{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:50:51Z","timestamp":1792691451898,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["1R01HL120585"],"award-info":[{"award-number":["1R01HL120585"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["RF1AG072295"],"award-info":[{"award-number":["RF1AG072295"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.redox.2023.102958","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T02:30:05Z","timestamp":1699237805000},"page":"102958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["A role for the cystathionine-\u03b2-synthase \/H2S axis in astrocyte dysfunction in the aging brain"],"prefix":"10.1016","volume":"68","author":[{"given":"Anindya","family":"Dey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pijush Kanti","family":"Pramanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra Kumar Dhar","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiifi","family":"Neizer-Ashun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhrajit","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyabrata","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohiuddin","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Csiszar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2523-0569","authenticated-orcid":false,"given":"Resham","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.redox.2023.102958_bib1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1113\/JP277478","article-title":"Ionic signalling in astroglia beyond calcium","volume":"598","author":"Verkhratsky","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.redox.2023.102958_bib2","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3389\/fphar.2019.01114","article-title":"Astrocytes: role and functions in brain pathologies","volume":"10","author":"Siracusa","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.redox.2023.102958_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5607\/en.2018.27.2.77","article-title":"Astrocytes, microglia, and Parkinson's disease","volume":"27","author":"Joe","year":"2018","journal-title":"Exp Neurobiol"},{"issue":"1","key":"10.1016\/j.redox.2023.102958_bib4","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s41467-019-14198-8","article-title":"Identification of region-specific astrocyte subtypes at single cell resolution","volume":"11","author":"Batiuk","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.redox.2023.102958_bib5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(18)30490-3","article-title":"The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications","volume":"18","author":"Arranz","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2023.102958_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105028","article-title":"Microglia and astrocyte dysfunction in Parkinson's disease","volume":"144","author":"Kam","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"12","key":"10.1016\/j.redox.2023.102958_bib7","doi-asserted-by":"crossref","first-page":"13098","DOI":"10.1096\/fj.201901304R","article-title":"Hydrogen sulfide signaling in mitochondria and disease","volume":"33","author":"Murphy","year":"2019","journal-title":"Faseb. J."},{"issue":"6","key":"10.1016\/j.redox.2023.102958_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067322","article-title":"Brain 3-mercaptopyruvate sulfurtransferase (3MST): cellular localization and downregulation after acute stroke","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102958_bib9","article-title":"Development and aging expression of cystathionine-beta synthase in the temporal lobe and cerebellum of down syndrome patients","volume":"4","author":"K.T.I.A.K.H.I.H.H.S.a.T","year":"2008","journal-title":"Neuroembryol. Aging"},{"issue":"13","key":"10.1016\/j.redox.2023.102958_bib10","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1096\/fj.05-3724fje","article-title":"Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia\/astrocyte lineage of developing mouse CNS","volume":"19","author":"Enokido","year":"2005","journal-title":"Faseb. J."},{"key":"10.1016\/j.redox.2023.102958_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102233","article-title":"Overproduction of hydrogen sulfide, generated by cystathionine beta-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome","volume":"51","author":"Panagaki","year":"2022","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2023.102958_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ng0598-91","article-title":"Correction of disease-causing CBS mutations in yeast","volume":"19","author":"Shan","year":"1998","journal-title":"Nat. Genet."},{"issue":"27","key":"10.1016\/j.redox.2023.102958_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz8534","article-title":"Cystathione beta-synthase regulates HIF-1alpha stability through persulfidation of PHD2","volume":"6","author":"Dey","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2023.102958_bib14","series-title":"Homocystinuria and Hyperhomocysteinemia","author":"Barshop","year":"2012"},{"issue":"6","key":"10.1016\/j.redox.2023.102958_bib15","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.cmet.2019.10.007","article-title":"Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration","volume":"30","author":"Zivanovic","year":"2019","journal-title":"Cell Metabol."},{"issue":"4","key":"10.1016\/j.redox.2023.102958_bib16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4103\/1673-5374.266911","article-title":"Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases","volume":"15","author":"Tabassum","year":"2020","journal-title":"Neural Regen Res"},{"issue":"4","key":"10.1016\/j.redox.2023.102958_bib17","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017225118","article-title":"Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation","volume":"118","author":"Giovinazzo","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2023.102958_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fcell.2018.00014","article-title":"Cystathionine beta-synthase is necessary for Axis development in vivo","volume":"6","author":"Prabhudesai","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.redox.2023.102958_bib19","doi-asserted-by":"crossref","first-page":"9372","DOI":"10.1096\/fj.202000173R","article-title":"Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells","volume":"34","author":"Rao","year":"2020","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.redox.2023.102958_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","article-title":"Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse","volume":"89","author":"Zhang","year":"2016","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.redox.2023.102958_bib21","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.chembiol.2021.01.024","article-title":"Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine gamma-lyase (CSE) represses trophoblast syncytialization","volume":"28","author":"Liu","year":"2021","journal-title":"Cell Chem. Biol."},{"issue":"1","key":"10.1016\/j.redox.2023.102958_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41392-020-00410-5","article-title":"Inhibition of cystathionine beta-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"51","key":"10.1016\/j.redox.2023.102958_bib23","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2023.102958_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-60761-756-3_18","article-title":"Measurement of oxidized\/reduced glutathione ratio","volume":"648","author":"Owen","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"36","key":"10.1016\/j.redox.2023.102958_bib25","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.redox.2023.102958_bib26","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41593-019-0491-3","article-title":"Single-cell transcriptomic profiling of the aging mouse brain","volume":"22","author":"Ximerakis","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.redox.2023.102958_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101039","article-title":"Astrocyte mitochondria: central players and potential therapeutic targets for neurodegenerative diseases and injury","volume":"59","author":"Gollihue","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.redox.2023.102958_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.redox.2017.08.021","article-title":"Regulation of platelet activation and thrombus formation by reactive oxygen species","volume":"14","author":"Qiao","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2023.102958_bib29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1096\/fj.15-278648","article-title":"Cystathionine beta-synthase regulates endothelial function via protein S-sulfhydration","volume":"30","author":"Saha","year":"2016","journal-title":"Faseb. J."},{"issue":"5","key":"10.1016\/j.redox.2023.102958_bib30","first-page":"376","article-title":"Oxidative stress in neurodegenerative diseases","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.redox.2023.102958_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101668","article-title":"Permanent cystathionine-beta-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity","volume":"42","author":"Comas","year":"2021","journal-title":"Redox Biol."},{"issue":"Pt 1","key":"10.1016\/j.redox.2023.102958_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/BJ20040243","article-title":"Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression","volume":"381","author":"Ishii","year":"2004","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.redox.2023.102958_bib33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tins.2017.04.001","article-title":"The role of astrocyte dysfunction in Parkinson's disease pathogenesis","volume":"40","author":"Booth","year":"2017","journal-title":"Trends Neurosci."},{"issue":"7","key":"10.1016\/j.redox.2023.102958_bib34","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tins.2017.05.002","article-title":"Unravelling and exploiting astrocyte dysfunction in huntington's disease","volume":"40","author":"Khakh","year":"2017","journal-title":"Trends Neurosci."},{"issue":"Pt A","key":"10.1016\/j.redox.2023.102958_bib35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.phrs.2016.08.023","article-title":"S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics","volume":"113","author":"Modis","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"96","key":"10.1016\/j.redox.2023.102958_bib36","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"issue":"15","key":"10.1016\/j.redox.2023.102958_bib37","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxidants Redox Signal."},{"issue":"10","key":"10.1016\/j.redox.2023.102958_bib38","doi-asserted-by":"crossref","first-page":"8558","DOI":"10.1074\/jbc.M310211200","article-title":"The dominant role of Sp1 in regulating the cystathionine beta-synthase -1a and -1b promoters facilitates potential tissue-specific regulation by Kruppel-like factors","volume":"279","author":"Maclean","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"Pt 1","key":"10.1016\/j.redox.2023.102958_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/bj3570097","article-title":"Transcriptional regulation of the human cystathionine beta-synthase -1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1\/Sp3","volume":"357","author":"Ge","year":"2001","journal-title":"Biochem. J."},{"issue":"17","key":"10.1016\/j.redox.2023.102958_bib40","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1073\/pnas.0509531103","article-title":"S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity","volume":"103","author":"Prudova","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.redox.2023.102958_bib41","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2217\/epi-2016-0002","article-title":"Oxidative stress signaling to chromatin in health and disease","volume":"8","author":"Kreuz","year":"2016","journal-title":"Epigenomics"},{"issue":"8","key":"10.1016\/j.redox.2023.102958_bib42","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/alz.12305","article-title":"Plasma hydrogen sulfide: a biomarker of Alzheimer's disease and related dementias","volume":"17","author":"Disbrow","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.redox.2023.102958_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102633","article-title":"Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias","volume":"62","author":"Reekes","year":"2023","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.redox.2023.102958_bib44","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1096\/fj.201701095R","article-title":"Cystathionine beta-synthase regulates mitochondrial morphogenesis in ovarian cancer","volume":"32","author":"Chakraborty","year":"2018","journal-title":"Faseb. J."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723003592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723003592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:34:21Z","timestamp":1761978861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723003592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":44,"alternative-id":["S2213231723003592"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102958","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A role for the cystathionine-\u03b2-synthase \/H2S axis in astrocyte dysfunction in the aging brain","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102958"}}