{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:58:36Z","timestamp":1788897516615,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FUR-UNIVR"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.redox.2020.101639","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T21:48:13Z","timestamp":1594504093000},"page":"101639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase"],"prefix":"10.1016","volume":"36","author":[{"given":"Alessandro","family":"Matt\u00e8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tibaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Di Paolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Federti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carpentieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Brunati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cesaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Turrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Gomez Manzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Marcial Quino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Pantaleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Xiuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iana","family":"Iatcenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Domenica","family":"Cappellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"Forni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"De Franceschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2020.101639_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(08)60073-2","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"371","author":"Cappellini","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2020.101639_bib2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1056\/NEJMra1708111","article-title":"Favism and glucose-6-phosphate dehydrogenase deficiency","volume":"378","author":"Luzzatto","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2020.101639_bib3","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1182\/blood.V87.7.2974.bloodjournal8772974","article-title":"Glucose 6-phosphate dehydrogenase mutations causing enzyme deficiency in a model of the tertiary structure of the human enzyme","volume":"87","author":"Naylor","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.redox.2020.101639_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1096\/fasebj.14.3.485","article-title":"Human mutations in glucose 6-phosphate dehydrogenase reflect evolutionary history","volume":"14","author":"Notaro","year":"2000","journal-title":"Faseb. J."},{"key":"10.1016\/j.redox.2020.101639_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0925-4439(93)90106-B","article-title":"Decreased catalase activity is the underlying mechanism of oxidant susceptibility in glucose-6-phosphate dehydrogenase-deficient erythrocytes","volume":"1181","author":"Scott","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2020.101639_bib6","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1096\/fj.14-250050","article-title":"Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants","volume":"28","author":"Cheah","year":"2014","journal-title":"Faseb. J."},{"key":"10.1016\/j.redox.2020.101639_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1182\/blood-2007-04-077412","article-title":"Glucose-6-phosphate dehydrogenase deficiency: a historical perspective","volume":"111","author":"Beutler","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.redox.2020.101639_bib8","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1182\/blood.V96.5.1985","article-title":"Red cells from glutathione peroxidase-1-deficient mice have nearly normal defenses against exogenous peroxides","volume":"96","author":"Johnson","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.redox.2020.101639_bib9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bcmd.2012.01.001","article-title":"Glucose-6-phosphate dehydrogenase (G6PD) mutations database: review of the \"old\" and update of the new mutations","volume":"48","author":"Minucci","year":"2012","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.redox.2020.101639_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1053\/beha.1999.0056","article-title":"Chronic non-spherocytic haemolytic disorders associated with glucose-6-phosphate dehydrogenase variants","volume":"13","author":"Fiorelli","year":"2000","journal-title":"Baillieres Best Pract Res Clin Haematol"},{"key":"10.1016\/j.redox.2020.101639_bib11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1708111","article-title":"Favism and glucose-6-phosphate dehydrogenase deficiency","volume":"378","author":"Luzzatto","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2020.101639_bib12","doi-asserted-by":"crossref","first-page":"21179","DOI":"10.3390\/ijms151121179","article-title":"The stability of G6PD is affected by mutations with different clinical phenotypes","volume":"15","author":"Gomez-Manzo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2020.101639_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0969-2126(00)00104-0","article-title":"Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency","volume":"8","author":"Au","year":"2000","journal-title":"Structure"},{"key":"10.1016\/j.redox.2020.101639_bib14","article-title":"Structural analysis of clinically relevant pathogenic G6PD variants reveals the importance of tetramerization for G6PD activity","volume":"2017","author":"Cunningham","year":"2017","journal-title":"Matters (Zur)"},{"key":"10.1016\/j.redox.2020.101639_bib15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.freeradbiomed.2009.01.028","article-title":"Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa\/fa, rat liver","volume":"47","author":"Gupte","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101639_bib16","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/ATVBAHA.109.184812","article-title":"Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells","volume":"29","author":"Pan","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2020.101639_bib17","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1038\/onc.2015.471","article-title":"Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis","volume":"35","author":"Kim","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2020.101639_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20030336","article-title":"Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1","volume":"376","author":"Sanguinetti","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2020.101639_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ajh.25295","article-title":"Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis","volume":"94","author":"Beneduce","year":"2019","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.redox.2020.101639_bib20","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1096\/fj.201601223RRR","article-title":"Sex difference in mouse metabolic response to erythropoietin","volume":"31","author":"Zhang","year":"2017","journal-title":"Faseb. J."},{"key":"10.1016\/j.redox.2020.101639_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2014.08.004","article-title":"The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and senescence","volume":"76","author":"Matte","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101639_bib22","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.4269\/ajtmh.12-0682","article-title":"An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines","volume":"88","author":"Zhang","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.redox.2020.101639_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2017.7051","article-title":"Peroxiredoxin-2: a novel regulator of iron homeostasis in ineffective erythropoiesis","volume":"28","author":"Matte","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2020.101639_bib24","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1182\/blood-2016-07-727321","article-title":"A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis","volume":"128","author":"Lupo","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.redox.2020.101639_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/liv.12900","article-title":"Protease inhibitors-based therapy induces acquired spherocytic-like anaemia and ineffective erythropoiesis in chronic hepatitis C virus patients","volume":"36","author":"Lupo","year":"2016","journal-title":"Liver Int."},{"key":"10.1016\/j.redox.2020.101639_bib26","first-page":"1","article-title":"Band 3 erythrocyte membrane protein acts as redox stress sensor leading to its phosphorylation by p (72) Syk","author":"Pantaleo","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.redox.2020.101639_bib27","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1182\/blood-2006-09-048728","article-title":"Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte","volume":"109","author":"Low","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.redox.2020.101639_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/BJ20081557","article-title":"Oxidized and poorly glycosylated band 3 is selectively phosphorylated by Syk kinase to form large membrane clusters in normal and G6PD-deficient red blood cells","volume":"418","author":"Pantaleo","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2020.101639_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.abb.2016.09.002","article-title":"Redox status in a model of cancer stem cells","volume":"617","author":"Zaccarin","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.redox.2020.101639_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.redox.2020.101639_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0014-5793(98)00185-9","article-title":"Plasmodium falciparum glutathione metabolism and growth are independent of glutathione system of host erythrocyte","volume":"424","author":"Ayi","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.redox.2020.101639_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.freeradbiomed.2012.10.543","article-title":"Membrane association of peroxiredoxin-2 in red cells is mediated by the N-terminal cytoplasmic domain of band 3","volume":"55","author":"Matte","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101639_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.freeradbiomed.2010.05.003","article-title":"Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress","volume":"49","author":"Matte","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101639_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015847","article-title":"Irreversible AE1 tyrosine phosphorylation leads to membrane vesiculation in G6PD deficient red cells","volume":"6","author":"Pantaleo","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.redox.2020.101639_bib35","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1182\/blood-2010-11-317024","article-title":"Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3","volume":"117","author":"Ferru","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.redox.2020.101639_bib36","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3324\/haematol.2013.084533","article-title":"Thalassemic erythrocytes release microparticles loaded with hemichromes by redox activation of p72Syk kinase","volume":"99","author":"Ferru","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.redox.2020.101639_bib37","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/ajh.24385","article-title":"Blood smear, a key diagnostic tool in hematology: lessons from two cases of acute hemolysis in previously undiagnosed G6PD deficiency","volume":"91","author":"Veneri","year":"2016","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.redox.2020.101639_bib38","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1128\/AAC.00600-16","article-title":"Single-dose primaquine in a preclinical model of glucose-6-phosphate dehydrogenase deficiency: implications for use in malaria transmission-blocking programs","volume":"60","author":"Wickham","year":"2016","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231720308442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231720308442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:30:35Z","timestamp":1784907035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231720308442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":38,"alternative-id":["S2213231720308442"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2020.101639","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2020.101639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101639"}}