{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:56:03Z","timestamp":1793476563037,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670317"],"award-info":[{"award-number":["81670317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071573"],"award-info":[{"award-number":["82071573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271605"],"award-info":[{"award-number":["82271605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.redox.2023.102763","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T21:54:59Z","timestamp":1686952499000},"page":"102763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK\/PI3K\/AKT pathway"],"prefix":"10.1016","volume":"64","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-rong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102763_bib1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102763_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCULATIONAHA.116.025684","article-title":"The role of efferocytosis in atherosclerosis","volume":"135","author":"Kojima","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2023.102763_bib3","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1189\/jlb.0209115","article-title":"Mechanisms and consequences of efferocytosis in advanced atherosclerosis","volume":"86","author":"Thorp","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.redox.2023.102763_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.atherosclerosis.2015.08.011","article-title":"Selective inactivation of NADPH oxidase 2 causes regression of vascularization and the size and stability of atherosclerotic plaques","volume":"242","author":"Quesada","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.redox.2023.102763_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141019","article-title":"Atherosclerotic plaque destabilization in mice: a comparative study","volume":"10","author":"Hartwig","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102763_bib6","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1161\/ATVBAHA.111.236158","article-title":"Endogenous renovascular hypertension combined with low shear stress induces plaque rupture in apolipoprotein E-deficient mice","volume":"32","author":"Jin","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2023.102763_bib7","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1172\/JCI90520","article-title":"MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis","volume":"127","author":"Cai","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2023.102763_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12581","article-title":"Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORalpha-dependent manner","volume":"67","author":"Ding","year":"2019","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.redox.2023.102763_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-2522-3_7","article-title":"Detecting reactive oxygen species by immunohistochemistry","volume":"1292","author":"Liou","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.redox.2023.102763_bib10","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1161\/CIRCULATIONAHA.117.027844","article-title":"Interferon regulatory factor 5 controls necrotic core formation in atherosclerotic lesions by impairing efferocytosis","volume":"136","author":"Seneviratne","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2023.102763_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature18935","article-title":"CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis","volume":"536","author":"Kojima","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102763_bib12","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.ATV.0000166517.18801.a7","article-title":"Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis","volume":"25","author":"Schrijvers","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2023.102763_bib13","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1161\/CIRCRESAHA.118.313028","article-title":"Myeloid-specific deletion of epsins 1 and 2 reduces atherosclerosis by preventing LRP-1 downregulation","volume":"124","author":"Brophy","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2023.102763_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/JCI137866","article-title":"Endoplasmic reticulum stress sensor IRE1alpha propels neutrophil hyperactivity in lupus","volume":"131","author":"Sule","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2023.102763_bib15","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1172\/JCI67390","article-title":"Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus","volume":"123","author":"Knight","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2023.102763_bib16","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1159\/000447902","article-title":"Luteolin attenuates foam cell formation and apoptosis in ox-LDL-stimulated macrophages by enhancing autophagy","volume":"39","author":"Zhang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.redox.2023.102763_bib17","doi-asserted-by":"crossref","first-page":"40322","DOI":"10.1074\/jbc.M110.137604","article-title":"Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages","volume":"285","author":"Petrusca","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102763_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000489751","article-title":"5-Aminolevulinic acid-mediated sonodynamic therapy alleviates atherosclerosis via enhancing efferocytosis and facilitating a shift in the Th1\/Th2 balance toward Th2 polarization","volume":"47","author":"Yang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.redox.2023.102763_bib19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bcp.2013.07.002","article-title":"Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis","volume":"86","author":"Lee","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.redox.2023.102763_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Herrero-Cervera","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.redox.2023.102763_bib21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","article-title":"Neutrophils as regulators of cardiovascular inflammation","volume":"17","author":"Silvestre-Roig","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.redox.2023.102763_bib22","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1093\/cvr\/cvz084","article-title":"Novel findings in neutrophil biology and their impact on cardiovascular disease","volume":"115","author":"Bonaventura","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2023.102763_bib23","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Tabas I: efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2023.102763_bib24","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1194\/jlr.M056689","article-title":"Macrophage SR-BI mediates efferocytosis via Src\/PI3K\/Rac1 signaling and reduces atherosclerotic lesion necrosis","volume":"56","author":"Tao","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.redox.2023.102763_bib25","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1172\/JCI67816","article-title":"MERTK receptor tyrosine kinase is a therapeutic target in melanoma","volume":"123","author":"Schlegel","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2023.102763_bib26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41569-019-0260-8","article-title":"NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets","volume":"17","author":"Zhang","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.redox.2023.102763_bib27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis","volume":"120","author":"Forstermann","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2023.102763_bib28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1089\/ars.2013.5790","article-title":"Clinical application of NOX activity and other oxidative biomarkers in cardiovascular disease: a critical review","volume":"23","author":"Violi","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2023.102763_bib29","first-page":"817","article-title":"Platelet NOX, a novel target for anti-thrombotic treatment","volume":"111","author":"Violi","year":"2014","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.redox.2023.102763_bib30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(19)30035-3","article-title":"Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications","volume":"18","author":"Saba","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2023.102763_bib31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/CIRCRESAHA.114.302355","article-title":"Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies","volume":"114","author":"Silvestre-Roig","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2023.102763_bib32","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1089\/ars.2014.6202","article-title":"Discovery of GSK2795039, a novel small molecule NADPH oxidase 2 inhibitor","volume":"23","author":"Hirano","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2023.102763_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101466","article-title":"A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action","volume":"32","author":"Reis","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102763_bib34","first-page":"549","article-title":"[Clinico-morphologic analysis of subacute sclerosing panencephalitis in patients up to the 19th year of life]","volume":"45","author":"Sobaniec-Lotowska","year":"1990","journal-title":"Pol. Tyg. Lek."},{"key":"10.1016\/j.redox.2023.102763_bib35","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.atherosclerosis.2015.05.011","article-title":"Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: a pathology study","volume":"241","author":"Otsuka","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.redox.2023.102763_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105699","article-title":"Dead cell and debris clearance in the atherosclerotic plaque: mechanisms and therapeutic opportunities to promote inflammation resolution","volume":"170","author":"Dhawan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.redox.2023.102763_bib37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature08296","article-title":"Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance","volume":"461","author":"Elliott","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102763_bib38","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/ATVBAHA.108.167197","article-title":"Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-\/- mice","volume":"28","author":"Thorp","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2023.102763_bib39","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/ATVBAHA.108.169078","article-title":"Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis","volume":"28","author":"Ait-Oufella","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2023.102763_bib40","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/ATVBAHA.109.202051","article-title":"Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation","volume":"30","author":"Yancey","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.redox.2023.102763_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/path.2381","article-title":"Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis","volume":"216","author":"Lutgens","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.redox.2023.102763_bib42","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1161\/CIRCULATIONAHA.106.662080","article-title":"Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice","volume":"115","author":"Ait-Oufella","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2023.102763_bib43","first-page":"132","article-title":"MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer","author":"Yan","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2023.102763_bib44","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1182\/blood-2006-04-017368","article-title":"Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells","volume":"109","author":"Sen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.redox.2023.102763_bib45","doi-asserted-by":"crossref","first-page":"33335","DOI":"10.1074\/jbc.M111.263020","article-title":"Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cdelta, and p38 mitogen-activated protein kinase (MAPK)","volume":"286","author":"Thorp","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102763_bib46","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1182\/blood-2006-05-021634","article-title":"A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation","volume":"109","author":"Sather","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.redox.2023.102763_bib47","doi-asserted-by":"crossref","first-page":"C776","DOI":"10.1152\/ajpcell.00145.2019","article-title":"Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT(1)R\/ROS\/p38 MAPK\/ADAM17 pathway","volume":"317","author":"Zhang","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.redox.2023.102763_bib48","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1073\/pnas.1524292113","article-title":"MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation","volume":"113","author":"Cai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:37:38Z","timestamp":1761979058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723001647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":48,"alternative-id":["S2213231723001647"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102763","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK\/PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102763","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102763"}}