{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:27:55Z","timestamp":1789464475234,"version":"build-2803163510"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL 142291"],"award-info":[{"award-number":["HL 142291"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL115195"],"award-info":[{"award-number":["HL115195"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL137962"],"award-info":[{"award-number":["HL137962"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570261"],"award-info":[{"award-number":["81570261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.redox.2020.101662","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T13:28:55Z","timestamp":1596115735000},"page":"101662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Genomic characterization reveals novel mechanisms underlying the valosin-containing protein-mediated cardiac protection against heart failure"],"prefix":"10.1016","volume":"36","author":[{"given":"Ning","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0881-2356","authenticated-orcid":false,"given":"Jing","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Leimena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaunrick","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangjian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCULATIONAHA.108.845792","article-title":"The progression of hypertensive heart disease","volume":"123","author":"Drazner","year":"2011","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/jch.13753","article-title":"An overview of hypertension and cardiac involvement in Asia: focus on heart failure","volume":"22","author":"Soenarta","year":"2020","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.redox.2020.101662_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40885-019-0132-x","article-title":"Blood pressure and heart failure","volume":"26","author":"Oh","year":"2020","journal-title":"Clin Hypertens"},{"issue":"4\u20135","key":"10.1016\/j.redox.2020.101662_bib4","first-page":"291","article-title":"Left ventricular hypertrophy and mortality-results from the Framingham Study","volume":"81","author":"Kannel","year":"1992","journal-title":"Cardiology"},{"issue":"5","key":"10.1016\/j.redox.2020.101662_bib5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s11906-014-0428-x","article-title":"Alterations in cardiac structure and function in hypertension","volume":"16","author":"Santos","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.hfc.2017.02.001","article-title":"Epidemiology, pathophysiology, and prognosis of heart failure in older adults","volume":"13","author":"Dharmarajan","year":"2017","journal-title":"Heart Fail. Clin."},{"key":"10.1016\/j.redox.2020.101662_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fmolb.2016.00079","article-title":"Mutations in the human AAA+ chaperone p97 and related diseases","volume":"3","author":"Tang","year":"2016","journal-title":"Front. Mol. Biosci."},{"issue":"11","key":"10.1016\/j.redox.2020.101662_bib8","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1074\/jbc.M111.302778","article-title":"The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97\/VCP","volume":"287","author":"Niwa","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"Pt 18","key":"10.1016\/j.redox.2020.101662_bib9","first-page":"3877","article-title":"The VCP\/p97 system at a glance: connecting cellular function to disease pathogenesis","volume":"127","author":"Meyer","year":"2014","journal-title":"J. Cell Sci."},{"issue":"11","key":"10.1016\/j.redox.2020.101662_bib10","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1245\/ASO.2005.07.002","article-title":"Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer","volume":"12","author":"Yamamoto","year":"2005","journal-title":"Ann. Surg Oncol."},{"issue":"7","key":"10.1016\/j.redox.2020.101662_bib11","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1245\/ASO.2004.10.018","article-title":"Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma","volume":"11","author":"Yamamoto","year":"2004","journal-title":"Ann. Surg Oncol."},{"issue":"9","key":"10.1016\/j.redox.2020.101662_bib12","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2174\/1566524018666180308111238","article-title":"VCP\/p97\/Cdc48, A linking of protein homeostasis and cancer therapy","volume":"17","author":"Lan","year":"2017","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.redox.2020.101662_bib13","series-title":"GeneReviews((R))","article-title":"Inclusion body myopathy with paget disease of bone and\/or frontotemporal dementia","author":"Kimonis","year":"1993"},{"issue":"22","key":"10.1016\/j.redox.2020.101662_bib14","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.1074\/jbc.RA119.007585","article-title":"Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis","volume":"294","author":"Brody","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.redox.2020.101662_bib15","article-title":"Cardiac-restricted expression of VCP\/TER94 RNAi or disease alleles perturbs Drosophila heart structure and impairs function","volume":"3","author":"Viswanathan","year":"2016","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"4","key":"10.1016\/j.redox.2020.101662_bib16","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/cvr\/cvt136","article-title":"The valosin-containing protein promotes cardiac survival through the inducible isoform of nitric oxide synthase","volume":"99","author":"Lizano","year":"2013","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.redox.2020.101662_bib17","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/acel.12653","article-title":"The valosin-containing protein is a novel repressor of cardiomyocyte hypertrophy induced by pressure overload","volume":"16","author":"Zhou","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.redox.2020.101662_bib18","doi-asserted-by":"crossref","first-page":"46324","DOI":"10.1038\/srep46324","article-title":"The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo","volume":"7","author":"Lizano","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.redox.2020.101662_bib19","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/CIRCULATIONAHA.110.013847","article-title":"H11 kinase\/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload","volume":"124","author":"Qiu","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2020.101662_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-2522-3_7","article-title":"Detecting reactive oxygen species by immunohistochemistry","volume":"1292","author":"Liou","year":"2015","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.redox.2020.101662_bib21","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1161\/RES.0000000000000110","article-title":"American heart association council on basic cardiovascular S: measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American heart association","volume":"119","author":"Griendling","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028449","article-title":"Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis","volume":"7","author":"Dhiman","year":"2012","journal-title":"PloS One"},{"issue":"19 Pt A","key":"10.1016\/j.redox.2020.101662_bib23","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.febslet.2015.08.028","article-title":"Control of p97 function by cofactor binding","volume":"589","author":"Buchberger","year":"2015","journal-title":"FEBS Lett."},{"issue":"15","key":"10.1016\/j.redox.2020.101662_bib24","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.redox.2020.101662_bib25","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12859-014-0366-2","article-title":"Rapid evaluation and quality control of next generation sequencing data with FaQCs","volume":"15","author":"Lo","year":"2014","journal-title":"BMC Bioinf."},{"issue":"17","key":"10.1016\/j.redox.2020.101662_bib26","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1093\/bioinformatics\/btz024","article-title":"ClusterMap: compare multiple Single Cell RNA-Seq datasets across different experimental conditions","volume":"35","author":"Gao","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.redox.2020.101662_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks402","article-title":"GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics","volume":"40","author":"Tabas-Madrid","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2020.101662_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkp416","article-title":"GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information","volume":"37","author":"Nogales-Cadenas","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib29","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1186\/gb-2007-8-1-r3","article-title":"GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists","volume":"8","author":"Carmona-Saez","year":"2007","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41588-017-0004-9","article-title":"Annotation-free quantification of RNA splicing using LeafCutter","volume":"50","author":"Li","year":"2018","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/cvr\/cvz016","article-title":"Lansoprazole alleviates pressure overload-induced cardiac hypertrophy and heart failure in mice by blocking the activation of beta-catenin","volume":"116","author":"Lin","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/CIRCHEARTFAILURE.114.001677","article-title":"Resveratrol treatment of mice with pressure-overload-induced heart failure improves diastolic function and cardiac energy metabolism","volume":"8","author":"Sung","year":"2015","journal-title":"Circ. Heart Fail"},{"key":"10.1016\/j.redox.2020.101662_bib33","article-title":"Transverse aortic constriction in mice","volume":"38","author":"deAlmeida","year":"2010","journal-title":"JoVE"},{"key":"10.1016\/j.redox.2020.101662_bib34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-4939-8597-5_14","article-title":"Conventional method of transverse aortic constriction in mice","volume":"1816","author":"Yoo","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"3\u20134","key":"10.1016\/j.redox.2020.101662_bib35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1242\/dmm.005017","article-title":"Heart failure and mouse models","volume":"3","author":"Breckenridge","year":"2010","journal-title":"Dis. Model. Mech."},{"issue":"4","key":"10.1016\/j.redox.2020.101662_bib36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00418-008-0541-5","article-title":"Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload","volume":"131","author":"Xia","year":"2009","journal-title":"Histochem. Cell Biol."},{"issue":"46","key":"10.1016\/j.redox.2020.101662_bib37","doi-asserted-by":"crossref","first-page":"35088","DOI":"10.1074\/jbc.M606791200","article-title":"Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex","volume":"281","author":"Yoon","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib38","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.4049\/jimmunol.169.3.1302","article-title":"Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors","volume":"169","author":"Usacheva","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2020.101662_bib39","doi-asserted-by":"crossref","first-page":"e2133","DOI":"10.1038\/cddis.2016.44","article-title":"IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways","volume":"7","author":"Shi","year":"2016","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/CIRCRESAHA.117.311147","article-title":"New insights into the role of mTOR signaling in the cardiovascular system","volume":"122","author":"Sciarretta","year":"2018","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.redox.2020.101662_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/08037050802029954","article-title":"The molecular sources of reactive oxygen species in hypertension","volume":"17","author":"Puddu","year":"2008","journal-title":"Blood Pres."},{"issue":"17","key":"10.1016\/j.redox.2020.101662_bib42","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1113\/jphysiol.2014.274704","article-title":"Mitochondrial reactive oxygen species production and respiratory complex activity in rats with pressure overload-induced heart failure","volume":"592","author":"Schwarzer","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.redox.2020.101662_bib43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yjmcc.2014.02.002","article-title":"Redox regulation of cardiac hypertrophy","volume":"73","author":"Sag","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.redox.2020.101662_bib44","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.3892\/mmr.2017.6849","article-title":"Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats","volume":"16","author":"Yang","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"9","key":"10.1016\/j.redox.2020.101662_bib45","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/01.CIR.0000117229.60628.2F","article-title":"Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox","volume":"109","author":"Maytin","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib47","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"issue":"11\u201312","key":"10.1016\/j.redox.2020.101662_bib48","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.bbabio.2012.12.002","article-title":"Superoxide generation by complex III: from mechanistic rationales to functional consequences","volume":"1827","author":"Bleier","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.redox.2020.101662_bib49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2020.101662_bib50","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1038\/ncomms4837","article-title":"Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice","volume":"5","author":"Miwa","year":"2014","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2174\/1570161054368616","article-title":"Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging","volume":"3","author":"Csiszar","year":"2005","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"2 Suppl","key":"10.1016\/j.redox.2020.101662_bib52","first-page":"II142","article-title":"Altered signal transduction in vascular smooth muscle cells of spontaneously hypertensive rats","volume":"19","author":"Bendhack","year":"1992","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib53","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/cvr\/cvp144","article-title":"PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats","volume":"83","author":"Bartha","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2020.101662_bib54","doi-asserted-by":"crossref","first-page":"7159592","DOI":"10.1155\/2019\/7159592","article-title":"Long noncoding RNAs in pathological cardiac remodeling: a review of the update literature","volume":"2019","author":"Zhou","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.redox.2020.101662_bib55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cellsig.2017.11.007","article-title":"The mechanism of myocardial hypertrophy regulated by the interaction between mhrt and myocardin","volume":"43","author":"Luo","year":"2018","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.redox.2020.101662_bib56","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","article-title":"Long noncoding RNAs in cardiovascular diseases","volume":"116","author":"Uchida","year":"2015","journal-title":"Circ. Res."},{"issue":"1\u20132","key":"10.1016\/j.redox.2020.101662_bib57","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0925-4773(02)00049-7","article-title":"Embryonic expression of mSharp-1\/mDEC2, which encodes a basic helix-loop-helix transcription factor","volume":"114","author":"Azmi","year":"2002","journal-title":"Mech. Dev."},{"issue":"8","key":"10.1016\/j.redox.2020.101662_bib58","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1073\/pnas.070526297","article-title":"Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms","volume":"97","author":"Sun","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.redox.2020.101662_bib59","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/sj.onc.1209842","article-title":"Hypoxic repression of STAT1 and its downstream genes by a pVHL\/HIF-1 target DEC1\/STRA13","volume":"26","author":"Ivanov","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12011-017-0983-5","article-title":"ATP5J and ATP5H proactive expression correlates with cardiomyocyte mitochondrial dysfunction induced by fluoride","volume":"180","author":"Wang","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib61","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10741-019-09873-3","article-title":"SERCA2a: a key protein in the Ca(2+) cycle of the heart failure","volume":"25","author":"Zhihao","year":"2020","journal-title":"Heart Fail. Rev."},{"issue":"5","key":"10.1016\/j.redox.2020.101662_bib62","doi-asserted-by":"crossref","first-page":"H1105","DOI":"10.1152\/ajpheart.00540.2018","article-title":"Sarco\/endoplasmic reticulum Ca(2+)-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes","volume":"317","author":"Li","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.redox.2020.101662_bib63","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1006\/jmcc.2001.1366","article-title":"SERCA pump level is a critical determinant of Ca(2+)homeostasis and cardiac contractility","volume":"33","author":"Periasamy","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.redox.2020.101662_bib64","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00395-013-0341-5","article-title":"NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury","volume":"108","author":"Sun","year":"2013","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib65","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00418-010-0776-9","article-title":"Variation of NDRG2 and c-Myc expression in rat heart during the acute stage of ischemia\/reperfusion injury","volume":"135","author":"Sun","year":"2011","journal-title":"Histochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib66","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jhh.2014.36","article-title":"Myocardial remodeling in hypertension","volume":"29","author":"Nadruz","year":"2015","journal-title":"J. Hum. Hypertens."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib68","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/hc0102.101365","article-title":"Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress","volume":"105","author":"Esposito","year":"2002","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.redox.2020.101662_bib69","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1161\/01.CIR.101.24.2863","article-title":"Cardiac hypertrophy is not a required compensatory response to short-term pressure overload","volume":"101","author":"Hill","year":"2000","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.redox.2020.101662_bib70","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: a new therapeutic target?","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.redox.2020.101662_bib71","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/toxsci\/kfz164","article-title":"The valosin-containing protein protects the heart against pathological Ca2+ overload by modulating Ca2+ uptake proteins","volume":"171","author":"Stoll","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"1 Pt 2","key":"10.1016\/j.redox.2020.101662_bib72","first-page":"H183","article-title":"Normal and hypertrophied senescent rat heart: mechanical and molecular characteristics","volume":"265","author":"Besse","year":"1993","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib73","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/01.RES.75.1.23","article-title":"Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components","volume":"75","author":"Boluyt","year":"1994","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.redox.2020.101662_bib74","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI119770","article-title":"Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium","volume":"100","author":"Lowes","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.redox.2020.101662_bib75","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.yjmcc.2007.07.045","article-title":"Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure","volume":"43","author":"Gupta","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib76","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0008-6363(00)00065-1","article-title":"Beta(2)-adrenergic receptor overexpression driven by alpha-MHC promoter is downregulated in hypertrophied and failing myocardium","volume":"47","author":"Sheridan","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"23","key":"10.1016\/j.redox.2020.101662_bib77","doi-asserted-by":"crossref","first-page":"13893","DOI":"10.1073\/pnas.95.23.13893","article-title":"Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways","volume":"95","author":"Mende","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2020.101662_bib78","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fphys.2014.00353","article-title":"Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations","volume":"5","author":"Kazmierczak","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.redox.2020.101662_bib79","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.yjmcc.2017.06.007","article-title":"Cardiomyocyte specific overexpression of a 37 amino acid domain of regulator of G protein signalling 2 inhibits cardiac hypertrophy and improves function in response to pressure overload in mice","volume":"108","author":"Lee","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.redox.2020.101662_bib80","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000331710","article-title":"Systemic heme oxygenase-1 transgenic overexpression aggravates pressure overload-induced cardiac hypertrophy in mice","volume":"28","author":"Chen","year":"2011","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231720308673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231720308673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:26:01Z","timestamp":1784906761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231720308673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":80,"alternative-id":["S2213231720308673"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2020.101662","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic characterization reveals novel mechanisms underlying the valosin-containing protein-mediated cardiac protection against heart failure","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2020.101662","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101662"}}