{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:31:10Z","timestamp":1789608670096,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.redox.2020.101742","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T02:52:59Z","timestamp":1601520779000},"page":"101742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1\u03b1-ERO1\u03b1-dependent oxidative stress manner"],"prefix":"10.1016","volume":"37","author":[{"given":"Yu","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuangYi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changtao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.redox.2020.101742_bib1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1053\/j.gastro.2016.02.066","article-title":"Pathogenesis of nonalcoholic steatohepatitis","volume":"150","author":"Machado","year":"2016","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.redox.2020.101742_bib2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbalip.2017.11.007","article-title":"Spontaneous development of hepatosteatosis in perilipin-1 null mice with adipose tissue dysfunction","volume":"1863","author":"Wei","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.redox.2020.101742_bib3","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tem.2014.08.001","article-title":"Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD","volume":"25","author":"Fuchs","year":"2014","journal-title":"Trends Endocrinol. Metabol."},{"issue":"9","key":"10.1016\/j.redox.2020.101742_bib4","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/j.1440-1746.2005.03891.x","article-title":"Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease","volume":"20","author":"Gulsen","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.redox.2020.101742_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-14-6","article-title":"Role of homocysteine in the development of cardiovascular disease","volume":"14","author":"Ganguly","year":"2015","journal-title":"Nutr. J."},{"issue":"8","key":"10.1016\/j.redox.2020.101742_bib6","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2337\/diacare.24.8.1403","article-title":"Fasting plasma homocysteine levels in the insulin resistance syndrome","volume":"24","author":"James","year":"2001","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.redox.2020.101742_bib7","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0026-0495(03)00262-2","article-title":"Hyperhomocysteinemia as a component of syndrome X","volume":"52","author":"Oron-Herman","year":"2003","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.redox.2020.101742_bib8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2337\/db07-0617","article-title":"Homocysteine upregulates resistin production from adipocytes in vivo and in vitro","volume":"57","author":"Li","year":"2008","journal-title":"Diabetes"},{"issue":"14","key":"10.1016\/j.redox.2020.101742_bib9","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1074\/jbc.M112.431627","article-title":"Hyperhomocysteinemia promotes insulin resistance by inducing endoplasmic reticulum stress in adipose tissue","volume":"288","author":"Li","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.redox.2020.101742_bib10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1194\/jlr.M066530","article-title":"Major role of adipocyte prostaglandin E2 in lipolysis-induced macrophage recruitment","volume":"57","author":"Hu","year":"2016","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.redox.2020.101742_bib11","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1530\/JME-13-0277","article-title":"Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease","volume":"52","author":"Nielsen","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.redox.2020.101742_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.biochi.2015.10.024","article-title":"Adipocyte lipolysis and insulin resistance","volume":"125","author":"Morigny","year":"2016","journal-title":"Biochimie"},{"issue":"17","key":"10.1016\/j.redox.2020.101742_bib13","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1111\/bph.12765","article-title":"Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease","volume":"171","author":"Dou","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.redox.2020.101742_bib14","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1074\/jbc.M111.299115","article-title":"Lipolysis response to endoplasmic reticulum stress in adipose cells","volume":"287","author":"Deng","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2020.101742_bib15","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1074\/jbc.R118.003214","article-title":"Adipose oxidative stress and protein carbonylation","volume":"294","author":"Hauck","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.redox.2020.101742_bib16","doi-asserted-by":"crossref","first-page":"C657","DOI":"10.1152\/ajpcell.00183.2014","article-title":"Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress","volume":"307","author":"Chambers","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"3","key":"10.1016\/j.redox.2020.101742_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.200311055","article-title":"Oxidative protein folding in eukaryotes: mechanisms and consequences","volume":"164","author":"Tu","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.redox.2020.101742_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.freeradbiomed.2015.02.007","article-title":"Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone","volume":"83","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"47","key":"10.1016\/j.redox.2020.101742_bib19","doi-asserted-by":"crossref","first-page":"39513","DOI":"10.1074\/jbc.M112.405050","article-title":"Hyperactivity of the Ero1alpha oxidase elicits endoplasmic reticulum stress but no broad antioxidant response","volume":"287","author":"Hansen","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.redox.2020.101742_bib20","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nrc2501","article-title":"Hypoxia signalling through mTOR and the unfolded protein response in cancer","volume":"8","author":"Wouters","year":"2008","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.redox.2020.101742_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","article-title":"Hypoxia, oxidative stress and inflammation","volume":"125","author":"McGarry","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2020.101742_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ebiom.2019.09.041","article-title":"Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1alpha-ADAM17 pathway","volume":"49","author":"Lian","year":"2019","journal-title":"EBioMedicine"},{"issue":"10","key":"10.1016\/j.redox.2020.101742_bib23","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.2337\/db11-0174","article-title":"Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice","volume":"60","author":"Jiang","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2020.101742_bib24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.redox.2018.09.021","article-title":"Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis","volume":"20","author":"Wu","year":"2019","journal-title":"Redox Biology"},{"key":"10.1016\/j.redox.2020.101742_bib25","doi-asserted-by":"crossref","unstructured":"Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, et al. Defective brain development in mice lacking the hif-1a gene in neural cells. Mol. Cell Biol..23(19):6739-6749.","DOI":"10.1128\/MCB.23.19.6739-6749.2003"},{"issue":"19","key":"10.1016\/j.redox.2020.101742_bib26","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1038\/sj.emboj.7601300","article-title":"Failure to prolyl hydroxylate hypoxia-inducible factor \u03b1 phenocopies VHL inactivation in vivo","volume":"25","author":"Kim","year":"2006","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.redox.2020.101742_bib27","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/j.gastro.2013.07.010","article-title":"Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice","volume":"145","author":"Xue","year":"2013","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.redox.2020.101742_bib28","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M112.426338","article-title":"Hypoxia-inducible factor 1 regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes","volume":"288","author":"Jiang","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.redox.2020.101742_bib29","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/bph.13988","article-title":"Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets","volume":"175","author":"Fu","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"24 Pt B","key":"10.1016\/j.redox.2020.101742_bib30","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1016\/j.febslet.2015.11.010","article-title":"High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-\/-) mice","volume":"589","author":"Yang","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.redox.2020.101742_bib31","doi-asserted-by":"crossref","first-page":"815210","DOI":"10.1155\/2015\/815210","article-title":"Quercetin increases hepatic homocysteine remethylation and transsulfuration in rats fed a methionine-enriched diet","volume":"2015","author":"Meng","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"52","key":"10.1016\/j.redox.2020.101742_bib32","doi-asserted-by":"crossref","first-page":"40236","DOI":"10.1074\/jbc.M608048200","article-title":"Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism","volume":"281","author":"Schweiger","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2020.101742_bib33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2011.12.018","article-title":"FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling","volume":"15","author":"Zechner","year":"2012","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.redox.2020.101742_bib34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/jcmm.12384","article-title":"Endoplasmic reticulum stress in adipose tissue augments lipolysis","volume":"19","author":"Bogdanovic","year":"2015","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.redox.2020.101742_bib35","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jhep.2011.10.018","article-title":"Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets","volume":"56","author":"Li","year":"2012","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.redox.2020.101742_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022931","article-title":"Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity","volume":"6","author":"Pulido","year":"2011","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.redox.2020.101742_bib37","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1083\/jcb.201704184","article-title":"Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions","volume":"217","author":"Xu","year":"2018","journal-title":"J. Cell Biol."},{"issue":"21","key":"10.1016\/j.redox.2020.101742_bib38","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1128\/MCB.25.21.9554-9575.2005","article-title":"AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress","volume":"25","author":"Terai","year":"2005","journal-title":"Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.redox.2020.101742_bib39","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1172\/JCI42845","article-title":"Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue","volume":"120","author":"Kosteli","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2020.101742_bib40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ebiom.2018.04.022","article-title":"Adipocyte-derived lysophosphatidylcholine activates adipocyte and adipose tissue macrophage nod-like receptor protein 3 inflammasomes mediating homocysteine-induced insulin resistance","volume":"31","author":"Zhang","year":"2018","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.redox.2020.101742_bib41","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jhep.2005.02.042","article-title":"Prevalence of and risk factors for fatty liver in a general population of Shanghai, China","volume":"43","author":"Fan","year":"2005","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.redox.2020.101742_bib42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/hep.28518","article-title":"Hyperhomocysteinemia activates the aryl hydrocarbon receptor\/CD36 pathway to promote hepatic steatosis in mice","volume":"64","author":"Yao","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2020.101742_bib43","doi-asserted-by":"crossref","unstructured":"Hakan, Fotbolcu, Elcin, Zorlu. Nonalcoholic fatty liver disease as a multi-systemic disease. World J. Gastroenterol.. (16):4079-4090.","DOI":"10.3748\/wjg.v22.i16.4079"},{"issue":"3","key":"10.1016\/j.redox.2020.101742_bib44","first-page":"300","author":"Trauner","year":"1801","journal-title":"Fatty liver and lipotoxicity"},{"issue":"1","key":"10.1016\/j.redox.2020.101742_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12944-017-0572-9","article-title":"A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease","volume":"16","author":"Chen","year":"2017","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.redox.2020.101742_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4291\/wjgp.v7.i1.17","article-title":"Adipose tissue-liver axis in alcoholic liver disease","volume":"7","author":"Wang","year":"2016","journal-title":"World J. Gastrointest. Pathophysiol."},{"issue":"1","key":"10.1016\/j.redox.2020.101742_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00400412","article-title":"Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes","volume":"39","author":"Christie","year":"1996","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.redox.2020.101742_bib48","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-201x.2001.00794.x","article-title":"Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed mice","volume":"171","author":"Ahr\u00e9n","year":"2001","journal-title":"Acta Physiol. Scand."},{"issue":"4","key":"10.1016\/j.redox.2020.101742_bib49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nm.3826","article-title":"Activation of AMPKalpha2 in adipocytes is essential for nicotine-induced insulin resistance in vivo","volume":"21","author":"Wu","year":"2015","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.redox.2020.101742_bib50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ygcen.2011.05.014","article-title":"Molecular cloning and characterization of the porcine Ero1L and ERp44 genes: potential roles in controlling energy metabolism","volume":"173","author":"Long","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.redox.2020.101742_bib51","doi-asserted-by":"crossref","unstructured":"Hudson DA, Gannon SA, Thorpe C. Oxidative protein folding: from thiol\u2013disulfide exchange reactions to the redox poise of the endoplasmic reticulum. Free Radical Biol. Med..80:171-182.","DOI":"10.1016\/j.freeradbiomed.2014.07.037"},{"issue":"1","key":"10.1016\/j.redox.2020.101742_bib52","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1074\/jbc.M806645200","article-title":"Reconstitution of human Ero1-Lalpha\/protein-disulfide isomerase oxidative folding pathway in vitro. Position-dependent differences in role between the a and a' domains of protein-disulfide isomerase","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"Pt 17","key":"10.1016\/j.redox.2020.101742_bib53","first-page":"3649","article-title":"Redox controls UPR to control redox","volume":"127","author":"Eletto","year":"2014","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.redox.2020.101742_bib54","doi-asserted-by":"crossref","first-page":"E869","DOI":"10.1152\/ajpendo.91011.2008","article-title":"Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes","volume":"296","author":"Zhou","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.redox.2020.101742_bib55","doi-asserted-by":"crossref","first-page":"100989","DOI":"10.1016\/j.plipres.2019.100989","article-title":"The biogenesis of lipid droplets: lipids take center stage","volume":"75","author":"Gao","year":"2019","journal-title":"Prog. Lipid Res."},{"issue":"31","key":"10.1016\/j.redox.2020.101742_bib56","doi-asserted-by":"crossref","first-page":"32154","DOI":"10.18632\/oncotarget.5168","article-title":"Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer","volume":"6","author":"Kong","year":"2015","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.redox.2020.101742_bib57","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2337\/db08-0536","article-title":"Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians","volume":"58","author":"Ortega","year":"2009","journal-title":"Diabetes."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231720309472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231720309472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:17:13Z","timestamp":1761977833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231720309472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":57,"alternative-id":["S2213231720309472"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2020.101742","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1\u03b1-ERO1\u03b1-dependent oxidative stress manner","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2020.101742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101742"}}