{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:07:48Z","timestamp":1791256068270,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803534"],"award-info":[{"award-number":["81803534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160685"],"award-info":[{"award-number":["82160685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.redox.2024.103079","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T11:58:24Z","timestamp":1707393504000},"page":"103079","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPK\u03b12 activation"],"prefix":"10.1016","volume":"70","author":[{"given":"Liang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-903X","authenticated-orcid":false,"given":"Huan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.redox.2024.103079_bib1","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1200\/JCO.2007.14.9401","article-title":"Anthracycline cardiotoxicity: from bench to bedside","volume":"26","author":"Gianni","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.redox.2024.103079_bib2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.jacc.2014.06.1167","article-title":"Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities","volume":"64","author":"Vejpongsa","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.redox.2024.103079_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/mol.119.115725","article-title":"Insights into doxorubicin-induced cardiotoxicity: molecular mechanisms, preventive strategies, and early monitoring","volume":"96","author":"Wenningmann","year":"2019","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.redox.2024.103079_bib4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1161\/CIRCULATIONAHA.111.021774","article-title":"Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms","volume":"124","author":"Scott","year":"2011","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.redox.2024.103079_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41419-021-03614-x","article-title":"Regulated cell death pathways in doxorubicin- induced cardiotoxicity","volume":"12","author":"Christidi","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.redox.2024.103079_bib6","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del Re","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2024.103079_bib7","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2024.103079_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102185","article-title":"Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPK\u03b12 and activating adaptive autophagy","volume":"48","author":"He","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2024.103079_bib9","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.freeradbiomed.2014.06.011","article-title":"Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity","volume":"74","author":"Dutta","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103079_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ijcard.2017.07.037","article-title":"Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: a proof-of-concept RCT","volume":"245","author":"Kirkham","year":"2017","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.redox.2024.103079_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2007.01.029","article-title":"Systemic adaptation to oxidative challenge induced by regular exercise","volume":"44","author":"Radak","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.redox.2024.103079_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12012-017-9411-5","article-title":"Modulatory effect of aerobic exercise training on doxorubicin-induced cardiotoxicity in rats with different ages","volume":"18","author":"Ahmadian","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"issue":"1","key":"10.1016\/j.redox.2024.103079_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12012-017-9412-4","article-title":"Exercise and doxorubicin treatment modulate cardiac mitochondrial quality control signaling","volume":"18","author":"Marques-Aleixo","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"issue":"12","key":"10.1016\/j.redox.2024.103079_bib14","doi-asserted-by":"crossref","first-page":"9652","DOI":"10.1002\/jcp.26880","article-title":"Aerobic exercise, but not metformin, prevents reduction of muscular performance by AMPk activation in mice on doxorubicin chemotherapy","volume":"233","author":"de Lima","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2024.103079_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153597","article-title":"Irisin protects against doxorubicin-induced cardiotoxicity by improving AMPK-Nrf2 dependent mitochondrial fusion and strengthening endogenous anti-oxidant defense mechanisms","volume":"494","author":"Zhuo","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.redox.2024.103079_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.freeradbiomed.2021.02.047","article-title":"AMP-activated protein kinase: a remarkable contributor to preserve a healthy heart against ROS injury","volume":"166","author":"Marino","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"29","key":"10.1016\/j.redox.2024.103079_bib17","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"J\u00e4ger","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.redox.2024.103079_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2017.09.026","article-title":"AMPK maintains cellular metabolic homeostasis through regulation of mitochondrial reactive oxygen species","volume":"21","author":"Rabinovitch","year":"2017","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.redox.2024.103079_bib19","doi-asserted-by":"crossref","first-page":"H1619","DOI":"10.1152\/ajpheart.00965.2013","article-title":"A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake","volume":"306","author":"Timmermans","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.redox.2024.103079_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101680","article-title":"Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process","volume":"80","author":"Zhang","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.redox.2024.103079_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/antiox7010007","article-title":"Exercise and mitochondrial dynamics: keeping in shape with ROS and AMPK","volume":"7","author":"Trewin","year":"2018","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.redox.2024.103079_bib22","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and function of AMPK in physiology and diseases","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp. Mol. Med."},{"issue":"8","key":"10.1016\/j.redox.2024.103079_bib23","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1089\/ars.2020.8036","article-title":"Modulating oxidant levels to promote healthy aging","volume":"33","author":"Vi\u00f1a","year":"2020","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2024.103079_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4093\/dmj.2013.37.1.1","article-title":"AMPK and exercise: glucose uptake and insulin sensitivity","volume":"37","author":"O'Neill","year":"2013","journal-title":"Diabetes Metab. J."},{"issue":"11","key":"10.1016\/j.redox.2024.103079_bib25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1089\/ars.2019.7949","article-title":"Redox signaling in widespread health benefits of exercise","volume":"33","author":"Louzada","year":"2020","journal-title":"Antioxidants Redox Signal."},{"issue":"15","key":"10.1016\/j.redox.2024.103079_bib26","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system xc-activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.redox.2024.103079_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114188","article-title":"Resolvin E1 protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress, autophagy and apoptosis by targeting AKT\/mTOR signaling","volume":"180","author":"Zhang","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.redox.2024.103079_bib28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41420-021-00568-z","article-title":"IRF-8\/miR-451a regulates M-MDSC differentiation via the AMPK\/mTOR signal pathway during lupus development","volume":"7","author":"Shi","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.redox.2024.103079_bib29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41420-021-00746-z","article-title":"Moderate- intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7\/AMPK\/mTOR axis","volume":"7","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.redox.2024.103079_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1249\/MSS.0000000000002094","article-title":"Endurance exercise attenuates doxorubicin-induced cardiotoxicity","volume":"52","author":"Lee","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"issue":"14","key":"10.1016\/j.redox.2024.103079_bib31","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1161\/CIRCULATIONAHA.121.055841","article-title":"Elevated MCU expression by CaMKII\u03b4B limits pathological cardiac remodeling","volume":"145","author":"Wang","year":"2022","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.redox.2024.103079_bib32","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","article-title":"A simplified, langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart","volume":"119","author":"Ackers-Johnson","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2024.103079_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113403","article-title":"Puerarin activates adaptive autophagy and protects the myocardium against doxorubicin-induced cardiotoxicity via the 14-3-3\u03b3\/PKC\u03b5 pathway","volume":"153","author":"Peng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2024.103079_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cbi.2019.01.032","article-title":"Oxidized phospholipids in Doxorubicin-induced cardiotoxicity","volume":"303","author":"Koleini","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.redox.2024.103079_bib35","article-title":"Salidroside pretreatment alleviates ferroptosis induced by myocardial ischemia\/reperfusion through mitochondrial superoxide-dependent AMPK\u03b12 activation","volume":"126","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.redox.2024.103079_bib36","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.freeradbiomed.2018.03.016","article-title":"The dual role of Reactive Oxygen Species in autoimmune and inflammatory diseases: evidence from preclinical models","volume":"125","author":"Hoffmann","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103079_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.freeradbiomed.2021.02.041","article-title":"Mitochondrial redox and TCA cycle metabolite signaling in the heart","volume":"166","author":"Vujic","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103079_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2021.01.018","article-title":"Coenzyme Q redox signalling and longevity","volume":"164","author":"Scialo","year":"2021","journal-title":"Free Radic. Biol. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724000557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724000557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:40:44Z","timestamp":1761979244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231724000557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":38,"alternative-id":["S2213231724000557"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103079","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPK\u03b12 activation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103079"}}