{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:13:15Z","timestamp":1792120395736,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800880"],"award-info":[{"award-number":["81800880"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870675"],"award-info":[{"award-number":["81870675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171085"],"award-info":[{"award-number":["82171085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020966","name":"Tianjin Medical University Eye Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.redox.2023.102836","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T12:18:21Z","timestamp":1690892301000},"page":"102836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Mechanism of action of platinum nanoparticles implying from antioxidant to metabolic programming in light-induced retinal degeneration model"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-6217","authenticated-orcid":false,"given":"Lin","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102836_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2017.07.025","article-title":"Retinal metabolism: a comparative look at energetics in the retina","volume":"1672","author":"Country","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.redox.2023.102836_bib2","article-title":"Oxidative stress, vascular endothelium, and the Pathology of neurodegeneration in retina","volume":"11","author":"Shi","year":"2022","journal-title":"ANTIOXIDANTS-BASEL"},{"key":"10.1016\/j.redox.2023.102836_bib3","article-title":"Oxidative stress and vascular dysfunction in the retina: therapeutic strategies","volume":"9","author":"Ruan","year":"2020","journal-title":"ANTIOXIDANTS-BASEL"},{"key":"10.1016\/j.redox.2023.102836_bib4","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1007\/s00018-016-2318-7","article-title":"Metabolic and redox signaling in the retina","volume":"74","author":"Leveillard","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.redox.2023.102836_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/ceo.12952","article-title":"Glucose metabolism in mammalian photoreceptor inner and outer segments","volume":"45","author":"Narayan","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.redox.2023.102836_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s42003-021-01765-3","article-title":"Photoreceptor metabolic reprogramming: current understanding and therapeutic implications","volume":"4","author":"Pan","year":"2021","journal-title":"COMMUN BIOL"},{"key":"10.1016\/j.redox.2023.102836_bib7","doi-asserted-by":"crossref","first-page":"16586","DOI":"10.1073\/pnas.1314575110","article-title":"Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina","volume":"110","author":"Du","year":"2013","journal-title":"P NATL ACAD SCI USA"},{"key":"10.1016\/j.redox.2023.102836_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00125-017-4435-8","article-title":"Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond","volume":"61","author":"Hammes","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.redox.2023.102836_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0039-6257(00)00140-5","article-title":"The role of oxidative stress in the pathogenesis of age-related macular degeneration","volume":"45","author":"Beatty","year":"2000","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.redox.2023.102836_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9208489","article-title":"Retinal diseases associated with oxidative stress and the effects of a free radical scavenger (edaravone)","author":"Masuda","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2023.102836_bib11","first-page":"1122","article-title":"Oxidative stress and diabetic retinopathy: development and treatment","volume":"31","author":"Calderon","year":"2017","journal-title":"Early Years Educat."},{"key":"10.1016\/j.redox.2023.102836_bib12","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1039\/C7CS00152E","article-title":"Platinum nanoparticles in nanobiomedicine","volume":"46","author":"Pedone","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.redox.2023.102836_bib13","article-title":"Applications of inorganic nanoparticles as therapeutic agents","volume":"25","author":"Kim","year":"2014","journal-title":"Nanotechnology"},{"key":"10.1016\/j.redox.2023.102836_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41392-022-01082-z","article-title":"Nanoparticles in the diagnosis and treatment of vascular aging and related diseases","volume":"7","author":"Xu","year":"2022","journal-title":"SIGNAL TRANSDUCT TAR"},{"key":"10.1016\/j.redox.2023.102836_bib15","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1039\/c3cs35486e","article-title":"Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes","volume":"42","author":"Wei","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.redox.2023.102836_bib16","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/s41467-022-29772-w","article-title":"Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury","volume":"13","author":"Mu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102836_bib17","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00204-010-0636-3","article-title":"Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations","volume":"85","author":"Gehrke","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.redox.2023.102836_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109288","article-title":"Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice","volume":"9","author":"Shibuya","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102836_bib19","article-title":"Biocompatibility of platinum nanoparticles in brain ex vivo models in physiological and pathological conditions","volume":"15","author":"Gulino","year":"2021","journal-title":"FRONT NEUROSCI-SWITZ"},{"issue":"6","key":"10.1016\/j.redox.2023.102836_bib20","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1039\/C5NR08358C","article-title":"Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model","volume":"8","author":"Moglianetti","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.redox.2023.102836_bib21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.redox.2023.102836_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-021-00736-9","article-title":"The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases","volume":"12","author":"Chang","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.redox.2023.102836_bib23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm3507","article-title":"FOXOs: signalling integrators for homeostasis maintenance","volume":"14","author":"Eijkelenboom","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2023.102836_bib24","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/s41388-018-0582-8","article-title":"The ERK and JNK pathways in the regulation of metabolic reprogramming","volume":"38","author":"Papa","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2023.102836_bib25","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.redox.2023.102836_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-020-0088-2","article-title":"Therapeutic strategies targeting FOXO transcription factors","volume":"20","author":"Calissi","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2023.102836_bib27","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.freeradbiomed.2012.06.024","article-title":"Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells","volume":"53","author":"Bian","year":"2012","journal-title":"FREE RADICAL BIO MED"},{"key":"10.1016\/j.redox.2023.102836_bib28","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1001\/jamaophthalmol.2015.3590","article-title":"Intakes of lutein, zeaxanthin, and other carotenoids and age-related macular degeneration during 2 decades of prospective follow-up","volume":"133","author":"Wu","year":"2015","journal-title":"JAMA OPHTHALMOL"},{"key":"10.1016\/j.redox.2023.102836_bib29","first-page":"513","article-title":"The diagnosis and treatment of age-related macular degeneration","volume":"117","author":"Stahl","year":"2020","journal-title":"DTSCH ARZTEBL INT"},{"key":"10.1016\/j.redox.2023.102836_bib30","first-page":"CD253","article-title":"Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration","volume":"7","author":"Evans","year":"2017","journal-title":"COCHRANE DB SYST REV"},{"key":"10.1016\/j.redox.2023.102836_bib31","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2023.102836_bib32","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.febslet.2013.05.020","article-title":"The cell stress machinery and retinal degeneration","volume":"587","author":"Athanasiou","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.redox.2023.102836_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101779","article-title":"Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration","volume":"37","author":"Ozawa","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102836_bib34","first-page":"3963","article-title":"Effects triggered by platinum nanoparticles on primary keratinocytes","volume":"8","author":"Konieczny","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.redox.2023.102836_bib35","article-title":"Biomimetic liposomal nanoplatinum for targeted cancer chemophototherapy","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.redox.2023.102836_bib36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pupt.2008.12.015","article-title":"Platinum nanoparticle antioxidants inhibit pulmonary inflammation in mice exposed to cigarette smoke","volume":"22","author":"Onizawa","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.redox.2023.102836_bib37","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1007\/s11064-021-03434-7","article-title":"Platinum nanoparticles protect against lipopolysaccharide-induced inflammation in microglial BV-2 cells via decreased oxidative damage and increased phagocytosis","volume":"46","author":"Elmazoglu","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.redox.2023.102836_bib38","doi-asserted-by":"crossref","first-page":"15389","DOI":"10.1021\/acsomega.8b01653","article-title":"Multifunctional Platinum@BSA-rapamycin nanocarriers for the combinatorial therapy of cerebral cavernous malformation","volume":"3","author":"De Luca","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.redox.2023.102836_bib39","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1038\/s41467-022-32272-6","article-title":"Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers","volume":"13","author":"Van Nyen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102836_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.preteyeres.2017.11.002","article-title":"Retinal energy demands control vascular supply of the retina in development and disease: the role of neuronal lipid and glucose metabolism","volume":"64","author":"Joyal","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.redox.2023.102836_bib41","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.molmed.2011.01.014","article-title":"Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase","volume":"17","author":"Perl","year":"2011","journal-title":"Trends Mol. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723002379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723002379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:36:06Z","timestamp":1761978966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723002379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":41,"alternative-id":["S2213231723002379"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102836","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism of action of platinum nanoparticles implying from antioxidant to metabolic programming in light-induced retinal degeneration model","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102836"}}