{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:00:00Z","timestamp":1792188000919,"version":"4.4.0"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:00:00Z","timestamp":1650672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400822"],"award-info":[{"award-number":["81400822"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973521"],"award-info":[{"award-number":["81973521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.redox.2022.102322","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T12:43:46Z","timestamp":1651063426000},"page":"102322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"special_numbering":"C","title":["Overexpression of NAG-1\/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation"],"prefix":"10.1016","volume":"52","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-3240","authenticated-orcid":false,"given":"Xingya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.redox.2022.102322_bib2","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of the non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"10","key":"10.1016\/j.redox.2022.102322_bib3","doi-asserted-by":"crossref","first-page":"20704","DOI":"10.3390\/ijms141020704","article-title":"Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)","volume":"14","author":"Takaki","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2022.102322_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2015.12.014","article-title":"Hepatocyte-specific Keap 1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development","volume":"91","author":"Ramadori","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cld.2017.08.007","article-title":"Pathophysiology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"22","author":"Manne","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.redox.2022.102322_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.595371","article-title":"Oxidative stress in non-alcoholic fatty liver disease. An updated mini review","volume":"8","author":"Delli Bovi","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.redox.2022.102322_bib7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.redox.2016.01.009","article-title":"Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance","volume":"8","author":"Kakimoto","year":"2016","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib8","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1159\/000447866","article-title":"Differential lipotoxic effects of palmitate and oleate in activated human hepatic stellate cells and epithelial hepatoma cells","volume":"39","author":"Hetherington","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gutjnl-2016-312431","article-title":"Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease","volume":"66","author":"Rotman","year":"2017","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.redox.2022.102322_bib10","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"10","key":"10.1016\/j.redox.2022.102322_bib11","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/MCB.20.10.3742-3751.2000","article-title":"Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury","volume":"20","author":"Hsiao","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-1119(97)00485-X","article-title":"Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta","volume":"203","author":"Lawton","year":"1997","journal-title":"Gene"},{"issue":"Suppl 1","key":"10.1016\/j.redox.2022.102322_bib13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/ggi.12724","article-title":"Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders","volume":"16","author":"Fujita","year":"2016","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.redox.2022.102322_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pharmthera.2019.02.008","article-title":"Growth differentiation factor 15 (GDF15): a survival protein with therapeutic potential in metabolic diseases","volume":"198","author":"Baek","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"12","key":"10.1016\/j.redox.2022.102322_bib15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.tem.2020.10.004","article-title":"Insights into mechanisms of GDF15 and receptor GFRAL: therapeutic targets","volume":"31","author":"Rochette","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib16","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.0530278100","article-title":"Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum","volume":"100","author":"Welsh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1530\/EJE-12-0466","article-title":"Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial","volume":"167","author":"Kempf","year":"2012","journal-title":"Eur. J. Endocrinol."},{"issue":"11","key":"10.1016\/j.redox.2022.102322_bib18","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jacc.2007.04.091","article-title":"Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure","volume":"50","author":"Kempf","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib19","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1681\/ASN.2016080919","article-title":"Growth differentiation factor-15 and risk of CKD progression","volume":"28","author":"Nair","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127518","article-title":"Association of serum level of growth differentiation factor 15 with liver cirrhosis and hepatocellular carcinoma","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5009\/gnl16049","article-title":"Growth differentiation factor 15 predicts chronic liver disease severity","volume":"11","author":"Lee","year":"2017","journal-title":"Gut Liver"},{"key":"10.1016\/j.redox.2022.102322_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fcvm.2020.00103","article-title":"Serum GDF15, a promising biomarker in obese patients undergoing heart surgery","volume":"7","author":"Sarkar","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1530\/EJE-09-0417","article-title":"Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet","volume":"161","author":"Dost\u00e1lov\u00e1","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.redox.2022.102322_bib24","first-page":"123","article-title":"Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: a nested case-control study, Wellcome","volume":"3","author":"Petry","year":"2018","journal-title":"Open. Res."},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133362","article-title":"Serum levels of human MIC-1\/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI","volume":"10","author":"Tsai","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.redox.2022.102322_bib26","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nm.4393","article-title":"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL","volume":"23","author":"Emmerson","year":"2017","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.redox.2022.102322_bib27","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/nm.4394","article-title":"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand","volume":"23","author":"Yang","year":"2017","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.redox.2022.102322_bib28","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/nm.4392","article-title":"GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates","volume":"23","author":"Mullican","year":"2017","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.redox.2022.102322_bib29","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/ijo.2014.27","article-title":"NAG-1\/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism","volume":"38","author":"Chrysovergis","year":"2014","journal-title":"Int. J. Obes."},{"issue":"11","key":"10.1016\/j.redox.2022.102322_bib30","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nm1677","article-title":"Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1","volume":"13","author":"Johnen","year":"2007","journal-title":"Nat. Med."},{"issue":"412","key":"10.1016\/j.redox.2022.102322_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan8732","article-title":"Long-acting MIC-1\/GDF15 molecules to treat obesity: evidence from mice to monkeys","volume":"9","author":"Xiong","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/liv.13587","article-title":"Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease","volume":"38","author":"Koo","year":"2018","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib33","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1038\/s41598-018-25098-0","article-title":"Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102181","article-title":"Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response","volume":"24","author":"Kang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.redox.2022.102322_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.redox.2018.01.013","article-title":"Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid \u03b2-oxidation and ketogenesis via activating XBP1 signaling in liver","volume":"16","author":"Zhang","year":"2018","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib36","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jhep.2019.12.004","article-title":"ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation","volume":"72","author":"Zhang","year":"2020","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib37","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"issue":"7237","key":"10.1016\/j.redox.2022.102322_bib38","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature07710","article-title":"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA","volume":"458","author":"Fernandes-Alnemri","year":"2009","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.redox.2022.102322_bib39","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1007\/s00125-019-04983-x","article-title":"Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance","volume":"62","author":"Gong","year":"2019","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.redox.2022.102322_bib40","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00296-018-4074-5","article-title":"Novel insights into the role of inflammasomes in autoimmune and metabolic rheumatic diseases","volume":"38","author":"Deuteraiou","year":"2018","journal-title":"Rheumatol. Int."},{"issue":"11","key":"10.1016\/j.redox.2022.102322_bib41","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1002\/ijc.31827","article-title":"AIM2 deficiency reduces the development of hepatocellular carcinoma in mice","volume":"143","author":"Mart\u00ednez-Cardona","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"9","key":"10.1016\/j.redox.2022.102322_bib42","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/liv.12537","article-title":"Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis","volume":"34","author":"Csak","year":"2014","journal-title":"Liver Int."},{"issue":"26","key":"10.1016\/j.redox.2022.102322_bib43","first-page":"8525","article-title":"High fat diet feeding results in gender specific steatohepatitis and inflammasome activation, World","volume":"20","author":"Ganz","year":"2014","journal-title":"J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib44","doi-asserted-by":"crossref","first-page":"G1034","DOI":"10.1152\/ajpgi.00431.2020","article-title":"Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease","volume":"320","author":"Xu","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41419-019-1653-7","article-title":"Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK\/ERK activation","volume":"10","author":"Pan","year":"2019","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib46","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1053\/j.gastro.2006.09.015","article-title":"Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia","volume":"131","author":"Baek","year":"2006","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ijc.26082","article-title":"DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1\/GDF15) in glioma cell lines","volume":"130","author":"Kadowaki","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cbi.2006.11.004","article-title":"A human hepatocellular in vitro model to investigate steatosis","volume":"165","author":"G\u00f3mez-Lech\u00f3n","year":"2007","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib49","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1440-1746.2008.05733.x","article-title":"Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes","volume":"24","author":"Ricchi","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib50","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2174\/092986711794940842","article-title":"In vitro models for the study of non-alcoholic fatty liver disease","volume":"18","author":"Chavez-Tapia","year":"2011","journal-title":"Curr. Med. Chem."},{"issue":"527","key":"10.1016\/j.redox.2022.102322_bib51","article-title":"Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis","volume":"12","author":"Govaere","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"16","key":"10.1016\/j.redox.2022.102322_bib52","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4254\/wjh.v9.i16.715","article-title":"Non-alcoholic fatty liver disease: an expanded review","volume":"9","author":"Benedict","year":"2017","journal-title":"World J. Hepatol."},{"issue":"9","key":"10.1016\/j.redox.2022.102322_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006884","article-title":"Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway","volume":"4","author":"Jiang","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003100","article-title":"Metabolic risk factors and incident advanced liver disease in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of population-based observational studies","volume":"17","author":"Jarvis","year":"2020","journal-title":"PLoS Med."},{"issue":"12","key":"10.1016\/j.redox.2022.102322_bib55","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41574-019-0256-9","article-title":"The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state","volume":"15","author":"Hodson","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib56","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrgastro.2015.94","article-title":"Inflammasome activation and function in liver disease","volume":"12","author":"Szabo","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"24","key":"10.1016\/j.redox.2022.102322_bib57","doi-asserted-by":"crossref","first-page":"12177","DOI":"10.18632\/aging.102559","article-title":"Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress","volume":"11","author":"Zilu","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.redox.2022.102322_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8597897","article-title":"Salidroside attenuates high-fat diet-induced nonalcoholic fatty liver disease via AMPK-dependent TXNIP\/NLRP3 pathway","author":"Zheng","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2022.102322_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101315","article-title":"Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling","volume":"28","author":"Kim","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2022.102322_bib60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biocel.2017.12.019","article-title":"Mitochondria in non-alcoholic fatty liver disease","volume":"95","author":"Sim\u00f5es","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.redox.2022.102322_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.05.020","article-title":"Mitochondrial DNA in liver inflammation and oxidative stress","volume":"236","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054059","article-title":"Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice","volume":"8","author":"Yuzefovych","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib63","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1172\/JCI127502","article-title":"Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice","volume":"130","author":"De Jesus","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2040-4603.2018.tb00008.x","article-title":"Triglyceride metabolism in the liver","volume":"8","author":"Alves-Bezerra","year":"2017","journal-title":"Compr. Physiol."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib65","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2337\/db08-1074","article-title":"Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver","volume":"58","author":"Kotronen","year":"2009","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib66","first-page":"505","article-title":"Expression of fatty acid synthase in nonalcoholic fatty liver disease","volume":"3","author":"Dorn","year":"2010","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib67","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cmet.2007.10.014","article-title":"Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis","volume":"6","author":"Miyazaki","year":"2007","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib68","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hep.31000","article-title":"Fatty acid synthase inhibitor TVB-2640 reduces hepatic de Novo lipogenesis in males with metabolic abnormalities","volume":"72","author":"Syed-Abdul","year":"2020","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib69","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/dom.14272","article-title":"Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: results from two early-phase randomized trials","volume":"23","author":"Beysen","year":"2021","journal-title":"Diabetes Obes. Metabol."},{"issue":"12","key":"10.1016\/j.redox.2022.102322_bib70","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib71","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cmet.2011.12.017","article-title":"The Scap\/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals","volume":"15","author":"Moon","year":"2012","journal-title":"Cell Metabol."},{"issue":"9","key":"10.1016\/j.redox.2022.102322_bib72","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"Rada","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib73","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1210\/en.2015-1866","article-title":"Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice","volume":"157","author":"Wilson","year":"2016","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib74","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1038\/s41467-020-16991-2","article-title":"Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation","volume":"11","author":"Barbier-Torres","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib75","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/liv.14309","article-title":"Dietary fatty acid oxidation is decreased in non-alcoholic fatty liver disease: a palmitate breath test study","volume":"40","author":"Naguib","year":"2020","journal-title":"Liver Int."},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib76","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3350\/cmh.2013.19.3.210","article-title":"Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis","volume":"19","author":"Koo","year":"2013","journal-title":"Clin. Mol. Hepatol."},{"issue":"18","key":"10.1016\/j.redox.2022.102322_bib77","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.redox.2022.102322_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101134","article-title":"Mitochondrial oxidative function in NAFLD: friend or foe?","volume":"50","author":"Shum","year":"2021","journal-title":"Mol. Metabol."},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib79","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.redox.2022.102322_bib80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2017.07.035","article-title":"Insights into the role of hepatocyte PPAR\u03b1 activity in response to fasting","volume":"471","author":"R\u00e9gnier","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib81","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.bbalip.2011.10.016","article-title":"Roles of PPARs in NAFLD: potential therapeutic targets","volume":"1821","author":"Tailleux","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib82","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jcmgh.2019.04.007","article-title":"Metabolic targets in nonalcoholic fatty liver disease","volume":"8","author":"Esler","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib83","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1038\/s41598-020-63579-3","article-title":"Hepatocyte-specific deletion of Ppar\u03b1 promotes NAFLD in the context of obesity","volume":"10","author":"R\u00e9gnier","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib84","doi-asserted-by":"crossref","first-page":"C215","DOI":"10.1152\/ajpcell.00133.2014","article-title":"Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity","volume":"309","author":"Xiao","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib85","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93626","article-title":"Peroxisomal \u03b2-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease","volume":"3","author":"Moreno-Fernandez","year":"2018","journal-title":"JCI insight"},{"issue":"11","key":"10.1016\/j.redox.2022.102322_bib86","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tem.2014.08.001","article-title":"Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD","volume":"25","author":"Fuchs","year":"2014","journal-title":"Trends Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib87","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hep.24338","article-title":"Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis","volume":"54","author":"Wu","year":"2011","journal-title":"Hepatology"},{"issue":"19","key":"10.1016\/j.redox.2022.102322_bib88","doi-asserted-by":"crossref","first-page":"13087","DOI":"10.1074\/jbc.M800533200","article-title":"Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis","volume":"283","author":"Reid","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"7675","key":"10.1016\/j.redox.2022.102322_bib89","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib90","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1083\/jcb.201607110","article-title":"Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis","volume":"216","author":"Chung","year":"2017","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib91","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00125-019-05082-7","article-title":"An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models","volume":"63","author":"Choi","year":"2020","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib92","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948804","article-title":"Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress","volume":"21","author":"Ost","year":"2020","journal-title":"EMBO Rep."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109501","article-title":"GDF15 mediates the metabolic effects of PPAR\u03b2\/\u03b4 by activating AMPK","volume":"36","author":"Aguilar-Recarte","year":"2021","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129834","article-title":"GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH","volume":"1865","author":"Kim","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib95","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood-2016-01-696617","article-title":"GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5\/TGF-\u03b2RII heterodimer","volume":"128","author":"Artz","year":"2016","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib96","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/hep4.1363","article-title":"Selective liver estrogen receptor \u03b1 modulation prevents steatosis, diabetes, and obesity through the anorectic growth differentiation factor 15 hepatokine in mice","volume":"3","author":"Guillaume","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.redox.2022.102322_bib97","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3389\/fimmu.2020.00951","article-title":"Growth\/differentiation factor-15 (GDF-15): from biomarker to novel targetable immune checkpoint","volume":"11","author":"Wischhusen","year":"2020","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib98","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1053\/j.gastro.2020.12.015","article-title":"Hepatic stellate cells in hepatocellular carcinoma promote tumor growth via growth differentiation factor 15 production","volume":"160","author":"Myojin","year":"2021","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib99","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib100","doi-asserted-by":"crossref","first-page":"E1027","DOI":"10.1152\/ajpendo.00642.2009","article-title":"Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C\/EBP homologous protein and chemical chaperones in palmitate-mediated cell death","volume":"298","author":"Pfaffenbach","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib101","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/carcin\/bgq008","article-title":"The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1\/MIC-1\/PTGF-beta)","volume":"31","author":"Yang","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.redox.2022.102322_bib102","article-title":"Hypoxia induces growth differentiation factor 15 to promote the metastasis of colorectal cancer via PERK-eIF2\u03b1 signaling","volume":"2020","author":"Zheng","year":"2020","journal-title":"BioMed Res. Int."},{"issue":"12","key":"10.1016\/j.redox.2022.102322_bib103","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.3390\/nu12123771","article-title":"Saturated fatty acids promote GDF15 expression in human macrophages through the PERK\/eIF2\/CHOP signaling pathway","volume":"12","author":"L'Homme","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib104","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.bbrc.2017.08.096","article-title":"Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese mice","volume":"498","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib105","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/ana.24506","article-title":"Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders","volume":"78","author":"Yatsuga","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.redox.2022.102322_bib106","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.1038\/srep05832","article-title":"Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study","volume":"4","author":"Zhang","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102322_bib107","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cellimm.2018.08.006","article-title":"Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release","volume":"332","author":"Pan","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.redox.2022.102322_bib108","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fimmu.2013.00050","article-title":"Mechanisms of disease: inflammasome activation and the development of type 2 diabetes","volume":"4","author":"Grant","year":"2013","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib109","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.celrep.2017.06.086","article-title":"AIM2 engages active but unprocessed caspase-1 to induce noncanonical activation of the NLRP3 inflammasome","volume":"20","author":"Cunha","year":"2017","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib110","first-page":"197","article-title":"NAFLD: a critical role for the NLRP3 inflammasome in NASH","volume":"14","author":"Thomas","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib111","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metabol."},{"issue":"37","key":"10.1016\/j.redox.2022.102322_bib112","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7384","key":"10.1016\/j.redox.2022.102322_bib113","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.redox.2022.102322_bib114","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00109-014-1170-1","article-title":"NLRP3 inflammasome activation is required for fibrosis development in NAFLD","volume":"92","author":"Wree","year":"2014","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hep.24341","article-title":"Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells","volume":"54","author":"Csak","year":"2011","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib116","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2022.102322_bib117","doi-asserted-by":"crossref","first-page":"24399","DOI":"10.1038\/srep24399","article-title":"A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib118","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.redox.2022.102322_bib119","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/oby.20638","article-title":"Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity","volume":"22","author":"Wang","year":"2014","journal-title":"Obesity"},{"issue":"1","key":"10.1016\/j.redox.2022.102322_bib120","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/imr.12903","article-title":"AIM2 in health and disease: inflammasome and beyond","volume":"297","author":"Kumari","year":"2020","journal-title":"Immunol. Rev."},{"issue":"11","key":"10.1016\/j.redox.2022.102322_bib121","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/eji.201848070","article-title":"Role of AIM2 inflammasome in inflammatory diseases, cancer and infection","volume":"49","author":"Sharma","year":"2019","journal-title":"Eur. J. Immunol."},{"issue":"18","key":"10.1016\/j.redox.2022.102322_bib122","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.3390\/ijms21186535","article-title":"The emerging relevance of AIM2 in liver disease","volume":"21","author":"Lozano-Ruiz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.redox.2022.102322_bib123","first-page":"142","article-title":"Increased levels of AIM2 and circulating mitochondrial DNA in type 2 diabetes, Iran","volume":"15","author":"Cata\u00f1o Ca\u00f1izales","year":"2018","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib124","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/10799893.2020.1726952","article-title":"Inevitable role of TGF-\u03b21 in progression of nonalcoholic fatty liver disease","volume":"40","author":"Nair","year":"2020","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"7","key":"10.1016\/j.redox.2022.102322_bib125","first-page":"1624","article-title":"Signal transductions and nonalcoholic fatty liver: a mini-review","volume":"7","author":"Zeng","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"3","key":"10.1016\/j.redox.2022.102322_bib126","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/10409238.2018.1448752","article-title":"The hedgehog pathway in nonalcoholic fatty liver disease","volume":"53","author":"Verdelho Machado","year":"2018","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"8","key":"10.1016\/j.redox.2022.102322_bib127","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.dld.2020.04.019","article-title":"Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration","volume":"52","author":"Ortiz","year":"2020","journal-title":"Dig. Liver Dis."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib128","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1039\/C7FO00090A","article-title":"Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-\u03b1 and Nrf2 activation, and NF-\u03baB down-regulation","volume":"8","author":"Valenzuela","year":"2017","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.redox.2022.102322_bib129","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/mnfr.201300458","article-title":"N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-\u03b1 upregulation and NF-\u03baB DNA binding abrogation","volume":"58","author":"Tapia","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"issue":"4","key":"10.1016\/j.redox.2022.102322_bib130","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3945\/jn.110.135210","article-title":"PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver","volume":"141","author":"Abdelmegeed","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.redox.2022.102322_bib131","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5109503","article-title":"Attenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HT","author":"Echeverr\u00eda","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2022.102322_bib132","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ebiom.2019.02.019","article-title":"Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice","volume":"41","author":"Rom","year":"2019","journal-title":"EBioMedicine"},{"issue":"572","key":"10.1016\/j.redox.2022.102322_bib133","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz2841","article-title":"Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome","volume":"12","author":"Rom","year":"2020","journal-title":"Sci. Transl. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722000945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722000945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:25:20Z","timestamp":1761978320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231722000945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":133,"alternative-id":["S2213231722000945"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102322","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of NAG-1\/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102322","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102322"}}