{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:27:17Z","timestamp":1791685637063,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2020YFC2008205"],"award-info":[{"award-number":["2020YFC2008205"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271091"],"award-info":[{"award-number":["82271091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670858"],"award-info":[{"award-number":["81670858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974134"],"award-info":[{"award-number":["81974134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171058"],"award-info":[{"award-number":["82171058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ31068"],"award-info":[{"award-number":["2021JJ31068"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"publisher","award":["CX20220339"],"award-info":[{"award-number":["CX20220339"]}],"id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101202"],"award-info":[{"award-number":["2021YFA1101202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101200"],"award-info":[{"award-number":["2021YFA1101200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.redox.2023.102713","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T11:10:48Z","timestamp":1682334648000},"page":"102713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Translocator protein 18\u00a0kDa regulates retinal neuron apoptosis and pyroptosis in glaucoma"],"prefix":"10.1016","volume":"63","author":[{"given":"Zhou","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengling","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meini","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-7395","authenticated-orcid":false,"given":"Xiaobo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102713_bib1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2023.102713_bib2","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1001\/jama.2022.6290","article-title":"Screening for glaucoma in adults: updated evidence report and systematic review for the US preventive services task force","volume":"327","author":"Chou","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.redox.2023.102713_bib3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults-screening, diagnosis, and management: a review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.redox.2023.102713_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2022.07.014","article-title":"Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma","author":"Margeta","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2023.102713_bib5","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.redox.2023.102713_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in Glaucoma: from the back to the front of the eye, and beyond","volume":"83","author":"Baudouin","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.redox.2023.102713_bib7","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1126\/science.aad8709","article-title":"From the RNA world to the clinic","volume":"352","author":"Sullenger","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.redox.2023.102713_bib8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nature10887","article-title":"Modular regulatory principles of large non-coding RNAs","volume":"482","author":"Guttman","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102713_bib9","first-page":"73","article-title":"Long non-coding RNAs in the cytoplasm","volume":"14","author":"Rashid","year":"2016","journal-title":"Dev. Reprod. Biol."},{"key":"10.1016\/j.redox.2023.102713_bib10","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/ajmg.c.31833","article-title":"Insights into the regulatory molecules involved in glaucoma pathogenesis","volume":"184","author":"Moazzeni","year":"2020","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.redox.2023.102713_bib11","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ajpath.2018.12.011","article-title":"Potential biomarkers for primary open-angle glaucoma identified by long noncoding RNA profiling in the aqueous humor","volume":"189","author":"Xie","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2023.102713_bib12","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1007\/s00417-021-05279-w","article-title":"The potential role of long noncoding RNAs in primary open-angle glaucoma","volume":"259","author":"Zhang","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.redox.2023.102713_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108915","article-title":"Construction and analysis of mRNA, lncRNA, and transcription factor regulatory networks after retinal ganglion cell injury","volume":"215","author":"Yang","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2023.102713_bib14","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.1111\/jcmm.15906","article-title":"Analysis of association between MALAT1 haplotype and the severity of normal-tension glaucoma (NTG)","volume":"25","author":"Yue","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2023.102713_bib15","first-page":"1329","article-title":"Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients","volume":"19","author":"Zheng","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.redox.2023.102713_bib16","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/02713683.2020.1843686","article-title":"Long non-coding RNA MALAT1 alleviates the elevated intraocular pressure (eiop)-induced glaucoma progression via sponging miR-149-5p","volume":"46","author":"Wang","year":"2021","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2023.102713_bib17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","article-title":"LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury","volume":"27","author":"Wan","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2023.102713_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111802","article-title":"Role of the long noncoding RNA H19 in TGF-beta1-induced Tenon's capsule fibroblast proliferation and extracellular matrix deposition","volume":"387","author":"Zhu","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.redox.2023.102713_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/bs.pbr.2020.07.004","article-title":"The role of neuroinflammation in the pathogenesis of glaucoma neurodegeneration","volume":"256","author":"Pinazo-Duran","year":"2020","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.redox.2023.102713_bib20","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1038\/s41467-022-30232-8","article-title":"Gasdermin-A3 pore formation propagates along variable pathways","volume":"13","author":"Mari","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102713_bib21","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/cr.2016.100","article-title":"Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis","volume":"26","author":"Chen","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2023.102713_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2023.102713_bib23","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1002\/jcp.30347","article-title":"Pathogenesis and prospects for therapeutic clinical application of noncoding RNAs in glaucoma: systematic perspectives","volume":"236","author":"Rong","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2023.102713_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s13205-020-02608-4","article-title":"Comparative miRNA signatures among Sahiwal and Frieswal cattle breeds during summer stress","volume":"11","author":"Deb","year":"2021","journal-title":"3 Biotech"},{"key":"10.1016\/j.redox.2023.102713_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.587273","article-title":"Toxocara canis differentially affects hepatic microrna expression in beagle dogs at different stages of infection","volume":"7","author":"Zou","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.redox.2023.102713_bib26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s12192-018-0911-4","article-title":"Identification of differentially expressed microRNAs in Sahiwal (Bos indicus) breed of cattle during thermal stress","volume":"23","author":"Sengar","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.redox.2023.102713_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/vde.12971","article-title":"Cutaneous microRNA expression in healthy Labrador and Golden retrievers and retrievers with allergic and inflammatory skin diseases","volume":"32","author":"Morlang","year":"2021","journal-title":"Vet. Dermatol."},{"key":"10.1016\/j.redox.2023.102713_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2007.12.004","article-title":"Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair","volume":"118","author":"Chen","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.redox.2023.102713_bib29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tips.2016.02.008","article-title":"TSPO finds NOX2 in microglia for redox homeostasis","volume":"37","author":"Guilarte","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.redox.2023.102713_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.tibs.2015.07.001","article-title":"Enigmatic translocator protein (TSPO) and cellular stress regulation","volume":"40","author":"Batoko","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.redox.2023.102713_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tem.2015.02.007","article-title":"The changing landscape in translocator protein (TSPO) function","volume":"26","author":"Selvaraj","year":"2015","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.redox.2023.102713_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109588","article-title":"Downregulation of TSPO expression inhibits oxidative stress and maintains mitochondrial homeostasis in cardiomyocytes subjected to anoxia\/reoxygenation injury","volume":"121","author":"Meng","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2023.102713_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41419-022-04911-9","article-title":"Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2023.102713_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/234104","article-title":"The mitochondrial translocator protein and arrhythmogenesis in ischemic heart disease","author":"Motloch","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102713_bib35","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nrd3295","article-title":"Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders","volume":"9","author":"Rupprecht","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2023.102713_bib36","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuropharm.2016.09.001","article-title":"TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model","volume":"111","author":"Ishikawa","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.redox.2023.102713_bib37","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1523\/JNEUROSCI.3153-13.2014","article-title":"Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina","volume":"34","author":"Wang","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.redox.2023.102713_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.643685","article-title":"Transneuronal degeneration in the brain during glaucoma","volume":"13","author":"You","year":"2021","journal-title":"Front. Aging Neurosci."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:01:02Z","timestamp":1778853662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723001143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":38,"alternative-id":["S2213231723001143"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102713","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translocator protein 18\u00a0kDa regulates retinal neuron apoptosis and pyroptosis in glaucoma","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102713"}}