{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:06:17Z","timestamp":1793066777661,"version":"4.5.0"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2311-B-007-012"],"award-info":[{"award-number":["107-2311-B-007-012"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2311-B-007-002-MY2"],"award-info":[{"award-number":["111-2311-B-007-002-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.redox.2023.102791","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T20:43:19Z","timestamp":1687466599000},"page":"102791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Action mechanism of snake venom l-amino acid oxidase and its double-edged sword effect on cancer treatment: Role of pannexin 1-mediated interleukin-6 expression"],"prefix":"10.1016","volume":"64","author":[{"given":"Nam V.","family":"Truong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinh T.T.","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Sheng","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan","family":"Phu Duc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih-Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Guey","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.redox.2023.102791_bib1","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1007\/s00253-021-11381-0","article-title":"Antimicrobial properties of L-amino acid oxidase: biochemical features and biomedical applications","volume":"105","author":"Kasai","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"5","key":"10.1016\/j.redox.2023.102791_bib2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jmb.2006.09.032","article-title":"Crystal structure of LAAO from Calloselasma rhodostoma with an L-phenylalanine substrate: insights into structure and mechanism","volume":"364","author":"Moustafa","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.redox.2023.102791_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41570-022-00393-7","article-title":"The chemistry of snake venom and its medicinal potential","author":"Oliveira","year":"2022","journal-title":"Nat. Rev. Chem"},{"issue":"16","key":"10.1016\/j.redox.2023.102791_bib4","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/emboj\/19.16.4204","article-title":"The structure of L-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site","volume":"19","author":"Pawelek","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2023.102791_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/srep18215","article-title":"Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-beta signal pathway","volume":"5","author":"Guo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102791_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/srep42673","article-title":"CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer","volume":"7","author":"Costa","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102791_bib7","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.ijbiomac.2019.05.174","article-title":"L-amino acid oxidase isolated from Micrurus mipartitus snake venom (MipLAAO) specifically induces apoptosis in acute lymphoblastic leukemia cells mostly via oxidative stress-dependent signaling mechanism","volume":"134","author":"Bedoya-Medina","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.redox.2023.102791_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2018.05.005","article-title":"CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress","volume":"404\u2013405","author":"Costa","year":"2018","journal-title":"Toxicology"},{"issue":"23","key":"10.1016\/j.redox.2023.102791_bib9","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1111\/j.1742-4658.2011.08115.x","article-title":"Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis","volume":"278","author":"Kang","year":"2011","journal-title":"FEBS J."},{"issue":"14","key":"10.1016\/j.redox.2023.102791_bib10","doi-asserted-by":"crossref","first-page":"9539","DOI":"10.1074\/jbc.272.14.9539","article-title":"Apoxin I, a novel apoptosis-inducing factor with L-amino acid oxidase activity purified from western diamondback rattlesnake venom","volume":"272","author":"Torii","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.redox.2023.102791_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.biochi.2011.07.022","article-title":"Cloning, characterization and mutagenesis of Russell's viper venom L-amino acid oxidase: insights into its catalytic mechanism","volume":"94","author":"Chen","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.redox.2023.102791_bib12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fphar.2020.00110","article-title":"Structure-Function studies and mechanism of action of snake venom L-amino acid oxidases","volume":"11","author":"Ullah","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.redox.2023.102791_bib13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.toxicon.2012.08.008","article-title":"Isolation and biochemical, functional and structural characterization of a novel l-amino acid oxidase from Lachesis muta snake venom","volume":"60","author":"Bregge-Silva","year":"2012","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.redox.2023.102791_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1039\/C0MB00101E","article-title":"The structure of a native l-amino acid oxidase, the major component of the Vipera ammodytes ammodytes venomic, reveals dynamic active site and quaternary structure stabilization by divalent ions","volume":"7","author":"Georgieva","year":"2011","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.redox.2023.102791_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fob.2013.01.010","article-title":"Irreversible inactivation of snake venom l-amino acid oxidase by covalent modification during catalysis of l-propargylglycine","volume":"3","author":"Mitra","year":"2013","journal-title":"FEBS Open Bio"},{"issue":"5","key":"10.1016\/j.redox.2023.102791_bib16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/bcpt.13060","article-title":"Cytotoxic, antiproliferative and apoptosis-inducing activity of L-amino acid oxidase from Malaysian Calloselasma rhodostoma on human colon cancer cells","volume":"123","author":"Zainal Abidin","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.redox.2023.102791_bib17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ijbiomac.2015.07.004","article-title":"Evaluating the microbicidal, antiparasitic and antitumor effects of CR-LAAO from Calloselasma rhodostoma venom","volume":"80","author":"Costa","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.redox.2023.102791_bib18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.toxicon.2018.06.064","article-title":"l-Amino acid oxidase from Cerastes vipera snake venom: isolation, characterization and biological effects on bacteria and tumor cell lines","volume":"150","author":"Salama","year":"2018","journal-title":"Toxicon"},{"issue":"37","key":"10.1016\/j.redox.2023.102791_bib19","doi-asserted-by":"crossref","first-page":"8546","DOI":"10.1039\/D0TB01425G","article-title":"Delivery of amino acid oxidase via catalytic nanocapsules to enable effective tumor inhibition","volume":"8","author":"Chu","year":"2020","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib20","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1021\/acs.nanolett.9b04263","article-title":"Oncolytic nanoreactors producing hydrogen peroxide for oxidative cancer therapy","volume":"20","author":"Jo","year":"2020","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2006.10.029","article-title":"Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy","volume":"252","author":"L\u00f3pez-L\u00e1zaro","year":"2007","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087371","article-title":"Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells","volume":"9","author":"Mahalingaiah","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.redox.2023.102791_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2020.05.054","article-title":"Origin and function of stress-induced IL-6 in murine models","volume":"182","author":"Qing","year":"2020","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.redox.2023.102791_bib24","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.immuni.2019.03.026","article-title":"Targeting interleukin-6 signaling in clinic","volume":"50","author":"Kang","year":"2019","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.redox.2023.102791_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12776","article-title":"IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-kappaB","volume":"53","author":"Liu","year":"2020","journal-title":"Cell Prolif."},{"issue":"12","key":"10.1016\/j.redox.2023.102791_bib26","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41419-020-03241-y","article-title":"Autocrine IL-6\/STAT3 signaling aids development of acquired drug resistance in Group 3 medulloblastoma","volume":"11","author":"Sreenivasan","year":"2020","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.redox.2023.102791_bib27","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1073\/pnas.1820459116","article-title":"Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma","volume":"116","author":"Ebbing","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib28","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1038\/s41467-021-26407-4","article-title":"Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy","volume":"12","author":"Bent","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.redox.2023.102791_bib29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","article-title":"Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer","volume":"15","author":"Johnson","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"33","key":"10.1016\/j.redox.2023.102791_bib30","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1038\/onc.2009.180","article-title":"Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells","volume":"28","author":"Sullivan","year":"2009","journal-title":"Oncogene"},{"issue":"7822","key":"10.1016\/j.redox.2023.102791_bib31","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41586-020-2357-y","article-title":"Structures of human pannexin 1 reveal ion pathways and mechanism of gating","volume":"584","author":"Ruan","year":"2020","journal-title":"Nature"},{"issue":"7317","key":"10.1016\/j.redox.2023.102791_bib32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature09413","article-title":"Pannexin 1 channels mediate \u2018find-me\u2019 signal release and membrane permeability during apoptosis","volume":"467","author":"Chekeni","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102791_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14324","article-title":"A quantized mechanism for activation of pannexin channels","volume":"8","author":"Chiu","year":"2017","journal-title":"Nat. Commun."},{"issue":"7801","key":"10.1016\/j.redox.2023.102791_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-020-2121-3","article-title":"Metabolites released from apoptotic cells act as tissue messengers","volume":"580","author":"Medina","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102791_bib35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64787","article-title":"ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels","volume":"10","author":"Narahari","year":"2021","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.redox.2023.102791_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1083\/jcb.200601115","article-title":"Functional implications of calcium permeability of the channel formed by pannexin 1","volume":"174","author":"Vanden Abeele","year":"2006","journal-title":"J. Cell Biol."},{"issue":"1\u20133","key":"10.1016\/j.redox.2023.102791_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.febslet.2004.07.009","article-title":"Pannexin membrane channels are mechanosensitive conduits for ATP","volume":"572","author":"Bao","year":"2004","journal-title":"FEBS Lett."},{"issue":"11","key":"10.1016\/j.redox.2023.102791_bib38","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.4049\/jimmunol.1901089","article-title":"Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium","volume":"204","author":"Yang","year":"2020","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.redox.2023.102791_bib39","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ncb3194","article-title":"Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival","volume":"17","author":"Furlow","year":"2015","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.redox.2023.102791_bib40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrc.2017.18","article-title":"The calcium-cancer signalling nexus","volume":"17","author":"Monteith","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.redox.2023.102791_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109090","article-title":"In vitro effect of Pannexin 1 channel on the invasion and migration of I-10 testicular cancer cells via ERK1\/2 signaling pathway","volume":"117","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/abio.2001.5381","article-title":"A spectrophotometric microplate assay for l-amino acid oxidase","volume":"298","author":"Kishimoto","year":"2001","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.redox.2023.102791_bib43","doi-asserted-by":"crossref","first-page":"e3142","DOI":"10.7717\/peerj.3142","article-title":"Comparative venom gland transcriptomics of Naja kaouthia (monocled cobra) from Malaysia and Thailand: elucidating geographical venom variation and insights into sequence novelty","volume":"5","author":"Tan","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.redox.2023.102791_bib44","article-title":"An introduction to sequence similarity (\"homology\") searching","volume":"3","author":"Pearson","year":"2013","journal-title":"Curr. Protoc. Bioinformatics Chapter"},{"issue":"7","key":"10.1016\/j.redox.2023.102791_bib45","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/s41587-021-01156-3","article-title":"SignalP 6.0 predicts all five types of signal peptides using protein language models","volume":"40","author":"Teufel","year":"2022","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.redox.2023.102791_bib46","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol. Biol. Evol."},{"issue":"3","key":"10.1016\/j.redox.2023.102791_bib47","first-page":"275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"Jones","year":"1992","journal-title":"Comput. Appl. Biosci."},{"issue":"W1","key":"10.1016\/j.redox.2023.102791_bib48","doi-asserted-by":"crossref","first-page":"W293","DOI":"10.1093\/nar\/gkab301","article-title":"Interactive Tree of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation","volume":"49","author":"Letunic","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"10.1016\/j.redox.2023.102791_bib49","doi-asserted-by":"crossref","first-page":"W252","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"Biasini","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"Suppl 9","key":"10.1016\/j.redox.2023.102791_bib50","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/prot.22570","article-title":"Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: four approaches that performed well in CASP8","volume":"77","author":"Krieger","year":"2009","journal-title":"Proteins"},{"issue":"Pt 2","key":"10.1016\/j.redox.2023.102791_bib51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"9","key":"10.1016\/j.redox.2023.102791_bib52","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.redox.2023.102791_bib53","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib54","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: more and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Cheminf."},{"issue":"16","key":"10.1016\/j.redox.2023.102791_bib56","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib57","first-page":"82","article-title":"Pymol: an open-source molecular graphics tool, CCP4 Newsl","volume":"40","author":"DeLano","year":"2002","journal-title":"Protein Crystallogr"},{"issue":"2","key":"10.1016\/j.redox.2023.102791_bib58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","article-title":"LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions","volume":"8","author":"Wallace","year":"1995","journal-title":"Protein Eng."},{"issue":"2","key":"10.1016\/j.redox.2023.102791_bib59","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/cr.2009.6","article-title":"DOG 1.0: illustrator of protein domain structures","volume":"19","author":"Ren","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2023.102791_bib60","first-page":"310","article-title":"Prediction of glycosylation across the human proteome and the correlation to protein function","author":"Gupta","year":"2002","journal-title":"Pac. Symp. Biocomput."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib61","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41389-022-00401-x","article-title":"Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics","volume":"11","author":"Phan","year":"2022","journal-title":"Oncogenesis"},{"issue":"6","key":"10.1016\/j.redox.2023.102791_bib62","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","author":"Murphy","year":"2022","journal-title":"Nat. Metab."},{"issue":"5","key":"10.1016\/j.redox.2023.102791_bib63","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"issue":"269","key":"10.1016\/j.redox.2023.102791_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib65","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41588-019-0559-8","article-title":"The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins","volume":"52","author":"Suryamohan","year":"2020","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib66","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1038\/s41467-018-05279-1","article-title":"Squamate reptiles challenge paradigms of genomic repeat element evolution set by birds and mammals","volume":"9","author":"Pasquesi","year":"2018","journal-title":"Nat. Commun."},{"issue":"7856","key":"10.1016\/j.redox.2023.102791_bib67","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41586-021-03451-0","article-title":"Towards complete and error-free genome assemblies of all vertebrate species","volume":"592","author":"Rhie","year":"2021","journal-title":"Nature"},{"issue":"D1","key":"10.1016\/j.redox.2023.102791_bib68","doi-asserted-by":"crossref","first-page":"D266","DOI":"10.1093\/nar\/gkaa1079","article-title":"CATH: increased structural coverage of functional space","volume":"49","author":"Sillitoe","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.lfs.2014.07.016","article-title":"Hydrogen peroxide inhibits proliferation and endothelial differentiation of bone marrow stem cells partially via reactive oxygen species generation","volume":"112","author":"Xiao","year":"2014","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.redox.2023.102791_bib70","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/sj.onc.1202325","article-title":"Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-\u03baB","volume":"18","author":"Dumont","year":"1999","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.redox.2023.102791_bib71","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s12276-020-0384-2","article-title":"ROS in cancer therapy: the bright side of the moon","volume":"52","author":"Perillo","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"24","key":"10.1016\/j.redox.2023.102791_bib72","first-page":"8851","article-title":"Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells","volume":"61","author":"Conze","year":"2001","journal-title":"Cancer Res."},{"issue":"34","key":"10.1016\/j.redox.2023.102791_bib73","doi-asserted-by":"crossref","first-page":"29184","DOI":"10.1074\/jbc.M112.377176","article-title":"Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype","volume":"287","author":"Penuela","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102791_bib74","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijbiomac.2016.07.022","article-title":"Mechanism of the cytotoxic effect of l-amino acid oxidase isolated from Bothrops alternatus snake venom","volume":"92","author":"Ribeiro","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.canlet.2008.02.031","article-title":"Reactive oxygen species in tumor metastasis","volume":"266","author":"Nishikawa","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.redox.2023.102791_bib76","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64806","article-title":"Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism","volume":"10","author":"Zeitler","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.redox.2023.102791_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/srep27439","article-title":"Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects","volume":"6","author":"Molavian","year":"2016","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.redox.2023.102791_bib78","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","article-title":"Pannexin-1 mediates large pore formation and interleukin-1\u03b2 release by the ATP-gated P2X7 receptor","volume":"25","author":"Pelegrin","year":"2006","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib79","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/s41467-022-29233-4","article-title":"Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation","volume":"13","author":"Filiberto","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102791_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102137","article-title":"Purinergic signaling in the modulation of redox biology","volume":"47","author":"Savio","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib81","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jmb.2006.11.071","article-title":"The structure of a bacterial L-amino acid oxidase from Rhodococcus opacus gives new evidence for the hydride mechanism for dehydrogenation","volume":"367","author":"Faust","year":"2007","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib82","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0141-0229(02)00072-8","article-title":"A new bacterial l-amino acid oxidase with a broad substrate specificity: purification and characterization","volume":"31","author":"Geueke","year":"2002","journal-title":"Enzym. Microb. Technol."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib83","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s42004-020-00432-8","article-title":"Ancestral L-amino acid oxidases for deracemization and stereoinversion of amino acids","volume":"3","author":"Nakano","year":"2020","journal-title":"Commun. Chem."},{"issue":"15","key":"10.1016\/j.redox.2023.102791_bib84","doi-asserted-by":"crossref","first-page":"7496","DOI":"10.1073\/pnas.93.15.7496","article-title":"Crystal structure of D-amino acid oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2","volume":"93","author":"Mattevi","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"23","key":"10.1016\/j.redox.2023.102791_bib85","doi-asserted-by":"crossref","first-page":"12463","DOI":"10.1073\/pnas.97.23.12463","article-title":"The x-ray structure of d-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation","volume":"97","author":"Umhau","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"17","key":"10.1016\/j.redox.2023.102791_bib86","doi-asserted-by":"crossref","first-page":"9958","DOI":"10.1016\/S0021-9258(18)33970-X","article-title":"Proton release during the reductive half-reaction of D-amino acid oxidase","volume":"257","author":"Fitzpatrick","year":"1982","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2023.102791_bib87","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/nar\/30.1.47","article-title":"BRENDA, enzyme data and metabolic information","volume":"30","author":"Schomburg","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2023.102791_bib88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biochi.2019.05.009","article-title":"Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom","volume":"163","author":"Wiezel","year":"2019","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.redox.2023.102791_bib89","first-page":"729","article-title":"Free amino acid pools of rodent mammary Tumors23, JNCI","volume":"69","author":"Pine","year":"1982","journal-title":"J. Natl. Cancer Inst."},{"issue":"5","key":"10.1016\/j.redox.2023.102791_bib90","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0404.1979.tb02985.x","article-title":"Composition of free amino acids in brain tumors","volume":"60","author":"Shibasaki","year":"1979","journal-title":"Acta Neurol. Scand."},{"issue":"10","key":"10.1016\/j.redox.2023.102791_bib91","first-page":"694","article-title":"Free amino acid content and transaminase activity of lymphatic tissues and lymphosarcomas","volume":"13","author":"Kit","year":"1953","journal-title":"Cancer Res."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723001921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:37:19Z","timestamp":1761979039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723001921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":91,"alternative-id":["S2213231723001921"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102791","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Action mechanism of snake venom l-amino acid oxidase and its double-edged sword effect on cancer treatment: Role of pannexin 1-mediated interleukin-6 expression","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102791"}}