{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:31:23Z","timestamp":1793331083518,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172381"],"award-info":[{"award-number":["82172381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.redox.2023.102707","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T17:22:01Z","timestamp":1682011321000},"page":"102707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":192,"special_numbering":"C","title":["The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3"],"prefix":"10.1016","volume":"62","author":[{"given":"Jian","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanqi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-0108","authenticated-orcid":false,"given":"Jiangang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102707_bib1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1186\/s12913-019-4773-y","article-title":"A national intervention to reduce imaging for low back pain by general practitioners: a retrospective economic program evaluation using Medicare Benefits Schedule data","volume":"19","author":"Morgan","year":"2019","journal-title":"BMC Health Serv. Res."},{"key":"10.1016\/j.redox.2023.102707_bib2","article-title":"Comparison of the effectiveness and outcome of microendoscopic and open discectomy in patients suffering from lumbar disc herniation","volume":"98","author":"Yadav","year":"2019","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.redox.2023.102707_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.berh.2010.10.002","article-title":"The Epidemiology of low back pain","volume":"24","author":"Hoy","year":"2010","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.redox.2023.102707_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.redox.2023.102707_bib5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41419-020-02882-3","article-title":"The circular RNA circ-GRB10 participates in the molecular circuitry inhibiting human intervertebral disc degeneration","volume":"11","author":"Guo","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2023.102707_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101733","article-title":"The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration","volume":"81","author":"Sun","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.redox.2023.102707_bib7","first-page":"1","article-title":"Cell senescence: a nonnegligible cell state under survival stress in pathology of intervertebral disc degeneration","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102707_bib8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.joca.2015.03.028","article-title":"Mechanics and biology in intervertebral disc degeneration: a vicious circle","volume":"23","author":"Vergroesen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.redox.2023.102707_bib9","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1097\/01.brs.0000146101.53784.b1","article-title":"Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix","volume":"29","author":"Roughley","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.redox.2023.102707_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arr.2007.08.001","article-title":"The cell biology of intervertebral disc aging and degeneration","volume":"6","author":"Zhao","year":"2007","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.redox.2023.102707_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00292-013-1813-y","article-title":"In-situ-Analyse von Pathomechanismen der humanen Bandscheibendegeneration","volume":"34","author":"Weiler","year":"2013","journal-title":"For. Pathol."},{"key":"10.1016\/j.redox.2023.102707_bib12","first-page":"1307","volume":"20","author":"Buckwalter","year":"1995","journal-title":"Aging and Degeneration of the Human Intervertebral Disc:, Spine."},{"key":"10.1016\/j.redox.2023.102707_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/2958584","article-title":"CGRP regulates nucleus pulposus cell apoptosis and inflammation via the MAPK\/NF-\u03baB signaling pathways during intervertebral disc degeneration","volume":"2021","author":"Sun","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102707_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.wneu.2019.05.169","article-title":"A preliminary attempt of nonintervention in the treatment of patients with intervertebral disc calcification combined with ossification of the posterior longitudinal ligament","volume":"129","author":"Zhu","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.redox.2023.102707_bib15","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/15384101.2021.1911914","article-title":"Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL-1\u03b2-induced extracellular matrix degradation","volume":"20","author":"Sun","year":"2021","journal-title":"Cell Cycle"},{"key":"10.1016\/j.redox.2023.102707_bib16","doi-asserted-by":"crossref","first-page":"e01426","DOI":"10.1128\/mBio.01426-14","article-title":"Apoptosis-like death, an extreme SOS response in Escherichia coli","volume":"5","author":"Erental","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.redox.2023.102707_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102707_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7515346","article-title":"Programmed cell death pathways in the pathogenesis of systemic lupus erythematosus","volume":"2019","author":"Yang","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.redox.2023.102707_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.arr.2015.04.002","article-title":"Programmed cell death in aging","volume":"23","author":"Tower","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.redox.2023.102707_bib20","doi-asserted-by":"crossref","first-page":"8813","DOI":"10.7150\/thno.62521","article-title":"Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment","volume":"11","author":"Hsu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.redox.2023.102707_bib21","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2023.102707_bib22","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.redox.2023.102707_bib23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2018.09.043","article-title":"The development of the concept of ferroptosis","volume":"133","author":"Hirschhorn","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102707_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol.J Hematol Oncol."},{"key":"10.1016\/j.redox.2023.102707_bib25","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s13311-020-00929-z","article-title":"FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson's disease","volume":"17","author":"Tian","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.redox.2023.102707_bib26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41590-020-0699-0","article-title":"Redox homeostasis maintained by GPX4 facilitates STING activation","volume":"21","author":"Jia","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.redox.2023.102707_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102707_bib28","first-page":"55","article-title":"Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis, Free Radic","volume":"171","author":"Zhou","year":"2021","journal-title":"Biol. Med."},{"key":"10.1016\/j.redox.2023.102707_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101947","article-title":"NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases","volume":"41","author":"Park","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102707_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6643382","article-title":"Crosstalk between oxidative stress and ferroptosis\/oxytosis in ischemic stroke: possible targets and molecular mechanisms","volume":"2021","author":"Ren","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102707_bib31","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1002\/jcp.29727","article-title":"SIRT3 deficiency is resistant to autophagy\u2010dependent ferroptosis by inhibiting the AMPK\/mTOR pathway and promoting GPX4 levels","volume":"235","author":"Han","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2023.102707_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2021.04.007","article-title":"SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition","volume":"510","author":"Liu","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.redox.2023.102707_bib33","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1002\/jcp.30319","article-title":"SIRT3 mitigates intervertebral disc degeneration by delaying oxidative stress\u2010induced senescence of nucleus pulposus cells","volume":"236","author":"Lin","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2023.102707_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2020.04.016","article-title":"Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function","volume":"508","author":"Zhang","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.redox.2023.102707_bib35","first-page":"9180","article-title":"SIRT3 retards intervertebral disc degeneration by anti-oxidative stress by activating the SIRT3\/FOXO3\/SOD2 signaling pathway","volume":"23","author":"Zhou","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.redox.2023.102707_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/cells7030022","article-title":"Receptor tyrosine kinase ubiquitination and de-ubiquitination in signal transduction and receptor trafficking","volume":"7","author":"Critchley","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.redox.2023.102707_bib37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ebiom.2019.08.061","article-title":"USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediated activation of ERK\/MAPK signaling pathway","volume":"48","author":"Sun","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2023.102707_bib38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41392-021-00580-w","article-title":"The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP","volume":"6","author":"Zhu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2023.102707_bib39","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/s41388-021-01660-5","article-title":"The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2","volume":"40","author":"Meng","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2023.102707_bib40","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.omtm.2021.01.015","article-title":"A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage","volume":"21","author":"Zhang","year":"2021","journal-title":"Mol. Ther. - Methods Clin. Dev."},{"key":"10.1016\/j.redox.2023.102707_bib41","article-title":"Gamabufotalin inhibits osteoclastgenesis and counteracts estrogen-deficient bone loss in mice by suppressing RANKL-induced NF-\u03baB and ERK\/MAPK pathways","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.redox.2023.102707_bib42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbrc.2022.03.001","article-title":"SIRT3 improves bone regeneration and rescues diabetic fracture healing by regulating oxidative stress","volume":"604","author":"Huang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2023.102707_bib43","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41419-019-1978-2","article-title":"CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p\/SIRT1 axis","volume":"10","author":"Xie","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2023.102707_bib44","doi-asserted-by":"crossref","first-page":"14565","DOI":"10.1074\/jbc.M110.104745","article-title":"Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair","volume":"285","author":"Wiltshire","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102707_bib45","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/cdd.2014.234","article-title":"USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics","volume":"22","author":"Lee","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2023.102707_bib46","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1038\/s41467-021-25459-w","article-title":"USP11 controls R-loops by regulating senataxin proteostasis","volume":"12","author":"Jurga","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102707_bib47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41392-021-00834-7","article-title":"MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3R\u03b1","volume":"7","author":"Feng","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2023.102707_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110354","article-title":"K48\/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy","volume":"38","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2023.102707_bib49","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41556-021-00732-8","article-title":"TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination","volume":"23","author":"Zhu","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2023.102707_bib50","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1038\/s41467-020-16587-w","article-title":"Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102707_bib51","doi-asserted-by":"crossref","first-page":"15856","DOI":"10.1073\/pnas.1004621107","article-title":"Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense","volume":"107","author":"Arimoto","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2023.102707_bib52","doi-asserted-by":"crossref","first-page":"20705","DOI":"10.1073\/pnas.0907052106","article-title":"Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation","volume":"106","author":"Harreman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2023.102707_bib53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.5455\/medarh.2019.73.421-424","article-title":"A brief review of the degenerative intervertebral disc disease","volume":"73","author":"Kos","year":"2019","journal-title":"Med. Arch."},{"key":"10.1016\/j.redox.2023.102707_bib54","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41419-019-1701-3","article-title":"Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1\/Nrf2\/p62 feedback loop to protect intervertebral disc from degeneration","volume":"10","author":"Tang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2023.102707_bib55","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.spinee.2021.04.016","article-title":"Intervertebral disc degeneration relates to biomechanical changes of spinal ligaments","volume":"21","author":"Cornaz","year":"2021","journal-title":"Spine J."},{"key":"10.1016\/j.redox.2023.102707_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.334","article-title":"Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo","volume":"7","author":"Chen","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2023.102707_bib57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11357-009-9121-4","article-title":"Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats","volume":"32","author":"Zhao","year":"2010","journal-title":"Age"},{"key":"10.1016\/j.redox.2023.102707_bib58","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrrheum.2010.213","article-title":"The role of mitochondria in osteoarthritis","volume":"7","author":"Blanco","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.redox.2023.102707_bib59","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1111\/bph.12453","article-title":"Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration","volume":"171","author":"Osellame","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2023.102707_bib60","doi-asserted-by":"crossref","first-page":"16224","DOI":"10.18632\/aging.103644","article-title":"SirT3 activates AMPK-related mitochondrial biogenesis and ameliorates sepsis-induced myocardial injury","volume":"12","author":"Xin","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.redox.2023.102707_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101915","article-title":"Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis","volume":"41","author":"Guo","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102707_bib62","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jchemneu.2017.11.009","article-title":"Mitochondrial SIRT3 and neurodegenerative brain disorders","volume":"95","author":"Anamika","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.redox.2023.102707_bib63","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.ccell.2019.05.002","article-title":"Non-oncogene addiction to SIRT3 plays a critical role in lymphomagenesis","volume":"35","author":"Li","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2023.102707_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6694964","article-title":"Promoting nrf2\/sirt3-dependent mitophagy suppresses apoptosis in nucleus pulposus cells and protects against intervertebral disc degeneration","volume":"2021","author":"Hu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102707_bib65","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2022.09.022","article-title":"Programmed cell death: past, present and future","volume":"633","author":"Kopeina","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2023.102707_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6670497","article-title":"Ferroportin-dependent iron homeostasis protects against oxidative stress-induced nucleus pulposus cell ferroptosis and ameliorates intervertebral disc degeneration in vivo","volume":"2021","author":"Lu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102707_bib67","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.joca.2021.06.010","article-title":"Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration","volume":"29","author":"Zhang","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.redox.2023.102707_bib68","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2022.05.024","article-title":"NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2\/Gpx4 pathway","volume":"187","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102707_bib69","first-page":"1","article-title":"The molecular mechanisms of regulating oxidative stress-induced ferroptosis and therapeutic strategy in tumors","volume":"2020","author":"Zhu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102707_bib70","article-title":"Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.redox.2023.102707_bib71","first-page":"1","article-title":"Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration","volume":"50","author":"Wang","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.redox.2023.102707_bib72","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cbpa.2019.11.012","article-title":"Targeted protein degradation: current and future challenges","volume":"56","author":"Hanzl","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102707_bib73","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/nm.3739","article-title":"Ubiquitination in disease pathogenesis and treatment","volume":"20","author":"Popovic","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.redox.2023.102707_bib74","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3390\/ijms19041080","article-title":"Ubiquitin system","volume":"19","author":"Nakamura","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2023.102707_bib75","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1021\/acs.jmedchem.9b01138","article-title":"Advances in discovering deubiquitinating enzyme (DUB) inhibitors","volume":"63","author":"Schauer","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.redox.2023.102707_bib76","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc6093","article-title":"Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization","volume":"7","author":"Chiang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2023.102707_bib77","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1111\/jcmm.16709","article-title":"USP11 degrades KLF4 via its deubiquitinase activity in liver diseases","volume":"25","author":"Yang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2023.102707_bib78","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1073\/pnas.1714938115","article-title":"Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses","volume":"115","author":"Deng","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2023.102707_bib79","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1093\/nar\/gkz726","article-title":"USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair","volume":"47","author":"Ting","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2023.102707_bib80","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1158\/0008-5472.CAN-20-0214","article-title":"A functional genomic screen identifies the deubiquitinase USP11 as a novel transcriptional regulator of ER\u03b1 in breast cancer","volume":"80","author":"Dwane","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2023.102707_bib81","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41418-021-00907-8","article-title":"USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1","volume":"29","author":"Rong","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2023.102707_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/4722647","article-title":"SIRT3-Mediated CypD-K166 deacetylation alleviates neuropathic pain by improving mitochondrial dysfunction and inhibiting oxidative stress","volume":"2022","author":"Yan","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102707_bib83","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/rapm-2020-101918","article-title":"SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats","volume":"46","author":"Zhou","year":"2021","journal-title":"Reg. Anesth. Pain Med."},{"key":"10.1016\/j.redox.2023.102707_bib84","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s12276-022-00745-9","article-title":"HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3","volume":"54","author":"Hu","year":"2022","journal-title":"Exp. Mol. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:33:46Z","timestamp":1761978826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723001088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":84,"alternative-id":["S2213231723001088"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102707","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102707","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102707"}}