{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:45:22Z","timestamp":1783683922644,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA244236"],"award-info":[{"award-number":["R01 CA244236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 CA156735"],"award-info":[{"award-number":["U54 CA156735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 MD012392"],"award-info":[{"award-number":["U54 MD012392"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA216051"],"award-info":[{"award-number":["R01 CA216051"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD023611"],"award-info":[{"award-number":["S10 OD023611"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA016086"],"award-info":[{"award-number":["P30 CA016086"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.redox.2023.102901","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T13:04:29Z","timestamp":1695387869000},"page":"102901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia"],"prefix":"10.1016","volume":"67","author":[{"given":"Chorlada","family":"Paiboonrungruang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Chembo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caizhi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon E.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ben Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-6156","authenticated-orcid":false,"given":"Xiaoxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102901_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/nyas.13144","article-title":"Personalized and targeted therapy of esophageal squamous cell carcinoma: an update","volume":"1381","author":"Liu","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.redox.2023.102901_bib2","doi-asserted-by":"crossref","first-page":"7648","DOI":"10.3748\/wjg.v21.i25.7648","article-title":"Personalized targeted therapy for esophageal squamous cell carcinoma","volume":"21","author":"Kang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.redox.2023.102901_bib3","first-page":"169","article-title":"Analysis Working Group: asan U, Agency BCC, Brigham, Women's H, Broad I, et al. Integrated genomic characterization of oesophageal carcinoma","volume":"541","author":"Cancer Genome Atlas Research","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102901_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14194702","article-title":"The KEAP1-NRF2 system and esophageal cancer","volume":"14","author":"Hirose","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.redox.2023.102901_bib5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1158\/0008-5472.CAN-18-2723","article-title":"NRF2 activation in cancer: from DNA to protein","volume":"79","author":"Cloer","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2023.102901_bib6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.molcel.2006.03.004","article-title":"The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer","volume":"21","author":"Hayes","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2023.102901_bib7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2006.01.013","article-title":"Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer","volume":"21","author":"Padmanabhan","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2023.102901_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/128_2012_339","article-title":"Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane","volume":"329","author":"Kensler","year":"2013","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.redox.2023.102901_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1158\/1940-6207.CAPR-12-0401-T","article-title":"Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis","volume":"6","author":"Ohkoshi","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.redox.2023.102901_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","article-title":"NRF2 and the hallmarks of cancer","volume":"34","author":"Rojo de la Vega","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2023.102901_bib11","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.225680.113","article-title":"The emerging role of the Nrf2-Keap1 signaling pathway in cancer","volume":"27","author":"Jaramillo","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.redox.2023.102901_bib12","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2023.102901_bib13","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1245\/s10434-014-3600-2","article-title":"Nrf2 is useful for predicting the effect of chemoradiation therapy on esophageal squamous cell carcinoma","volume":"21","author":"Kawasaki","year":"2014","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.redox.2023.102901_bib14","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1593\/neo.11750","article-title":"NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer","volume":"13","author":"Shibata","year":"2011","journal-title":"Neoplasia"},{"key":"10.1016\/j.redox.2023.102901_bib15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41379-022-01010-0","article-title":"High expression of nuclear NRF2 combined with NFE2L2 alterations predicts poor prognosis in esophageal squamous cell carcinoma patients","volume":"35","author":"Jiang","year":"2022","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.redox.2023.102901_bib16","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1038\/srep02650","article-title":"Comprehensive identification of mutational cancer driver genes across 12 tumor types","volume":"3","author":"Tamborero","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102901_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.freeradbiomed.2016.09.010","article-title":"An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy","volume":"99","author":"Zhu","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102901_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ng1248","article-title":"Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation","volume":"35","author":"Wakabayashi","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2023.102901_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14577","article-title":"Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus","volume":"8","author":"Suzuki","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102901_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110105","article-title":"Development of targeted therapy of NRF2(high) esophageal squamous cell carcinoma","volume":"86","author":"Paiboonrungruang","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.redox.2023.102901_bib21","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1158\/1535-7163.MCT-21-0210","article-title":"A novel Nrf2 pathway inhibitor sensitizes keap1-mutant lung cancer cells to chemotherapy","volume":"20","author":"Zhang","year":"2021","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.redox.2023.102901_bib22","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1074\/jbc.M111.316471","article-title":"Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein","volume":"287","author":"Camp","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102901_bib23","series-title":"Antiparasitic Agents. Infectious Diseases.","first-page":"1345","author":"Kuhlmann","year":"2017"},{"key":"10.1016\/j.redox.2023.102901_bib24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/med.21364","article-title":"Mitoxantrone, more than just another topoisomerase II poison","volume":"36","author":"Evison","year":"2016","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.redox.2023.102901_bib25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/path.5504","article-title":"A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue","volume":"252","author":"Bowman","year":"2020","journal-title":"J. Pathol."},{"key":"10.1016\/j.redox.2023.102901_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13550-020-00726-x","article-title":"Differences in [(18)F]FDG uptake in BAT of UCP1 -\/- and UCP1 +\/+ during adrenergic stimulation of non-shivering thermogenesis","volume":"10","author":"McHugh","year":"2020","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.redox.2023.102901_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s40268-017-0206-8","article-title":"Adverse event profile of pyrimethamine-based therapy in toxoplasmosis: a systematic review","volume":"17","author":"Ben-Harari","year":"2017","journal-title":"Drugs R"},{"key":"10.1016\/j.redox.2023.102901_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A simple statistical parameter for use in evaluation and validation of high throughput screening assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen"},{"key":"10.1016\/j.redox.2023.102901_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101531","article-title":"The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase","volume":"298","author":"Heppler","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102901_bib30","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1158\/1535-7163.MCT-18-0936","article-title":"Antimalarial drug pyrimethamine plays a dual role in antitumor proliferation and metastasis through targeting DHFR and TP","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.redox.2023.102901_bib31","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1158\/1535-7163.MCT-10-0108","article-title":"Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype","volume":"9","author":"Singh","year":"2010","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.redox.2023.102901_bib32","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2016.12.041","article-title":"Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation","volume":"103","author":"Tsuchida","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102901_bib33","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/mc.22609","article-title":"Brusatol overcomes chemoresistance through inhibition of protein translation","volume":"56","author":"Harder","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.redox.2023.102901_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31281-0","article-title":"A catalogue of somatic NRF2 gain-of-function mutations in cancer","volume":"8","author":"Kerins","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2023.102901_bib35","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/ana.24950","article-title":"Pyrimethamine significantly lowers cerebrospinal fluid Cu\/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations","volume":"81","author":"Lange","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.redox.2023.102901_bib36","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1002\/ijc.28199","article-title":"Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways","volume":"133","author":"Dai","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.redox.2023.102901_bib37","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1158\/0008-5472.CAN-08-0222","article-title":"Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism","volume":"68","author":"Giammarioli","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2023.102901_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082962","article-title":"Anticancer properties of distinct antimalarial drug classes","volume":"8","author":"Hooft van Huijsduijnen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102901_bib39","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1186\/s12885-016-2816-x","article-title":"Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes","volume":"16","author":"Jang","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.redox.2023.102901_bib40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13046-016-0409-9","article-title":"New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study","volume":"35","author":"Tommasino","year":"2016","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.redox.2023.102901_bib41","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/acschembio.7b01025","article-title":"A complementary chemical and genomic screening approach for druggable targets in the Nrf2 pathway and small molecule inhibitors to overcome cancer cell drug resistance","volume":"13","author":"Matthews","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.redox.2023.102901_bib42","first-page":"27","article-title":"[Local application of mitoxantrone in inoperable, stenosing esophageal carcinoma. Preliminary report]","volume":"9","author":"Hoffmanns","year":"1986","journal-title":"Onkologie"},{"key":"10.1016\/j.redox.2023.102901_bib43","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1021\/jm9013407","article-title":"Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA","volume":"52","author":"Liu","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.redox.2023.102901_bib44","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1158\/1078-0432.CCR-11-0235","article-title":"Mitoxantrone inhibits HIF-1alpha expression in a topoisomerase II-independent pathway","volume":"17","author":"Toh","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.redox.2023.102901_bib45","doi-asserted-by":"crossref","first-page":"13943","DOI":"10.1073\/pnas.93.24.13943","article-title":"NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development","volume":"93","author":"Chan","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2023.102901_bib46","first-page":"4850","article-title":"Plasma and cellular pharmacokinetics of mitoxantrone in high-dose chemotherapeutic regimen for refractory lymphomas","volume":"53","author":"Canal","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2023.102901_bib47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cotox.2016.10.005","article-title":"NRF2-targeted therapeutics: new targets and modes of NRF2 regulation","volume":"1","author":"de la Vega","year":"2016","journal-title":"Curr.Opin. Toxicol."},{"key":"10.1016\/j.redox.2023.102901_bib48","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.3390\/molecules25122763","article-title":"Anticancer activity of pyrimethamine via ubiquitin mediated degradation of AIMP2-DX2","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.redox.2023.102901_bib49","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1038\/onc.2017.153","article-title":"A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer","volume":"36","author":"Choi","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2023.102901_bib50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1074\/jbc.RA118.005963","article-title":"Hyperactivity of the transcription factor NRF2 causes metabolic reprogramming in mouse esophagus","volume":"294","author":"Fu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102901_bib51","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.2042-7158.1985.tb05034.x","article-title":"Pyrimethamine pharmacokinetics and its tissue localization in mice: effect of dose size","volume":"37","author":"Coleman","year":"1985","journal-title":"J. Pharm. Pharmacol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723003026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723003026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:01:05Z","timestamp":1778853665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723003026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":51,"alternative-id":["S2213231723003026"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102901","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.12.05.519147","asserted-by":"object"}]},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102901","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102901"}}