{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:59:54Z","timestamp":1793159994473,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970239"],"award-info":[{"award-number":["81970239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070315"],"award-info":[{"award-number":["82070315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011663"],"award-info":[{"award-number":["2021A1515011663"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.redox.2022.102446","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T02:32:30Z","timestamp":1661221950000},"page":"102446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"special_numbering":"C","title":["LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization"],"prefix":"10.1016","volume":"56","author":[{"given":"Yijin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangkai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-1502","authenticated-orcid":false,"given":"Jianping","family":"Bin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/CIRCRESAHA.117.308428","article-title":"Multimodal regulation of cardiac myocyte proliferation","volume":"121","author":"Yuan","year":"2017","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.redox.2022.102446_bib2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jacbts.2020.04.008","article-title":"Hypoxia induces cardiomyocyte proliferation in humans","volume":"5","author":"Ahmed","year":"2020","journal-title":"JACC Basic Translat. Sci."},{"issue":"2","key":"10.1016\/j.redox.2022.102446_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s42255-020-0169-x","article-title":"Mitochondrial substrate utilization regulates cardiomyocyte cell cycle progression","volume":"2","author":"Cardoso","year":"2020","journal-title":"Nature metabolism"},{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.redox.2022.102446_bib5","doi-asserted-by":"crossref","first-page":"8669","DOI":"10.1038\/s41598-021-88159-x","article-title":"GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration","volume":"11","author":"Fajardo","year":"2021","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.redox.2022.102446_bib6","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.119.043067","article-title":"Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration","volume":"141","author":"Magadum","year":"2020","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.redox.2022.102446_bib7","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1161\/CIRCULATIONAHA.120.049952","article-title":"Malonate promotes adult cardiomyocyte proliferation and heart regeneration","volume":"143","author":"Bae","year":"2021","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.redox.2022.102446_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bpa.12299","article-title":"The regulation and function of lactate dehydrogenase A: therapeutic potential in brain tumor","volume":"26","author":"Valvona","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.redox.2022.102446_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2022.06.003","article-title":"Deletion of lactate dehydrogenase-A impairs oncogene-induced mouse hepatocellular carcinoma development","author":"Serra","year":"2022","journal-title":"Cellular Mol. Gastroenterol. Hepatology"},{"issue":"18","key":"10.1016\/j.redox.2022.102446_bib10","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1158\/1078-0432.CCR-12-3300","article-title":"Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors","volume":"19","author":"Rizwan","year":"2013","journal-title":"Clin. Cancer Res. : an official journal of the American Association for Cancer Research"},{"issue":"9","key":"10.1016\/j.redox.2022.102446_bib11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ncb3575","article-title":"Lactate dehydrogenase activity drives hair follicle stem cell activation","volume":"19","author":"Flores","year":"2017","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.redox.2022.102446_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108087","article-title":"Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress","volume":"32","author":"Dai","year":"2020","journal-title":"Cell Rep."},{"issue":"10","key":"10.1016\/j.redox.2022.102446_bib13","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1007\/s11064-019-02780-x","article-title":"Succinylation links metabolism to protein functions","volume":"44","author":"Yang","year":"2019","journal-title":"Neurochem. Res."},{"issue":"1464","key":"10.1016\/j.redox.2022.102446_bib14","first-page":"2335","article-title":"Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress","volume":"360","author":"Tretter","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.redox.2022.102446_bib15","first-page":"4320","article-title":"Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function","volume":"vol. 113","author":"Sadhukhan","year":"2016"},{"issue":"6311","key":"10.1016\/j.redox.2022.102446_bib16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Science (New York, NY)"},{"issue":"5","key":"10.1016\/j.redox.2022.102446_bib17","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.immuni.2021.04.008","article-title":"Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses","volume":"54","author":"Xu","year":"2021","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.redox.2022.102446_bib18","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","article-title":"Endothelial lactate controls muscle regeneration from ischemia by inducing M2-like macrophage polarization","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.redox.2022.102446_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/CIRCRESAHA.118.314223","article-title":"Transient introduction of miR-294 in the heart promotes cardiomyocyte cell cycle reentry after injury","volume":"125","author":"Borden","year":"2019","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00395-015-0489-2","article-title":"Transgenic systems for unequivocal identification of cardiac myocyte nuclei and analysis of cardiomyocyte cell cycle status","volume":"110","author":"Raulf","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.redox.2022.102446_bib21","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/ncomms2089","article-title":"Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle","volume":"3","author":"Hesse","year":"2012","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.redox.2022.102446_bib22","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/CIRCRESAHA.118.312792","article-title":"Midbody positioning and distance between daughter nuclei enable unequivocal identification of cardiomyocyte cell division in mice","volume":"123","author":"Hesse","year":"2018","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib23","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1039\/C5MB00853K","article-title":"SuccinSite: a computational tool for the prediction of protein succinylation sites by exploiting the amino acid patterns and properties","volume":"12","author":"Hasan","year":"2016","journal-title":"Mol. Biosyst."},{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.03.011","article-title":"A lactate-induced response to hypoxia","volume":"161","author":"Lee","year":"2015","journal-title":"Cell"},{"issue":"42","key":"10.1016\/j.redox.2022.102446_bib25","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1038\/onc.2009.229","article-title":"Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth","volume":"28","author":"Zhao","year":"2009","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.redox.2022.102446_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41392-021-00595-3","article-title":"Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli","volume":"6","author":"Wu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.redox.2022.102446_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080793","article-title":"Short overview of ROS as cell function regulators and their implications in therapy concepts","volume":"8","author":"Milkovic","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.redox.2022.102446_bib28","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.molcel.2019.03.021","article-title":"Regulation of UCP1 and mitochondrial metabolism in Brown adipose tissue by reversible succinylation","volume":"74","author":"Wang","year":"2019","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib29","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41419-018-1271-9","article-title":"Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress","volume":"10","author":"Qi","year":"2019","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.redox.2022.102446_bib30","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/hep.30467","article-title":"Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma","volume":"69","author":"Lee","year":"2019","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.redox.2022.102446_bib31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41419-019-2035-x","article-title":"ROS-mediated inactivation of the PI3K\/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin","volume":"10","author":"Wen","year":"2019","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cardfail.2019.01.017","article-title":"Ischemic cardiomyopathy affects the thioredoxin system in the human myocardium","volume":"25","author":"Neidhardt","year":"2019","journal-title":"J. Card. Fail."},{"issue":"2","key":"10.1016\/j.redox.2022.102446_bib33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/eurjhf\/hfn012","article-title":"Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level","volume":"11","author":"Wang","year":"2009","journal-title":"Eur. J. Heart Fail."},{"issue":"4","key":"10.1016\/j.redox.2022.102446_bib34","doi-asserted-by":"crossref","first-page":"L545","DOI":"10.1152\/ajplung.00214.2018","article-title":"The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms","volume":"315","author":"Dunigan","year":"2018","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.redox.2022.102446_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7674565","article-title":"TXNRD1: a key regulator involved in the ferroptosis of CML cells induced by cysteine depletion in vitro","volume":"2021","author":"Liu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.redox.2022.102446_bib36","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/15384101.2015.1136038","article-title":"TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-\u043a\u03b2 inhibition","volume":"15","author":"Raninga","year":"2016","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.redox.2022.102446_bib37","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1038\/s41467-020-17242-0","article-title":"LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis","volume":"11","author":"Arra","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.redox.2022.102446_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2020.09.014","article-title":"Modification of proteins by metabolites in immunity","volume":"54","author":"Diskin","year":"2021","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.redox.2022.102446_bib39","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCULATIONAHA.120.049438","article-title":"Short-chain Enoyl-CoA hydratase mediates histone crotonylation and contributes to cardiac homeostasis","volume":"143","author":"Tang","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102446_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114031","article-title":"Metabolomics bridging proteomics along metabolites\/oncometabolites and protein modifications: paving the way toward integrative multiomics","volume":"199","author":"Nalbantoglu","year":"2021","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.redox.2022.102446_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69413-0","article-title":"Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells","volume":"10","author":"Zogbi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102446_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.yjmcc.2021.07.003","article-title":"Can polarization of macrophage metabolism enhance cardiac regeneration?","volume":"160","author":"Lantz","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.redox.2022.102446_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6901345","article-title":"Hyperlactatemia and the outcome of type 2 diabetic patients suffering acute myocardial infarction","volume":"2016","author":"Aleksandar","year":"2016","journal-title":"J. Diabetes Res."},{"issue":"4","key":"10.1016\/j.redox.2022.102446_bib44","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0008-6363(02)00836-2","article-title":"Role of the cardiac Na+\/H+ exchanger during ischemia and reperfusion","volume":"57","author":"Allen","year":"2003","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.redox.2022.102446_bib45","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1186\/cc13793","article-title":"Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial","volume":"18","author":"Nalos","year":"2014","journal-title":"Crit. Care"},{"key":"10.1016\/j.redox.2022.102446_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5530541","article-title":"Sodium lactate accelerates M2 macrophage polarization and improves cardiac function after myocardial infarction in mice","volume":"2021","author":"Zhang","year":"2021","journal-title":"Cardiovascular therapeutics"},{"issue":"6","key":"10.1016\/j.redox.2022.102446_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11060750","article-title":"Lactate dehydrogenases as metabolic links between tumor and stroma in the tumor microenvironment","volume":"11","author":"Mishra","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.redox.2022.102446_bib48","article-title":"Lactate dehydrogenase B is required for pancreatic cancer cell immortalization through activation of telomerase activity","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.redox.2022.102446_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112414","article-title":"Cancer\/testis antigen LDHC promotes proliferation and metastasis by activating the PI3K\/Akt\/GSK-3\u03b2-signaling pathway and the in lung adenocarcinoma","volume":"398","author":"Chen","year":"2021","journal-title":"Exp. Cell Res."},{"issue":"15","key":"10.1016\/j.redox.2022.102446_bib50","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.7150\/thno.58380","article-title":"Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment","volume":"11","author":"Frank","year":"2021","journal-title":"Theranostics"},{"issue":"7","key":"10.1016\/j.redox.2022.102446_bib51","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCRESAHA.119.316303","article-title":"Modulation of mammalian cardiomyocyte cytokinesis by the extracellular matrix","volume":"127","author":"Wu","year":"2020","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.redox.2022.102446_bib52","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2020.06.030","article-title":"Type V collagen in scar tissue regulates the size of scar after heart injury","volume":"182","author":"Yokota","year":"2020","journal-title":"Cell"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172200218X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172200218X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:27:15Z","timestamp":1761978435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221323172200218X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":52,"alternative-id":["S221323172200218X"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102446","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102446"}}