{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:30:39Z","timestamp":1790281839557,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703499"],"award-info":[{"award-number":["81703499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100405"],"award-info":[{"award-number":["82100405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1456900"],"award-info":[{"award-number":["22ZR1456900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.redox.2022.102519","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:15:09Z","timestamp":1666934109000},"page":"102519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Cystathionine \u03b3 lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction"],"prefix":"10.1016","volume":"58","author":[{"given":"Dan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-6491","authenticated-orcid":false,"given":"Qingxun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2022.102519_bib1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.redox.2022.102519_bib2","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/eurjpc\/zwaa147","article-title":"Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017","volume":"28","author":"Bragazzi","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.redox.2022.102519_bib3","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/CIRCULATIONAHA.119.040551","article-title":"Unlocking the secrets of mitochondria in the cardiovascular system: path to a cure in heart failure-A report from the 2018 national heart, lung, and blood Institute workshop","volume":"140","author":"Tian","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102519_bib4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-021-00610-8","article-title":"Boosting mitochondrial metabolism with dietary supplements in heart failure","volume":"18","author":"O'Brien","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.redox.2022.102519_bib5","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2022.102519_bib6","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"Zhou","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2022.102519_bib7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yjmcc.2020.04.015","article-title":"The role of Drp1 in mitophagy and cell death in the heart","volume":"142","author":"Tong","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.redox.2022.102519_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2017.09.023","article-title":"2nd. Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial senescence","volume":"26","author":"Song","year":"2017","journal-title":"Cell Metabol."},{"key":"10.1016\/j.redox.2022.102519_bib9","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/CIRCRESAHA.116.303356","article-title":"Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress","volume":"116","author":"Ikeda","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2022.102519_bib10","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.115.020502","article-title":"Drp1-Dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure","volume":"133","author":"Shirakabe","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102519_bib11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/CIRCRESAHA.117.311307","article-title":"Mitochondrial reactive oxygen species in lipotoxic hearts induce post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission","volume":"122","author":"Tsushima","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2022.102519_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/CIRCRESAHA.119.315252","article-title":"Increased Drp1 acetylation by lipid overload induces cardiomyocyte death and heart dysfunction","volume":"126","author":"Hu","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2022.102519_bib13","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.bbadis.2017.09.004","article-title":"Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart","volume":"1864","author":"Wang","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.redox.2022.102519_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13189","article-title":"CaMKII induces permeability transition through Drp1 phosphorylation during chronic beta-AR stimulation","volume":"7","author":"Xu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2022.102519_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/bs.mie.2014.11.021","article-title":"Protein sulfhydration","volume":"555","author":"Paul","year":"2015","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.redox.2022.102519_bib16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCRESAHA.118.311134","article-title":"Evolution of hydrogen sulfide therapeutics to treat cardiovascular disease","volume":"123","author":"Li","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2022.102519_bib17","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"(2)S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase","volume":"127","author":"Kondo","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102519_bib18","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1021\/jacs.6b01373","article-title":"pH-controlled hydrogen sulfide release for myocardial ischemia-reperfusion injury","volume":"138","author":"Kang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.redox.2022.102519_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.redox.2017.11.020","article-title":"Novel H2S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure","volume":"15","author":"Wu","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2022.102519_bib20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.niox.2014.11.006","article-title":"Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes","volume":"46","author":"Wu","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.redox.2022.102519_bib21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.redox.2018.08.008","article-title":"Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca(2+)\/calmodulin-dependent protein kinase II","volume":"19","author":"Wu","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2022.102519_bib22","doi-asserted-by":"crossref","first-page":"re2","DOI":"10.1126\/scisignal.268re2","article-title":"Signaling by gasotransmitters","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2022.102519_bib23","article-title":"New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS\/MS","volume":"7","author":"Tan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102519_bib24","first-page":"1","article-title":"Genetically encoded biosensors for evaluating NAD(+)\/NADH ratio in cytosolic and mitochondrial compartments","author":"Hu","year":"2021","journal-title":"Cell Rep Methods"},{"key":"10.1016\/j.redox.2022.102519_bib25","doi-asserted-by":"crossref","first-page":"ra87","DOI":"10.1126\/scisignal.2005478","article-title":"The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide","volume":"7","author":"Altaany","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2022.102519_bib26","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1161\/CIRCULATIONAHA.116.022495","article-title":"Normalization of NAD+ redox balance as a therapy for heart failure","volume":"134","author":"Lee","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102519_bib27","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","article-title":"Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes","volume":"192","author":"Zorov","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2022.102519_bib28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.redox.2022.102519_bib29","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/CIRCULATIONAHA.119.043319","article-title":"Increasing fatty acid oxidation prevents high-fat diet-induced cardiomyopathy through regulating parkin-mediated mitophagy","volume":"142","author":"Shao","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102519_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109565","article-title":"Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation","volume":"36","author":"Valera-Alberni","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2022.102519_bib31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/CIRCULATIONAHA.120.051877","article-title":"Mapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function","volume":"143","author":"Bibli","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102519_bib32","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.tibs.2015.08.007","article-title":"H2S: a novel gasotransmitter that signals by sulfhydration","volume":"40","author":"Paul","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.redox.2022.102519_bib33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.redox.2022.102519_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111485","article-title":"VDAC1 at the intersection of cell metabolism, apoptosis, and diseases","volume":"10","author":"Shoshan-Barmatz","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.redox.2022.102519_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.15698\/cst2017.10.104","article-title":"VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress","volume":"1","author":"Shoshan-Barmatz","year":"2017","journal-title":"Cell Stress"},{"key":"10.1016\/j.redox.2022.102519_bib36","doi-asserted-by":"crossref","first-page":"24986","DOI":"10.1074\/jbc.M116.744284","article-title":"Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction","volume":"291","author":"Ben-Hail","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2022.102519_bib37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ars.2012.4888","article-title":"Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats","volume":"20","author":"Liu","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2022.102519_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/srep34398","article-title":"Fragment-based de novo design of a cystathionine gamma-lyase selective inhibitor blocking hydrogen sulfide production","volume":"6","author":"Corvino","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102519_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101772","article-title":"Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics","volume":"38","author":"Paul","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2022.102519_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaw1920","article-title":"Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload","volume":"12","author":"Nishimura","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2022.102519_bib41","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2022.102519_bib42","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s41467-017-01311-y","article-title":"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics","volume":"8","author":"Akaike","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722002919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722002919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:28:11Z","timestamp":1761978491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231722002919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":42,"alternative-id":["S2213231722002919"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102519","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cystathionine \u03b3 lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102519"}}