{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:49Z","timestamp":1787067409628,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Airc Italian Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.redox.2022.102272","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T12:07:53Z","timestamp":1645186073000},"page":"102272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death"],"prefix":"10.1016","volume":"51","author":[{"given":"Liaisan","family":"Arslanbaeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ravazzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-7305","authenticated-orcid":false,"given":"Manuela","family":"Simonato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco A.","family":"Tucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Pece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-5085","authenticated-orcid":false,"given":"Massimo M.","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2022.102272_bib1","doi-asserted-by":"crossref","first-page":"101753","DOI":"10.1016\/j.redox.2020.101753","article-title":"Adaptive redox homeostasis in cutaneous melanoma","volume":"37","author":"Arslanbaeva","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2022.102272_bib2","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.18632\/oncotarget.3131","article-title":"Inhibition of PI3K\/AKT\/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells","volume":"6","author":"Hambright","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2022.102272_bib3","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1158\/0008-5472.CAN-19-3588","article-title":"An integrative gene expression and mathematical flux balance analysis identifies targetable redox vulnerabilities in melanoma cells","volume":"80","author":"Bishal Paudel","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2022.102272_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-84852-z","article-title":"Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer","volume":"11","author":"Dadali","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102272_bib5","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1158\/2159-8290.CD-21-0558","article-title":"Redox regulation in cancer cells during metastasis","volume":"11","author":"Tasdogan","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.redox.2022.102272_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12113147","article-title":"Lipid metabolic reprogramming: role in melanoma progression and therapeutic perspectives","volume":"12","author":"Pellerin","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.redox.2022.102272_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-020-2623-z","article-title":"Lymph protects metastasizing melanoma cells from ferroptosis","volume":"585","author":"Ubellacker","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.redox.2022.102272_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04664-0","article-title":"Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy","volume":"9","author":"Talebi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2022.102272_bib9","series-title":"The Lipogenic Regulator SREBF2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis","first-page":"678","volume":"11","author":"Hong","year":"2021"},{"key":"10.1016\/j.redox.2022.102272_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-2143-7","article-title":"Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis","volume":"10","author":"Gagliardi","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2022.102272_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.redox.2022.102272_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2019.12.007","article-title":"The antioxidant role of non-mitochondrial CoQ10: mystery solved","volume":"31","author":"Santoro","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.redox.2022.102272_bib13","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.redox.2022.102272_bib14","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.redox.2022.102272_bib15","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.biopha.2018.09.159","article-title":"NQO1 induction mediated by photodynamic therapy synergizes with \u03b2-Lapachone-halogenated derivative against melanoma","volume":"108","author":"Lamberti","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2022.102272_bib16","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.redox.2022.102272_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbamem.2003.11.012","article-title":"Metabolism and function of coenzyme Q","volume":"1660","author":"Turunen","year":"2004","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.redox.2022.102272_bib18","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.exger.2005.07.003","article-title":"Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet","volume":"40","author":"Bello","year":"2005","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.redox.2022.102272_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biology8020028","article-title":"Coq10 and aging","volume":"8","author":"De Barcelos","year":"2019","journal-title":"Biology"},{"key":"10.1016\/j.redox.2022.102272_bib20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3390\/antiox10060927","article-title":"Coenzyme Q10 phytosome formulation improves CoQ10 bioavailability and mitochondrial functionality in cultured cells","volume":"10","author":"Rizzardi","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2022.102272_bib21","doi-asserted-by":"crossref","first-page":"7480","DOI":"10.1002\/jcp.26602","article-title":"UBIAD1 protects against oxygen-glucose deprivation\/reperfusion-induced multiple subcellular organelles injury through PI3K\/AKT pathway in N2A cells","volume":"233","author":"Huang","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2022.102272_bib22","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cell.2013.01.013","article-title":"Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis","volume":"152","author":"Mugoni","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.redox.2022.102272_bib23","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.clnu.2017.10.004","article-title":"The maternal-fetal gradient of free and esterified phytosterols at the time of delivery in humans","volume":"37","author":"Correani","year":"2018","journal-title":"Clin. Nutr."},{"issue":"7","key":"10.1016\/j.redox.2022.102272_bib24","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic classification of cutaneous melanoma","volume":"161","author":"Akbani","year":"2015","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.redox.2022.102272_bib25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.redox.2022.102272_bib26","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2022.102272_bib27","series-title":"A Package for Survival Analysis in R. R Package Version 3.2","first-page":"13","author":"Therneau","year":"2021"},{"key":"10.1016\/j.redox.2022.102272_bib28","series-title":"R: A Language and Environment for Statistical Computing","year":"2021"},{"key":"10.1016\/j.redox.2022.102272_bib29","series-title":"Forest Plots from Regression Models","author":"Kennedy","year":"2020"},{"key":"10.1016\/j.redox.2022.102272_bib30","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1194\/jlr.M068759","article-title":"Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi","volume":"57","author":"Schumacher","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.redox.2022.102272_bib31","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1146\/annurev.biochem.75.103004.142443","article-title":"Ribonucleotide reductases","volume":"75","author":"Nordlund","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.redox.2022.102272_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1479-5876-10-53","article-title":"NF-\u03baB as potential target in the treatment of melanoma","volume":"10","author":"Madonna","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.redox.2022.102272_bib33","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1038\/s41388-019-0689-6","article-title":"KLF9-dependent ROS regulate melanoma progression in stage-specific manner","volume":"38","author":"Bagati","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2022.102272_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2022.102272_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21186869","article-title":"Alternative options for skin cancer therapy via regulation of AKT and related signaling pathways","volume":"21","author":"Hwang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2022.102272_bib36","series-title":"Methods in Enzymology Methods to Monitor ROS Production by Fluorescence Microscopy and Fluorometry","first-page":"243","volume":"542","author":"Wojtala","year":"2014"},{"key":"10.1016\/j.redox.2022.102272_bib37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/humu.22230","article-title":"The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes","volume":"34","author":"Nickerson","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.redox.2022.102272_bib38","first-page":"1","article-title":"The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase","volume":"4:e05560","author":"Schumacher","year":"2015","journal-title":"eLife 2015"},{"key":"10.1016\/j.redox.2022.102272_bib39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.taap.2014.08.014","article-title":"Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity","volume":"280","author":"Xiong","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.redox.2022.102272_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2022.102272_bib41","doi-asserted-by":"crossref","first-page":"101950","DOI":"10.1016\/j.redox.2021.101950","article-title":"The diverse functionality of NQO1 and its roles in redox control","volume":"41","author":"Ross","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2022.102272_bib42","first-page":"973","article-title":"The expression of NAD(P)H:quinone oxidoreductase 1 is increased along with NF-kappaB p105\/p50 in human cutaneous melanomas","volume":"23","author":"Cheng","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.redox.2022.102272_bib43","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.freeradbiomed.2010.03.003","article-title":"The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells","volume":"48","author":"Garate","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2022.102272_bib44","first-page":"651","article-title":"UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats","volume":"19","author":"Bingju","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.redox.2022.102272_bib45","first-page":"1","article-title":"Role of UBIAD1 in intracellular cholesterol metabolism and vascular cell calcification","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2022.102272_bib46","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1167\/iovs.07-0845","article-title":"Mutations in the UBIAD1 gene on chromosome short arm 1, region 36, cause Schnyder crystalline corneal dystrophy","volume":"48","author":"Weiss","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2022.102272_bib47","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1089\/dna.2011.1315","article-title":"The bladder tumor suppressor protein TERE1 (UBIAD1)Modulates cell cholesterol: implications for tumor progression","volume":"30","author":"Fredericks","year":"2011","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.redox.2022.102272_bib48","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/sj.onc.1204143","article-title":"Isolation and characterization of the TERE1 gene, a gene down-regulated in transitional cell carcinoma of the bladder","volume":"20","author":"McGarvey","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2022.102272_bib49","first-page":"1","article-title":"A novel Golgi retention signal RPWS for tumor suppressor UBIAD1","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2022.102272_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cosmetics5010009","article-title":"Significance of Ubiad1 for epidermal keratinocytes involves more than CoQ10 synthesis: implications for skin aging","volume":"5","author":"Labarrade","year":"2018","journal-title":"Cosmetics"},{"key":"10.1016\/j.redox.2022.102272_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10517-018-4101-2","article-title":"Effect of coenzyme Q10 on expression of UbiAd1 gene in rat model of local cerebral ischemia","volume":"165","author":"Povarova","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.redox.2022.102272_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0125737","article-title":"Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1","volume":"10","author":"Hirota","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2022.102272_bib53","doi-asserted-by":"crossref","first-page":"101840","DOI":"10.1016\/j.redox.2020.101840","article-title":"A redox-mediated conformational change in NQO1 controls binding to microtubules and \u03b1-tubulin acetylation","volume":"39","author":"Siegel","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2022.102272_bib54","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ccr.2013.02.003","article-title":"Article oncogenic BRAF regulates oxidative metabolism via PGC1 a and MITF","volume":"23","author":"Haq","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2022.102272_bib55","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.7150\/jca.27295","article-title":"Utilization of reactive oxygen species targeted therapy to prolong the efficacy of BRAF inhibitors in melanoma","volume":"9","author":"Yuan","year":"2018","journal-title":"J. Cancer"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722000441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722000441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:27:24Z","timestamp":1761978444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231722000441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":55,"alternative-id":["S2213231722000441"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102272","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102272"}}