{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:40:16Z","timestamp":1793817616965,"version":"4.6.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202865\/Z\/16\/Z"],"award-info":[{"award-number":["202865\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.redox.2022.102350","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T23:28:10Z","timestamp":1653607690000},"page":"102350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and -independent actions on macrophages"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-2425","authenticated-orcid":false,"given":"Daiana","family":"Drehmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo","family":"Mesquita Luiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Augusto Speck","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Alves-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Hussell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Andrew","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Moncada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2022.102350_bib1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2022.102350_bib2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.redox.2022.102350_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2019.06.021","article-title":"Pas de Deux: control of anti-tumor immunity by cancer-associated inflammation","volume":"51","author":"Shalapour","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2022.102350_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/149185","article-title":"Chronic inflammation and cytokines in the tumor microenvironment","volume":"2014","author":"Landskron","year":"2014","journal-title":"Journal of Immunology Research"},{"key":"10.1016\/j.redox.2022.102350_bib5","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.redox.2022.102350_bib6","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine-nitric oxide pathway","volume":"329","author":"Epstein","year":"1993","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.redox.2022.102350_bib7","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1073\/pnas.1401799111","article-title":"Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression","volume":"111","author":"Heinecke","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.redox.2022.102350_bib8","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/sj.onc.1209984","article-title":"Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression","volume":"26","author":"Cronauer","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2022.102350_bib9","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/ijc.21767","article-title":"Tumor iNOS predicts poor survival for stage III melanoma patients","volume":"119","author":"Ekmekcioglu","year":"2006","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.redox.2022.102350_bib10","article-title":"Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression","volume":"58","author":"Ambs","year":"1998","journal-title":"Cancer Research"},{"key":"10.1016\/j.redox.2022.102350_bib11","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.redox.2022.102350_bib12","series-title":"Nitric Oxide in Breast Cancer: Induction of Vascular Endothelial Growth Factor-C and Correlation with Metastasis and Poor Prognosis","author":"Nakamura","year":"2006"},{"key":"10.1016\/j.redox.2022.102350_bib13","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1158\/1078-0432.CCR-12-1554","article-title":"Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target","volume":"19","author":"Grimm","year":"2013","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.redox.2022.102350_bib14","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1073\/pnas.0812347106","article-title":"Nitric oxide and TNF-\u03b1 trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice","volume":"106","author":"Erdman","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.redox.2022.102350_bib15","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1136\/gut.2003.030684","article-title":"Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase","volume":"53","author":"Nam","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.redox.2022.102350_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/gut.45.2.199","article-title":"Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase","volume":"45","author":"Zingarelli","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.redox.2022.102350_bib17","doi-asserted-by":"crossref","first-page":"13030","DOI":"10.1073\/pnas.1709119114","article-title":"Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer","volume":"114","author":"Basudhar","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.redox.2022.102350_bib18","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.7150\/ijbs.41653","article-title":"Downregulation of nitric oxide collaborated with radiotherapy to promote anti-tumor immune response via inducing cd8+ t cell infiltration","volume":"16","author":"Xu","year":"2020","journal-title":"International Journal of Biological Sciences"},{"key":"10.1016\/j.redox.2022.102350_bib19","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1158\/0008-5472.CAN-19-2991","article-title":"INOS regulates the therapeutic response of pancreatic cancer cells to radiotherapy A C","volume":"80","author":"Pereira","year":"2020","journal-title":"Cancer Research"},{"key":"10.1016\/j.redox.2022.102350_bib20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s40425-019-0698-6","article-title":"Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition","volume":"7","author":"Newton","year":"2019","journal-title":"Journal for ImmunoTherapy of Cancer"},{"key":"10.1016\/j.redox.2022.102350_bib21","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1158\/1078-0432.CCR-17-0691","article-title":"Nitric oxide production by myeloid-derived suppressor cells plays a role in impairing Fc receptor\u2013mediated natural killer cell function","volume":"24","author":"Stiff","year":"2018","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.redox.2022.102350_bib22","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1158\/1055-9965.EPI-17-0503","article-title":"A prospective study of chronic inflammation in benign prostate tissue and risk of prostate cancer: linked PCPT and SELECT cohorts","volume":"26","author":"Platz","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"10.1016\/j.redox.2022.102350_bib23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrurol.2016.168","article-title":"Inflammatory mediators in the development and progression of benign prostatic hyperplasia","volume":"13","author":"de Nunzio","year":"2016","journal-title":"Nature Reviews Urology"},{"key":"10.1016\/j.redox.2022.102350_bib24","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41422-020-0355-0","article-title":"A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling","volume":"30","author":"Qian","year":"2020","journal-title":"Cell Research"},{"key":"10.1016\/j.redox.2022.102350_bib25","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.freeradbiomed.2017.04.015","article-title":"Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system","volume":"108","author":"Lee","year":"2017","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.redox.2022.102350_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2022.102350_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-14433-7","article-title":"Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase","volume":"11","author":"Palmieri","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.redox.2022.102350_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101147","article-title":"Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide - a divergent role for glycolysis","volume":"22","author":"Vijayan","year":"2019","journal-title":"Redox Biology"},{"key":"10.1016\/j.redox.2022.102350_bib29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.20150900","article-title":"The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease","volume":"213","author":"Shirai","year":"2016","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.redox.2022.102350_bib30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.redox.2022.102350_bib31","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1172\/JCI84426","article-title":"Hypoxia-inducible factors: key regulators of myeloid cells during inflammation","volume":"126","author":"Lin","year":"2016","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.redox.2022.102350_bib32","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.3389\/fimmu.2019.02321","article-title":"Hypoxia induces macrophage tnfa expression via cyclooxygenase and prostaglandin E2 in vivo","author":"Lewis","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib33","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/bj20031155","article-title":"Regulation of hypoxia-inducible factor-1\u03b1 by nitric oxide through mitochondria-dependent and -independent pathways","volume":"376","author":"Mateo","year":"2003","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.redox.2022.102350_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ncb1080","article-title":"Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway","volume":"6","author":"Almeida","year":"2004","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.redox.2022.102350_bib35","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.0901698","article-title":"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation","volume":"185","author":"Rodr\u00edguez-Prados","year":"2010","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib36","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Research"},{"key":"10.1016\/j.redox.2022.102350_bib37","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.celrep.2016.09.008","article-title":"Mitochondrial dysfunction prevents repolarization of inflammatory macrophages","volume":"17","author":"van den Bossche","year":"2016","journal-title":"Cell Reports"},{"key":"10.1016\/j.redox.2022.102350_bib38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.redox.2016.09.005","article-title":"Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production","volume":"10","author":"Baseler","year":"2016","journal-title":"Redox Biology"},{"key":"10.1016\/j.redox.2022.102350_bib39","first-page":"1 135","article-title":"Toll-like receptors and innate immunity","author":"Medzhitov","year":"2001","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib40","first-page":"13 227","article-title":"Molecular mechanisms of T cell co-stimulation and co-inhibition","author":"Chen","year":"2013","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.immunol.25.022106.141609","article-title":"Immunosuppressive strategies that are mediated BY tumor cells","volume":"25","author":"Rabinovich","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.redox.2022.102350_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/2326-6066.CIR-14-0209","article-title":"Tumors: wounds that do not heal-redux","volume":"3","author":"Dvorak","year":"2015","journal-title":"Cancer Immunology Research"},{"key":"10.1016\/j.redox.2022.102350_bib43","first-page":"14 399","article-title":"Tumour-associated macrophages as treatment targets in oncology","author":"Mantovani","year":"2017","journal-title":"Nature Reviews Clinical Oncology"},{"key":"10.1016\/j.redox.2022.102350_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123805","article-title":"Regulation of iNOS on immune cells and its role in diseases","volume":"19","author":"Xue","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.redox.2022.102350_bib45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1046\/j.1365-3083.2001.00885.x","article-title":"Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein \u03b2IG-H3","volume":"53","author":"Gratchev","year":"2001","journal-title":"Scandinavian Journal of Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib46","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.4049\/jimmunol.1200662","article-title":"Efficient clearance of early apoptotic cells by human macrophages requires \u201cM2c\u201d polarization and MerTK induction","volume":"189","author":"Zizzo","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.redox.2022.102350_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fimmu.2011.00057","article-title":"Modulation of macrophage efferocytosis in inflammation","volume":"2","author":"Korns","year":"2011","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib48","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1172\/JCI42059","article-title":"Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients","volume":"120","author":"Glynn","year":"2010","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.redox.2022.102350_bib49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13058-015-0527-x","article-title":"Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer","volume":"17","author":"Granados-Principal","year":"2015","journal-title":"Breast Cancer Research"},{"key":"10.1016\/j.redox.2022.102350_bib50","first-page":"1","article-title":"iNOS associates with poor survival in melanoma: a role for nitric oxide in the PI3K-AKT pathway stimulation and PTEN S-nitrosylation","volume":"11","author":"Ding","year":"2021","journal-title":"Frontiers in Oncology"},{"key":"10.1016\/j.redox.2022.102350_bib51","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1080\/21645515.2016.1276682","article-title":"Targeting iNOS to increase efficacy of immunotherapies","volume":"13","author":"Ekmekcioglu","year":"2017","journal-title":"Human Vaccines and Immunotherapeutics"},{"key":"10.1016\/j.redox.2022.102350_bib52","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.4049\/jimmunol.1301758","article-title":"Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses","volume":"192","author":"Gross","year":"2014","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib53","article-title":"Species differences in macrophage NO production are important (multiple letters)","volume":"3 102","author":"Schneemann","year":"2002","journal-title":"Nature Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib54","first-page":"10 1","article-title":"Nitric oxide in macrophage immunometabolism: hiding in plain sight","author":"Palmieri","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.redox.2022.102350_bib55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1164\/rccm.2201023","article-title":"Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis","volume":"166","author":"Choi","year":"2002","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.redox.2022.102350_bib56","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0140-6736(00)02063-8","article-title":"Compartmentalised inducible nitric-oxide synthase activity in septic shock","volume":"355","author":"Annane","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2022.102350_bib57","first-page":"9 179","article-title":"Nitric oxide in inflammatory bowel disease","author":"Cross","year":"2003","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.redox.2022.102350_bib58","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0008-6363(98)00304-6","article-title":"Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque","volume":"41","author":"Depre","year":"1999","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.redox.2022.102350_bib59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/bjc.1995.274","article-title":"Nitric oxide synthase activity in human breast cancer","volume":"72","author":"Thomsen","year":"1995","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.redox.2022.102350_bib60","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1172\/JCI72058","article-title":"Collective nitric oxide production provides tissue-wide immunity during Leishmania infection","volume":"124","author":"Olekhnovitch","year":"2014","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.redox.2022.102350_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7676","article-title":"Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization","volume":"6","author":"Lu","year":"2015","journal-title":"Nature Communications"},{"key":"10.1016\/j.redox.2022.102350_bib62","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/cyto.2002.1955","article-title":"Modulation of PGE2 and TNF\u03b1 by nitric oxide in resting and LPS-activated raw 264.7 cells","volume":"19","author":"Guastadisegni","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.redox.2022.102350_bib63","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1006\/cyto.1995.0056","article-title":"The modulation of IL-6 and TNF-alpha release by nitric oxide following stimulation of J774 cells with LPS and IFN-gamma","volume":"7","author":"Am","year":"1995","journal-title":"Cytokine"},{"key":"10.1016\/j.redox.2022.102350_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101354","article-title":"Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level","volume":"28","author":"Somasundaram","year":"2020","journal-title":"Redox Biology"},{"key":"10.1016\/j.redox.2022.102350_bib65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/thx.51.2.143","article-title":"Interleukin 10 (IL-10) regulation of tumour necrosis factor alpha (TNF-alpha) from human alveolar macrophages and peripheral blood monocytes","volume":"51","author":"Armstrong","year":"1996","journal-title":"Thorax"},{"key":"10.1016\/j.redox.2022.102350_bib66","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1126\/science.1088805","article-title":"Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha","volume":"302","author":"T","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.redox.2022.102350_bib67","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.molcel.2007.02.024","article-title":"Regulation of HIF-1\u03b1 stability through S-nitrosylation","volume":"26","author":"Li","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.redox.2022.102350_bib68","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.4049\/jimmunol.181.12.8633","article-title":"Adenosine 5\u2032-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype","volume":"181","author":"Sag","year":"2008","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib69","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1189\/jlb.0313157","article-title":"AMPK\u03b11 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling","volume":"94","author":"Carroll","year":"2013","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.redox.2022.102350_bib70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.redox.2022.102350_bib71","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.ccell.2016.10.010","article-title":"Deubiquitination and stabilization of PD-L1 by CSN5","volume":"30","author":"Lim","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2022.102350_bib72","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.4049\/jimmunol.167.6.3231","article-title":"Down-regulation of CD28 expression by TNF-\u03b1","volume":"167","author":"Bryl","year":"2001","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.redox.2022.102350_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms15620","article-title":"Glucose represses dendritic cell-induced T cell responses","volume":"8","author":"Lawless","year":"2017","journal-title":"Nature Communications"},{"key":"10.1016\/j.redox.2022.102350_bib74","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1084\/jem.20101956","article-title":"Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells","volume":"208","author":"Molon","year":"2011","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.redox.2022.102350_bib75","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20042028","article-title":"Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers","volume":"201","author":"Bronte","year":"2005","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.redox.2022.102350_bib76","doi-asserted-by":"crossref","first-page":"10094","DOI":"10.1073\/pnas.1800695115","article-title":"Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers","volume":"115","author":"Feng","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.redox.2022.102350_bib77","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/physiol.00034.2020","article-title":"Intratumoral hypoxia and mechanisms of immune evasion mediated by hypoxia- inducible factors","volume":"36","author":"Semenza","year":"2021","journal-title":"Physiology"},{"key":"10.1016\/j.redox.2022.102350_bib78","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2015.08.015","article-title":"Cyclooxygenase-dependent tumor growth through evasion of immunity","volume":"162","author":"Zelenay","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.redox.2022.102350_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41523-020-00204-6","article-title":"S-nitrosylated and non-nitrosylated COX2 have differential expression and distinct subcellular localization in normal and breast cancer tissue","volume":"6","author":"Jindal","year":"2020","journal-title":"npj Breast Cancer"},{"key":"10.1016\/j.redox.2022.102350_bib80","article-title":"Browser: making single-cell data easily accessible","volume":"1","author":"Le","year":"2020","journal-title":"Ngoc Pham"},{"key":"10.1016\/j.redox.2022.102350_bib81","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722001227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722001227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:24:52Z","timestamp":1761978292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231722001227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":81,"alternative-id":["S2213231722001227"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102350","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and -independent actions on macrophages","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102350"}}