{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:15:44Z","timestamp":1791771344734,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871722"],"award-info":[{"award-number":["81871722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472024"],"award-info":[{"award-number":["81472024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.redox.2019.101355","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T13:06:24Z","timestamp":1571835984000},"page":"101355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish"],"prefix":"10.1016","volume":"28","author":[{"given":"Jing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2019.101355_bib1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nature08301","article-title":"Function and biogenesis of iron\u2013sulphur proteins","volume":"460","author":"Lill","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.redox.2019.101355_bib2","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1021\/bi1004798","article-title":"Human Iron\u2212Sulfur cluster Assembly, cellular iron homeostasis, and disease","volume":"49","author":"Ye","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.redox.2019.101355_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrm1620","article-title":"Iron\u2013sulphur cluster biogenesis and mitochondrial iron homeostasis","volume":"6","author":"Rouault","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2019.101355_bib4","doi-asserted-by":"crossref","first-page":"9231","DOI":"10.1074\/jbc.M708077200","article-title":"A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis","volume":"283","author":"Song","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2019.101355_bib5","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1038\/sj.emboj.7600216","article-title":"The hydrogenase\u2010like Nar1p is essential for maturation of cytosolic and nuclear iron\u2013sulphur proteins","volume":"23","author":"Balk","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2019.101355_bib6","doi-asserted-by":"crossref","first-page":"15797","DOI":"10.1074\/jbc.M110.201731","article-title":"Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis","volume":"286","author":"Song","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2019.101355_bib7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/BJ20060635","article-title":"IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1\u03b1 activity","volume":"401","author":"Huang","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2019.101355_bib8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.freeradbiomed.2015.08.026","article-title":"The iron-sulfur cluster assembly network component NARFL is a key element in the cellular defense against oxidative stress","volume":"89","author":"Corbin","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2019.101355_bib9","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.18632\/oncotarget.13156","article-title":"A novel mutation in nuclear prelamin a recognition factor-like causes diffuse pulmonary arteriovenous malformations","volume":"8","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2019.101355_bib10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood-2013-09-512749","article-title":"Oxidative stress in angiogenesis and vascular disease","volume":"123","author":"Kim","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.redox.2019.101355_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jocn.2019.02.019","article-title":"Oxidative stress-induced angiogenesis","volume":"63","author":"Huang","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.redox.2019.101355_bib12","doi-asserted-by":"crossref","first-page":"2304018","DOI":"10.1155\/2019\/2304018","article-title":"Emerging roles of redox-mediated angiogenesis and oxidative stress in dermatoses","volume":"2019","author":"Xian","year":"2019","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"10.1016\/j.redox.2019.101355_bib13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jacc.2017.05.035","article-title":"Impact of oxidative stress on the heart and vasculature: Part 2 of a 3-Part Series","volume":"70","author":"M\u00fcnzel","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.redox.2019.101355_bib14","doi-asserted-by":"crossref","first-page":"6167","DOI":"10.1158\/0008-5472.CAN-05-3640","article-title":"Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesis","volume":"66","author":"Kim","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2019.101355_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/a392bbef-b0ec-4c70-b403-74a7bad85178","article-title":"Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPAR\u03b1 mediated mechanism","volume":"6","author":"Garrido-Urbani","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2019.101355_bib16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1089\/ars.2011.4489","article-title":"NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts","volume":"16","author":"Coso","year":"2012","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2019.101355_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.redox.2018.04.013","article-title":"MGST1, a GSH transferase\/peroxidase essential for development and hematopoietic stem cell differentiation","volume":"17","author":"Br\u00e4utigam","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2019.101355_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00865","article-title":"Reactive oxygen species and pulmonary vasculature during hypobaric hypoxia","volume":"9","author":"Siques","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.redox.2019.101355_bib19","doi-asserted-by":"crossref","first-page":"18928","DOI":"10.1038\/srep18928","article-title":"Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1\u03b1 activation","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2019.101355_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206883","article-title":"Deletion of Pr72 causes cardiac developmental defects in Zebrafish","volume":"13","author":"Song","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2019.101355_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.redox.2019.101355_bib22","article-title":"Whole mount RNA in situ hybridization on zebrafish embryos: hybridization","volume":"2008","author":"Moens","year":"2008","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.redox.2019.101355_bib23","article-title":"Whole mount RNA in situ hybridization on zebrafish embryos: mounting","volume":"2008","author":"Moens","year":"2008","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.redox.2019.101355_bib24","article-title":"Whole mount RNA in situ hybridization on zebrafish embryos: probe synthesis","volume":"2008","author":"Moens","year":"2008","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.redox.2019.101355_bib25","first-page":"963","article-title":"Functional characterization of Klippel\u2013Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis","volume":"22","author":"Li","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.redox.2019.101355_bib26","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2144\/000112619","article-title":"Method for isolation of PCR-ready genomic DNA from zebrafish tissues","volume":"43","author":"Meeker","year":"2007","journal-title":"Biotechniques"},{"key":"10.1016\/j.redox.2019.101355_bib27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.stemcr.2016.12.025","article-title":"TP53 modulates oxidative stress in Gata1(+) erythroid cells","volume":"8","author":"Kramer","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.redox.2019.101355_bib28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ydbio.2015.10.017","article-title":"Patterning mechanisms of the sub-intestinal venous plexus in zebrafish","volume":"409","author":"Goi","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.redox.2019.101355_bib29","article-title":"Angiopoietin-1\/Tie2 receptor signaling in vascular quiescence and angiogenesis","volume":"25","author":"Shigetomo","year":"2010","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.redox.2019.101355_bib30","doi-asserted-by":"crossref","first-page":"13524","DOI":"10.1002\/anie.201608094","article-title":"A macrocyclic Ruthenium(III) complex inhibits angiogenesis with down-regulation of vascular endothelial growth factor receptor-2 and suppresses tumor growth in vivo","volume":"55","author":"Kwong","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.redox.2019.101355_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jep.2017.04.006","article-title":"Dalbergia odorifera extract promotes angiogenesis through upregulation of VEGFRs and PI3K\/MAPK signaling pathways","volume":"204","author":"Fan","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.redox.2019.101355_bib32","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.2337\/db16-0881","article-title":"PDGFR\u03b2 regulates adipose tissue expansion and glucose metabolism via vascular remodeling in diet-induced obesity","volume":"66","author":"Onogi","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2019.101355_bib33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ebiom.2018.06.003","article-title":"IL-33 initiates vascular remodelling in hypoxic pulmonary hypertension by up-regulating HIF-1\u03b1 and VEGF expression in vascular endothelial cells","volume":"33","author":"Liu","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2019.101355_bib34","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2337\/db17-0833","article-title":"Pericyte-derived Dickkopf2 regenerates damaged penile neurovasculature through an Angiopoietin-1-Tie2 pathway","volume":"67","author":"Yin","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2019.101355_bib35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/abbs\/gmy169","article-title":"Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress","volume":"51","author":"Wu","year":"2019","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.redox.2019.101355_bib36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.omtn.2019.02.014","article-title":"MicroRNA-26b-5p inhibits mouse liver fibrogenesis and angiogenesis by targeting PDGF receptor-beta","volume":"16","author":"Yang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.redox.2019.101355_bib37","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.redox.2019.101355_bib38","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.drudis.2018.05.016","article-title":"Prolyl hydroxylase 2: a promising target to inhibit hypoxia-induced cellular metabolism in cancer cells","volume":"23","author":"Singh","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.redox.2019.101355_bib39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.semcdb.2005.03.010","article-title":"Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression","volume":"16","author":"Kietzmann","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2019.101355_bib40","article-title":"Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells","volume":"385 249","author":"BelAiba","year":"2004"},{"key":"10.1016\/j.redox.2019.101355_bib41","doi-asserted-by":"crossref","first-page":"31963","DOI":"10.1074\/jbc.M200082200","article-title":"Vanadate-induced expression of hypoxia-inducible factor 1\u03b1 and vascular endothelial growth factor through phosphatidylinositol 3-kinase\/Akt pathway and reactive oxygen species","volume":"277","author":"Gao","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.redox.2019.101355_bib42","doi-asserted-by":"crossref","first-page":"26765","DOI":"10.1016\/S0021-9258(19)61441-9","article-title":"Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1\u03b1) in vascular smooth muscle cells","volume":"275","author":"Richard","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2019.101355_bib43","doi-asserted-by":"crossref","first-page":"27280","DOI":"10.1038\/srep27280","article-title":"HIF-1\u03b1 and HIF-2\u03b1 induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide","volume":"6","author":"Feng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2019.101355_bib44","first-page":"4266","article-title":"Venous-derived angioblasts generate organ-specific vessels during zebrafish embryonic development","volume":"142","author":"Hen","year":"2015","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.redox.2019.101355_bib45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mcn.2015.06.007","article-title":"Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons","volume":"67","author":"Chandrasekaran","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.redox.2019.101355_bib46","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/jbmr.2848","article-title":"Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling","volume":"31","author":"Wang","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.redox.2019.101355_bib47","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.tcb.2010.06.009","article-title":"The yolk syncytial layer in early zebrafish development","volume":"20","author":"Carvalho","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.redox.2019.101355_bib48","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/35001596","article-title":"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter","volume":"403","author":"Donovan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.redox.2019.101355_bib49","series-title":"Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease","author":"Zemskov","year":"2019"},{"key":"10.1016\/j.redox.2019.101355_bib50","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1042\/CS20180316","article-title":"New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease","volume":"133","author":"Brassington","year":"2019","journal-title":"Clin. Sci."},{"key":"10.1016\/j.redox.2019.101355_bib51","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4353462","article-title":"Pentaerythritol tetranitrate in vivo treatment improves oxidative stress and vascular dysfunction by suppression of endothelin-1 signaling in monocrotaline-induced pulmonary hypertension","volume":"2017","author":"Steven","year":"2017","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"10.1016\/j.redox.2019.101355_bib52","series-title":"Redox Biology of Peroxisome Proliferator-Activated Receptor-\u03b3 in Pulmonary Hypertension","author":"Tseng","year":"2018"},{"key":"10.1016\/j.redox.2019.101355_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/956792","article-title":"Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants","volume":"2013","author":"Poljsak","year":"2013","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"10.1016\/j.redox.2019.101355_bib54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mam.2018.08.001","article-title":"Oxidative stress in chronic lung disease: from mitochondrial dysfunction to dysregulated redox signaling","volume":"63","author":"van der Vliet","year":"2018","journal-title":"Mol. Asp. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231719307712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231719307712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:10:18Z","timestamp":1761977418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231719307712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":54,"alternative-id":["S2213231719307712"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2019.101355","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2019.101355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101355"}}