{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:23:33Z","timestamp":1794050613278,"version":"4.8.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL119053"],"award-info":[{"award-number":["HL119053"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL123302"],"award-info":[{"award-number":["HL123302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL135854"],"award-info":[{"award-number":["HL135854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL147313"],"award-info":[{"award-number":["HL147313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["657293"],"award-info":[{"award-number":["657293"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007165","name":"University of Missouri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.redox.2022.102524","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T19:11:36Z","timestamp":1666984296000},"page":"102524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Nanoparticle endothelial delivery of PGC-1\u03b1 attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling"],"prefix":"10.1016","volume":"58","author":[{"given":"Dunpeng","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-8649","authenticated-orcid":false,"given":"Shi-You","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2022.102524_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024969","article-title":"Mortality in pulmonary arterial hypertension in the modern era: early insights from the pulmonary hypertension association registry","volume":"11","author":"Chang","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.redox.2022.102524_bib2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra035488","article-title":"Pulmonary arterial hypertension","volume":"351","author":"Farber","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2022.102524_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ccm.2013.08.009","article-title":"Pathology of pulmonary hypertension","volume":"34","author":"Tuder","year":"2013","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.redox.2022.102524_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-642-38664-0_3","article-title":"Pulmonary hypertension: pathology","volume":"218","author":"Dorfmuller","year":"2013","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.redox.2022.102524_bib5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s10439-005-9050-z","article-title":"Pulmonary vascular resistance and impedance in isolated mouse lungs: effects of pulmonary emboli","volume":"34","author":"Tuchscherer","year":"2006","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.redox.2022.102524_bib6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.drudis.2014.05.022","article-title":"How do we measure pathology in PAH (lung and RV) and what does it tell us about the disease","volume":"19","author":"Tuder","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.redox.2022.102524_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/2045893217752912","article-title":"Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)","volume":"8","author":"Ranchoux","year":"2018","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.redox.2022.102524_bib8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/CIRCULATIONAHA.114.008750","article-title":"Endothelial-to-mesenchymal transition in pulmonary hypertension","volume":"131","author":"Ranchoux","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102524_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8120639","article-title":"Endothelial to mesenchymal transition in pulmonary vascular diseases","volume":"8","author":"Yun","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.redox.2022.102524_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12964-019-0449-9","article-title":"Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-beta signalling: implications for PAH vascular remodelling","volume":"17","author":"de la Cuesta","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.redox.2022.102524_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092585","article-title":"TGF-Beta and BMPR2 signaling in PAH: two black sheep in one family","volume":"19","author":"Rol","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2022.102524_bib12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/resp.12712","article-title":"BMPR2 gene delivery reduces mutation-related PAH and counteracts TGF-beta-mediated pulmonary cell signalling","volume":"21","author":"Feng","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.redox.2022.102524_bib13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4097\/kjae.2010.58.1.4","article-title":"Nitric oxide and pulmonary hypertension","volume":"58","author":"Sim","year":"2010","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.redox.2022.102524_bib14","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1161\/01.ATV.20.8.1873","article-title":"Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy","volume":"20","author":"Channon","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2022.102524_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/CIRCRESAHA.116.306531","article-title":"Thirty years of saying NO: sources, fate, actions, and misfortunes of the endothelium-derived vasodilator mediator","volume":"119","author":"Vanhoutte","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2022.102524_bib16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1164\/rccm.201304-0686PP","article-title":"Nitric oxide deficiency and endothelial dysfunction in pulmonary arterial hypertension","volume":"188","author":"Klinger","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.redox.2022.102524_bib17","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1096\/fj.04-2317fje","article-title":"Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension","volume":"18","author":"Xu","year":"2004","journal-title":"Faseb. J."},{"key":"10.1016\/j.redox.2022.102524_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.767002","article-title":"Therapy for pulmonary arterial hypertension: glance on nitric oxide pathway","volume":"12","author":"Tettey","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.redox.2022.102524_bib19","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150076","article-title":"PGC-1\u03b1 overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice","volume":"35","author":"Zhao","year":"2015","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.redox.2022.102524_bib20","doi-asserted-by":"crossref","first-page":"L1233","DOI":"10.1152\/ajplung.00356.2015","article-title":"Suppression of endothelial PGC-1\u03b1 is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial hypertension","volume":"310","author":"Ye","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.redox.2022.102524_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/236572","article-title":"PGC-1\u03b1 induction in pulmonary arterial hypertension","volume":"2012","author":"Mata","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2022.102524_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cmet.2013.12.014","article-title":"Endothelial PGC-1\u03b1 mediates vascular dysfunction in diabetes","volume":"19","author":"Sawada","year":"2014","journal-title":"Cell Metabol."},{"key":"10.1016\/j.redox.2022.102524_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/srep38210","article-title":"PGC-1\u03b1 dictates endothelial function through regulation of eNOS expression","volume":"6","author":"Craige","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102524_bib24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.vph.2016.05.005","article-title":"PGC-1\u03b1 ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells","volume":"83","author":"Li","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.redox.2022.102524_bib25","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1086\/678508","article-title":"The Sugen 5416\/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up","volume":"4","author":"Vitali","year":"2014","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.redox.2022.102524_bib26","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/CIRCULATIONAHA.113.002434","article-title":"Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension","volume":"127","author":"Mouraret","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2022.102524_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110196","article-title":"Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA","volume":"38","author":"Zhang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2022.102524_bib28","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nprot.2010.76","article-title":"Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier","volume":"5","author":"Bernas","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.redox.2022.102524_bib29","first-page":"374","article-title":"The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye","volume":"22","author":"LeBlanc","year":"2016","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2022.102524_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1161\/CIRCIMAGING.109.887109","article-title":"Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension","volume":"3","author":"Thibault","year":"2010","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.redox.2022.102524_bib31","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1161\/01.RES.76.5.907","article-title":"Echocardiographic assessment of left ventricular mass and systolic function in mice","volume":"76","author":"Gardin","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2022.102524_bib32","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1113\/EP087117","article-title":"Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels","volume":"103","author":"Strielkov","year":"2018","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.redox.2022.102524_bib33","first-page":"50328","article-title":"Assessing murine resistance artery function using pressure myography","volume":"76","author":"Shahid","year":"2013","journal-title":"JoVE"},{"key":"10.1016\/j.redox.2022.102524_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1559-0275-11-4","article-title":"Efficient extraction of proteins from formalin-fixed paraffin-embedded tissues requires higher concentration of tris(hydroxymethyl)aminomethane","volume":"11","author":"Kawashima","year":"2014","journal-title":"Clin. Proteonomics"},{"key":"10.1016\/j.redox.2022.102524_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/a42e114f-a708-4423-8a3e-a1d8919b9b60","article-title":"Successful protein extraction from over-fixed and long-term stored formalin-fixed tissues","volume":"6","author":"Wolff","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2022.102524_bib36","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/ppul.23430","article-title":"Neonatal hyperoxia increases airway reactivity and inflammation in adult mice","volume":"51","author":"Kumar","year":"2016","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.redox.2022.102524_bib37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.21037\/sci.2017.05.11","article-title":"Rescuing BMPR2-driven endothelial dysfunction in PAH: a novel treatment strategy for the future?","volume":"4","author":"Quarck","year":"2017","journal-title":"Stem Cell Invest."},{"key":"10.1016\/j.redox.2022.102524_bib38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fimmu.2018.00294","article-title":"Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction","volume":"9","author":"Cho","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.redox.2022.102524_bib39","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s11095-016-1911-7","article-title":"Liposomal aerosols of nitric oxide (NO) donor as a long-acting substitute for the ultra-short-acting inhaled NO in the treatment of PAH","volume":"33","author":"Nahar","year":"2016","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.redox.2022.102524_bib40","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1183\/09031936.00010609","article-title":"Soluble guanylate cyclase stimulators as a potential therapy for PAH: enthusiasm, pragmatism and concern","volume":"33","author":"Michelakis","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.redox.2022.102524_bib41","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/art.30317","article-title":"Protein kinase Cdelta and c-Abl kinase are required for transforming growth factor beta induction of endothelial-mesenchymal transition in vitro","volume":"63","author":"Li","year":"2011","journal-title":"Arthritis Rheum."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722002968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722002968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:30:17Z","timestamp":1761978617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231722002968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":41,"alternative-id":["S2213231722002968"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102524","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoparticle endothelial delivery of PGC-1\u03b1 attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102524"}}