{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:27:11Z","timestamp":1790141231491,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM121307"],"award-info":[{"award-number":["GM121307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008246","name":"Tufts University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012612","name":"LSU Health Shreveport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.redox.2023.102620","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T21:49:18Z","timestamp":1675201758000},"page":"102620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia"],"prefix":"10.1016","volume":"60","author":[{"given":"Eiki","family":"Kanemaru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizo","family":"Marutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Ezaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsaku","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuo","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4535-1632","authenticated-orcid":false,"given":"Fumito","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102620_bib1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1136\/heartjnl-2013-305131","article-title":"Surgical management of thoracoabdominal aneurysms","volume":"100","author":"Ziganshin","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.redox.2023.102620_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ejvs.2016.06.005","article-title":"Editor's choice - management of descending thoracic aorta diseases: clinical practice guidelines of the European society for vascular surgery (ESVS)","volume":"53","author":"Riambau","year":"2017","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.redox.2023.102620_bib3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jtcvs.2007.11.002","article-title":"Paraplegia after extensive thoracic and thoracoabdominal aortic aneurysm repair: does critical spinal cord ischemia occur postoperatively?","volume":"135","author":"Etz","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.redox.2023.102620_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jvs.2011.03.259","article-title":"Risk factors, outcomes, and clinical manifestations of spinal cord ischemia following thoracic endovascular aortic repair","volume":"54","author":"Ullery","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.redox.2023.102620_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuint.2013.11.002","article-title":"Role of hydrogen sulfide in secondary neuronal injury","volume":"64","author":"Wang","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.redox.2023.102620_bib6","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/STROKEAHA.110.600429","article-title":"Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice","volume":"42","author":"Kakinohana","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.redox.2023.102620_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2023.102620_bib8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/bph.14579","article-title":"Signalling by hydrogen sulfide and polysulfides via protein S-sulfuration","volume":"177","author":"Kimura","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2023.102620_bib9","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2023.102620_bib10","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3390\/biom10091245","article-title":"Enzymatic regulation and biological functions of reactive cysteine persulfides and polysulfides","volume":"10","author":"Sawa","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.redox.2023.102620_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2019.02.003","article-title":"Enhanced cellular polysulfides negatively regulate TLR4 signaling and mitigate lethal endotoxin shock","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102620_bib12","article-title":"Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals","author":"Barayeu","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102620_bib13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1089\/ars.2014.5869","article-title":"Signaling molecules: hydrogen sulfide and polysulfide","volume":"22","author":"Kimura","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2023.102620_bib14","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1074\/jbc.RA119.012357","article-title":"Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation","volume":"295","author":"Braunstein","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102620_bib15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.freeradbiomed.2018.12.003","article-title":"Breathing hydrogen sulfide prevents delayed paraplegia in mice","volume":"131","author":"Kakinohana","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102620_bib16","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1476-5381.2010.00704.x","article-title":"A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood","volume":"160","author":"Wintner","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2023.102620_bib17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/bph.14372","article-title":"The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems","volume":"176","author":"Bianco","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2023.102620_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep41984","article-title":"Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors","volume":"7","author":"Kunikata","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102620_bib19","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1136\/thoraxjnl-2016-209359","article-title":"Production of reactive persulfide species in chronic obstructive pulmonary disease","volume":"72","author":"Numakura","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/j.redox.2023.102620_bib20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fphar.2014.00196","article-title":"Glutathione: new roles in redox signaling for an old antioxidant","volume":"5","author":"Aquilano","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.redox.2023.102620_bib21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroscience.2013.07.017","article-title":"Oral administration of glutathione improves memory deficits following transient brain ischemia by reducing brain oxidative stress","volume":"250","author":"Yabuki","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.redox.2023.102620_bib22","first-page":"225","article-title":"Glutathione disulfide liposomes - a research tool for the study of glutathione disulfide associated functions and dysfunctions","volume":"7","author":"Sadhu","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.redox.2023.102620_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1582-4934.2004.tb00275.x","article-title":"From redox regulation of protein functions to human diseases","volume":"8","author":"Giustarini","year":"2004","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2023.102620_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2010.3540","article-title":"From molecular mechanisms to health outcomes","volume":"15","author":"Xiong","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2023.102620_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3390\/ijms22010403","article-title":"Natural molecules and neuroprotection: kynurenic acid, pantethine and \u03b1-lipoic acid","volume":"22","author":"T\u00f3th","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2023.102620_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/brain\/awt325","article-title":"Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model","volume":"137","author":"Brunetti","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.redox.2023.102620_bib27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s13311-019-00754-z","article-title":"Long-term pantethine treatment counteracts pathologic gene dysregulation and decreases alzheimer's disease pathogenesis in a transgenic mouse model","volume":"16","author":"Baranger","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.redox.2023.102620_bib28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2010.12.025","article-title":"Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia","volume":"174","author":"Smith","year":"2012","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.redox.2023.102620_bib29","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1161\/CIRCULATIONAHA.111.080275","article-title":"The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury","volume":"126","author":"Smith","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2023.102620_bib30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","article-title":"Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration","volume":"127","author":"Thorne","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.redox.2023.102620_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1517\/17425247.2013.751372","article-title":"Current options for drug delivery to the spinal cord","volume":"10","author":"Rossi","year":"2013","journal-title":"Expet Opin. Drug Deliv."},{"key":"10.1016\/j.redox.2023.102620_bib32","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/ana.22421","article-title":"The blood-spinal cord barrier: morphology and clinical implications","volume":"70","author":"Bartanusz","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.redox.2023.102620_bib33","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/ALN.0b013e3181ec61ee","article-title":"A mouse model of ischemic spinal cord injury with delayed paralysis caused by aortic cross-clamping","volume":"113","author":"Awad","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.redox.2023.102620_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.redox.2023.102620_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.niox.2021.09.002","article-title":"Methods in sulfide and persulfide research","volume":"116","author":"Takata","year":"2021","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.redox.2023.102620_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101096","article-title":"Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis","volume":"21","author":"Hamid","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102620_bib37","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1089\/ars.2020.8073","article-title":"High-precision sulfur metabolomics innovated by a new specific probe for trapping reactive sulfur species","volume":"34","author":"Kasamatsu","year":"2021","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2023.102620_bib38","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1039\/C6CC08372B","article-title":"Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application","volume":"53","author":"Takano","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.redox.2023.102620_bib39","doi-asserted-by":"crossref","first-page":"32124","DOI":"10.1074\/jbc.M112.374124","article-title":"A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death","volume":"287","author":"Marutani","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102620_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.redox.2023.102620_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102155","article-title":"Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells","volume":"47","author":"Switzer","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102620_bib42","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/13880209.2018.1502326","article-title":"Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2\/HO-1 pathway","volume":"56","author":"Gao","year":"2018","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.redox.2023.102620_bib43","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1161\/CIRCULATIONAHA.112.000024","article-title":"Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury","volume":"128","author":"Bell","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2023.102620_bib44","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.STR.32.5.1208","article-title":"Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain","volume":"32","author":"Ito","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.redox.2023.102620_bib45","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1039\/C4MD00180J","article-title":"Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur","volume":"5","author":"Marutani","year":"2014","journal-title":"Medchemcomm"},{"key":"10.1016\/j.redox.2023.102620_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002125","article-title":"Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia","volume":"4","author":"Marutani","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.redox.2023.102620_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/426069","article-title":"Glutathione suppresses cerebral infarct volume and cell death after ischemic injury: involvement of FOXO3 inactivation and Bcl2 expression","volume":"2015","author":"Song","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102620_bib48","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/jnen\/nlz128","article-title":"Intranasal methylprednisolone effectively reduces neuroinflammation in mice with experimental autoimmune encephalitis","volume":"79","author":"Rassy","year":"2020","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"Suppl 3","key":"10.1016\/j.redox.2023.102620_bib49","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2202-9-S3-S5","article-title":"Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease","volume":"9","author":"Hanson","year":"2008","journal-title":"BMC Neurosci."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723000216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723000216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:30:46Z","timestamp":1761978646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723000216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":49,"alternative-id":["S2213231723000216"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102620","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102620"}}