{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:20:05Z","timestamp":1793910005182,"version":"4.8.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023989","name":"Wonju College of Medicine, Yonsei University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2018R1A5A2024418"],"award-info":[{"award-number":["NRF-2018R1A5A2024418"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2020R1A2C2010082"],"award-info":[{"award-number":["NRF-2020R1A2C2010082"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2023-00252102"],"award-info":[{"award-number":["RS-2023-00252102"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.redox.2023.103023","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T16:33:48Z","timestamp":1703954028000},"page":"103023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment"],"prefix":"10.1016","volume":"69","author":[{"given":"Ji Sun","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Jin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenzheng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngkyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-6106","authenticated-orcid":false,"given":"Hong-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.redox.2023.103023_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/JLB.1RU0818-310R","article-title":"Macrophage immunomodulation in chronic osteolytic diseases-the case of periodontitis","volume":"105","author":"Sima","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.redox.2023.103023_bib2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fphys.2017.00439","article-title":"The role of reactive oxygen species and autophagy in periodontitis and their potential linkage","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.redox.2023.103023_bib3","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1600-051X.2007.01091.x","article-title":"Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis","volume":"34","author":"Akalin","year":"2007","journal-title":"J. Clin. Periodontol."},{"issue":"10","key":"10.1016\/j.redox.2023.103023_bib4","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1034\/j.1600-051x.2000.027010758.x","article-title":"Cytokine, elastase and oxygen radical release by fusobacterium nucleatum-activated leukocytes: a possible pathogenic factor in periodontitis","volume":"27","author":"Sheikhi","year":"2000","journal-title":"J. Clin. Periodontol."},{"issue":"8","key":"10.1016\/j.redox.2023.103023_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161482","article-title":"Effects of porphyromonas gingivalis lipopolysaccharide tolerized monocytes on inflammatory responses in neutrophils","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2023.103023_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1741-7015-10-122","article-title":"Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation","volume":"10","author":"Bullon","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.redox.2023.103023_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.biocel.2016.08.034","article-title":"Energy metabolism in osteoclast formation and activity","volume":"79","author":"Lemma","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"8","key":"10.1016\/j.redox.2023.103023_bib8","doi-asserted-by":"crossref","first-page":"9167","DOI":"10.1096\/fj.201900010RR","article-title":"Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages","volume":"33","author":"Angireddy","year":"2019","journal-title":"FASEB J"},{"issue":"8","key":"10.1016\/j.redox.2023.103023_bib9","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1007\/s00018-021-03772-3","article-title":"At the heart of mitochondrial quality control: many roads to the top Cell","volume":"78","author":"Gottlieb","year":"2021","journal-title":"Mol Life Sci"},{"issue":"1","key":"10.1016\/j.redox.2023.103023_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbrc.2019.06.017","article-title":"Mitofusin 2, a mitochondria-ER tethering protein, facilitates osteoclastogenesis by regulating the calcium-calcineurin-NFATc1 axis","volume":"516","author":"Jung","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.redox.2023.103023_bib11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1873-3468.13963","article-title":"Dynamin-related protein 1 positively regulates osteoclast differentiation and bone loss","volume":"595","author":"Jeong","year":"2021","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.redox.2023.103023_bib12","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/jbmr.3398","article-title":"PGC1beta organizes the osteoclast cytoskeleton by mitochondrial biogenesis and activation","volume":"33","author":"Zhang","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"7565","key":"10.1016\/j.redox.2023.103023_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"issue":"7097","key":"10.1016\/j.redox.2023.103023_bib14","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nature04788","article-title":"Mitochondrial dysfunction in drosophila PINK1 mutants is complemented by parkin","volume":"441","author":"Park","year":"2006","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.redox.2023.103023_bib15","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.stemcr.2016.08.012","article-title":"Parkin and PINK1 Patient iPSC-derived midbrain dopamine neurons exhibit mitochondrial dysfunction and alpha-synuclein accumulation","volume":"7","author":"Chung","year":"2016","journal-title":"Stem Cell Rep."},{"issue":"5","key":"10.1016\/j.redox.2023.103023_bib16","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/glia.22475","article-title":"PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation","volume":"61","author":"Choi","year":"2013","journal-title":"and downregulation of EGFR Glia"},{"issue":"Pt 7","key":"10.1016\/j.redox.2023.103023_bib17","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1242\/jcs.078303","article-title":"Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance","volume":"124","author":"Heeman","year":"2011","journal-title":"J. Cell Sci."},{"issue":"6180","key":"10.1016\/j.redox.2023.103023_bib18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1126\/science.1249161","article-title":"PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling","volume":"344","author":"Morais","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.redox.2023.103023_bib19","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1038\/ncomms5514","article-title":"PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1","volume":"5","author":"Requejo-Aguilar","year":"2014","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.redox.2023.103023_bib20","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3390\/jcm8111849","article-title":"Pink1-mediated chondrocytic mitophagy contributes to cartilage degeneration in osteoarthritis","volume":"8","author":"Shin","year":"2019","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.redox.2023.103023_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051772","article-title":"PINK1\/Parkin mediated mitophagy, Ca(2+) signalling, and ER-mitochondria contacts in Parkinson's disease","volume":"21","author":"Barazzuol","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"35","key":"10.1016\/j.redox.2023.103023_bib22","doi-asserted-by":"crossref","first-page":"24366","DOI":"10.1074\/jbc.M114.563817","article-title":"Defective entry into mitosis 1 (Dim1) negatively regulates osteoclastogenesis by inhibiting the expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1)","volume":"289","author":"An","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.redox.2023.103023_bib23","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1038\/emboj.2011.337","article-title":"After half a century mitochondrial calcium in- and efflux machineries reveal themselves","volume":"30","author":"Drago","year":"2011","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.redox.2023.103023_bib24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2023.103023_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.675385","article-title":"The role of osteoclast energy metabolism in the occurrence and development of osteoporosis","volume":"12","author":"Da","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.redox.2023.103023_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrm.2017.129","article-title":"Building and decoding ubiquitin chains for mitophagy","volume":"19","author":"Harper","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.redox.2023.103023_bib27","first-page":"1653","volume":"9","author":"Dolman","year":"2013","journal-title":"Tools and techniques to measure mitophagy using fluorescence microscopy Autophagy"},{"key":"10.1016\/j.redox.2023.103023_bib28","first-page":"6374","volume":"359","author":"Madeo","year":"2018","journal-title":"Spermidine in health and disease Science"},{"issue":"3","key":"10.1016\/j.redox.2023.103023_bib29","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1476-5381.2012.01856.x","article-title":"The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice","volume":"166","author":"Yamamoto","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"6046","key":"10.1016\/j.redox.2023.103023_bib30","first-page":"1109","volume":"333","author":"Green","year":"2011","journal-title":"Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Science"},{"key":"10.1016\/j.redox.2023.103023_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2010.05634.x","article-title":"Oxidative stress caused by mitochondrial calcium overload","volume":"1201","author":"Peng","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.redox.2023.103023_bib32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1749-6632.2009.05377.x","article-title":"Role of mitochondrial reactive oxygen species in osteoclast differentiation","volume":"1192","author":"Srinivasan","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.redox.2023.103023_bib33","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.1400853","article-title":"Macrophage depletion abates porphyromonas gingivalis-induced alveolar bone resorption in mice","volume":"193","author":"Lam","year":"2014","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.redox.2023.103023_bib34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3390\/pathogens10060675","article-title":"Bacterial cyclic dinucleotides and the cGAS-cGAMP-STING pathway: a role in periodontitis?","volume":"10","author":"Elmanfi","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.redox.2023.103023_bib35","volume":"vol. 217","author":"Wu","year":"2022"},{"issue":"7722","key":"10.1016\/j.redox.2023.103023_bib36","first-page":"258","volume":"561","author":"Sliter","year":"2018","journal-title":"Parkin and PINK1 mitigate STING-induced inflammation Nature"},{"issue":"6","key":"10.1016\/j.redox.2023.103023_bib37","first-page":"1441","article-title":"Innate and adaptive immunity of periodontal disease","volume":"28","author":"Becerra-Ruiz","year":"2022","journal-title":"From etiology to alveolar bone loss Oral Dis"},{"issue":"8","key":"10.1016\/j.redox.2023.103023_bib38","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/glia.23337","article-title":"Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop","volume":"66","author":"Mouton-Liger","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.redox.2023.103023_bib39","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2020.09.015","article-title":"PINK1-mediated mitophagy protects against hepatic ischemia\/reperfusion injury by restraining NLRP3 inflammasome activation Free","volume":"160","author":"Xu","year":"2020","journal-title":"Radic Biol Med"},{"issue":"2","key":"10.1016\/j.redox.2023.103023_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12973","article-title":"NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation","volume":"54","author":"Chen","year":"2021","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.redox.2023.103023_bib41","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/odi.13003","article-title":"Upregulation of proteins of the NLRP3 inflammasome in patients with periodontitis and uncontrolled type 2","volume":"25","author":"Garcia-Hernandez","year":"2019","journal-title":"diabetes Oral Dis"},{"issue":"11","key":"10.1016\/j.redox.2023.103023_bib42","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1177\/0022034520933533","article-title":"Targeting NLRP3 inflammasome reduces age-related experimental alveolar bone loss","volume":"99","author":"Zang","year":"2020","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.redox.2023.103023_bib43","doi-asserted-by":"crossref","first-page":"p200","DOI":"10.3389\/fcell.2020.00200","article-title":"Mitophagy: an emerging role in aging and age-associated diseases","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.redox.2023.103023_bib44","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10545-017-0046-2","article-title":"Risk factors for poor bone health in primary mitochondrial disease","volume":"40","author":"Gandhi","year":"2017","journal-title":"J. Inherit. Metab. Dis."},{"issue":"1","key":"10.1016\/j.redox.2023.103023_bib45","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1186\/s13287-021-02656-4","article-title":"PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis","volume":"12","author":"Lee","year":"2021","journal-title":"Stem Cell Res. Ther."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172300424X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172300424X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T07:47:16Z","timestamp":1729496836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221323172300424X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":45,"alternative-id":["S221323172300424X"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2023.103023","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2023.103023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103023"}}