaling pathway regulates the expression and distribution of tight junction proteins in the mouse proximal epididymis","volume":"94","author":"Kim","year":"2016","journal-title":"Biol. Reprod."},{"issue":"11","key":"10.1016\/j.redox.2018.101090_bib34","doi-asserted-by":"crossref","first-page":"10331","DOI":"10.1074\/jbc.M308013200","article-title":"Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.redox.2018.101090_bib35","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.3892\/mmr.2015.4327","article-title":"Combination of early and delayed ischemic postconditioning enhances brain-derived neurotrophic factor production by upregulating the ERK-CREB pathway in rats with focal ischemia","volume":"12","author":"Wu","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.redox.2018.101090_bib36","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s10534-014-9735-6","article-title":"Behavioral effects of bovine lactoferrin administration during postnatal development of rats","volume":"27","author":"Shumake","year":"2014","journal-title":"Biometals"},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12035-014-8856-9","article-title":"Lactoferrin promotes early neurodevelopment and cognition in postnatal piglets by upregulating the BDNF signaling pathway and polysialylation","volume":"52","author":"Chen","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.redox.2018.101090_bib38","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fped.2016.00004","article-title":"Dietary prebiotics, milk fat globule membrane, and lactoferrin affects structural neurodevelopment in the young piglet","volume":"4","author":"Mudd","year":"2016","journal-title":"Front. Pediatr."},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1139\/bcb-2016-0066","article-title":"Lactoferrin and prematurity: a promising milk protein?","volume":"95","author":"Ochoa","year":"2017","journal-title":"Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib40","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/cne.10979","article-title":"Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum","volume":"468","author":"Mengual","year":"2004","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.redox.2018.101090_bib41","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1210\/en.2006-1293","article-title":"Tyrosine hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: involvement in dopamine-induced apoptosis","volume":"148","author":"Jaubert","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.redox.2018.101090_bib42","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.neuroscience.2015.01.032","article-title":"Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro","volume":"290","author":"Sivasubramanian","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.redox.2018.101090_bib43","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1186\/1471-2164-15-1154","article-title":"Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease","volume":"15","author":"Krishna","year":"2014","journal-title":"BMC Genom."},{"issue":"1\u20132","key":"10.1016\/j.redox.2018.101090_bib44","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11010-011-1028-6","article-title":"PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl\/Bax-caspase9-caspase3 pathway","volume":"359","author":"Wu","year":"2012","journal-title":"Mol. Cell Biochem."},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbagen.2011.06.018","article-title":"Lactoferrin a multiple bioactive protein: an overview","volume":"1820","author":"Garcia-Montoya","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.redox.2018.101090_bib46","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1124\/mol.113.087965","article-title":"The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis","volume":"84","author":"Rousseau","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib47","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1038\/emm.2016.159","article-title":"Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease","volume":"49","author":"Chung","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.redox.2018.101090_bib48","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.2147\/IJN.S120939","article-title":"Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson's disease treatment","volume":"11","author":"Bi","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.redox.2018.101090_bib49","doi-asserted-by":"crossref","first-page":"1639720","DOI":"10.1155\/2016\/1639720","article-title":"Lactoferrin decreases the intestinal inflammation triggered by a soybean meal-based diet in zebrafish","volume":"2016","author":"Ulloa","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.redox.2018.101090_bib50","doi-asserted-by":"crossref","DOI":"10.2174\/1389203719666180514150921","article-title":"Lactoferrin: major physiological functions and applications","author":"Hao","year":"2018","journal-title":"Curr. Protein Pept. Sci."},{"issue":"2","key":"10.1016\/j.redox.2018.101090_bib51","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ncpgasthep0094","article-title":"Technology insight: calprotectin, lactoferrin and nitric oxide as novel markers of inflammatory bowel disease","volume":"2","author":"Lundberg","year":"2005","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2018.101090_bib52","doi-asserted-by":"crossref","first-page":"10729","DOI":"10.1038\/srep10729","article-title":"The protective effect of lactoferrin on ventral mesencephalon neurons against MPP + is not connected with its iron binding ability","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2018.101090_bib53","doi-asserted-by":"crossref","DOI":"10.1007\/s10534-018-0111-9","article-title":"Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin","author":"Zakharova","year":"2018","journal-title":"Biometals"},{"issue":"6","key":"10.1016\/j.redox.2018.101090_bib54","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s10534-012-9586-y","article-title":"Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha","volume":"25","author":"Zakharova","year":"2012","journal-title":"Biometals"},{"issue":"46","key":"10.1016\/j.redox.2018.101090_bib55","doi-asserted-by":"crossref","first-page":"35863","DOI":"10.1074\/jbc.M005643200","article-title":"The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia","volume":"275","author":"Agani","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/syn.890180105","article-title":"MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels","volume":"18","author":"Ali","year":"1994","journal-title":"Synapse"},{"issue":"33","key":"10.1016\/j.redox.2018.101090_bib57","doi-asserted-by":"crossref","first-page":"25130","DOI":"10.1074\/jbc.M001914200","article-title":"Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing","volume":"275","author":"Chandel","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2018.101090_bib58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10072-010-0216-6","article-title":"Protective effects of heme oxygenase-1 against MPP(+)-induced cytotoxicity in PC-12 cells","volume":"31","author":"Bae","year":"2010","journal-title":"Neurol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.redox.2018.101090_bib59","first-page":"14","article-title":"The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression","volume":"41","author":"Hung","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"1","key":"10.1016\/j.redox.2018.101090_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(95)00029-1","article-title":"Oxidative stress and antioxidant therapy in Parkinson's disease","volume":"48","author":"Ebadi","year":"1996","journal-title":"Prog. Neurobiol."},{"issue":"5","key":"10.1016\/j.redox.2018.101090_bib61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0301-0082(94)90009-4","article-title":"Functions of brain-derived neurotrophic factor, insulin-like growth factor-I and basic fibroblast growth factor in the development and maintenance of dopaminergic neurons","volume":"44","author":"Beck","year":"1994","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.redox.2018.101090_bib62","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijdevneu.2008.11.007","article-title":"Extracellular guanosine and GTP promote expression of differentiation markers and induce S-phase cell-cycle arrest in human SH-SY5Y neuroblastoma cells","volume":"27","author":"Guarnieri","year":"2009","journal-title":"Int J. Dev. Neurosci."},{"issue":"2","key":"10.1016\/j.redox.2018.101090_bib63","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1517\/14728222.7.2.187","article-title":"MAPKs: new targets for neurodegeneration","volume":"7","author":"Harper","year":"2003","journal-title":"Expert Opin. Ther. Targets"},{"issue":"12","key":"10.1016\/j.redox.2018.101090_bib64","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s007020100015","article-title":"Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK\/ERK), stress-activated protein kinase\/c-Jun N-terminal kinase (SAPK\/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies","volume":"108","author":"Ferrer","year":"2001","journal-title":"J. Neural Transm."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718312084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718312084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:09:17Z","timestamp":1761977357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231718312084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":64,"alternative-id":["S2213231718312084"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2018.101090","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2018.101090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101090"}}