{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:53:58Z","timestamp":1792000438903,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA217797"],"award-info":[{"award-number":["P01 CA217797"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA244091"],"award-info":[{"award-number":["P01 CA244091"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA256301"],"award-info":[{"award-number":["R21 CA256301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA078586"],"award-info":[{"award-number":["T32 CA078586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001634","name":"Gateway for Cancer Research","doi-asserted-by":"publisher","award":["G-17-1500"],"award-info":[{"award-number":["G-17-1500"]}],"id":[{"id":"10.13039\/100001634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015515","name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa","doi-asserted-by":"publisher","award":["P30 CA086862"],"award-info":[{"award-number":["P30 CA086862"]}],"id":[{"id":"10.13039\/100015515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.redox.2023.102651","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T02:10:45Z","timestamp":1678155045000},"page":"102651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7581-1172","authenticated-orcid":false,"given":"M.S.","family":"Petronek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Teferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Caster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Stolwijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Buatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.I.","family":"Wafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.G.","family":"Gillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"St \u2013 Aubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.R.","family":"Buettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Spitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.A.","family":"Magnotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.G.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102651_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2017.02.018","article-title":"O2 \u2212 and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate","volume":"31","author":"Schoenfeld","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2023.102651_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00280-013-2070-8","article-title":"Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial","volume":"71","author":"Welsh","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.redox.2023.102651_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029794","article-title":"Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer","volume":"7","author":"Monti","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102651_bib4","doi-asserted-by":"crossref","first-page":"222ra18","DOI":"10.1126\/scitranslmed.3007154","article-title":"High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy","volume":"6","author":"Ma","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.redox.2023.102651_bib5","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1158\/1078-0432.CCR-19-0594","article-title":"First-in-Human phase I clinical trial of pharmacologic ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma","volume":"25","author":"Allen","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.redox.2023.102651_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.redox.2017.09.012","article-title":"Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models","volume":"14","author":"Schoenfeld","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102651_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2307\/3579271","article-title":"Catalytic metals, ascorbate and free radicals: combinations to avoid","volume":"145","author":"Buettner","year":"1996","journal-title":"Radiat. Res."},{"key":"10.1016\/j.redox.2023.102651_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.redox.2013.11.005","article-title":"Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer","volume":"2","author":"Moser","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102651_bib9","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0891-5849(99)00002-7","article-title":"Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations: an electron paramagnetic resonance spin trapping study","volume":"26","author":"Qian","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102651_bib10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2307\/3579270","article-title":"Fenton chemistry: an introduction","volume":"145","author":"Wardman","year":"1996","journal-title":"Radiat. Res."},{"key":"10.1016\/j.redox.2023.102651_bib11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3390\/cancers11081077","article-title":"Linking cancer metabolic dysfunction and genetic instability through the lens of iron metabolism","volume":"11","author":"Petronek","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.redox.2023.102651_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mrfmmm.2003.08.004","article-title":"Labile iron pool: the main determinant of cellular response to oxidative stress","volume":"531","author":"Kruszewski","year":"2003","journal-title":"Mutat. Res. Fund Mol. Mech. Mutagen"},{"key":"10.1016\/j.redox.2023.102651_bib13","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1517\/14656560903224998","article-title":"Ferumoxytol for treatment of iron deficiency anemia in patients with chronic kidney disease","volume":"10","author":"Coyne","year":"2009","journal-title":"Expet Opin. Pharmacother."},{"key":"10.1016\/j.redox.2023.102651_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1159\/000087212","article-title":"Pharmacokinetic study of ferumoxytol: a new iron replacement therapy in normal subjects and hemodialysis patients","volume":"25","author":"Landry","year":"2005","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.redox.2023.102651_bib15","article-title":"Diagnosis of pseudoprogression using ferumoxytol perfusion MRI in patients with glioblastoma to predict better outcome","volume":"32","author":"Neuwelt","year":"2014","journal-title":"J. Clin. Orthod."},{"key":"10.1016\/j.redox.2023.102651_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2217\/cns.14.42","article-title":"Diagnosis of pseudoprogression using MRI perfusion in patients with glioblastoma multiforme may predict improved survival","volume":"3","author":"Gahramanov","year":"2014","journal-title":"CNS Oncology"},{"key":"10.1016\/j.redox.2023.102651_bib17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.addr.2019.01.005","article-title":"Iron oxide nanoparticles: diagnostic, therapeutic and theranostic applications","volume":"138","author":"Dadfar","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.redox.2023.102651_bib18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1227\/01.NEU.0000255350.71700.37","article-title":"The potential of ferumoxytol nanoparticle magnetic resonance imaging, perfusion, and angiography in central nervous system malignancy: a pilot study","volume":"60","author":"Neuwelt","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1016\/j.redox.2023.102651_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.kint.2016.12.037","article-title":"Current and potential imaging applications of ferumoxytol for magnetic resonance imaging","volume":"92","author":"Toth","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.redox.2023.102651_bib20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41565-019-0406-1","article-title":"FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels","volume":"14","author":"Trujillo-Alonso","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.redox.2023.102651_bib21","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/nnano.2016.168","article-title":"Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues","volume":"11","author":"Zanganeh","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.redox.2023.102651_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/jrr\/rrac008","article-title":"Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study","author":"Petronek","year":"2022","journal-title":"Journal of Radiation Research rrac008"},{"key":"10.1016\/j.redox.2023.102651_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-022X(88)90100-5","article-title":"In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals","volume":"16","author":"Buettner","year":"1988","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/j.redox.2023.102651_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00305-7","article-title":"Quantum chemical insight into the effects of the local electron environment on T2*-based MRI","volume":"11","author":"Petronek","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102651_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/10715769009145927","article-title":"Ascorbate oxidation: UV absorbance of ascorbate and ESR spectroscopy of the ascorbyl radical as assays for iron","volume":"10","author":"Buettner","year":"1990","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.redox.2023.102651_bib26","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1038\/srep05955","article-title":"Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study","volume":"4","author":"Moji\u0107","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102651_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170442","article-title":"Peroxiporin expression is an important factor for cancer cell susceptibility to therapeutic H2O2: implications for pharmacological ascorbate therapy","volume":"12","author":"Erudaitius","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102651_bib28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1006\/abbi.1996.0268","article-title":"Extracellular iron(II) can protect cells from hydrogen peroxide","volume":"330","author":"Hempel","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.redox.2023.102651_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.redox.2017.08.017","article-title":"Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells","volume":"14","author":"Brandt","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102651_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-022X(88)90100-5","article-title":"In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals","volume":"16","author":"Buettner","year":"1988","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/j.redox.2023.102651_bib31","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1124\/jpet.118.252809","article-title":"Single dose of a polyanhydride particle-based vaccine generates potent antigen-specific antitumor immune responses","volume":"370","author":"Wafa","year":"2019","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.redox.2023.102651_bib32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.actbio.2017.01.005","article-title":"The effect of polyanhydride chemistry in particle-based cancer vaccines on the magnitude of the anti-tumor immune response","volume":"50","author":"Wafa","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2023.102651_bib33","doi-asserted-by":"crossref","DOI":"10.1021\/ac60289a016","article-title":"Ferrozine-A new spectrophotometric reagent for iron","volume":"42","author":"Stookey","year":"1970","journal-title":"Anal. Chem."},{"key":"10.1016\/j.redox.2023.102651_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910880","article-title":"Utilization of pharmacological ascorbate to enhance hydrogen peroxide-mediated radiosensitivity in cancer therapy","volume":"22","author":"Mehdi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2023.102651_bib35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.redox.2013.11.005","article-title":"Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer","volume":"2","author":"Moser","year":"2013","journal-title":"Redox Biol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723000526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723000526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:35:24Z","timestamp":1761978924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723000526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":35,"alternative-id":["S2213231723000526"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102651","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102651","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102651"}}