{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T15:42:04Z","timestamp":1794238924804,"version":"4.9.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.redox.2024.103059","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T16:08:20Z","timestamp":1706803700000},"page":"103059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"special_numbering":"C","title":["A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization"],"prefix":"10.1016","volume":"70","author":[{"given":"Chunlu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengsi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongde","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-1993","authenticated-orcid":false,"given":"Liu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.redox.2024.103059_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.it.2021.04.007","article-title":"Tissue-resident macrophages: guardians of organ homeostasis","volume":"42","author":"Nobs","year":"2021","journal-title":"Trends Immunol."},{"issue":"9","key":"10.1016\/j.redox.2024.103059_bib2","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.redox.2024.103059_bib3","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The role of macrophages in the resolution of inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.redox.2024.103059_bib4","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00011-020-01378-2","article-title":"Macrophage polarization and its role in the pathogenesis of acute lung injury\/acute respiratory distress syndrome","volume":"69","author":"Chen","year":"2020","journal-title":"Inflamm. Res."},{"issue":"2","key":"10.1016\/j.redox.2024.103059_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jhep.2014.03.031","article-title":"Modulation of monocyte\/macrophage function: a therapeutic strategy in the treatment of acute liver failure","volume":"61","author":"Possamai","year":"2014","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12916-017-0930-5","article-title":"Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis","volume":"15","author":"Kyriazopoulou","year":"2017","journal-title":"BMC Med."},{"issue":"5","key":"10.1016\/j.redox.2024.103059_bib7","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/ndt\/gfk047","article-title":"Macrophages contribute to the initiation of ischaemic acute renal failure in rats","volume":"21","author":"Jo","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"issue":"7344","key":"10.1016\/j.redox.2024.103059_bib8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.redox.2024.103059_bib9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.arplant.55.031903.141701","article-title":"Reactive oxygen species: metabolism, oxidative stress, and signal transduction","volume":"55","author":"Apel","year":"2004","journal-title":"Annu. Rev. Plant Biol."},{"issue":"10","key":"10.1016\/j.redox.2024.103059_bib10","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.redox.2024.103059_bib11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"issue":"52","key":"10.1016\/j.redox.2024.103059_bib12","doi-asserted-by":"crossref","first-page":"21105","DOI":"10.1073\/pnas.1111919109","article-title":"Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress","volume":"108","author":"Bauer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.redox.2024.103059_bib13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/jmcb\/mju045","article-title":"CHK2 kinase in the DNA damage response and beyond","volume":"6","author":"Zannini","year":"2014","journal-title":"J. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.redox.2024.103059_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122675","article-title":"CHEK2 germline variants in cancer predisposition: stalemate rather than checkmate","volume":"9","author":"Stolarova","year":"2020","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.redox.2024.103059_bib15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2024.103059_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-319-63245-2_8","article-title":"ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)","volume":"967","author":"Kellner","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.redox.2024.103059_bib17","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.imbio.2018.11.010","article-title":"Reactive oxygen species (ROS) in macrophage activation and function in diabetes","volume":"224","author":"Rendra","year":"2019","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.0901698","article-title":"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation","volume":"185","author":"Rodriguez-Prados","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2024.103059_bib19","article-title":"Metabolic characterization of polarized M1 and M2 bone marrow-derived macrophages using real-time extracellular flux analysis","volume":"105","author":"Van den Bossche","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"4","key":"10.1016\/j.redox.2024.103059_bib20","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1002\/jcp.27261","article-title":"Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model","volume":"234","author":"Zhong","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.redox.2024.103059_bib21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.redox.2024.103059_bib22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","article-title":"The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases","volume":"75","author":"Harper","year":"1993","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1074-7613(00)80085-0","article-title":"Interferon gamma induces the expression of p21waf-1 and arrests macrophage cell cycle, preventing induction of apoptosis","volume":"11","author":"Xaus","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2024.103059_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101084","article-title":"ROS and the DNA damage response in cancer","volume":"25","author":"Srinivas","year":"2019","journal-title":"Redox Biol."},{"issue":"51","key":"10.1016\/j.redox.2024.103059_bib25","doi-asserted-by":"crossref","first-page":"53272","DOI":"10.1074\/jbc.M406879200","article-title":"Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species","volume":"279","author":"Kurz","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.redox.2024.103059_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cancers9050041","article-title":"Targeting the ATR-CHK1 Axis in cancer therapy","volume":"9","author":"Rundle","year":"2017","journal-title":"Cancers"},{"issue":"12","key":"10.1016\/j.redox.2024.103059_bib27","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1016\/j.celrep.2020.03.008","article-title":"TLR4-Mediated pathway triggers interferon-independent G0 arrest and antiviral SAMHD1 activity in macrophages","volume":"30","author":"Mlcochova","year":"2020","journal-title":"Cell Rep."},{"issue":"5459","key":"10.1016\/j.redox.2024.103059_bib28","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.287.5459.1824","article-title":"DNA damage-induced activation of p53 by the checkpoint kinase Chk2","volume":"287","author":"Hirao","year":"2000","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.redox.2024.103059_bib29","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/cdd.2014.212","article-title":"A unique role for p53 in the regulation of M2 macrophage polarization","volume":"22","author":"Li","year":"2015","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.redox.2024.103059_bib30","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.bbamcr.2006.11.010","article-title":"ERK implication in cell cycle regulation","volume":"1773","author":"Chambard","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.redox.2024.103059_bib31","doi-asserted-by":"crossref","first-page":"L709","DOI":"10.1152\/ajplung.00341.2013","article-title":"Diverse macrophage populations mediate acute lung inflammation and resolution","volume":"306","author":"Aggarwal","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"2","key":"10.1016\/j.redox.2024.103059_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/toxsci\/kfy309","article-title":"Role of macrophages in acute lung injury and chronic fibrosis induced by pulmonary toxicants","volume":"168","author":"Laskin","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.redox.2024.103059_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fimmu.2011.00065","article-title":"Acute lung injury: how macrophages orchestrate resolution of inflammation and tissue repair","volume":"2","author":"Herold","year":"2011","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.redox.2024.103059_bib34","doi-asserted-by":"crossref","first-page":"946","DOI":"10.4049\/jimmunol.1200660","article-title":"Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease","volume":"189","author":"Duan","year":"2012","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.redox.2024.103059_bib35","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1182\/blood-2004-05-1868","article-title":"NADPH oxidase mediates vascular endothelial cadherin phosphorylation and endothelial dysfunction","volume":"104","author":"Nwariaku","year":"2004","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.redox.2024.103059_bib36","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/cr.2013.75","article-title":"ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages","volume":"23","author":"Zhang","year":"2013","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-kappaB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2024.103059_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/529219","article-title":"Roles nrf2 plays in myeloid cells and related disorders","volume":"2013","author":"Kobayashi","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.redox.2024.103059_bib39","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/sj.bjp.0704467","article-title":"Redox\/ROS regulation of lipopolysaccharide-induced mitogen-activated protein kinase (MAPK) activation and MAPK-mediated TNF-alpha biosynthesis","volume":"135","author":"Haddad","year":"2002","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.redox.2024.103059_bib40","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"7035","key":"10.1016\/j.redox.2024.103059_bib41","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature03482","article-title":"DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis","volume":"434","author":"Bartkova","year":"2005","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.redox.2024.103059_bib42","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nm.3651","article-title":"Stem cell aging: mechanisms, regulators and therapeutic opportunities","volume":"20","author":"Oh","year":"2014","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.redox.2024.103059_bib43","first-page":"147","article-title":"DNA damage response in hematopoietic stem cell ageing","volume":"14","author":"Li","year":"2016","journal-title":"Dev. Reprod. Biol."},{"key":"10.1016\/j.redox.2024.103059_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/B978-0-12-380888-2.00003-0","article-title":"The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer","volume":"108","author":"Smith","year":"2010","journal-title":"Adv. Cancer Res."},{"issue":"6003","key":"10.1016\/j.redox.2024.103059_bib45","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tibs.2011.10.002","article-title":"The ATM protein kinase and cellular redox signaling: beyond the DNA damage response","volume":"37","author":"Ditch","year":"2012","journal-title":"Trends Biochem. Sci."},{"issue":"7119","key":"10.1016\/j.redox.2024.103059_bib47","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature05268","article-title":"Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints","volume":"444","author":"Bartkova","year":"2006","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.redox.2024.103059_bib48","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.it.2014.06.003","article-title":"DNA damage and innate immunity: links and trade-offs","volume":"35","author":"Chatzinikolaou","year":"2014","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.redox.2024.103059_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/genes11040409","article-title":"Replication stress, DNA damage, inflammatory cytokines and innate immune response","volume":"11","author":"Ragu","year":"2020","journal-title":"Genes"},{"issue":"22","key":"10.1016\/j.redox.2024.103059_bib50","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1182\/blood-2015-04-637371","article-title":"NBS1 is required for macrophage homeostasis and functional activity in mice","volume":"126","author":"Pereira-Lopes","year":"2015","journal-title":"Blood"},{"issue":"34","key":"10.1016\/j.redox.2024.103059_bib51","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1038\/s41388-021-01933-z","article-title":"The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer","volume":"40","author":"Yu","year":"2021","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metabol."},{"issue":"7444","key":"10.1016\/j.redox.2024.103059_bib53","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"6337","key":"10.1016\/j.redox.2024.103059_bib54","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/science.aal3535","article-title":"Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages","volume":"356","author":"Ip","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.redox.2024.103059_bib55","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/eji.200838676","article-title":"Regulation of macrophage activation and septic shock susceptibility via p21(WAF1\/CIP1)","volume":"39","author":"Trakala","year":"2009","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib56","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/art.33311","article-title":"Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis","volume":"64","author":"Mavers","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.redox.2024.103059_bib57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1165\/rcmb.2007-0342OC","article-title":"Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice","volume":"39","author":"Yao","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.redox.2024.103059_bib58","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.2353\/ajpath.2006.050555","article-title":"p21Cip1 is required for the development of monocytes and their response to serum transfer-induced arthritis","volume":"168","author":"Scatizzi","year":"2006","journal-title":"Am. J. Pathol."},{"issue":"19","key":"10.1016\/j.redox.2024.103059_bib59","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1093\/emboj\/cdf506","article-title":"Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription","volume":"21","author":"Takai","year":"2002","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.redox.2024.103059_bib60","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103111","article-title":"ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress","volume":"39","author":"Guo","year":"2020","journal-title":"EMBO J."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724000351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724000351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:39:48Z","timestamp":1761979188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231724000351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":60,"alternative-id":["S2213231724000351"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103059","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103059"}}