{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:29:25Z","timestamp":1781627365534,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL071158"],"award-info":[{"award-number":["R01 HL071158"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY015836"],"award-info":[{"award-number":["R01 EY015836"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY001319"],"award-info":[{"award-number":["P30 EY001319"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.redox.2024.103235","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T23:55:17Z","timestamp":1718236517000},"page":"103235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis"],"prefix":"10.1016","volume":"75","author":[{"given":"Kye-Im","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Nehrke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-6156","authenticated-orcid":false,"given":"Krystel R.","family":"Huxlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.redox.2024.103235_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097777","article-title":"Molecular and cellular mechanisms of corneal scarring and advances in therapy","volume":"24","author":"Fuest","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2024.103235_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108272","article-title":"Corneal myofibroblasts and fibrosis","volume":"201","author":"Wilson","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.redox.2024.103235_bib3","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor-beta in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2024.103235_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108594","article-title":"TGF beta -1, -2 and -3 in the modulation of fibrosis in the cornea and other organs","volume":"207","author":"Wilson","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.redox.2024.103235_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1350-9462(98)00021-4","article-title":"Corneal stromal wound healing in refractive surgery: the role of myofibroblasts","volume":"18","author":"Jester","year":"1999","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.redox.2024.103235_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jtos.2023.04.012","article-title":"The corneal fibroblast: the Dr. Jekyll underappreciated overseer of the responses to stromal injury","volume":"29","author":"Wilson","year":"2023","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.redox.2024.103235_bib7","first-page":"2598","article-title":"Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-\u03b2 type II receptor (sTGF\u03b2RII) gene transfer","volume":"18","author":"Sharma","year":"2012","journal-title":"Mol. Vis."},{"issue":"1","key":"10.1016\/j.redox.2024.103235_bib8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.exer.2011.11.018","article-title":"Electrophilic PPAR\u03b3 ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring","volume":"94","author":"Kuriyan","year":"2012","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.redox.2024.103235_bib9","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1167\/iovs.08-2277","article-title":"Optical effects of anti-TGFbeta treatment after photorefractive keratectomy in a cat model","volume":"50","author":"Buhren","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.redox.2024.103235_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00003226-199703000-00010","article-title":"Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF beta in the rabbit","volume":"16","author":"Jester","year":"1997","journal-title":"Cornea"},{"issue":"7","key":"10.1016\/j.redox.2024.103235_bib11","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1076\/ceyr.17.7.736.5163","article-title":"Neutralizing antibody to TGFbeta modulates stromal fibrosis but not regression of photoablative effect following PRK","volume":"17","author":"Moller-Pedersen","year":"1998","journal-title":"Curr. Eye Res."},{"issue":"5","key":"10.1016\/j.redox.2024.103235_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3928\/1081597X-20090422-09","article-title":"Corneal molecular and cellular biology update for the refractive surgeon","volume":"25","author":"Salomao","year":"2009","journal-title":"J. Refract. Surg."},{"issue":"2","key":"10.1016\/j.redox.2024.103235_bib13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1167\/iovs.17-23308","article-title":"Novel combination BMP7 and HGF gene therapy instigates selective myofibroblast apoptosis and reduces corneal haze in vivo","volume":"59","author":"Gupta","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2024.103235_bib14","first-page":"5","article-title":"BRD4 inhibitor JQ1 inhibits and reverses mechanical injury-induced corneal scarring","volume":"4","author":"Qu","year":"2018","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.redox.2024.103235_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070785","article-title":"Topical Rosiglitazone is an effective anti-scarring agent in the cornea","volume":"8","author":"Huxlin","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.redox.2024.103235_bib16","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.ajpath.2014.01.026","article-title":"Inhibitory effects of PPAR\u03b3 ligands on TGF\u03b21-induced corneal myofibroblast transformation","volume":"184","author":"Jeon","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"9271","key":"10.1016\/j.redox.2024.103235_bib17","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/S0140-6736(00)04960-6","article-title":"Lessons from the glitazones: a story of drug development","volume":"357","author":"Gale","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2024.103235_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.624112","article-title":"PPARgamma in metabolism, immunity, and cancer: unified and diverse mechanisms of action","volume":"12","author":"Hernandez-Quiles","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.redox.2024.103235_bib19","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2310\/JIM.0b013e31816464e9","article-title":"The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis","volume":"56","author":"Sime","year":"2008","journal-title":"J. Invest. Med."},{"issue":"14","key":"10.1016\/j.redox.2024.103235_bib20","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1073\/pnas.1303360110","article-title":"Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier","volume":"110","author":"Divakaruni","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.redox.2024.103235_bib21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1167\/iovs.64.13.36","article-title":"Blocking mitochondrial pyruvate transport alters corneal myofibroblast phenotype: a new target for treating fibrosis","volume":"64","author":"Jeon","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6090","key":"10.1016\/j.redox.2024.103235_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.1218099","article-title":"A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans","volume":"337","author":"Bricker","year":"2012","journal-title":"Science"},{"issue":"6090","key":"10.1016\/j.redox.2024.103235_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1218530","article-title":"Identification and functional expression of the mitochondrial pyruvate carrier","volume":"337","author":"Herzig","year":"2012","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.redox.2024.103235_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s42255-018-0002-y","article-title":"Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer","volume":"1","author":"Bader","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.redox.2024.103235_bib25","article-title":"Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease","author":"Habibi","year":"2023","journal-title":"bioRxiv"},{"issue":"11","key":"10.1016\/j.redox.2024.103235_bib26","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s42255-020-00276-5","article-title":"Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy","volume":"2","author":"Fernandez-Caggiano","year":"2020","journal-title":"Nat. Metab."},{"issue":"11","key":"10.1016\/j.redox.2024.103235_bib27","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s42255-020-00296-1","article-title":"Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice","volume":"2","author":"McCommis","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.redox.2024.103235_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52558","article-title":"Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis","volume":"9","author":"Panic","year":"2020","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.redox.2024.103235_bib29","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.celrep.2020.02.042","article-title":"Mitochondrial pyruvate carrier 1 promotes peripheral T cell homeostasis through metabolic regulation of thymic development","volume":"30","author":"Ramstead","year":"2020","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.redox.2024.103235_bib30","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s42255-020-00288-1","article-title":"Mitochondrial pyruvate carriers are required for myocardial stress adaptation","volume":"2","author":"Zhang","year":"2020","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.redox.2024.103235_bib31","doi-asserted-by":"crossref","first-page":"E33","DOI":"10.1152\/ajpendo.00074.2022","article-title":"The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism","volume":"323","author":"Yiew","year":"2022","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.redox.2024.103235_bib32","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.celrep.2018.04.104","article-title":"Accumulation of succinate in cardiac ischemia primarily occurs via canonical Krebs cycle activity","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.redox.2024.103235_bib33","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nprot.2011.319","article-title":"Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst","volume":"6","author":"Xia","year":"2011","journal-title":"Nat. Protoc."},{"issue":"697","key":"10.1016\/j.redox.2024.103235_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aay1027","article-title":"Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis","volume":"14","author":"Selvarajah","year":"2021","journal-title":"Sci. Signal."},{"issue":"4","key":"10.1016\/j.redox.2024.103235_bib35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1165\/rcmb.2019-0051OC","article-title":"Inhibition of glutaminase 1 attenuates experimental pulmonary fibrosis","volume":"61","author":"Cui","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.redox.2024.103235_bib36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1165\/rcmb.2017-0238OC","article-title":"Glutaminolysis promotes collagen translation and stability via alpha-Ketoglutarate-mediated mTOR activation and proline hydroxylation","volume":"58","author":"Ge","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.redox.2024.103235_bib37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1165\/rcmb.2019-0008OC","article-title":"Glutamine metabolism is required for collagen protein synthesis in lung fibroblasts","volume":"61","author":"Hamanaka","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"12","key":"10.1016\/j.redox.2024.103235_bib38","doi-asserted-by":"crossref","first-page":"E773","DOI":"10.1002\/lary.28493","article-title":"Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis","volume":"130","author":"Tsai","year":"2020","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.redox.2024.103235_bib39","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1089\/ars.2013.5724","article-title":"Myofibroblast differentiation: main features, biomedical relevance, and the role of reactive oxygen species","volume":"21","author":"Siani","year":"2014","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.redox.2024.103235_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/ars.2017.7273","article-title":"Reactive oxygen species and mitochondrial homeostasis as regulators of stem cell fate and function","volume":"29","author":"Tan","year":"2018","journal-title":"Antioxidants Redox Signal."},{"issue":"5930","key":"10.1016\/j.redox.2024.103235_bib41","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.1164097","article-title":"ATP-citrate lyase links cellular metabolism to histone acetylation","volume":"324","author":"Wellen","year":"2009","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.redox.2024.103235_bib42","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nrm3841","article-title":"The growing landscape of lysine acetylation links metabolism and cell signalling","volume":"15","author":"Choudhary","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2024.103235_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105910","article-title":"Epigenetic regulation in fibrosis progress","volume":"173","author":"Xue","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.redox.2024.103235_bib44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jcp.22110","article-title":"TGFbeta mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylation","volume":"224","author":"Zhou","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2024.103235_bib45","first-page":"2556","article-title":"Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells","volume":"14","author":"Zhou","year":"2008","journal-title":"Mol. Vis."},{"issue":"6","key":"10.1016\/j.redox.2024.103235_bib46","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1167\/iovs.08-2919","article-title":"Trichostatin a inhibits corneal haze in vitro and in vivo","volume":"50","author":"Sharma","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.redox.2024.103235_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCRESAHA.120.316958","article-title":"Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation","volume":"127","author":"Gibb","year":"2020","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.redox.2024.103235_bib48","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103334","article-title":"Proline biosynthesis is a vent for TGFbeta-induced mitochondrial redox stress","volume":"39","author":"Schworer","year":"2020","journal-title":"EMBO J."},{"issue":"14","key":"10.1016\/j.redox.2024.103235_bib49","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1007\/s00018-013-1539-2","article-title":"Regulation of pyruvate metabolism and human disease","volume":"71","author":"Gray","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.redox.2024.103235_bib50","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","article-title":"Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport","volume":"56","author":"Yang","year":"2014","journal-title":"Mol. Cell"},{"issue":"50","key":"10.1016\/j.redox.2024.103235_bib51","doi-asserted-by":"crossref","first-page":"36129","DOI":"10.1074\/jbc.M113.507285","article-title":"Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina","volume":"288","author":"Du","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2024.103235_bib52","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41467-023-38437-1","article-title":"Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis","volume":"14","author":"Conroy","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.redox.2024.103235_bib53","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tcb.2020.09.010","article-title":"Metabolic coordination of cell fate by alpha-ketoglutarate-dependent dioxygenases","volume":"31","author":"Baksh","year":"2021","journal-title":"Trends Cell Biol."},{"issue":"12","key":"10.1016\/j.redox.2024.103235_bib54","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00726-021-02968-y","article-title":"Collagen metabolism as a regulator of proline dehydrogenase\/proline oxidase-dependent apoptosis\/autophagy","volume":"53","author":"Palka","year":"2021","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.redox.2024.103235_bib55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jhep.2019.10.023","article-title":"Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase IIb study","volume":"72","author":"Harrison","year":"2020","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.redox.2024.103235_bib57","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1158\/2159-8290.CD-13-0572","article-title":"A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor","volume":"4","author":"Elhammali","year":"2014","journal-title":"Cancer Discov."},{"issue":"49","key":"10.1016\/j.redox.2024.103235_bib58","doi-asserted-by":"crossref","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis","volume":"104","author":"DeBerardinis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"49","key":"10.1016\/j.redox.2024.103235_bib59","doi-asserted-by":"crossref","first-page":"19611","DOI":"10.1073\/pnas.1117773108","article-title":"Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability","volume":"108","author":"Wise","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.redox.2024.103235_bib60","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949634","article-title":"Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling","volume":"21","author":"Veliova","year":"2020","journal-title":"EMBO Rep."},{"issue":"4","key":"10.1016\/j.redox.2024.103235_bib61","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.exer.2004.12.023","article-title":"Cellular and molecular events in corneal wound healing: significance of lipid signalling","volume":"80","author":"Bazan","year":"2005","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.redox.2024.103235_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0039-6257(91)90205-T","article-title":"The cornea and disorders of lipid metabolism","volume":"36","author":"Barchiesi","year":"1991","journal-title":"Surv. Ophthalmol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T15:43:24Z","timestamp":1724082204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231724002131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":61,"alternative-id":["S2213231724002131"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103235","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103235","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103235"}}