{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:57:15Z","timestamp":1792155435053,"version":"4.4.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800100"],"award-info":[{"award-number":["2022YFD1800100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.redox.2023.102769","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T02:20:47Z","timestamp":1685499647000},"page":"102769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis"],"prefix":"10.1016","volume":"64","author":[{"given":"Yueming","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baokun","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunkai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen F.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-8105","authenticated-orcid":false,"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102769_bib1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrmicro.2018.11","article-title":"The spread and evolution of rabies virus: conquering new frontiers","volume":"16","author":"Fisher","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.redox.2023.102769_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-015-1511-3","article-title":"Neurotropic virus infections as the cause of immediate and delayed neuropathology","volume":"131","author":"Ludlow","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.redox.2023.102769_bib3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.424742","article-title":"Semliki forest virus: cause of a fatal case of human encephalitis","volume":"203","author":"Willems","year":"1979","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.redox.2023.102769_bib4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.coviro.2017.12.003","article-title":"New advances in CNS immunity against viral infection","volume":"28","author":"Manglani","year":"2018","journal-title":"Current opinion in virology"},{"issue":"Suppl 2","key":"10.1016\/j.redox.2023.102769_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/135502802901068000","article-title":"Pathogenesis of Semliki forest virus encephalitis","volume":"8","author":"Fazakerley","year":"2002","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.redox.2023.102769_bib6","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1073\/pnas.1520489113","article-title":"Nuclear receptor REV-ERB\u03b1 mediates circadian sensitivity to mortality in murine vesicular stomatitis virus-induced encephalitis","volume":"113","author":"Gagnidze","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.redox.2023.102769_bib7","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1016\/j.vaccine.2010.03.039","article-title":"The immune response to rabies virus infection and vaccination","volume":"28","author":"Johnson","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.redox.2023.102769_bib8","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202135","article-title":"Neuroinvasion of SARS-CoV-2 in human and mouse brain","volume":"218","author":"Song","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2023.102769_bib9","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s10072-020-04575-3","article-title":"Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients","volume":"41","author":"Yachou","year":"2020","journal-title":"Neurol. Sci. : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology"},{"key":"10.1016\/j.redox.2023.102769_bib10","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1073\/pnas.1214441110","article-title":"LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus","volume":"110","author":"Finkelshtein","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.redox.2023.102769_bib11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41467-018-03432-4","article-title":"Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein","volume":"9","author":"Nikolic","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102769_bib12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1126\/science.7053569","article-title":"Is the acetylcholine receptor a rabies virus receptor?","volume":"215","author":"Lentz","year":"1982","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.redox.2023.102769_bib13","doi-asserted-by":"crossref","first-page":"7181","DOI":"10.1128\/JVI.72.9.7181-7190.1998","article-title":"The neural cell adhesion molecule is a receptor for rabies virus","volume":"72","author":"Thoulouze","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.redox.2023.102769_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001127","article-title":"The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis","volume":"6","author":"Cureton","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.redox.2023.102769_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000394","article-title":"Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization","volume":"5","author":"Cureton","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.redox.2023.102769_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/JVI.01864-08","article-title":"Host cell factors and functions involved in vesicular stomatitis virus entry","volume":"83","author":"Johannsdottir","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.redox.2023.102769_bib17","doi-asserted-by":"crossref","first-page":"11637","DOI":"10.1128\/JVI.01648-13","article-title":"Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin","volume":"87","author":"Piccinotti","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.redox.2023.102769_bib18","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1146\/annurev.biochem.78.072407.103859","article-title":"Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain","volume":"78","author":"Russell","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.redox.2023.102769_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.696778","article-title":"Cholesterol hydroxylating cytochrome P450 46A1: from mechanisms of action to clinical applications","volume":"13","author":"Pikuleva","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.redox.2023.102769_bib20","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/brain\/awv166","article-title":"CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease","volume":"138","author":"Djelti","year":"2015","journal-title":"Brain : J. Neurol."},{"key":"10.1016\/j.redox.2023.102769_bib21","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1093\/brain\/awz174","article-title":"CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease","volume":"142","author":"Kacher","year":"2019","journal-title":"Brain : J. Neurol."},{"key":"10.1016\/j.redox.2023.102769_bib22","article-title":"Association of cholesterol 7\u03b1-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population","author":"Sezer","year":"2021","journal-title":"Neurol. Sci. : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology"},{"key":"10.1016\/j.redox.2023.102769_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2020.568641","article-title":"Effects of CYP46A1 inhibition on long-term-depression in hippocampal slices ex vivo and 24S-hydroxycholesterol levels in mice in vivo","volume":"13","author":"Popiolek","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.redox.2023.102769_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068534","article-title":"Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?","volume":"8","author":"Maioli","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102769_bib25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/gps.2196","article-title":"Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study","volume":"24","author":"Fu","year":"2009","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.redox.2023.102769_bib26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.kjms.2014.03.005","article-title":"Effects of metabolic syndrome, apolipoprotein E, and CYP46 on cognition among Taiwanese Chinese","volume":"30","author":"Lai","year":"2014","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.redox.2023.102769_bib27","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.biochi.2012.09.025","article-title":"24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases","volume":"95","author":"Leoni","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.redox.2023.102769_bib28","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s13311-019-00731-6","article-title":"Cholesterol 24-hydroxylation by CYP46A1: benefits of modulation for brain diseases","volume":"16","author":"Petrov","year":"2019","journal-title":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics"},{"key":"10.1016\/j.redox.2023.102769_bib29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/jnc.15228","article-title":"24S-hydroxycholesterol: cellular effects and variations in brain diseases","volume":"157","author":"Sodero","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.redox.2023.102769_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105902","article-title":"Plasma oxysterols: altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder","volume":"211","author":"Guidara","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.redox.2023.102769_bib31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.redox.2018.05.009","article-title":"A silver lining for 24-hydroxycholesterol in Alzheimer's disease: the involvement of the neuroprotective enzyme sirtuin 1","volume":"17","author":"Testa","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102769_bib32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/1073858414568122","article-title":"24(S)-Hydroxycholesterol as a modulator of neuronal signaling and survival","volume":"22","author":"Sun","year":"2016","journal-title":"Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry"},{"key":"10.1016\/j.redox.2023.102769_bib33","article-title":"Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19. Biochimica et biophysica acta","volume":"1870","author":"Chen","year":"2021","journal-title":"Proteins and proteomics"},{"key":"10.1016\/j.redox.2023.102769_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1955643","article-title":"Statins significantly repress rotavirus replication through downregulation of cholesterol synthesis","volume":"13","author":"Ding","year":"2021","journal-title":"Gut Microb."},{"key":"10.1016\/j.redox.2023.102769_bib35","volume":"vol. 10","author":"Zhou","year":"2021"},{"key":"10.1016\/j.redox.2023.102769_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65962","article-title":"SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation","volume":"10","author":"Sanders","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.redox.2023.102769_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000598","article-title":"Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis","volume":"9","author":"Blanc","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.redox.2023.102769_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hep.25631","article-title":"Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner","volume":"56","author":"Clark","year":"2012","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.redox.2023.102769_bib39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.chom.2013.04.002","article-title":"The greasy response to virus infections","volume":"13","author":"Tanner","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.redox.2023.102769_bib40","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature10348","article-title":"Ebola virus entry requires the cholesterol transporter Niemann-Pick C1","volume":"477","author":"Carette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102769_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1128\/JVI.78.1.33-41.2004","article-title":"Cholesterol removal by methyl-beta-cyclodextrin inhibits poliovirus entry","volume":"78","author":"Danthi","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.redox.2023.102769_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.antiviral.2011.11.014","article-title":"U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication","volume":"93","author":"Poh","year":"2012","journal-title":"Antivir. Res."},{"key":"10.1016\/j.redox.2023.102769_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/10084","article-title":"Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport","volume":"1","author":"Kobayashi","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2023.102769_bib44","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ceb.2009.03.008","article-title":"Viruses and endosome membrane dynamics","volume":"21","author":"Gruenberg","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.redox.2023.102769_bib45","first-page":"1","article-title":"Lessons in self-defence: inhibition of virus entry by intrinsic immunity","author":"Majdoul","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2023.102769_bib46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41594-020-00548-4","article-title":"Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry","volume":"28","author":"Lee","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.redox.2023.102769_bib47","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.chom.2013.03.006","article-title":"The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry","volume":"13","author":"Amini-Bavil-Olyaee","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.redox.2023.102769_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2022.100057","article-title":"Trim25 restricts rabies virus replication by destabilizing phosphoprotein","volume":"1","author":"Yuan","year":"2022","journal-title":"Cell Insight"},{"key":"10.1016\/j.redox.2023.102769_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.107931","article-title":"Gypenosides mediate cholesterol efflux and suppress oxidized LDL induced inflammation in retinal pigment epithelium cells","volume":"191","author":"Biswas","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2023.102769_bib50","doi-asserted-by":"crossref","first-page":"10610","DOI":"10.18632\/aging.102480","article-title":"Ets2 suppresses inflammatory cytokines through MAPK\/NF-\u03baB signaling and directly binds to the IL-6 promoter in macrophages","volume":"11","author":"Ma","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.redox.2023.102769_bib51","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2012.11.005","article-title":"Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol","volume":"38","author":"Liu","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2023.102769_bib52","first-page":"139","article-title":"Mitogen-activated protein kinase cascades as regulators of stress responses","volume":"851","author":"Karin","year":"1998","journal-title":"Stress of Life"},{"key":"10.1016\/j.redox.2023.102769_bib53","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1007\/s00705-019-04415-6","article-title":"Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry","volume":"164","author":"Yuan","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.redox.2023.102769_bib54","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.immuni.2017.02.012","article-title":"25-Hydroxycholesterol protects host against Zika virus infection and its associated microcephaly in a mouse model","volume":"46","author":"Li","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2023.102769_bib55","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.redox.2018.09.003","article-title":"25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes","volume":"19","author":"Civra","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102769_bib56","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.116.2.307","article-title":"Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding","volume":"116","author":"Ridgway","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.redox.2023.102769_bib57","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbamem.2007.09.022","article-title":"Kinetics of cholesterol extraction from lipid membranes by methyl-beta-cyclodextrin--a surface plasmon resonance approach","volume":"1778","author":"Besenicar","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2023.102769_bib58","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.cellbio.042308.113334","article-title":"The diverse functions of oxysterol-binding proteins","volume":"26","author":"Raychaudhuri","year":"2010","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2023.102769_bib59","doi-asserted-by":"crossref","first-page":"12961","DOI":"10.1074\/jbc.M109.082602","article-title":"Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies","volume":"285","author":"Furuita","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102769_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrm1591","article-title":"Lipid traffic: floppy drives and a superhighway","volume":"6","author":"Holthuis","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2023.102769_bib61","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1002\/jmv.26917","article-title":"In vitro activity of itraconazole against SARS-CoV-2","volume":"93","author":"Van Damme","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.redox.2023.102769_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103288","article-title":"Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial","volume":"66","author":"Liesenborghs","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2023.102769_bib63","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1038\/s41598-021-85049-0","article-title":"The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue","volume":"11","author":"Zimniak","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102769_bib64","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1111\/bph.15418","article-title":"Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro","volume":"178","author":"Schloer","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2023.102769_bib65","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/22221751.2018.1559709","article-title":"The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo","volume":"8","author":"Schloer","year":"2019","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.redox.2023.102769_bib66","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1080\/22221751.2020.1829082","article-title":"Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine","volume":"9","author":"Schloer","year":"2020","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.redox.2023.102769_bib67","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/22221751.2021.2020598","article-title":"Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro","volume":"11","author":"Kummer","year":"2022","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.redox.2023.102769_bib68","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/s41422-020-00398-1","article-title":"25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor","volume":"30","author":"Zu","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2023.102769_bib69","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12250-017-3968-9","article-title":"Rabies virus co-localizes with early (Rab5) and late (Rab7) endosomal proteins in neuronal and SH-SY5Y cells","volume":"32","author":"Ahmad","year":"2017","journal-title":"Virol. Sin."},{"key":"10.1016\/j.redox.2023.102769_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105016","article-title":"Broad spectrum compounds targeting early stages of rabies virus (RABV) infection","volume":"188","author":"Kali","year":"2021","journal-title":"Antivir. Res."},{"key":"10.1016\/j.redox.2023.102769_bib71","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ncb1269","article-title":"Endosome-to-cytosol transport of viral nucleocapsids","volume":"7","author":"Le Blanc","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2023.102769_bib72","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-0854.2008.00820.x","article-title":"The ESCRT-I subunit TSG101 controls endosome-to-cytosol release of viral RNA","volume":"9","author":"Luyet","year":"2008","journal-title":"Traffic (Copenhagen, Denmark)"},{"key":"10.1016\/j.redox.2023.102769_bib73","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106057","article-title":"Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol","volume":"39","author":"Wang","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2023.102769_bib74","doi-asserted-by":"crossref","first-page":"32105","DOI":"10.1073\/pnas.2012197117","article-title":"Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion","volume":"117","author":"Zang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:37:30Z","timestamp":1761979050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723001702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":74,"alternative-id":["S2213231723001702"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102769","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102769"}}