{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:54:51Z","timestamp":1792036491904,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"Europ\u00e4ische Kommission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BE2376\/8-1"],"award-info":[{"award-number":["BE2376\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CA1708\/1-1"],"award-info":[{"award-number":["CA1708\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["I04844"],"award-info":[{"award-number":["I04844"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P35271"],"award-info":[{"award-number":["P35271"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003494","name":"Herzfelder'sche Familienstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["859890"],"award-info":[{"award-number":["859890"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.redox.2022.102528","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T19:21:36Z","timestamp":1667244096000},"page":"102528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and \u2018inflammaging'"],"prefix":"10.1016","volume":"58","author":[{"given":"Annette","family":"Brandt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Hern\u00e1ndez-Arriaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Nier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaela","family":"Staltner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Rajcic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schmeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto W.","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Franzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lia","family":"Camarinha-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-4115","authenticated-orcid":false,"given":"Ina","family":"Bergheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10258","key":"10.1016\/j.redox.2022.102528_bib1","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0140-6736(20)30977-6","article-title":"Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2022.102528_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jnutbio.2015.08.013","article-title":"Nutritional modulation of gut microbiota - the impact on metabolic disease pathophysiology","volume":"28","author":"Ojeda","year":"2016","journal-title":"J. Nutr. Biochem."},{"issue":"11","key":"10.1016\/j.redox.2022.102528_bib3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.redox.2022.102528_bib4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/17474124.2017.1343143","article-title":"The intestinal barrier: a fundamental role in health and disease","volume":"11","author":"Vancamelbeke","year":"2017","journal-title":"Expet Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.redox.2022.102528_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.redox.2022.102528_bib6","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1373208","article-title":"Intestinal barrier and gut microbiota: shaping our immune responses throughout life","volume":"5","author":"Takiishi","year":"2017","journal-title":"Tissue Barriers"},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1755-8794-5-38","article-title":"Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL\/6J mice","volume":"5","author":"Steegenga","year":"2012","journal-title":"BMC Med. Genom."},{"issue":"5","key":"10.1016\/j.redox.2022.102528_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/jcp.45.5.450","article-title":"Ageing and duodenal morphometry","volume":"45","author":"Lipski","year":"1992","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.redox.2022.102528_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12979-017-0101-8","article-title":"Ileal antimicrobial peptide expression is dysregulated in old age","volume":"14","author":"Tremblay","year":"2017","journal-title":"Immun. Ageing"},{"issue":"9","key":"10.1016\/j.redox.2022.102528_bib10","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/gerona\/glt106","article-title":"Age-associated remodeling of the intestinal epithelial barrier","volume":"68","author":"Tran","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"10.1016\/j.redox.2022.102528_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s40520-013-0148-0","article-title":"Age-related changes in small intestinal mucosa epithelium architecture and epithelial tight junction in rat models","volume":"26","author":"Ren","year":"2014","journal-title":"Aging Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.redox.2022.102528_bib12","doi-asserted-by":"crossref","first-page":"151500","DOI":"10.1016\/j.ijmm.2021.151500","article-title":"Microbiota profiling in aging-associated inflammation and liver degeneration","volume":"311","author":"Baumann","year":"2021","journal-title":"Int. J. Med. Microbiol."},{"issue":"3","key":"10.1016\/j.redox.2022.102528_bib13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01297055","article-title":"Aging-associated increase in intestinal permeability to polyethylene glycol 900","volume":"32","author":"Katz","year":"1987","journal-title":"Dig. Dis. Sci."},{"issue":"6","key":"10.1016\/j.redox.2022.102528_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134049","article-title":"Intestinal alkaline phosphatase targets the gut barrier to prevent aging","volume":"5","author":"K\u00fchn","year":"2020","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.redox.2022.102528_bib15","doi-asserted-by":"crossref","first-page":"G736","DOI":"10.1152\/ajpgi.00345.2018","article-title":"Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels","volume":"318","author":"Jin","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib16","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41598-018-35228-3","article-title":"Age-associated impairment of the mucus barrier function is associated with profound changes in microbiota and immunity","volume":"9","author":"Sovran","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12866-016-0708-5","article-title":"Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study","volume":"16","author":"Odamaki","year":"2016","journal-title":"BMC Microbiol."},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib18","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12866-019-1616-2","article-title":"Aging progression of human gut microbiota","volume":"19","author":"Xu","year":"2019","journal-title":"BMC Microbiol."},{"issue":"4","key":"10.1016\/j.redox.2022.102528_bib19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.chom.2017.03.002","article-title":"Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction","volume":"21","author":"Thevaranjan","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib20","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41598-017-01751-y","article-title":"Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102528_bib21","doi-asserted-by":"crossref","first-page":"101879","DOI":"10.1016\/j.redox.2021.101879","article-title":"Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase","volume":"41","author":"Rajcic","year":"2021","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.redox.2022.102528_bib22","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/clinchem\/25.8.1440","article-title":"A simplified, colorimetric micromethod for xylose in serum or urine, with phloroglucinol","volume":"25","author":"Eberts","year":"1979","journal-title":"Clin. Chem."},{"issue":"9","key":"10.1016\/j.redox.2022.102528_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183282","article-title":"Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: studies in children","volume":"12","author":"Nier","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.redox.2022.102528_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051659","article-title":"Markers of intestinal permeability are rapidly improved by alcohol withdrawal in patients with alcohol-related liver disease","volume":"13","author":"Jung","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.redox.2022.102528_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chemosphere.2019.06.080","article-title":"Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice","volume":"234","author":"Liu","year":"2019","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.redox.2022.102528_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/nu9091013","article-title":"Short-term intake of a fructose-, fat- and cholesterol-rich diet causes hepatic steatosis in mice: effect of antibiotic treatment","volume":"9","author":"Brandt","year":"2017","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.redox.2022.102528_bib27","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1179\/2046023613Y.0000000032","article-title":"Immunohistochemical detection of arginase-I expression in formalin-fixed lung and other tissues","volume":"36","author":"Hochstedler","year":"2013","journal-title":"J. Histotechnol."},{"issue":"7","key":"10.1016\/j.redox.2022.102528_bib28","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/labinvest.2012.75","article-title":"Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function","volume":"92","author":"Spruss","year":"2012","journal-title":"Lab. Invest."},{"issue":"11","key":"10.1016\/j.redox.2022.102528_bib29","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1017\/S0007114515003621","article-title":"Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)","volume":"114","author":"Jin","year":"2015","journal-title":"Br. J. Nutr."},{"issue":"9","key":"10.1016\/j.redox.2022.102528_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7090283","article-title":"Changes in oral microbial ecology of C57BL\/6 mice at different ages associated with sampling methodology","volume":"7","author":"Hern\u00e1ndez-Arriaga","year":"2019","journal-title":"Microorganisms"},{"issue":"17","key":"10.1016\/j.redox.2022.102528_bib31","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"issue":"16","key":"10.1016\/j.redox.2022.102528_bib32","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.redox.2022.102528_bib33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2307\/1942268","article-title":"An ordination of the upland forest communities of southern Wisconsin","volume":"27","author":"Bray","year":"1957","journal-title":"Ecol. Monogr."},{"key":"10.1016\/j.redox.2022.102528_bib34","series-title":"Change in m arine com m unities: an Approach to Statistical Analysis a n d Interpretation","author":"Clarke","year":"2001"},{"key":"10.1016\/j.redox.2022.102528_bib35","series-title":"Change in marine Communities: an Approach to Statistical Analysis and Interpretation","first-page":"172","author":"Clarke","year":"2001"},{"issue":"6","key":"10.1016\/j.redox.2022.102528_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/3001968","article-title":"Individual comparisons by ranking methods","volume":"1","author":"Wilcoxon","year":"1945","journal-title":"Biometrics"},{"issue":"5","key":"10.1016\/j.redox.2022.102528_bib37","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/bioinformatics\/btw725","article-title":"Calypso: a user-friendly web-server for mining and visualizing microbiome-environment interactions","volume":"33","author":"Zakrzewski","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.redox.2022.102528_bib38","series-title":"R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing","author":"Core Team","year":"2020"},{"key":"10.1016\/j.redox.2022.102528_bib39","first-page":"100046","article-title":"Growth differentiation factor-15, a novel systemic biomarker of oxidative stress, inflammation, and cellular aging: potential role in cardiovascular diseases","volume":"9","author":"di Candia","year":"2021","journal-title":"AHJ Plus: Cardiol. Res. Pract."},{"issue":"8","key":"10.1016\/j.redox.2022.102528_bib40","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1161\/ATVBAHA.117.309451","article-title":"Plasminogen activator inhibitor-1 is a marker and a mediator of senescence","volume":"37","author":"Vaughan","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.redox.2022.102528_bib41","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/ijc.27316","article-title":"Cellular senescence and tumor suppressor gene p16","volume":"130","author":"Rayess","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"7","key":"10.1016\/j.redox.2022.102528_bib42","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.3390\/ijms20071755","article-title":"The role of nitric oxide in regulating intestinal redox status and intestinal epithelial cell functionality","volume":"20","author":"Mu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.redox.2022.102528_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3233\/NHA-170030","article-title":"Gut microbiome and aging: physiological and mechanistic insights","volume":"4","author":"Nagpal","year":"2018","journal-title":"Nutr. Healthy Aging"},{"key":"10.1016\/j.redox.2022.102528_bib44","doi-asserted-by":"crossref","first-page":"111077","DOI":"10.1016\/j.exger.2020.111077","article-title":"Effects of treadmill exercise on the regulation of tight junction proteins in aged mice","volume":"141","author":"Shin","year":"2020","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.redox.2022.102528_bib45","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1532-5415.1995.tb06382.x","article-title":"Changes in small-intestine permeability with aging","volume":"43","author":"Saltzman","year":"1995","journal-title":"J. Am. Geriatr. Soc."},{"issue":"4","key":"10.1016\/j.redox.2022.102528_bib46","article-title":"Small intestinal permeability in older adults","volume":"2","author":"Valentini","year":"2014","journal-title":"Phys. Rep."},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41598-019-57106-2","article-title":"Intestinal barrier function is maintained with aging \u2013 a comprehensive study in healthy subjects and irritable bowel syndrome patients","volume":"10","author":"Wilms","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2022.102528_bib48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0927-5193(03)80017-7","article-title":"Economic production of biopharmaceuticals by high-speed membrane adsorbers","author":"Demmer","year":"2003","journal-title":"Membr. Sci. Technol."},{"issue":"2","key":"10.1016\/j.redox.2022.102528_bib49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1096\/fasebj.8.2.8119492","article-title":"Bacterial endotoxin: molecular relationships of structure to activity and function","volume":"8","author":"Rietschel","year":"1994","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib50","first-page":"12","article-title":"For the assessment of intestinal permeability, size matters","volume":"19","author":"Vojdani","year":"2013","journal-title":"Alternative Ther. Health Med."},{"key":"10.1016\/j.redox.2022.102528_bib51","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10956","article-title":"Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction","volume":"5","author":"Regan","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.redox.2022.102528_bib52","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3389\/fimmu.2017.01385","article-title":"Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice","volume":"8","author":"Fransen","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.redox.2022.102528_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.17175","article-title":"Alterations of nitric oxide homeostasis as trigger of intestinal barrier dysfunction in non-alcoholic fatty liver disease","author":"Baumann","year":"2022","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.redox.2022.102528_bib54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00024382-200202000-00010","article-title":"Nitric oxide directly impairs intestinal barrier function","volume":"17","author":"Xu","year":"2002","journal-title":"Shock"},{"issue":"11","key":"10.1016\/j.redox.2022.102528_bib55","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1172\/JCI126923","article-title":"Arginase impedes the resolution of colitis by altering the microbiome and metabolome","volume":"130","author":"Baier","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"10 Suppl","key":"10.1016\/j.redox.2022.102528_bib56","doi-asserted-by":"crossref","first-page":"2760S","DOI":"10.1093\/jn\/134.10.2760S","article-title":"Structure and function of arginases","volume":"134","author":"Ash","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.redox.2022.102528_bib57","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3389\/fphys.2017.00682","article-title":"Arginase-II deficiency extends lifespan in mice","volume":"8","author":"Xiong","year":"2017","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.redox.2022.102528_bib58","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1476-5381.2011.01584.x","article-title":"Oxidative species increase arginase activity in endothelial cells through the RhoA\/Rho kinase pathway","volume":"165","author":"Chandra","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.redox.2022.102528_bib59","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1124\/mol.63.3.714","article-title":"Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylation","volume":"63","author":"Hunter","year":"2003","journal-title":"Mol. Pharmacol."},{"issue":"12","key":"10.1016\/j.redox.2022.102528_bib60","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1002\/ijc.22599","article-title":"IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src\/RhoA\/ROCK signaling pathway","volume":"120","author":"Lin","year":"2007","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.redox.2022.102528_bib61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12979-016-0076-x","article-title":"Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study","volume":"13","author":"Puzianowska-Ku\u017anicka","year":"2016","journal-title":"Immun. Ageing"},{"issue":"14","key":"10.1016\/j.redox.2022.102528_bib62","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1073\/pnas.1810692116","article-title":"Age-related inflammation triggers skeletal stem\/progenitor cell dysfunction","volume":"116","author":"Josephson","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722003007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231722003007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:28:06Z","timestamp":1761978486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231722003007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":62,"alternative-id":["S2213231722003007"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2022.102528","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and \u2018inflammaging'","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2022.102528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102528"}}