{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:24:17Z","timestamp":1793741057153,"version":"4.6.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1039 TP B04"],"award-info":[{"award-number":["CRC 1039 TP B04"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.redox.2022.102365","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T22:15:03Z","timestamp":1654812903000},"page":"102365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"special_numbering":"C","title":["A graphical journey through iron metabolism, microRNAs, and hypoxia in ferroptosis"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-9387","authenticated-orcid":false,"given":"Dominik C.","family":"Fuhrmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-2841","authenticated-orcid":false,"given":"Bernhard","family":"Br\u00fcne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2022.102365_bib1","series-title":"Harry Potter and the Philosopher's Stone","author":"Rowling","year":"1997"},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1084\/jem.102.1.37","article-title":"The specific amino acid requirements of a human carcinoma cell (Stain HeLa) in tissue culture","volume":"102","author":"Eagle","year":"1955","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.redox.2022.102365_bib3","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of non-apoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.redox.2022.102365_bib4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2022.102365_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2021.126911","article-title":"The role of non-coding RNAs in ferroptosis regulation","volume":"70","author":"Qi","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"7784","key":"10.1016\/j.redox.2022.102365_bib7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.redox.2022.102365_bib8","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin receptor is a specific ferroptosis marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.redox.2022.102365_bib9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","article-title":"A red carpet for iron metabolism","volume":"168","author":"Muckenthaler","year":"2017","journal-title":"Cell"},{"issue":"27","key":"10.1016\/j.redox.2022.102365_bib10","doi-asserted-by":"crossref","first-page":"24393","DOI":"10.18632\/oncotarget.5162","article-title":"Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death","volume":"6","author":"Kwon","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2022.102365_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-021-02420-x","article-title":"FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis","volume":"21","author":"Hu","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.redox.2022.102365_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101670","article-title":"Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis","volume":"36","author":"Fuhrmann","year":"2020","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.redox.2022.102365_bib13","first-page":"3826","article-title":"Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells","volume":"22","author":"Geng","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.redox.2022.102365_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109633","article-title":"Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells","volume":"72","author":"Shang","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.redox.2022.102365_bib15","article-title":"Mitochondria and ferroptosis","volume":"25","author":"Javadov","year":"2022","journal-title":"Curr. Opin. Physiol."},{"issue":"6","key":"10.1016\/j.redox.2022.102365_bib16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/10715762.2020.1780229","article-title":"Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs)","volume":"54","author":"Homma","year":"2020","journal-title":"Free Radic. Res."},{"issue":"9","key":"10.1016\/j.redox.2022.102365_bib17","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41419-021-04128-2","article-title":"CISD3 inhibition drives cystine-deprivation induced ferroptosis","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.redox.2022.102365_bib18","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbrc.2016.08.034","article-title":"CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbrc.2016.01.040","article-title":"His-87 ligand in mitoNEET is crucial for the transfer of iron sulfur clusters from mitochondria to cytosolic aconitase","volume":"470","author":"Tan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.redox.2022.102365_bib20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbrc.2019.05.147","article-title":"miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis","volume":"515","author":"Xiao","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13046-021-02208-x","article-title":"Epigenetic regulation of ferroptosis via ETS1\/miR-23a-3p\/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma","volume":"41","author":"Lu","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4149\/neo_2020_200707N705","article-title":"Tumor suppressor miR-424-5p abrogates ferroptosis in ovarian cancer through targeting ACSL4","volume":"68","author":"Ma","year":"2021","journal-title":"Neoplasma"},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib23","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1080\/21655979.2021.1951070","article-title":"Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p\/acyl-CoA synthetase long chain family member 4 axis","volume":"12","author":"Chen","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.redox.2022.102365_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24859-2","article-title":"GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis","volume":"12","author":"Kremer","year":"2021","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.redox.2022.102365_bib25","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/mc.22878","article-title":"miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma","volume":"57","author":"Zhang","year":"2018","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.redox.2022.102365_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbrc.2021.05.100","article-title":"miR-190a-5p regulates cardiomyocytes response to ferroptosis via directly targeting GLS2","volume":"566","author":"Zhou","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2022.102365_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116893","article-title":"Physcion 8-O-\u03b2-glucopyranoside induced ferroptosis via regulating miR-103a-3p\/GLS2 axis in gastric cancer","volume":"237","author":"Niu","year":"2019","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.redox.2022.102365_bib28","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41418-017-0053-8","article-title":"miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma","volume":"25","author":"Luo","year":"2018","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.redox.2022.102365_bib29","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41419-020-03135-z","article-title":"miR-182-5p and miR-378a-3p regulate ferroptosis in I\/R-induced renal injury","volume":"11","author":"Ding","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2022.102365_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.759346","article-title":"MiR-27a-3p promotes non-small cell lung cancer through SLC7A11-mediated-ferroptosis","volume":"11","author":"Lu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.redox.2022.102365_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.canlet.2021.09.033","article-title":"SLC7A11\/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells","volume":"522","author":"Yadav","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.redox.2022.102365_bib32","first-page":"1","article-title":"MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4","author":"Xu","year":"2022","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.redox.2022.102365_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112376","article-title":"LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p\/SLC7A11 signaling","volume":"220","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.redox.2022.102365_bib34","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s11064-021-03320-2","article-title":"Isorhynchophylline relieves ferroptosis-induced nerve damage after intracerebral hemorrhage via miR-122-5p\/TP53\/SLC7A11 pathway","volume":"46","author":"Zhao","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.redox.2022.102365_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174403","article-title":"The Egr-1\/miR-15a-5p\/GPX4 axis regulates ferroptosis in acute myocardial infarction","volume":"909","author":"Fan","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.redox.2022.102365_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3892\/ol.2022.13186","article-title":"MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression","volume":"23","author":"Xu","year":"2022","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.redox.2022.102365_bib37","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/cbin.11444","article-title":"CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR-541-3p\/GPX4 axis","volume":"44","author":"Xu","year":"2020","journal-title":"Cell Biol. Int."},{"issue":"12","key":"10.1016\/j.redox.2022.102365_bib38","doi-asserted-by":"crossref","first-page":"16500","DOI":"10.18632\/aging.203172","article-title":"Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"7-8","key":"10.1016\/j.redox.2022.102365_bib39","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1002\/jcp.29496","article-title":"MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells","volume":"235","author":"Bai","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.redox.2022.102365_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13235","article-title":"Targeting miR-124\/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model","volume":"19","author":"Bao","year":"2020","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.redox.2022.102365_bib41","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4894","article-title":"miR-335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease","volume":"47","author":"Li","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.redox.2022.102365_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.626390","article-title":"Ferroptosis enhanced diabetic renal tubular injury via HIF-1\u03b1\/HO-1 pathway in db\/db mice","volume":"12","author":"Feng","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1\u03b1\/SLC7A11 pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif"},{"issue":"12","key":"10.1016\/j.redox.2022.102365_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143691","article-title":"HIF-2\u03b1 activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron","volume":"131","author":"Singhal","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.redox.2022.102365_bib45","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1111\/jog.15009","article-title":"Activation of Nrf2 signaling protects hypoxia-induced HTR-8\/SVneo cells against ferroptosis","volume":"47","author":"Wang","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"11","key":"10.1016\/j.redox.2022.102365_bib46","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1002\/2211-5463.13276","article-title":"Icariin inhibits hypoxia\/reoxygenation-induced ferroptosis of cardiomyocytes via regulation of the Nrf2\/HO-1 signaling pathway","volume":"11","author":"Liu","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"1","key":"10.1016\/j.redox.2022.102365_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41419-020-03319-7","article-title":"Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis","volume":"12","author":"K\u00fcper","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2022.102365_bib48","article-title":"Stearoyl-CoA desaturase 1 potentiates hypoxic plus nutrient-deprived pancreatic cancer cell ferroptosis resistance","author":"Gao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2022.102365_bib49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2021.04.027","article-title":"Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis","volume":"169","author":"Ni","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2022.102365_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101297","article-title":"Carbonic anhydrase 9 confers resistance to ferroptosis\/apoptosis in malignant mesothelioma under hypoxia","volume":"26","author":"Li","year":"2019","journal-title":"Redox Biol."},{"issue":"51","key":"10.1016\/j.redox.2022.102365_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904197","article-title":"Recent progress in ferroptosis inducers for cancer therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv. Mater."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722001379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722001379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:27:59Z","timestamp":1761978479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231722001379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":51,"alternative-id":["S2213231722001379"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102365","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A graphical journey through iron metabolism, microRNAs, and hypoxia in ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102365","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102365"}}