{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:47:10Z","timestamp":1783039630655,"version":"3.54.6"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL139562-01A1"],"award-info":[{"award-number":["1R01HL139562-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["4R00HL114648-03"],"award-info":[{"award-number":["4R00HL114648-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.redox.2019.101224","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T23:27:40Z","timestamp":1559172460000},"page":"101224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis"],"prefix":"10.1016","volume":"27","author":[{"given":"Pushpankur","family":"Ghoshal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupesh","family":"Singla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Cherian-Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Tritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb A.","family":"Padgett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farlyn","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Stansfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Cs\u00e1nyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3 Pt 1","key":"10.1016\/j.redox.2019.101224_bib1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1542\/peds.105.3.608","article-title":"Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children","volume":"105","author":"DeBella","year":"2000","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.redox.2019.101224_bib2","first-page":"297","article-title":"Neurofibromin in neurofibromatosis type 1 - mutations in NF1gene as a cause of disease","volume":"18","author":"Abramowicz","year":"2014","journal-title":"Dev Period Med"},{"issue":"10","key":"10.1016\/j.redox.2019.101224_bib3","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1074\/jbc.M009202200","article-title":"Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-\/- cells","volume":"276","author":"Hiatt","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2019.101224_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ajpath.2013.09.022","article-title":"Ras-Mek-Erk signaling regulates Nf1 heterozygous neointima formation","volume":"184","author":"Stansfield","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.redox.2019.101224_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jvs.2007.03.055","article-title":"Vascular abnormalities in patients with neurofibromatosis syndrome type I: clinical spectrum, management, and results","volume":"46","author":"Oderich","year":"2007","journal-title":"J. Vasc. Surg."},{"issue":"3","key":"10.1016\/j.redox.2019.101224_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00125817-200205000-00002","article-title":"Cardiovascular disease in neurofibromatosis 1: report of the NF1 cardiovascular task force","volume":"4","author":"Friedman","year":"2002","journal-title":"Genet. Med."},{"issue":"5","key":"10.1016\/j.redox.2019.101224_bib7","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1086\/320121","article-title":"Mortality in neurofibromatosis 1: an analysis using U.S. death certificates","volume":"68","author":"Rasmussen","year":"2001","journal-title":"Am. J. Hum. Genet."},{"issue":"11","key":"10.1016\/j.redox.2019.101224_bib8","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/CIRCULATIONAHA.113.006320","article-title":"Neurofibromin-deficient myeloid cells are critical mediators of aneurysm formation in vivo","volume":"129","author":"Li","year":"2014","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.redox.2019.101224_bib9","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI41443","article-title":"Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans","volume":"120","author":"Lasater","year":"2010","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.redox.2019.101224_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0008-6363(98)00108-4","article-title":"Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis","volume":"39","author":"Carmeliet","year":"1998","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.redox.2019.101224_bib11","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/hmg\/dds502","article-title":"Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway","volume":"22","author":"Stansfield","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.redox.2019.101224_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-012-1056-7","article-title":"Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition","volume":"125","author":"Prada","year":"2013","journal-title":"Acta Neuropathol."},{"issue":"7451","key":"10.1016\/j.redox.2019.101224_bib13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature12138","article-title":"Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells","volume":"497","author":"Commisso","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.redox.2019.101224_bib14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3389\/fimmu.2018.00537","article-title":"PKCdelta-mediated Nox2 activation promotes fluid-phase pinocytosis of antigens by immature dendritic cells","volume":"9","author":"Singla","year":"2018","journal-title":"Front. Immunol."},{"issue":"Pt 4","key":"10.1016\/j.redox.2019.101224_bib15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1242\/jcs.113.4.709","article-title":"The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement","volume":"113","author":"Chubb","year":"2000","journal-title":"J. Cell Sci."},{"issue":"Pt 18","key":"10.1016\/j.redox.2019.101224_bib16","first-page":"4296","article-title":"Two distinct functions for PI3-kinases in macropinocytosis","volume":"126","author":"Hoeller","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.redox.2019.101224_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cellsig.2018.09.018","article-title":"PKCdelta stimulates macropinocytosis via activation of SSH1-cofilin pathway","volume":"53","author":"Singla","year":"2019","journal-title":"Cell. Signal."},{"issue":"6","key":"10.1016\/j.redox.2019.101224_bib18","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.ymthe.2004.08.010","article-title":"Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement","volume":"10","author":"Nakase","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.redox.2019.101224_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04940","article-title":"Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium","volume":"4","author":"Bloomfield","year":"2015","journal-title":"Elife"},{"issue":"16","key":"10.1016\/j.redox.2019.101224_bib20","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1089\/ars.2016.6834","article-title":"CD47 and Nox1 mediate dynamic fluid-phase macropinocytosis of native LDL","volume":"26","author":"Csanyi","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"3","key":"10.1016\/j.redox.2019.101224_bib21","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1074\/jbc.M407167200","article-title":"Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein","volume":"280","author":"Kruth","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.redox.2019.101224_bib22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1128\/CVI.00328-07","article-title":"Differentiation of C2D macrophage cells after adoptive transfer","volume":"15","author":"Potts","year":"2008","journal-title":"Clin. Vaccine Immunol."},{"issue":"11","key":"10.1016\/j.redox.2019.101224_bib23","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1089\/ars.2010.3669","article-title":"Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production","volume":"14","author":"Chen","year":"2011","journal-title":"Antioxidants Redox Signal."},{"issue":"10","key":"10.1016\/j.redox.2019.101224_bib24","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1158\/0008-5472.CAN-08-3467","article-title":"Loss of the SMRT\/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma","volume":"69","author":"Ghoshal","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2019.101224_bib25","doi-asserted-by":"crossref","first-page":"27031","DOI":"10.3402\/jev.v4.27031","article-title":"Optimized exosome isolation protocol for cell culture supernatant and human plasma","volume":"4","author":"Lobb","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"18","key":"10.1016\/j.redox.2019.101224_bib26","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1111\/bph.14429","article-title":"Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs","volume":"175","author":"Lin","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.redox.2019.101224_bib27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200908086","article-title":"Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling","volume":"188","author":"Koivusalo","year":"2010","journal-title":"J. Cell Biol."},{"issue":"Suppl 3","key":"10.1016\/j.redox.2019.101224_bib28","doi-asserted-by":"crossref","first-page":"S957","DOI":"10.1093\/infdis\/jir326","article-title":"Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis","volume":"204","author":"Aleksandrowicz","year":"2011","journal-title":"J. Infect. Dis."},{"issue":"21","key":"10.1016\/j.redox.2019.101224_bib29","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1101\/gad.246603.114","article-title":"NF1 regulation of RAS\/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development","volume":"28","author":"Sanchez-Ortiz","year":"2014","journal-title":"Genes Dev."},{"issue":"24","key":"10.1016\/j.redox.2019.101224_bib30","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1523\/JNEUROSCI.18-24-10420.1998","article-title":"p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons","volume":"18","author":"Klesse","year":"1998","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.redox.2019.101224_bib31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.stem.2007.07.008","article-title":"Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms","volume":"1","author":"Hegedus","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"20","key":"10.1016\/j.redox.2019.101224_bib32","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gad.1957110","article-title":"Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner","volume":"24","author":"Lee","year":"2010","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.redox.2019.101224_bib33","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.cell.2007.03.051","article-title":"Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice","volume":"129","author":"Gupta","year":"2007","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.redox.2019.101224_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11060-010-0502-4","article-title":"Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas","volume":"104","author":"Chaponis","year":"2011","journal-title":"J. Neuro Oncol."},{"issue":"7","key":"10.1016\/j.redox.2019.101224_bib35","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/35083070","article-title":"The PX domains of p47phox and p40phox bind to lipid products of PI(3)K","volume":"3","author":"Kanai","year":"2001","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.redox.2019.101224_bib36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1006\/bbrc.1993.2016","article-title":"Activation of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate","volume":"195","author":"Singh","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"33","key":"10.1016\/j.redox.2019.101224_bib37","doi-asserted-by":"crossref","first-page":"22759","DOI":"10.1074\/jbc.M114.561159","article-title":"Molecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production","volume":"289","author":"Meijles","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.redox.2019.101224_bib38","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/cdd.2014.34","article-title":"Novel signaling axis for ROS generation during K-Ras-induced cellular transformation","volume":"21","author":"Park","year":"2014","journal-title":"Cell Death Differ."},{"issue":"16","key":"10.1016\/j.redox.2019.101224_bib39","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1089\/ars.2016.6639","article-title":"Nox2-Mediated PI3K and cofilin activation confers alternate redox control of macrophage pinocytosis","volume":"26","author":"Ghoshal","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"4","key":"10.1016\/j.redox.2019.101224_bib40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1159\/000188966","article-title":"A case of renovascular hypertension associated with neurofibromatosis","volume":"72","author":"Hirayama","year":"1996","journal-title":"Nephron"},{"issue":"3","key":"10.1016\/j.redox.2019.101224_bib41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1634\/stemcells.22-3-377","article-title":"Mesenchymal stem cells can be differentiated into endothelial cells in vitro","volume":"22","author":"Oswald","year":"2004","journal-title":"Stem Cell."},{"issue":"11","key":"10.1016\/j.redox.2019.101224_bib42","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1172\/JCI18730","article-title":"Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta\/delta, and gamma","volume":"114","author":"Li","year":"2004","journal-title":"J. Clin. Investig."},{"issue":"12","key":"10.1016\/j.redox.2019.101224_bib43","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2019.101224_bib44","doi-asserted-by":"crossref","first-page":"6827237","DOI":"10.1155\/2018\/6827237","article-title":"Roles of macrophage subtypes in bowel anastomotic healing and anastomotic leakage","volume":"2018","author":"Shi","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.redox.2019.101224_bib45","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.redox.2019.101224_bib46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/imm.12173","article-title":"A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo","volume":"141","author":"Arnold","year":"2014","journal-title":"Immunology"},{"issue":"12","key":"10.1016\/j.redox.2019.101224_bib47","doi-asserted-by":"crossref","first-page":"e0145342","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel markers to delineate murine M1 and M2 macrophages","volume":"10","author":"Jablonski","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.redox.2019.101224_bib48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/PAP.0000000000000197","article-title":"Recent advances in the diagnosis and pathogenesis of neurofibromatosis type 1 (NF1)-associated peripheral nervous system neoplasms","volume":"25","author":"Longo","year":"2018","journal-title":"Adv. Anat. Pathol."},{"issue":"7","key":"10.1016\/j.redox.2019.101224_bib49","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/sj.leu.2402945","article-title":"Signal transduction mediated by the Ras\/Raf\/MEK\/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.redox.2019.101224_bib50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fendo.2017.00261","article-title":"Macropinocytosis: a metabolic adaptation to nutrient stress in cancer","volume":"8","author":"Recouvreux","year":"2017","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.redox.2019.101224_bib51","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S1474-4422(14)70063-8","article-title":"Neurofibromatosis type 1: a multidisciplinary approach to care","volume":"13","author":"Hirbe","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2019.101224_bib52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-59745-178-9_2","article-title":"Pharmacological inhibition of endocytic pathways: is it specific enough to be useful?","volume":"440","author":"Ivanov","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.redox.2019.101224_bib53","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3389\/fphys.2014.00374","article-title":"Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation","volume":"5","author":"Egami","year":"2014","journal-title":"Front. Physiol."},{"issue":"Suppl 2","key":"10.1016\/j.redox.2019.101224_bib54","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1517\/14728222.2011.639361","article-title":"The RAS\/RAF\/MEK\/ERK and the PI3K\/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches","volume":"16","author":"De Luca","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"issue":"11","key":"10.1016\/j.redox.2019.101224_bib55","doi-asserted-by":"crossref","first-page":"E978","DOI":"10.1073\/pnas.1311029111","article-title":"Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis","volume":"111","author":"Maekawa","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.redox.2019.101224_bib56","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2019.101224_bib57","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.freeradbiomed.2016.06.002","article-title":"Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans","volume":"97","author":"Bessler","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"15","key":"10.1016\/j.redox.2019.101224_bib58","doi-asserted-by":"crossref","first-page":"25700","DOI":"10.18632\/oncotarget.14878","article-title":"Emerging role of exosome-mediated intercellular communication in vascular remodeling","volume":"8","author":"Su","year":"2017","journal-title":"Oncotarget"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718312850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231718312850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:13:07Z","timestamp":1761977587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231718312850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":58,"alternative-id":["S2213231718312850"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2019.101224","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2019.101224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101224"}}