{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:21:01Z","timestamp":1793532061602,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008608","name":"Sumitomo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H05380"],"award-info":[{"award-number":["16H05380"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H05930"],"award-info":[{"award-number":["17H05930"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K06977"],"award-info":[{"award-number":["18K06977"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H04887"],"award-info":[{"award-number":["19H04887"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03608"],"award-info":[{"award-number":["20H03608"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["S2603"],"award-info":[{"award-number":["S2603"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0107088"],"award-info":[{"award-number":["JP20dm0107088"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.redox.2021.102057","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T09:37:02Z","timestamp":1624527422000},"page":"102057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8593-3269","authenticated-orcid":false,"given":"Kazuya","family":"Toriumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Berto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8079-8013","authenticated-orcid":false,"given":"Noriyoshi","family":"Usui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-4329","authenticated-orcid":false,"given":"Kazuhiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-2514","authenticated-orcid":false,"given":"Yasue","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-9796","authenticated-orcid":false,"given":"Kenichiro","family":"Nagahama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-4548","authenticated-orcid":false,"given":"Hsiao-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Kano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanari","family":"Itokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Konopka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-9815","authenticated-orcid":false,"given":"Makoto","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2015.01.140","article-title":"Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease","volume":"458","author":"Rabbani","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.redox.2021.102057_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.14336\/AD.2016.1030","article-title":"On the relationship between energy metabolism, proteostasis, aging and Parkinson's disease: possible causative role of methylglyoxal and alleviative potential of carnosine","volume":"8","author":"Hipkiss","year":"2017","journal-title":"Aging Dis"},{"issue":"19","key":"10.1016\/j.redox.2021.102057_bib3","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1042\/CS20160025","article-title":"Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments","volume":"130","author":"Rabbani","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.nbd.2009.09.008","article-title":"Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus","volume":"37","author":"Valente","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.redox.2021.102057_bib5","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00726-010-0773-2","article-title":"Advanced glycation endproducts: from precursors to RAGE: round and round we go","volume":"42","author":"Ramasamy","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.redox.2021.102057_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/9780470511848.ch17","article-title":"Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage","volume":"285","author":"Thornalley","year":"2007","journal-title":"Novartis Found. Symp."},{"issue":"6","key":"10.1016\/j.redox.2021.102057_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archgenpsychiatry.2010.62","article-title":"Enhanced carbonyl stress in a subpopulation of schizophrenia","volume":"67","author":"Arai","year":"2010","journal-title":"Arch. Gen. Psychiatr."},{"issue":"6","key":"10.1016\/j.redox.2021.102057_bib8","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1093\/schbul\/sbt234","article-title":"Significance of measurements of peripheral carbonyl stress markers in a cross-sectional and longitudinal study in patients with acute-stage schizophrenia","volume":"40","author":"Katsuta","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"3","key":"10.1016\/j.redox.2021.102057_bib9","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1503\/jpn.170053","article-title":"Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis","volume":"43","author":"Tomioka","year":"2018","journal-title":"J. Psychiatr. Neurosci."},{"issue":"5","key":"10.1016\/j.redox.2021.102057_bib10","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/schbul\/sbt129","article-title":"Clinical features of schizophrenia with enhanced carbonyl stress","volume":"40","author":"Miyashita","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41398-020-0835-5","article-title":"Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders","volume":"10","author":"Carvalho","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/pcn.12613","article-title":"Pyridoxamine: a novel treatment for schizophrenia with enhanced carbonyl stress","volume":"72","author":"Itokawa","year":"2018","journal-title":"Psychiatr. Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/BST20140010","article-title":"Measurement of glyoxalase activities","volume":"42","author":"Arai","year":"2014","journal-title":"Biochem. Soc. Trans."},{"issue":"6","key":"10.1016\/j.redox.2021.102057_bib14","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/npp.2011.324","article-title":"Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex","volume":"37","author":"Toriumi","year":"2012","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"key":"10.1016\/j.redox.2021.102057_bib15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainresbull.2018.11.025","article-title":"Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain","volume":"144","author":"Koike","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.redox.2021.102057_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jchromb.2016.07.019","article-title":"Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1,2-diamino-4,5-methylenedioxybenzene","volume":"1029\u20131030","author":"Ogasawara","year":"2016","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.redox.2021.102057_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/bs.mie.2014.10.059","article-title":"ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals","volume":"551","author":"Takahashi","year":"2015","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.redox.2021.102057_bib19","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"10.1016\/j.redox.2021.102057_bib20","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","article-title":"RSeQC: quality control of RNA-seq experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib21","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.redox.2021.102057_bib23","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.redox.2021.102057_bib24","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.redox.2021.102057_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"issue":"11","key":"10.1016\/j.redox.2021.102057_bib27","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.redox.2021.102057_bib28","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2018.07.028","article-title":"Molecular diversity and specializations among the cells of the adult mouse brain","volume":"174","author":"Saunders","year":"2018","journal-title":"Cell"},{"issue":"3\u20134","key":"10.1016\/j.redox.2021.102057_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1242\/dmm.005439","article-title":"SFARI Gene: an evolving database for the autism research community","volume":"3","author":"Banerjee-Basu","year":"2010","journal-title":"Dis Model Mech"},{"issue":"7351","key":"10.1016\/j.redox.2021.102057_bib30","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature10110","article-title":"Transcriptomic analysis of autistic brain reveals convergent molecular pathology","volume":"474","author":"Voineagu","year":"2011","journal-title":"Nature"},{"issue":"D1","key":"10.1016\/j.redox.2021.102057_bib31","doi-asserted-by":"crossref","first-page":"D804","DOI":"10.1093\/nar\/gkw865","article-title":"denovo-db: a compendium of human de novo variants","volume":"45","author":"Turner","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.redox.2021.102057_bib32","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/bioinformatics\/bts040","article-title":"SynaptomeDB: an ontology-based knowledgebase for synaptic genes","volume":"28","author":"Pirooznia","year":"2012","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.redox.2021.102057_bib33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/mp.2009.93","article-title":"SZGR: a comprehensive schizophrenia gene resource","volume":"15","author":"Jia","year":"2010","journal-title":"Mol. Psychiatr."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2011.06.013","article-title":"FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism","volume":"146","author":"Darnell","year":"2011","journal-title":"Cell"},{"issue":"Database issue","key":"10.1016\/j.redox.2021.102057_bib35","doi-asserted-by":"crossref","first-page":"D893","DOI":"10.1093\/nar\/gku943","article-title":"EpilepsyGene: a genetic resource for genes and mutations related to epilepsy","volume":"43","author":"Ran","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"6420","key":"10.1016\/j.redox.2021.102057_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat8127","article-title":"Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder","volume":"362","author":"Gandal","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.redox.2021.102057_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2164-10-22","article-title":"BioMart--biological queries made easy","volume":"10","author":"Smedley","year":"2009","journal-title":"BMC Genom."},{"issue":"3","key":"10.1016\/j.redox.2021.102057_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11357-018-0021-3","article-title":"Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research","volume":"40","author":"Sakamuri","year":"2018","journal-title":"Geroscience"},{"issue":"7","key":"10.1016\/j.redox.2021.102057_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021746","article-title":"High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria","volume":"6","author":"Rogers","year":"2011","journal-title":"PloS One"},{"issue":"9","key":"10.1016\/j.redox.2021.102057_bib40","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/pcn.12216","article-title":"Carbonyl stress and schizophrenia","volume":"68","author":"Arai","year":"2014","journal-title":"Psychiatr. Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"Selhub","year":"1999","journal-title":"Annu. Rev. Nutr."},{"issue":"7","key":"10.1016\/j.redox.2021.102057_bib42","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1016\/S0021-9258(18)42844-X","article-title":"Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications","volume":"267","author":"Vander Jagt","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2021.102057_bib43","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0009-2797(02)00212-0","article-title":"Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase","volume":"143\u2013144","author":"Vander Jagt","year":"2003","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.redox.2021.102057_bib44","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1074\/jbc.M116.760132","article-title":"Loss of glyoxalase 1 induces compensatory mechanism to achieve dicarbonyl detoxification in mammalian schwann cells","volume":"292","author":"Morgenstern","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2021.102057_bib45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molmet.2018.09.005","article-title":"Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes","volume":"18","author":"Schumacher","year":"2018","journal-title":"Mol Metab"},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib46","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/mp.2017.14","article-title":"Identification of a novel, fast-acting GABAergic antidepressant","volume":"23","author":"McMurray","year":"2018","journal-title":"Mol. Psychiatr."},{"issue":"28","key":"10.1016\/j.redox.2021.102057_bib47","doi-asserted-by":"crossref","first-page":"21177","DOI":"10.1074\/jbc.M003263200","article-title":"Pyridoxamine, an inhibitor of advanced glycation reactions, also inhibits advanced lipoxidation reactions. Mechanism of action of pyridoxamine","volume":"275","author":"Onorato","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2021.102057_bib48","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1021\/tx0300535","article-title":"2nd, Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls","volume":"17","author":"Amarnath","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.redox.2021.102057_bib49","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbr.2017.07.011","article-title":"Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats","volume":"333","author":"Sun","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.redox.2021.102057_bib50","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.brainres.2012.06.003","article-title":"Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia","volume":"1469","author":"Zhang","year":"2012","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.stem.2017.06.012","article-title":"Human iPSC glial mouse chimeras reveal glial contributions to schizophrenia","volume":"21","author":"Windrem","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.redox.2021.102057_bib52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0074-7742(04)59011-6","article-title":"Mitochondria, synaptic plasticity, and schizophrenia","volume":"59","author":"Ben-Shachar","year":"2004","journal-title":"Int. Rev. Neurobiol."},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib53","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0920-9964(00)00075-X","article-title":"Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia","volume":"48","author":"Maurer","year":"2001","journal-title":"Schizophr. Res."},{"issue":"11","key":"10.1016\/j.redox.2021.102057_bib54","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1038\/s41380-019-0423-3","article-title":"iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function","volume":"25","author":"Ni","year":"2020","journal-title":"Mol. Psychiatr."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib55","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/hmg\/ddi022","article-title":"Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis","volume":"14","author":"Iwamoto","year":"2005","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.redox.2021.102057_bib56","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/mp.2013.67","article-title":"Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients","volume":"18","author":"Robicsek","year":"2013","journal-title":"Mol. Psychiatr."},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib57","doi-asserted-by":"crossref","first-page":"F52","DOI":"10.1152\/ajprenal.00302.2001","article-title":"Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal","volume":"283","author":"Rosca","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib58","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1471-4159.2003.01513.x","article-title":"Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals","volume":"84","author":"Sipos","year":"2003","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbr.2011.10.020","article-title":"Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder","volume":"226","author":"Kulak","year":"2012","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib60","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/157015911795596595","article-title":"Oxidative stress in schizophrenia","volume":"9","author":"Boskovic","year":"2011","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"10.1016\/j.redox.2021.102057_bib61","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12017-018-8505-y","article-title":"Neuroprotective effect of hydrogen sulfide in hyperhomocysteinemia is mediated through antioxidant action involving Nrf2","volume":"20","author":"Kumar","year":"2018","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.redox.2021.102057_bib62","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.mito.2019.11.004","article-title":"Hydrogen sulfide attenuates hyperhomocysteinemia-induced mitochondrial dysfunctions in brain","volume":"50","author":"Kumar","year":"2020","journal-title":"Mitochondrion"},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib63","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.expneurol.2006.12.010","article-title":"Mitochondrial complex I inhibition in cerebral cortex of immature rats following homocysteic acid-induced seizures","volume":"204","author":"Folbergrova","year":"2007","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/sj.mp.4001746","article-title":"Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis","volume":"11","author":"Muntjewerff","year":"2006","journal-title":"Mol. Psychiatr."},{"issue":"5","key":"10.1016\/j.redox.2021.102057_bib65","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/schbul\/sbt154","article-title":"Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia","volume":"40","author":"Nishi","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"1\u20132","key":"10.1016\/j.redox.2021.102057_bib66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.psychres.2009.01.013","article-title":"Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism","volume":"175","author":"Kale","year":"2010","journal-title":"Psychiatr. Res."},{"issue":"7","key":"10.1016\/j.redox.2021.102057_bib67","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00406-012-0302-2","article-title":"Homocysteine and cognition in first-episode psychosis patients","volume":"262","author":"Ayesa-Arriola","year":"2012","journal-title":"Eur. Arch. Psychiatr. Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.redox.2021.102057_bib68","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/schbul\/sbt001","article-title":"Pro-\/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia","volume":"40","author":"Garcia-Bueno","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"11\u201312","key":"10.1016\/j.redox.2021.102057_bib69","first-page":"513","article-title":"Serum total homocystein, folate and vitamin B12 levels and their correlation with antipsychotic drug doses in adult male patients with chronic schizophrenia","volume":"56","author":"Eren","year":"2010","journal-title":"Clin. Lab."},{"issue":"9","key":"10.1016\/j.redox.2021.102057_bib70","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1176\/appi.ajp.161.9.1705","article-title":"Folate, homocysteine, and negative symptoms in schizophrenia","volume":"161","author":"Goff","year":"2004","journal-title":"Am. J. Psychiatr."},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.psychres.2010.04.008","article-title":"Plasma homocysteine in schizophrenia: determinants and clinical correlations in Tunisian patients free from antipsychotics","volume":"179","author":"Bouaziz","year":"2010","journal-title":"Psychiatr. Res."},{"issue":"3","key":"10.1016\/j.redox.2021.102057_bib72","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s11011-014-9534-3","article-title":"Elevated homocysteine level in first-episode schizophrenia patients--the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse","volume":"29","author":"Misiak","year":"2014","journal-title":"Metab. Brain Dis."},{"issue":"8","key":"10.1016\/j.redox.2021.102057_bib73","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.pnpbp.2008.09.009","article-title":"Plasma homocysteine levels in young male patients in the exacerbation and remission phase of schizophrenia","volume":"32","author":"Petronijevic","year":"2008","journal-title":"Progress in neuro-psychopharmacology & biological psychiatry"},{"issue":"4","key":"10.1016\/j.redox.2021.102057_bib74","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1212\/WNL.16.4.407","article-title":"Homocystinuria. A recently discovered cause of mental defect and cerebrovascular thrombosis","volume":"16","author":"Dunn","year":"1966","journal-title":"Neurology"},{"issue":"201","key":"10.1016\/j.redox.2021.102057_bib75","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/adc.38.201.425","article-title":"Homocystinuria: a new inborn error of metabolism associated with mental deficiency","volume":"38","author":"Carson","year":"1963","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.redox.2021.102057_bib76","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/jama.1965.03090090017003","article-title":"Homocystinuria. Studies of 20 families with 38 affected members","volume":"193","author":"Schimke","year":"1965","journal-title":"J. Am. Med. Assoc."},{"issue":"5","key":"10.1016\/j.redox.2021.102057_bib77","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/archneur.1965.00470050003001","volume":"13","author":"White","year":"1965","journal-title":"Homocystinuria, Arch Neurol"},{"issue":"7","key":"10.1016\/j.redox.2021.102057_bib78","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng.171","article-title":"Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database","volume":"40","author":"Allen","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2021.102057_bib79","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ebiom.2019.05.062","article-title":"Investigation of betaine as a novel psychotherapeutic for schizophrenia","volume":"45","author":"Ohnishi","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2021.102057_bib80","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mad.2016.03.004","article-title":"Novel insights in the dysfunction of human blood-brain barrier after glycation","volume":"155","author":"Hussain","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.redox.2021.102057_bib81","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2016.03.038","article-title":"The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stress","volume":"96","author":"Wang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.redox.2021.102057_bib82","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S2215-0366(14)00122-9","article-title":"Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment","volume":"2","author":"Khandaker","year":"2015","journal-title":"Lancet Psychiatry"},{"issue":"5","key":"10.1016\/j.redox.2021.102057_bib83","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/schbul\/sby024","article-title":"Inflammation in schizophrenia: pathogenetic aspects and therapeutic considerations","volume":"44","author":"Muller","year":"2018","journal-title":"Schizophr. Bull."},{"issue":"9","key":"10.1016\/j.redox.2021.102057_bib84","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2174\/1871527313666140806144831","article-title":"Receptor for AGEs (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress","volume":"13","author":"Tobon-Velasco","year":"2014","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"issue":"1","key":"10.1016\/j.redox.2021.102057_bib85","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41398-021-01381-z","article-title":"Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment","volume":"11","author":"Toriumi","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"10","key":"10.1016\/j.redox.2021.102057_bib86","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1101\/gr.133744.111","article-title":"Detecting differential usage of exons from RNA-seq data","volume":"22","author":"Anders","year":"2012","journal-title":"Genome Res."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231721002160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231721002160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:18:51Z","timestamp":1761977931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231721002160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":86,"alternative-id":["S2213231721002160"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2021.102057","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2021.102057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102057"}}