{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T16:45:44Z","timestamp":1793551544759,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["ECS00000041"],"award-info":[{"award-number":["ECS00000041"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["20-0188"],"award-info":[{"award-number":["20-0188"]}],"id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["21-0156"],"award-info":[{"award-number":["21-0156"]}],"id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["19852"],"award-info":[{"award-number":["19852"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["21392"],"award-info":[{"award-number":["21392"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["23029"],"award-info":[{"award-number":["23029"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG2021 ID 26140"],"award-info":[{"award-number":["IG2021 ID 26140"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010607","name":"Universit\u00e0 degli Studi di Perugia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.redox.2023.102962","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T16:26:41Z","timestamp":1700497601000},"page":"102962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Organic Selenium induces ferroptosis in pancreatic cancer cells"],"prefix":"10.1016","volume":"68","author":[{"given":"Roberta","family":"No\u00e8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Inglese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Romani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thauan","family":"Serafini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Paoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Calciolari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fantuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Zamborlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta C.","family":"Surdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Spada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Spacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Volta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Ermini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulietta","family":"Di Benedetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Frusca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Santi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Lefkimmiatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirio","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Voliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Sancineto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9300-6879","authenticated-orcid":false,"given":"Alessandro","family":"Carrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2023.102962_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.redox.2023.102962_bib2","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1016\/j.molcel.2022.06.005","article-title":"Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis","volume":"82","author":"He","year":"2022","journal-title":"Mol. Cell."},{"key":"10.1016\/j.redox.2023.102962_bib3","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.cell.2017.08.051","article-title":"Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer","volume":"171","author":"Bar-Peled","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.redox.2023.102962_bib4","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1182\/blood-2011-10-385658","article-title":"Rac2-MRC-cIII\u2013generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors","volume":"119","author":"Nieborowska-Skorska","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.redox.2023.102962_bib5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41556-022-00843-w","article-title":"Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance","volume":"24","author":"Romani","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2023.102962_bib6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.redox.2023.102962_bib7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/ncb3005","article-title":"Organelle-specific initiation of cell death","volume":"16","author":"Galluzzi","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2023.102962_bib8","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106700","article-title":"Cell death pathways: intricate connections and disease implications","volume":"40","author":"Kist","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2023.102962_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature17403","article-title":"The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression","volume":"532","author":"Seifert","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102962_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228015","article-title":"Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5","volume":"15","author":"Ando","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.102962_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612633","article-title":"The dual role of necroptosis in pancreatic ductal adenocarcinoma","volume":"24","author":"Giansante","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2023.102962_bib12","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41575-021-00486-6","article-title":"Cell death in pancreatic cancer: from pathogenesis to therapy","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2023.102962_bib13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.redox.2023.102962_bib14","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.molcel.2023.03.005","article-title":"Ferroptosis: a flexible constellation of related biochemical mechanisms","volume":"83","author":"Dixon","year":"2023","journal-title":"Mol. Cell."},{"key":"10.1016\/j.redox.2023.102962_bib15","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cell.2016.06.056","article-title":"NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer","volume":"166","author":"Chio","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.redox.2023.102962_bib16","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1158\/2159-8290.CD-22-0043","article-title":"NCOA4-Mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron\u2013sulfur cluster proteins","volume":"12","author":"Santana-Codina","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.redox.2023.102962_bib17","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1158\/2159-8290.CD-22-0044","article-title":"Coordinated transcriptional and catabolic programs support iron-dependent adaptation to RAS\u2013MAPK pathway inhibition in pancreatic cancer","volume":"12","author":"Ravichandran","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.redox.2023.102962_bib18","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bbabio.2006.08.001","article-title":"Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts","volume":"1757","author":"Chiaradonna","year":"2006","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.redox.2023.102962_bib19","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2023.102962_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/ars.2017.7115","article-title":"GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues","volume":"29","author":"Maiorino","year":"2017","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2023.102962_bib21","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.redox.2023.102962_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.redox.2023.102962_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101807","article-title":"FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells","volume":"38","author":"Ye","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102962_bib24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/ars.2015.6362","article-title":"Synthetic lethality of a novel small molecule against mutant KRAS-expressing cancer cells involves AKT-dependent ROS production","volume":"24","author":"Iskandar","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2023.102962_bib25","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","article-title":"Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173\/STING-dependent DNA sensor pathway","volume":"11","author":"Dai","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2023.102962_bib26","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.trecan.2021.04.005","article-title":"Targeting ferroptosis in pancreatic cancer: a double-edged sword","volume":"7","author":"Chen","year":"2021","journal-title":"Trends in Cancer"},{"key":"10.1016\/j.redox.2023.102962_bib27","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1074\/jbc.R800045200","article-title":"Selenoproteins","volume":"284","author":"Lu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102962_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101877","article-title":"A matter of concern \u2013 trace element dyshomeostasis and genomic stability in neurons","volume":"41","author":"Wandt","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102962_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/2212796816666220422135204","article-title":"Biological activity of synthetic organoselenium compounds: what do we know about the mechanism?","volume":"16","author":"Nogara","year":"2022","journal-title":"Curr. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102962_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.redox.2015.12.007","article-title":"Virtual issue by COST Action BM1203 (EU-ROS) \u201cEmerging concepts in redox biology and oxidative stress,\u201d","volume":"8","author":"Daiber","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102962_bib31","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.bbagen.2014.10.008","article-title":"Selenium compounds as therapeutic agents in cancer","volume":"1850","author":"Fernandes","year":"2015","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.redox.2023.102962_bib32","article-title":"Selenium reduction of ubiquinone via SQOR suppresses ferroptosis","author":"Lee","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.redox.2023.102962_bib33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chembiol.2020.03.012","article-title":"Selenium: tracing another essential element of ferroptotic cell death","volume":"27","author":"Conrad","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.redox.2023.102962_bib34","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41589-022-01033-3","article-title":"Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability","volume":"18","author":"Li","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102962_bib35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.redox.2023.102962_bib36","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1158\/0008-5472.CAN-22-0408","article-title":"Selenium modulates cancer cell response to pharmacologic ascorbate","volume":"82","author":"Jankowski","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2023.102962_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101617","article-title":"Metabolic regulation of ferroptosis in the tumor microenvironment","volume":"298","author":"Mbah","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2023.102962_bib38","series-title":"Acetyl-CoA Metabolism Supports Multi-step Pancreatic Tumorigenesis","author":"Carrer","year":"2019"},{"key":"10.1016\/j.redox.2023.102962_bib39","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1038\/onc.2012.6","article-title":"Targeting tumor cell metabolism with statins","volume":"31","author":"Clendening","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2023.102962_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1158\/0008-5472.CAN-19-0644","article-title":"Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic antitumor response","volume":"80","author":"McGregor","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2023.102962_bib41","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102962_bib42","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102962_bib43","first-page":"246","article-title":"Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7","volume":"25","author":"Deshwal","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2023.102962_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102272","article-title":"UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death","volume":"51","author":"Arslanbaeva","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102962_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.immuni.2018.06.006","article-title":"Tumor cell-intrinsic factors underlie heterogeneity of immune cell infiltration and response to article tumor cell-intrinsic factors underlie heterogeneity of immune cell infiltration and response to immunotherapy","volume":"49","author":"Li","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2023.102962_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.24820\/ark.5550190.p010.981","article-title":"Ultrasound-assisted synthesis of alkali metals diselenides (M2Se2) and their application for the gram-scale preparation of 2,2\u2019-diselenobis(benzoic acid)","author":"Krasowska","year":"2019","journal-title":"ARKIVOC (Gainesville, FL, U. S.)"},{"key":"10.1016\/j.redox.2023.102962_bib47","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.1039\/D0NJ01605E","article-title":"Fast and easy conversion of ortho amidoaryldiselenides into the corresponding ebselen-like derivatives driven by theoretical investigations","volume":"44","author":"Nascimento","year":"2020","journal-title":"New J. Chem."},{"key":"10.1016\/j.redox.2023.102962_bib48","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1002\/ejoc.200800869","article-title":"Preparation of the First bench-stable phenyl selenolate: an interesting \u201con water\u201d nucleophilic reagent","author":"Santi","year":"2008","journal-title":"Eur. J. Org Chem."},{"key":"10.1016\/j.redox.2023.102962_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110056","article-title":"Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis","volume":"37","author":"Dorsch","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2023.102962_bib50","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1158\/0008-5472.CAN-19-0650","article-title":"Mevalonate pathway provides ubiquinone to maintain pyrimidine synthesis and survival in p53-deficient cancer cells exposed to metabolic stress","volume":"80","author":"Kaymak","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2023.102962_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102962_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26144230","article-title":"Ebselen and analogues: pharmacological properties and synthetic strategies for their preparation","volume":"26","author":"Santi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.redox.2023.102962_bib53","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1039\/D2TB01930B","article-title":"Hybrid nano-architectures loaded with metal complexes for the co-chemotherapy of head and neck carcinomas","volume":"11","author":"Santi","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.redox.2023.102962_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/ppsc.201800464","article-title":"Biodegradable ultrasmall-in-nano gold architectures: mid-period in vivo distribution and excretion assessment, part","volume":"36","author":"Cassano","year":"2019","journal-title":"Part. Syst. Charact."},{"key":"10.1016\/j.redox.2023.102962_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103980","article-title":"Chorioallantoic membrane tumor models highlight the effects of cisplatin compounds in oral carcinoma treatment","volume":"25","author":"Sarogni","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.redox.2023.102962_bib56","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2023.102962_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102232","article-title":"Inactivation of RIP3 kinase sensitizes to 15LOX\/PEBP1-mediated ferroptotic death","volume":"50","author":"Lamade","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102962_bib58","doi-asserted-by":"crossref","first-page":"10775","DOI":"10.1073\/pnas.0912925107","article-title":"Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol","volume":"107","author":"Richardson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2023.102962_bib59","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-physiol-020518-114742","article-title":"Mitochondrial iron in human Health and disease","volume":"81","author":"Ward","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.redox.2023.102962_bib60","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/cdd.2017.149","article-title":"How do we fit ferroptosis in the family of regulated cell death?","volume":"24","author":"Fearnhead","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2023.102962_bib61","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/imr.12533","article-title":"Ferroptosis: bug or feature?","volume":"277","author":"Dixon","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.redox.2023.102962_bib62","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.celrep.2019.07.031","article-title":"Drp1 promotes KRas-driven metabolic changes to drive pancreatic tumor growth","volume":"28","author":"Nagdas","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2023.102962_bib63","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1073\/pnas.1003428107","article-title":"Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity","volume":"107","author":"Weinberg","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2023.102962_bib64","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1073\/pnas.1307237110","article-title":"Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids","volume":"110","author":"Kamphorst","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2023.102962_bib65","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2023.102962_bib66","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.redox.2023.102962_bib67","first-page":"718","article-title":"The interplay between cell signalling and the mevalonate pathway in cancer","volume":"16","author":"Mullen","year":"2016","journal-title":"Nat. Publ. Gr."},{"key":"10.1016\/j.redox.2023.102962_bib68","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12951-021-01058-1","article-title":"Simvastatin induced ferroptosis for triple-negative breast cancer therapy","volume":"19","author":"Yao","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2023.102962_bib69","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73245","article-title":"Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context","volume":"11","author":"Kerk","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.redox.2023.102962_bib70","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.cmet.2016.09.006","article-title":"Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin","volume":"24","author":"Gui","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.redox.2023.102962_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102021","article-title":"Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes","volume":"45","author":"Jang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2023.102962_bib72","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2023.102962_bib73","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mito.2015.02.001","article-title":"Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders","volume":"21","author":"Mena","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.redox.2023.102962_bib74","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell."},{"key":"10.1016\/j.redox.2023.102962_bib75","article-title":"Mitochondria and ferroptosis","volume":"25","author":"Javadov","year":"2022","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.redox.2023.102962_bib76","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.79311","article-title":"Selenocyanate derived Se-incorporation into the nitrogenase Fe protein cluster","volume":"11","author":"Buscagan","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.redox.2023.102962_bib77","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1021\/ja3010539","article-title":"Selenium as a structural surrogate of sulfur: template-assisted assembly of five types of tungsten\u2013iron\u2013sulfur\/selenium clusters and the structural fate of chalcogenide reactants","volume":"134","author":"Zheng","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.redox.2023.102962_bib78","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/ejic.202000033","article-title":"Sulfur vs. Selenium as bridging ligand in di-iron complexes: a theoretical analysis","author":"Spiller","year":"2020","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.redox.2023.102962_bib79","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2018.05.001","article-title":"Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment","volume":"127","author":"Gandin","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102962_bib80","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.freeradbiomed.2015.06.039","article-title":"Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides","volume":"88","author":"Bartolini","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2023.102962_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24162914","article-title":"Diselenides and benzisoselenazolones as antiproliferative agents and glutathione-S-transferase inhibitors","volume":"24","author":"Krasowska","year":"2019","journal-title":"Molecules"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723003634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231723003634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:33:08Z","timestamp":1761978788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231723003634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":81,"alternative-id":["S2213231723003634"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.102962","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organic Selenium induces ferroptosis in pancreatic cancer cells","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.102962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102962"}}