{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:23:13Z","timestamp":1790716993138,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["216S838"],"award-info":[{"award-number":["216S838"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.redox.2020.101502","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T11:23:34Z","timestamp":1584789814000},"page":"101502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib"],"prefix":"10.1016","volume":"32","author":[{"given":"Ayse Tarbin","family":"Jannuzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Mine","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulce","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande","family":"Beklen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazim Yalcin","family":"Arga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Karademir Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket","family":"Alpertunga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2020.101502_bib1","first-page":"1","article-title":"Relationship between the proteasomal system and autophagy","volume":"4","author":"Lilienbaum","year":"2013","journal-title":"Int. J. Biochem. Mol. Biol."},{"key":"10.1016\/j.redox.2020.101502_bib2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bbadis.2008.10.002","article-title":"Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection","volume":"1782","author":"Nedelsky","year":"2008","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.redox.2020.101502_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.14348\/molcells.2017.0115","article-title":"Crosstalk and interplay between the ubiquitin-proteasome system and autophagy","volume":"40","author":"Ji","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2020.101502_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2009.04.001","article-title":"The proteasomal system","author":"Jung","year":"2009","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.redox.2020.101502_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2016.12.007","article-title":"Proteasome inhibitors in cancer therapy: treatment regimen and peripheral neuropathy as a side effect","volume":"103","author":"Kaplan","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101502_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12079-011-0121-7","article-title":"Proteasome inhibitors in cancer therapy","volume":"5","author":"Crawford","year":"2011","journal-title":"J. Cell Commun. Signal"},{"key":"10.1016\/j.redox.2020.101502_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuro.2014.02.001","article-title":"Neurotoxicity induced by antineoplastic proteasome inhibitors","volume":"43","author":"Ale","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.redox.2020.101502_bib8","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1158\/1078-0432.CCR-13-0755","article-title":"US Food and Drug Administration approval: carfilzomib for the treatment of multiple myeloma","volume":"19","author":"Herndon","year":"2013","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.redox.2020.101502_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2016.12.007","article-title":"Proteasome inhibitors in cancer therapy: treatment regimen and peripheral neuropathy as a side effect","volume":"103","author":"Kaplan","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101502_bib10","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S1470-2045(17)30578-8","article-title":"Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial","volume":"18","author":"Dimopoulos","year":"2017","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.redox.2020.101502_bib11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s12640-014-9514-8","article-title":"Toxic effects of bortezomib on primary sensory neurons and Schwann cells of adult mice","volume":"27","author":"Al\u00e9","year":"2015","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.redox.2020.101502_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.expneurol.2012.08.023","article-title":"Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy","volume":"238","author":"Zheng","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.redox.2020.101502_bib13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.bbadis.2011.03.007","article-title":"PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons","volume":"1812","author":"Wang","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.redox.2020.101502_bib14","first-page":"107","article-title":"Study on mechanism of bortezomib inducing peripheral neuropathy and the reversing effect of reduced glutathione","volume":"32","author":"Wang","year":"2011","journal-title":"Zhonghua Xue Ye Xue Za Zhi= Zhonghua Xueyexue Zazhi."},{"key":"10.1016\/j.redox.2020.101502_bib15","article-title":"Mitochondrial trafficking in neurons","volume":"3","author":"Schwarz","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.redox.2020.101502_bib16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.neuron.2008.10.010","article-title":"Mitochondria in neuroplasticity and neurological disorders","volume":"60","author":"Mattson","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.redox.2020.101502_bib17","doi-asserted-by":"crossref","first-page":"16318","DOI":"10.1038\/s41598-018-34507-3","article-title":"Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib","volume":"8","author":"Karademir","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2020.101502_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks1055","article-title":"The ConsensusPathDB interaction database: 2013 Update","author":"Kamburov","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2020.101502_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky962","article-title":"New approach for understanding genome variations in KEGG","author":"Kanehisa","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2020.101502_bib20","article-title":"The gene ontology resource: 20 years and still GOing strong","author":"Carbon","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2020.101502_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.acthis.2017.03.001","article-title":"A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture","volume":"119","author":"Valente","year":"2017","journal-title":"Acta Histochem."},{"key":"10.1016\/j.redox.2020.101502_bib22","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.redox.2020.101502_bib23","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ncb836","article-title":"Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism","volume":"4","author":"Bota","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2020.101502_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10863-008-9147-9","article-title":"Uncovering the role of VDAC in the regulation of cell life and death","volume":"40","author":"Shoshan-Barmatz","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.redox.2020.101502_bib25","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.freeradbiomed.2007.08.011","article-title":"Mitochondrial uncoupling proteins\u2014what is their physiological role?","volume":"43","author":"Echtay","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101502_bib26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1590\/s1679-45082011rw2220","article-title":"Chemotherapy-induced peripheral neuropathy: a literature review","volume":"9","author":"Martin","year":"2011","journal-title":"Einstein (S\u00e3o Paulo)."},{"key":"10.1016\/j.redox.2020.101502_bib27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ana.24951","article-title":"Chemotherapy\u2010induced peripheral neuropathy: a current review","volume":"81","author":"Staff","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.redox.2020.101502_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1529-8027.2008.00156.x","article-title":"Chemotherapy\u2010induced neuropathy","volume":"13","author":"Windebank","year":"2008","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.redox.2020.101502_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.expneurol.2008.08.013","article-title":"Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy","volume":"214","author":"Melli","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.redox.2020.101502_bib30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.redox.2014.01.006","article-title":"Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy","volume":"2","author":"Areti","year":"2014","journal-title":"Redox Biol"},{"key":"10.1016\/j.redox.2020.101502_bib31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.drudis.2007.07.013","article-title":"The significance of mitochondrial toxicity testing in drug development","volume":"12","author":"Dykens","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.redox.2020.101502_bib32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuron.2017.09.055","article-title":"Mitostasis in neurons: maintaining mitochondria in an extended cellular architecture","volume":"96","author":"Misgeld","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.redox.2020.101502_bib33","first-page":"1","article-title":"Relapsed refractory multiple myeloma: a comprehensive overview","author":"Bazarbachi","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.redox.2020.101502_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1470-2045(15)00464-7","article-title":"Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study","volume":"17","author":"Dimopoulos","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.redox.2020.101502_bib35","doi-asserted-by":"crossref","first-page":"17802","DOI":"10.1038\/s41598-017-17596-4","article-title":"Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events","volume":"7","author":"Tsakiri","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2020.101502_bib36","first-page":"307","article-title":"Novel agents for the treatment of multiple myeloma: proteasome inhibitors and immunomodulatory agents","volume":"4","author":"Kurtin","year":"2013","journal-title":"J. Adv. Pract. Oncol."},{"key":"10.1016\/j.redox.2020.101502_bib37","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1182\/blood-2012-10-459883","volume":"121","author":"Kortuem","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.redox.2020.101502_bib38","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1158\/1078-0432.CCR-10-1950","article-title":"Non-proteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events","volume":"17","author":"Arastu-Kapur","year":"2011","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.redox.2020.101502_bib39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbamcr.2013.06.031","article-title":"Protein quality control and elimination of protein waste: the role of the ubiquitin\u2013proteasome system","volume":"1843","author":"Amm","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.redox.2020.101502_bib40","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35008096","article-title":"Rapid degradation of a large fraction of newly synthesized proteins by proteasomes","volume":"404","author":"Schubert","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.redox.2020.101502_bib41","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1242\/jcs.01284","article-title":"The stress of dying\u2019: the role of heat shock proteins in the regulation of apoptosis","volume":"117","author":"Beere","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.redox.2020.101502_bib42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1242\/dmm.014563","article-title":"Barcoding heat shock proteins to human diseases: looking beyond the heat shock response","volume":"7","author":"Kakkar","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.redox.2020.101502_bib43","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0968-0004(99)01373-0","article-title":"Hsp90 & Co.\u2013a holding for folding","volume":"24","author":"Buchner","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.redox.2020.101502_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2014.08.012","article-title":"Regulation of protein turnover by heat shock proteins","volume":"77","author":"Bozaykut","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101502_bib45","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.freeradbiomed.2011.06.015","article-title":"HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress","volume":"51","author":"Grune","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101502_bib46","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.redox.2020.101502_bib47","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.94.20.10925","article-title":"Reduced stress defense in heme oxygenase 1-deficient cells","volume":"94","author":"Poss","year":"1997","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.redox.2020.101502_bib48","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nrneurol.2014.77","article-title":"Mitotoxicity in distal symmetrical sensory peripheral neuropathies","volume":"10","author":"Bennett","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.redox.2020.101502_bib49","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2174\/1570159X14666151126215358","article-title":"Potential therapeutic benefits of maintaining mitochondrial health in peripheral neuropathies","volume":"14","author":"Areti","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"80-.","key":"10.1016\/j.redox.2020.101502_bib50","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.redox.2020.101502_bib51","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1038\/srep05896","article-title":"Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition","volume":"4","author":"Maharjan","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2020.101502_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2020.101502_bib53","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2011.08.016","article-title":"Functional deficits in peripheral nerve mitochondria in rats with paclitaxel-and oxaliplatin-evoked painful peripheral neuropathy","volume":"232","author":"Zheng","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.redox.2020.101502_bib54","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1089\/ars.2011.4394","article-title":"p62 at the interface of autophagy, oxidative stress signaling, and cancer","volume":"17","author":"Nezis","year":"2012","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2020.101502_bib55","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.redox.2020.101502_bib56","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/hmg\/ddr048","article-title":"Broad activation of the ubiquitin\u2013proteasome system by Parkin is critical for mitophagy","volume":"20","author":"Chan","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.redox.2020.101502_bib57","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1038\/ncomms3428","article-title":"Bit-by-bit autophagic removal of parkin-labelled mitochondria","volume":"4","author":"Yang","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2020.101502_bib58","doi-asserted-by":"crossref","first-page":"20699","DOI":"10.1074\/jbc.M313579200","article-title":"Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover","volume":"279","author":"Sullivan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2020.101502_bib59","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fphys.2013.00082","article-title":"Cytoskeleton and regulation of mitochondrial function: the role of beta-tubulin II","volume":"4","author":"V Kuznetsov","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.redox.2020.101502_bib60","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbabio.2006.04.013","article-title":"The relationship between mitochondrial shape and function and the cytoskeleton","volume":"1757","author":"Anesti","year":"2006","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.redox.2020.101502_bib61","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1365-2443.2010.01426.x","article-title":"p62\/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria","volume":"15","author":"Okatsu","year":"2010","journal-title":"Gene Cell."},{"key":"10.1016\/j.redox.2020.101502_bib62","doi-asserted-by":"crossref","DOI":"10.1006\/abbi.2000.1717","article-title":"Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress","author":"Reinheckel","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.redox.2020.101502_bib63","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0300-9084(01)01250-0","article-title":"Degradation of oxidized proteins by the 20S proteasome","volume":"83","author":"Davies","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.redox.2020.101502_bib64","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molcel.2012.10.023","article-title":"Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease","volume":"49","author":"Lu","year":"2013","journal-title":"Mol. Cell."},{"key":"10.1016\/j.redox.2020.101502_bib65","article-title":"Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM, Biosci","volume":"37","author":"Lan","year":"2017","journal-title":"For. Rep."},{"key":"10.1016\/j.redox.2020.101502_bib66","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrm1592","article-title":"The mitochondrial uncoupling-protein homologues","volume":"6","author":"Krauss","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2020.101502_bib67","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/ana.10543","article-title":"Mitochondrial uncoupling protein\u20102 protects the immature brain from excitotoxic neuronal death","volume":"53","author":"Sullivan","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.redox.2020.101502_bib68","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1242\/jcs.060004","article-title":"Degradation of an intramitochondrial protein by the cytosolic proteasome","author":"Azzu","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.redox.2020.101502_bib69","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1210\/en.2003-0667","article-title":"Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning","volume":"144","author":"Diano","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.redox.2020.101502_bib70","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nm903","article-title":"Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma","volume":"9","author":"Mattiasson","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.redox.2020.101502_bib71","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1073\/pnas.0600103103","article-title":"The expression level of the voltage-dependent anion channel controls life and death of the cell","volume":"103","author":"Abu-Hamad","year":"2006","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.redox.2020.101502_bib72","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231719314375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231719314375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:16:06Z","timestamp":1761977766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231719314375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":72,"alternative-id":["S2213231719314375"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2020.101502","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2020.101502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101502"}}