{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:55:37Z","timestamp":1787849737502,"version":"build-2784847793"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18H05277"],"award-info":[{"award-number":["18H05277"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["19K07341"],"award-info":[{"award-number":["19K07341"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20K07306"],"award-info":[{"award-number":["20K07306"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20K21496"],"award-info":[{"award-number":["20K21496"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21H05263"],"award-info":[{"award-number":["21H05263"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["S22098"],"award-info":[{"award-number":["S22098"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR2024"],"award-info":[{"award-number":["JPMJCR2024"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/19\/87\/34792"],"award-info":[{"award-number":["PG\/19\/87\/34792"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21zf0127001"],"award-info":[{"award-number":["JP21zf0127001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.redox.2023.102605","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T13:27:47Z","timestamp":1673357267000},"page":"102605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?"],"prefix":"10.1016","volume":"60","author":[{"given":"Kayleigh","family":"Griffiths","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Ida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reece J.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Frenneaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"Fukuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Akaike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Madhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.redox.2023.102605_bib1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1089\/ars.2017.7083","article-title":"The reactive species interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine","volume":"27","author":"Cortese-Krott","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"4","key":"10.1016\/j.redox.2023.102605_bib2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/tx2005234","article-title":"Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species","volume":"25","author":"Fukuto","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.redox.2023.102605_bib3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCRESAHA.118.311134","article-title":"Evolution of hydrogen sulfide therapeutics to treat cardiovascular disease","volume":"123","author":"Li","year":"2018","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.redox.2023.102605_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00395-017-0664-8","article-title":"Pre- and postconditioning the heart with hydrogen sulfide (H2S) against ischemia\/reperfusion injury in vivo: a systematic review and meta-analysis","volume":"113","author":"Karwi","year":"2018","journal-title":"Basic Res. Cardiol."},{"issue":"12","key":"10.1016\/j.redox.2023.102605_bib5","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/1873-3468.13090","article-title":"Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology","volume":"592","author":"Fukuto","year":"2018","journal-title":"FEBS Lett."},{"issue":"4\u20136","key":"10.1016\/j.redox.2023.102605_bib6","first-page":"244","article-title":"The biological\/physiological utility of hydropersulfides (RSSH) and related species: what is old is new again","volume":"36","author":"Fukuto","year":"2021","journal-title":"Antioxidants Redox Signal."},{"issue":"1","key":"10.1016\/j.redox.2023.102605_bib7","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s41467-017-01311-y","article-title":"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics","volume":"8","author":"Akaike","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.redox.2023.102605_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1021\/jacs.5b10494","article-title":"Biosynthesis and reactivity of cysteine persulfides in signaling","volume":"138","author":"Yadav","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.redox.2023.102605_bib9","doi-asserted-by":"crossref","first-page":"5672","DOI":"10.1038\/s41467-021-25798-8","article-title":"Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase","volume":"12","author":"Meng","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.redox.2023.102605_bib10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/bph.14372","article-title":"The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems","volume":"176","author":"Bianco","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.redox.2023.102605_bib11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1021\/acs.chemrestox.8b00340","article-title":"The uptake and release of polysulfur cysteine species by cells: physiological and toxicological implications","volume":"32","author":"Lin","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.redox.2023.102605_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102155","article-title":"Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells","volume":"47","author":"Switzer","year":"2021","journal-title":"Redox Biol."},{"issue":"39","key":"10.1016\/j.redox.2023.102605_bib13","doi-asserted-by":"crossref","first-page":"11749","DOI":"10.1002\/anie.201704117","article-title":"An esterase-sensitive prodrug approach for controllable delivery of persulfide species","volume":"56","author":"Zheng","year":"2017","journal-title":"Angew Chem. Int. Ed. Engl."},{"issue":"5","key":"10.1016\/j.redox.2023.102605_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11051010","article-title":"Hydropersulfides (RSSH) outperform post-conditioning and other reactive sulfur species in limiting ischemia-reperfusion injury in the isolated mouse heart","volume":"11","author":"Pharoah","year":"2022","journal-title":"Antioxidants"},{"issue":"25","key":"10.1016\/j.redox.2023.102605_bib15","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.redox.2023.102605_bib16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: the evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102605_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107819","article-title":"Nitrite and myocardial ischaemia reperfusion injury. Where are we now?","volume":"223","author":"Griffiths","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.redox.2023.102605_bib18","doi-asserted-by":"crossref","first-page":"C12","DOI":"10.1152\/ajpcell.00131.2021","article-title":"Mitochondrial redox regulation and myocardial ischemia-reperfusion injury","volume":"322","author":"Chen","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"6","key":"10.1016\/j.redox.2023.102605_bib19","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1155\/2013\/974358","article-title":"Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage","volume":"35","author":"Rodrigo","year":"2013","journal-title":"Dis. Markers"},{"issue":"2","key":"10.1016\/j.redox.2023.102605_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0045-2068(80)90026-7","article-title":"Persulfide properties of thiocystine and related trisulfides","volume":"9","author":"Abdolrasulnia","year":"1980","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.redox.2023.102605_bib21","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1021\/acs.chemrestox.9b00494","article-title":"Cysteine trisulfide protects E. coli from electrophile-induced death through the generation of cysteine hydropersulfide","volume":"33","author":"Henderson","year":"2020","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.redox.2023.102605_bib22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.chembiol.2019.02.003","article-title":"Enhanced cellular polysulfides negatively regulate TLR4 signaling and mitigate lethal endotoxin shock","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem Biol"},{"issue":"34","key":"10.1016\/j.redox.2023.102605_bib23","doi-asserted-by":"crossref","first-page":"15825","DOI":"10.1021\/jacs.2c06804","article-title":"Hydropersulfides inhibit lipid peroxidation and protect cells from ferroptosis","volume":"144","author":"Wu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.redox.2023.102605_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41589-022-01145-w","article-title":"Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals","volume":"19","author":"Barayeu","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102605_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102433","article-title":"Shining a light on SSP4: a comprehensive analysis and biological applications for the detection of sulfane sulfurs","volume":"56","author":"Shieh","year":"2022","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.redox.2023.102605_bib26","doi-asserted-by":"crossref","first-page":"H827","DOI":"10.1152\/ajpheart.00129.2010","article-title":"Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury","volume":"299","author":"Madhani","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.redox.2023.102605_bib27","first-page":"5231","article-title":"The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia\/reperfusion injury","volume":"15","author":"Prompunt","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.redox.2023.102605_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.niox.2021.09.002","article-title":"Methods in sulfide and persulfide research","volume":"116","author":"Takata","year":"2021","journal-title":"Nitric Oxide"},{"issue":"21","key":"10.1016\/j.redox.2023.102605_bib29","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.redox.2023.102605_bib30","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/cbic.202000661","article-title":"Hydrogen sulfide oxidation by sulfide quinone oxidoreductase","volume":"22","author":"Landry","year":"2021","journal-title":"Chembiochem"},{"issue":"Suppl 1","key":"10.1016\/j.redox.2023.102605_bib31","doi-asserted-by":"crossref","first-page":"2494S","DOI":"10.1093\/jn\/nxaa094","article-title":"Metabolism of sulfur-containing amino acids: how the body copes with excess methionine, cysteine, and sulfide","volume":"150","author":"Stipanuk","year":"2020","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.redox.2023.102605_bib32","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1038\/s41467-021-23363-x","article-title":"Sulfide catabolism ameliorates hypoxic brain injury","volume":"12","author":"Marutani","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.redox.2023.102605_bib33","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1515\/cclm-2012-0551","article-title":"Hydrogen sulfide as an oxygen sensor","volume":"51","author":"Olson","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.redox.2023.102605_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101113","article-title":"Pushing arterial-venous plasma biomarkers to new heights: a model for personalised redox metabolomics?","volume":"21","author":"Cumpstey","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102605_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102486","article-title":"The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species","volume":"57","author":"Switzer","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102605_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.911564","article-title":"Roles of ferroptosis in cardiovascular diseases","volume":"9","author":"Guo","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.redox.2023.102605_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108391","article-title":"The reactions of hydropersulfides (RSSH) with myoglobin","volume":"687","author":"Alvarez","year":"2020","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172300006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172300006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:31:21Z","timestamp":1761978681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221323172300006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":37,"alternative-id":["S221323172300006X"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102605","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102605"}}